The hepatic stellate (Ito) cell: Its role in human liver disease

Virchows Archiv

Volumn 430, Issue 3, 1997, Pages 195-207

  Hautekeete, Marc L ^a   Geerts, Albert ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Fat storing cell; Fibrosis; Hepatic stellate cell; Ito cell; Lipocyte

Indexed keywords

ALPHA ACTIN; CYTOKINE; DESMIN; FAT DROPLET; ICOSANOID; REACTIVE OXYGEN METABOLITE; RETINOL;

CELL COMMUNICATION; CELL DIFFERENTIATION; HUMAN; HUMAN CELL; INFLAMMATORY CELL; ITO CELL; KUPFFER CELL; LIPID STORAGE; LIVER CELL; LIVER DISEASE; LIVER INJURY; MYOFIBROBLAST; PRIORITY JOURNAL; REVIEW; STELLATE CELL; THROMBOCYTE;

ACUTE DISEASE; CHRONIC DISEASE; HUMANS; HYPERVITAMINOSIS A; LIVER; LIVER DISEASES; LIVER NEOPLASMS;

EID: 0030948502     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01324802     Document Type: Review

References (125)

1. Ahmed Q, Hines JE, Harrison D, Burt AD (1991) Expression of muscle-associated cytoskeletal proteins by human sinusoidal liver cells. In: Wisse E, Knook DL, McCuskey RS (eds) Cells of the hepatic sinusoid, vol 4. The Kupffer Cell Foundation, Leiden, pp 203-206
2. Arthur MJP (1994) Matrix degradation in the liver. In: Surrenti C, Casini A, Milani S, Pinzani M (eds) Fat-storing cells and liver fibrosis. Kluwer, Dordrecht, pp 110-127
3. Arthur MJP, Stanley A, Iredale JP, Rafferty JA, Hembry RM, Friedman SL (1992) Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes: analysis of gene expression, protein synthesis and proteinase activity. Biochem J 287:701-707
4. Aterman K (1986) The parasinusoidal cells of the liver: a historical account. Histochem J 18:279-305
5. Bachem MG, Riess U, Melchior R, Sell KM, Gressner AM (1989) Transforming growth factors (TGF α and TGF β1) stimulate chondroitin sulfate and hyaluronate synthesis in cultured rat liver fat-storing cells. FEBS Lett 257:134-137
6. Bachem MG, Meyer D, Riess U, Melchior R, Sell KM, Bittinger A (1991) Paracrine stimulation of fat-storing cells via soluble mediators produced by myofibroblast-like cells. In: Wisse E, Knook D (eds) Cells of the hepatic sinusoid, vol 3. The Kupffer Cell Foundation, Leiden, pp 164-170
7. Ballardini G, Gruff P, DeGiorgi LB, Schuppan D, Bianchi FB (1994) Ito cell heterogeneity: desmin-negative Ito cells in normal rat liver. Hepatology 19:440-446
8. Bathal PS (1972) Presence of modified fibroblasts in cirrhotic livers in man. Pathology 4:139-144
9. Bedossa P, Peltier E, Terris B, Franco D, Poynard T (1995) Transforming growth factor-beta 1 (TGF-β1) and TGF-β1 receptors in normal, cirrhotic, and neoplastic human livers. Hepatology 21:760-766
10. Bhunchet E, Wake K (1992) Role of mesenchymal cell populations in porcine serum-induced rat liver fibrosis. Hepatology 16:1452-1473
11. Bioulac-Sage P, Lafon ME, LeBail B, Balabaud C (1988) Perisinusoidal and pit cells in liver sinusoids. In: Bioulac-Sage P, Balabuud C (eds) Sinusoids in human liver: health and disease. Kupffer Cell Foundation, Leiden, pp 39-62
12. Bioulac-Sage P, Lafon ME, LeBail B, Boulard A, Dubuisson L, Quinton A, Lamouliatte H, Saric J, Balabaud C (1988) Ultrastructure of sinusoids in liver disease. In: Bioulac-Sage P, Balabuud C (eds) Sinusoids in human liver: health and disease. Kupffer Cell Foundation, Leiden, pp 223-278
13. Bronfenmajer S, Schaffner F, Popper H (1966) Fat-storing cells (lipocytes) in human liver. Arch Pathol Lab Med 82:447-453
14. Buniatian G, Gebhardt R, Schrenk D, Hamprecht B (1996) Colocalization of three types of intermediate filament proteins in perisinusoidal stellate cells: glial fibrillary acidic protein as a new cellular marker. Eur J Cell Biol 70:23-32
15. Burt AD (1993) Cellular and molecular aspects of hepatic fibrosis. J Pathol 170:105-114
16. Callea F, Mebis J, Desmet VJ (1982) Myofibroblasts in focal nodular hyperplasia of the liver. Virchows Arch [A] 396: 155-166
