Anti-adhesion methods as novel therapeutics for bacterial infections

Expert Review of Anti-Infective Therapy

Volumn 10, Issue 12, 2012, Pages 1457-1468

  Cozens, Daniel ^a   Read, Robert C ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

adhesins; anti adhesion therapy; antibiotic resistance; bacterial adherence

Indexed keywords

2 METHACRYLOYLOXYETHYLPHOSPHORYLCHOLINE; 2 PYRIDONE DERIVATIVE; 3' SIALYLLACTOSE; 6' SIALYLNEOLACTOTETRAOSE; ADHESIN; ADHESIN DERIVATIVE; ANTIBIOTIC AGENT; BACTERIAL VACCINE; CARBOHYDRATE DERIVATIVE; COILICIDE; CRANBERRY EXTRACT; CURCUMA LONGA EXTRACT; FUCOSYL OLIGOSACCHARIDE; GREEN TEA EXTRACT; GUARANA EXTRACT; GUAVA EXTRACT; LACTOFERRIN; METHYL ALPHA DEXTRO GALACTOSIDE; METHYL ALPHA DEXTRO MANNOPYROSIDE; METHYL ALPHA LEVO FUCOSIDE; MOUTHWASH; N ACETYLGALACTOSAMINYLTRANSFERASE; OXACILLIN; PILICIDE; PROBIOTIC AGENT; RIFAMPICIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VITIS VINIFERA EXTRACT; XYLOOLIGOSACCHARIDE;

ANTIBIOTIC RESISTANCE; BACTERIAL INFECTION; BACTERIUM ADHERENCE; BACTERIUM PILUS; BIFIDOBACTERIUM; CAMPYLOBACTER JEJUNI; CHEMICAL INTERACTION; CLINICAL TRIAL (TOPIC); DENTAL CARIES; DIET SUPPLEMENTATION; DRUG TARGETING; ESCHERICHIA COLI; HELICOBACTER PYLORI; HOST CELL; HUMAN; HYDROPHOBICITY; INHIBITION KINETICS; LACTOBACILLUS ACIDOPHILUS; LACTOBACILLUS PLANTARUM; LACTOBACILLUS RHAMNOSUS; LISTERIA MONOCYTOGENES; META ANALYSIS (TOPIC); MINIMUM INHIBITORY CONCENTRATION; MOUTH INFECTION; NEISSERIA MENINGITIDIS; NONHUMAN; PROTEIN INTERACTION; PSEUDOMONAS AERUGINOSA; REVIEW; STREPTOCOCCUS GORDONII; STREPTOCOCCUS MUTANS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS THERMOPHILUS; URINARY TRACT INFECTION; UROPATHOGENIC ESCHERICHIA COLI; VAGINITIS; YERSINIA PESTIS;

ADHESINS, BACTERIAL; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL ADHESION; BACTERIAL INFECTIONS; BACTERIAL VACCINES; DRUG RESISTANCE, BACTERIAL; HUMANS; OLIGOSACCHARIDES; PROBIOTICS;

EID: 84871420688     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/eri.12.145     Document Type: Review

References (106)