17. Casini A, Cunninghum M, Rojkind M, Lieber CS (1991) Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism. Hepatology 13: 758-765
18. Casini A, Pinzani M, Milani S, Grappone C, Galli G, Jezequel AM, Schuppan D, Rotella CM, Surrenti C (1993) Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells. Gastroenterology 105:245-253
19. Casini A, Galli G, Salzano R, Rotella CM, Surrenti C (1993) Acetaldehyde-protein adducts, but not lactate and pyruvate, stimulate gene transcription of collagen and fibronectin in hepatic fat-storing cells. J Hepatol 19:385-392
20. Casini A, Ceni E, Salzano R, Schuppan D, Milani S, Pellegrini G, Surrenti C (1994) Regulation of undulin synthesis and gene expression in human fat-storing cells by acetaldehyde and transforming growth factor-β1: comparison with fibronectin. Biochem Biophys Res Commun 199:1019-1026
21. Davis BH (1988) Transforming growth factor beta responsiveness is modulated by the extracellular collagen matrix during hepatic Ito cell culture. J Cell Physiol 136:547-553
22. Davis BH, Coll D, Beno DW (1993) Retinoic acid suppresses the response to platelet-derived growth factor in human hepatic Ito-cell-like myofibroblasts: a post-receptor mechanism independent of raf/fos/jun/egr activation. Biochem J 294:785-791
23. 4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-β in cocultures with sinusoidal endothelial cells. Hepatology 21:1429-1437
24. DeLeeuw A, McCarthy S, Geerts A, Knook D (1984) Purified rat liver fat-storing cells in culture divide and contain collagen. Hepatology 4:392-403
25. Dennis P, Rifkin D (1991) Cellular activation of latent TGF-β requires binding to the cation-independent mannose-6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci USA 88:580-584
26. Desmoulière A, Tuchweber B, Gabbiani G (1995) Role of the myofibroblast differentiation during liver fibrosis. J Hepatol [Suppl 2] 22:61-64
27. Dupon M, Kosaifi T, LeBail B, Lacut Y, Balabaud C, Bioulac-Sage P (1991) Lipid-laden perisinusoidal cells in patients with acquired immunodeficiency syndrome. Liver 11:211-219
28. Enzan H, Himeno H, Iwamura S, Saibara T, Onishi S, Yamamoto Y, Hara H (1994) Immunohistochemical identification of Ito cells and their myofibroblastic transformation in adult human liver. Virchows Arch 424:249-256
29. Enzan H, Himeno H, Iwamura S, Onishi S, Saibara T, Yamamoto Y, Hara H (1994) α-smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma. Hepatology 19:895-903
30. Fausto N, Mead JE (1989) Regulation of liver growth: protooncogenes and transforming growth factors. Lab Invest 60:4-13
31. Friedman S (1992) The molecular basis for Kupffer cell/lipocyte interactions. In: Gressner A, Ramadori G (eds) Molecular and cell biology of molecular fibrogenesis. Kluwer, Dordrecht, pp 385-392
32. Friedinan SL (1993) The cellular basis of hepatic fibrosis: mechanisms and treatment strategies. N Engl J Med 328: 1828-1835
33. Friedman SL, Arthur MJ (1989) Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium: direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Invest 84:1780-1785
34. Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G (1992) Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture. Hepatology 15:234-243
35. Gampieri MP, Jezequel AM, Orlandi F (1981) The lipocytes in normal human liver: a quantitave study. Digestion 22:165-169
36. Gard L, White F, Dutton G (1985) Extra-neural glial fibrillary acidic protein (GFAP) immunoreactivity in perisinusoidal stellate cells of rat liver. J Neuroimmunol 8:359-375
37. Geerts A, Vrijsen R, Rauterberg J, Burt A, Schellinck P, Wisse E (1989) In vitro transition of fat-storing cells to myofibroblast-like cells parallels marked increase of collagen synthesis and secretion. J Hepatol 9:59-68
38. Geerts A, Lazou JM, DeBleser P, Wisse E (1991) Tissue distribution, quantitation and proliferation kinetics of fat-storing cells in carbon tetrachloride-injured rat liver. Hepatology 13:1193-1202
39. Geerts A, DeBleser P, Hautekeete ML, Niki T, Wisse E (1994) Fat-storing (Ito) cell biology. In: Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter DA, Schaffritz DA (eds) The liver: biology and pathobiology, 3rd edn. Raven Press. New York, pp 819-838
40. Geubel AP, DeGalocsy C, Alves N, Rahier J, Dive C (1991) Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases. Gastroenterology 100:1701-1709
41. Gressner AM (1994) Perisinusoidal lipocytes and fibrogenesis. Gut 35:1331-1333
42. Gressner AM (1995) Cytokines and cellular crosstalk involved in the activation of fat-storing cells. J Hepatol [Suppl 2] 22:28-36
43. Gressner A, Zerbe O (1987) Kupffer cell-mediated induction of synthesis and secretion of proteoglycans by rat liver fat-storing cells in culture. J Hepatol 5:299-310
44. Gressner AM, Althaus M (1988) Effects of ethanol, acetaldehyde, and lactate on proteoglycan synthesis and proliferation of cultured rat liver fat-storing cells. Gastroenterology 94:797-807
45. Gressner A, Lofti S, Gressner G, Lahme B (1992) Identification and partial characterization of a hepatocyte-derived factor promoting proliferation of cultured fat-storing cells (parasinusoidal lipocytes). Hepatology 16:1250-1266
46. Gressner A, Brenzel A, Voszmeyer T (1993) Hepatocyte-conditioned medium potentiates insulin-like growth factor (IGF) 1 and 2 stimulates DNA synthesis of cultured fat-storing cells. Liver 13:86-94
47. Guarascio P, Portmann B, Visco G, Williams R (1983) Liver damage with reversible portal hypertension from vitamin A intoxication: demonstration of Ito cells. J Clin Pathol 36:769-771
48. Hautekeete ML, Geerts A, Seynaeve C, Lazou JM, Klöppel G. Wisse E (1993) The human fat-storing cell studied using light and transmission electron microscopy. In: Knook DL, Wisse H (eds) Cells of the hepatic sinusoid, vol 4. The Kupffer Cell Foundation, Leiden, pp 263-267
49. Hautekeete ML, Niki T, Van den Berg K, Delvaux G, Geerts A (1996) A fraction of stellate cells in human liver express glial fibrillary acidic protein (GFAP). J Hepatol [Suppl 1] 25:112
50. Hendriks HFJ, Brekelmans PJAM, Buytenhek R, Brouwer A, DeLeeuw AM, Knook DL (1987) Liver parenchymal cells differ from the fat-storing cells in their lipid composition. Lipids 22:266-273
51. Hendriks HFJ, Bosma A, Brouwer A (1993) Fat-storing cells: hyper- and hypovitaminosis A and the relationships with liver fibrosis. Semin Liver Dis 13:72-79
52. Hines JE, Johnson SJ, Burt AD (1993) In vivo responses of macrophages and perisinusoidal cells to cholestatic liver injury. Am J Pathol 142:511-518
53. Hopwood D, Nyfors A (1976) Effect of methotrexate therapy in psoriatics on the Ito cells in liver biopsies, assessed by point-counting. J Clin Pathol 29:689-703
54. Horn T, Lyon H, Christoffersen P (1986) The blood-hepatocyte barrier: a light microscopical, transmission- and scanning electron microscopic study. Liver 6:233-245
55. Horn T, Junge J, Christoffersen P (1986) Early alcoholic liver injury: activation of lipocytes in acinar zone 3 and correlation to degree of collagen formation in the Disse space. J Hepatol 3:333-340
56. Horn T, Junge J, Nielsen O, Christoffersen P (1988) Light microscopical demonstration and zonal distribution of parasinusoidal cells (Ito cells) in normal human liver. Virchows Arch [A] 413:147-149
57. Horvath E, Kovacs K, Ross RC (1973) Liver ultrastructure in methotrexate treatment of psoriasis. Arch Dermatol 108:427-428
58. Housset C, Rockey DC, Bissel DM (1993) Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin-1. Proc Natl Acad Sci USA 90:9266-9270
59. Hruban Z, Russell RM, Boyer JL, Glagov S, Bagheri SA (1974) Ultrastructural changes in livers of two patients with hypervitaminosis A. Am J Pathol 76:451-461
60. Inuzuka S, Ueno T, Torimura T, Sata M, Abe H, Tanikawa K (1990) Immunohistochemistry of the hepatic extracellular matrix in acute viral hepatitis. Hepatology 12:249-256
61. Iredale JP, Murphy G, Hembry RM, Friedman SL, Arthur MJP (1992) Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1: implications for regulation of matrix degradation in liver. J Clin Invest 90:282-287
62. Ito T, Nemoto M (1952) †ber die Kupfferschen Sternzellen und die "Fettspeicherungszellen" ("fat-storing cells") in der Blutkapillarenwand der menschlichen Leber. Okajimas Folia Anat Jpn 24:243-258
63. Jacques FA, Buschmann RJ, Layden TJ (1979) The histopathologic progression of vitamin-A induced hepatic injury. Gastroenterology 76:599-602
64. Johnson SJ, Hines JF, Burt AD (1992) Macrophage and perisinusoidal cell kinetics in acute liver injury. J Pathol 166:351-358
65. Jorens PG, Michielsen PA, Pelekmans PA, Fevery J, Desmet VJ, Geubel AP, Rahier J, Van Maercke YM (1992) Vitamin A abuse: development of cirrhosis despite cessation of vitamin A: a six-year clinical and histopathologic follow-up. Liver 12:381-386
66. Knittel T, Aurisch S, Neubauer K, Eichhorst S, Ramadori G (1996) Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of ral liver: upregulation durum in vitro activation and in hepatic tissue repair. J Hepatol [Suppl 1] 25:113
67. Kobayashi Y, Fujiyama S (1981) Pathological study on gold impregnation of fat-storing cells in human liver. Acta Pathol Jpn 31:65-74
68. Latry P, Bioulac-Sage P, Echinard E, Gin H, Boussarie L, Grimaud JA, Balabaud C (1987) Perisinusoidal fibrosis is and basement membrane-like material in liver of diabetic patients. Hum Pathol 18:755-760
69. LeBail B, Bioulac-Sage P, Senuita R, Quinton A, Saric J, Balabaud C (1990) Fine structure of hepatic sinusoids and sinusoidal cells in disease. J Electron Microsc Tech 14:257-282
70. Leo MA, Lieber CS (1982) Hepatic vitamin A depletion in alcoholic liver injury. N Engl J Med 307:597-601
71. Leo MA, Sato M, Lieber CS (1983) Effect of hepatic vitamin A depletion on the liver in humans and rats. Gastroenterology 84:562-572
72. Maher J (1989) Fat-storing cells and other myofibroblasts: one cell or two? Hepatology 9:903-904
73. Malizia G, Brunt EM, Peters MG, Rizzo A, Broekelmann TJ, McDonald JA (1995) Growth factor and procollagen type I gene expression in human liver disease. Gastroenterology 108:145-156
74. Mallat A, Preaux AM, Blazejewski S, Rosenbaum J, Dhumeaux D, Mavier P (1995) Interferon alfa and gamma inhibit proliferation and collagen synthesis of human Ito cells in culture. Hepatology 21:1003-1010
75. Marra F, Valente AJ, Pinzani M, Abboud HE (1993) Cultured human liver fat-storing cells produce monocyte chemotactic protein-1: regulation by proinflammatory cytokines. J Clin Invest 92:1674-1680
76. Marra F, Choudhury GG, Pinzani M, Abboud HE (1994) Regulation of platelet-derived growth factor secretion and gene expression in human liver fat-storing cells. Gastroenterology 107:1110-1117
77. Marra F, Grandaliano G, Valente AJ, Abboud HE (1995) Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: potential role in liver injury. Hepatology 22:780-787
78. Mathew J, Hines JE, James OFW, Burt AD (1994) Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. J Hepatol 20:537-541
79. Matsuoka M, Tsukamoto H (1990) Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor β: implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology 11:599-605
80. Matsuoka M, Pham N, Tsukamoto H (1989) Different effects of interleukin-l α, tumour necrosis factor α, and transforming growth factor β 1 on cell proliferation and collagen formation by cultured fat-storing cells. Liver 9:71-78
81. Meyer DH, Bachem MG, Gressner AM (1990) Transformed fat storing cells inhibit the proliferation of cultured hepatocytes by secretion of transforming growth factor beta. J Hepatol 11:86-91
82. Meyer DH, Bachem M, Gressner A (1991) Bidirectional effects of Kupffer cells on hepatocyte proliferation in vitro. FEBS Lett 283:150-154
83. Milani S, Herbst H, Schuppan D, Grappone C, Pellegrini G, Pinzani M, Casini A, Calabró A, Ciancio G, Stefanini F, Burroughs AK, Surrenti C (1994) Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol 144:528-537
84. Minato Y, Hasumura Y, Tackeuchi J (1983) The role of fatstoring cells in Disse space fibrogenesis in alcoholic liver disease. Hepatology 3: 559-566
85. Moshage H, Casini A, Lieber CS (1990) Acetaldehyde selectively stimulates collagen production in cultured rat liver fat-storing cells but not in hepatocytes. Hepatology 12:511-518
86. Nakano M, Worner TM, Lieber CS (1982) Perivenular fibrosis in alcoholic liver injury: ultrastructure and histologic progression. Gastroenterology 83:777-785
87. Nakatani K, Seki S, Kawada N, Sakaguchi H, Kawakita N, Yanai A, Kitada T, Sakai Y, Yamada T, Masuichi H, Kuroki T, Kobayashi K, Kaneda K (1995) Expression of neural cell adhesion molecule (N-CAM) on the stellate cells of human liver. In: Wisse E, Knook DL, Wake K (eds) Cells of the hepatic sinusoid, vol 5. The Kupffer Cell Foundation, Leiden, pp 267-269
88. Neubauer K, Knittel T, Aurisch S, Fellmer P, Ramadori G (1996) Glial fibrillary acidic protein - a cell type specific marker for Ito cells in vivo and in vitro. J Hepatol 24: 719-730
89. 4-induced fibrotic rat livers. Hepatology 23:1538-1545
90. Nouchi T, Tanaka Y, Tsukada T, Sato C, Marumo F (1991) Appearance of α-smooth-muscle-actin-positive cells in hepatic fibrosis. Liver 11:100-105
91. Nyberg A, Berne B, Nordlinger H, Busch C, Eriksson U, Lööf L, Vahlquist A (1988) Impaired release of vitamin A from liver in primary biliary cirrhosis. Hepatology 8:136-141
92. Ogawa K, Suzuki J, Mukai H, Mori M (1986) Sequential changes of extracellular matrix and proliferation of Ito cells with enhanced expression of desmin and actin in focal hepatic injury. Am J Pathol 125:611-619
93. Okanoue T, Burbige EJ, French SW (1983) The role of the Ito cell in perivenular and intralobular fibrosis in alcoholic hepatitis. Arch Pathol Lab Med 107: 459-463
94. Parola M, Pinzani M, Casini A, Albano E, Poli G, Gentilini A, Gentilini P, Dianzani MU (1993) Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen-alpha 1 (I) gene expression in human liver fat-storing cells. Biochem Biophys Res Commun 194:1044-1050
95. Pinzani M (1995) Hepatic stellate (Ito) cells: expanding roles for a liver-specific pericyte. J Hepatol 22:700-706
96. Pinzani M, Failli P, Ruocco C, Casini A, Milani S, Baldi E, Giotti A, Gentilini P (1992) Fat-storing cells as liver-specific pericytes. J Clin Invest 90:642-646
97. Pinzani M, Gentilini A, Caligiuri A, DeFranco R, Pellegrini G, Milani S, Marra F, Gentilini P (1995) Transforming growth factor-β1 regulates platelet-derived receptor β subunit in human liver fat-storing cells. Hepatology 21:232-239
98. Pinzani M, Milani S, DeFranco R, Grappone C, Caligiuri A, Gentilini A, Tosti-Guerra C, Maggi M, Failli P, Ruocco C, Gentilini P (1996) Endothelin-1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 110:534-548
99. Ramadori G (1991) The stellate cell (Ito cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. Virchows Arch [B] 61:147-158
100. Reid LM, Fiorino AS, Sigal SH, Brill S, Hoist PA (1992) Extracellular matrix gradients in the space of Disse: relevance to liver biology. Hepatology 15:1198-1203
101. Rieder H, Meyer Zum Buschenfelde K, Ramadori G (1992) Functional spectrum of sinusoidal endothelial liver cells. J Hepatol 15:237-250
102. Rockey D, Maher J, Jarnagin W, Gabbiani G, Friedman S (1992) Inhibition of rat hepatic lipocyte activation in culture by interteron-γ. Hepatology 16:776-784
103. Rockey DC, Housset CN, Friedman SL (1993) Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. J Clin Invest 92:1795-1804
104. Ross R, Raines EW, Bowen-Pope DF (1986) The biology of platelet-derived growth factor. Cell 46:155-169
105. Rudolph R, McClure WJ, Woodward M (1979) Contractile fibroblasts in chronic alcoholic cirrhosis. Gastroenterology 76:704-709
106. Russel RM, Boyer JL, Bagheri SA, Hruban Z (1974) Hepatic injury from chronic hypervitaminosis A resulting in portal hypertension and ascites. N Engl J Med 291:435-440
107. Sakamoto M, Ueno T, Kin M, Ohira H, Torimura T, Inuzuka S, Sata M, Tanikawa K (1993) Ito cell contraction in response to endothelin-1 and substance P. Hepatology 18:978-983
108. Schmitt-Gräff A, Krüger S, Bochard F, Gabbiani G, Denk H (1991) Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am J Pathol 138:1233-1242
109. Schmitt-Gräff A, Chakroun G, Gabbiani G (1993) Modulation of perisinusoidal and cytoskeletal features during experimental hepatic fibrosis. Virchows Arch [A] 422:99-107
110. 4-induced fibrotic livers stimulate proliferation of fat-storing cells. J Hepatol 3:294-303
111. Stroebel P, Mayer F, Zerban H, Bannasch P (1995) Spongiotic pericytoma: a benign neoplasm deriving from the perisinusoidal (Ito) cells in rat liver. Am J Pathol 146:903-913
112. Sztark F, Dubroca J, Latry P, Quinton A, Balabaud C, Bioulac-Sage P (1986) Perisinusoidal cells in patients with normal liver histology: a morphometric study. J Hepatol 2:358-369
113. Takase S, Leo M, Nouchi T, Lieber C (1988) Desmin distinguishes cultured fat-storing cells from myofibroblasts, smooth muscle cells and fibroblasts in the rat. J Hepatol 6:267-276
114. Tiggelman AMBC, Boers W, Linthorst C, Brand HS, Sala M, Chamuleau RAFM (1995) Interleukin-6 production by human liver (myo)fibroblasts in culture: evidence for a regulatory role of LPS, IL-1β and TNF α. J Hepatol 23:295-306
115. Tiggelman AMBC, Boers W, Linthorst C, Sala M, Chamuleau RAFM (1995) Collagen synthesis by human liver (myo)fibroblasts in culture: evidence for a regulatory role of IL-1β, IL-4, TGF-β and IFN gamma. J Hepatol 23:307-317
116. Tozuka S, Hasumura Y, Takeuchi J (1985) Histochemical characteristics of fat-storing cells in alcoholic liver disease: a study by the gold chloride method using needle biopsy of the liver. Am J Clin Pathol 83:47-52
117. Trinchieri G, Perussia B (1985) Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol Today 6:131-136
118. Von Kupffer C (1876) †ber Sternzellen der Leber. Briefliche Mittheilung an Professor Waldeyer. Arch Mikr Anat 12:353-358
119. Wake K (1971) "Sternzellen" in the liver: perisinusoidal cells with special reference to storage of vitamin A. Am J Anat 132:429-462
120. Wake K, Kishiye T, Yamamoto H, Bhunchet E, Sakamoto Y, Sato T (1993) Kupffer cells modulate the configuration of perisinusoidal stellate cells. In: Knook DL, Wisse E (eds) Cells of the hepatic sinusoid, vol 4. The Kupffer Cell Foundation, Leiden, pp 157-160
121. Weiner F, Giambrone M, Czaja M, Shah A, Annoni G, Takahashi S, Eghbali M, Zern M (1990) Ito-cell gene expression and collagen regulation. Hepatology 11:111-117
122. Yamaoka K, Nouchi T, Marumo F, Sato C (1993) α-Smooth-muscle actin expression in normal and fibrotic human livers. Dig Dis Sci 38:1473-1479
123. Yokoi Y, Namihisa T, Kuroda H, Komatsu I, Miyazaki A, Watanabe S, Usui K (1984) Immunocytochemical detection of desmin in fat-storing cells (Ito cells). Hepatology 4:709-714
124. Zafrani ES, Bernuau D, Feldmann G (1984) Peliosis-like ultrastructural changes of the hepatic sinusoids in human chronic hypervitaminosis A: report of three cases. Hum Pathol 15:1166-1170
125. Zajicek G, Ariel I, Arber N (1988) The streaming liver III: littoral cells accompany the streaming hepatocyte. Liver 8:213-218