1. Beachey EH. Bacterial adherence: Adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. J. Infect. Dis. 143(3), 325-345 (1981). (Pubitemid 11113653)
2. Ofek I, Hasty DL, Doyle RJ. Bacterial Adhesion to Animal Cells and Tissues. American Society for Microbiology, DC, USA (2003).
3. Ofek I, Hasty DL, Sharon N. Anti-adhesion therapy of bacterial diseases: Prospects and problems. FEMS Immunol. Med. Microbiol. 38(3), 181-191 (2003). (Pubitemid 37289742)
4. Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J. Clin. Invest. 109(5), 571-577 (2002). (Pubitemid 34204834)
5. Busscher HJ, Weerkamp AH. Specific and nonspecific interactions in bacterial adhesion to solid substrata. FEMS Microbiol. Rev. 46(2), 165-173 (1987).
6. Miörner H, Johansson G, Kronvall G. Lipoteichoic acid is the major cell wall component responsible for surface hydrophobicity of group A streptococci. Infect. Immun. 39(1), 336-343 (1983). (Pubitemid 13212534)
7. Doyle RJ. Contribution of the hydrophobic effect to microbial infection. Microbes Infect. 2(4), 391-400 (2000). (Pubitemid 30241041)
8. Sokurenko EV, Chesnokova V, Doyle RJ, Hasty DL. Diversity of the Escherichia coli type 1 fimbrial lectin. Differential binding to mannosides and uroepithelial cells. J. Biol. Chem. 272(28), 17880-17886 (1997). (Pubitemid 27311232)
9. Roberts JA, Marklund BI, Ilver D et al. The Gal(α 1-4)Gal-specific tip adhesin of Escherichia coli P-fimbriae is needed for pyelonephritis to occur in the normal urinary tract. Proc. Natl Acad. Sci. USA 91(25), 11889-11893 (1994). (Pubitemid 24368569)
10. Cywes C, Stamenkovic I, Wessels MR. CD44 as a receptor for colonization of the pharynx by group A Streptococcus. J. Clin. Invest. 106(8), 995-1002 (2000).
11. Sharon N. Bacterial lectins, cellYcell recognition and infectious disease. FEBS Lett. 217(2), 145-157 (1987). (Pubitemid 17086739)
12. Virji M. Meningococcal disease: Epidemiology and pathogenesis. Trends Microbiol. 4(12), 466-469; discussion 469 (1996).
13. de Vries FP, Cole R, Dankert J, Frosch M, van Putten JP. Neisseria meningitidis producing the Opc adhesin binds epithelial cell proteoglycan receptors. Mol. Microbiol. 27(6), 1203-1212 (1998). (Pubitemid 28137972)
14. Sa E Cunha C, Griffiths NJ, Murillo I, Virji M. Neisseria meningitidis Opc invasin binds to the cytoskeletal protein α-actinin. Cell. Microbiol. 11(3), 389-405 (2009).
15. Holmes AR, McNab R, Millsap KW et al. The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence. Mol. Microbiol. 41(6), 1395-1408 (2001). (Pubitemid 32939510)
16. Bergmann S, Rohde M, Chhatwal GS, Hammerschmidt S. α-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface. Mol. Microbiol. 40(6), 1273-1287 (2001). (Pubitemid 32635298)
17. Cundell DR, Gerard NP, Gerard C, Idanpaan-Heikkila I, Tuomanen EI. Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature 377(6548), 435-438 (1995).
18. Sharon N. Carbohydrates as future anti-adhesion drugs for infectious diseases. Biochim. Biophys. Acta 1760(4), 527-537 (2006).
19. Aronson M, Medalia O, Schori L, Mirelman D, Sharon N, Ofek I. Prevention of colonization of the urinary tract of mice with Escherichia coli by blocking of bacterial adherence with methyl α-dmannopyranoside. J. Infect. Dis. 139(3), 329-332 (1979). (Pubitemid 9147972)
20. Yang JC, Shun CT, Chien CT, Wang TH. Effective prevention and treatment of Helicobacter pylori infection using a combination of catechins and sialic acid in AGS cells and BALB/c mice. J. Nutr. 138(11), 2084-2090 (2008).
21. Parente F, Cucino C, Anderloni A, Grandinetti G, Bianchi Porro G Treatment of Helicobacter pylori infection using a novel antiadhesion compound ́sialyllactose sodium salt).A double blind, placebo-controlled clinical study. Helicobacter 8(4), 252-256 (2003). (Pubitemid 37093010)
22. Chemani C, Imberty A, de Bentzmann S et al. Role of LecA and LecB lectins in Pseudomonas aeruginosa-induced lung injury and effect of carbohydrate ligands. Infect. Immun. 77(5), 2065-2075 (2009).
23. Bouckaert J, Berglund J, Schembri M et al. Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin. Mol. Microbiol. 55(2), 441-455 (2005). (Pubitemid 40179379)
24. Han Z, Pinkner JS, Ford B et al. Structurebased drug design and optimization of mannoside bacterial FimH antagonists. J. Med. Chem. 53(12), 4779-4792 (2010).
25. Jiang X, Abgottspon D, Kleeb S et al. Antiadhesion therapy for urinary tract infections Y a balanced PK/PD profile proved to be key for success. J. Med. Chem. 55(10), 4700-4713 (2012).
26. Ukkonen P, Varis K, Jernfors M et al. Treatment of acute otitis media with an antiadhesive oligosaccharide: A randomised, double-blind, placebo-controlled trial. Lancet 356(9239), 1398-1402 (2000).
27. Kelly CG, Lehner T. Peptide inhibitors of Streptococcus mutans in the control of dental caries. Int. J. Pept. Res. Ther. 13(4), 517-523 (2007). (Pubitemid 350060779)
28. Okuda K, Hanada N, Usui Y et al. Inhibition of Streptococcus mutans adherence and biofilm formation using analogues of the SspB peptide. Arch. Oral Biol. 55(10), 754-762 (2010).
29. Jay CM, Bhaskaran S, Rathore KS, Waghela SD. Enterotoxigenic K99+Escherichia coli attachment to host cell receptors inhibited by recombinant pili protein. Vet. Microbiol. 101(3), 153-160 (2004). (Pubitemid 38829656)
30. Wizemann TM, Adamou JE, Langermann S. Adhesins as targets for vaccine development. Emerging Infect. Dis. 5(3), 395-403 (1999). (Pubitemid 29289453)
31. Klemm P, Vejborg RM, Hancock V. Prevention of bacterial adhesion. Appl. Microbiol. Biotechnol. 88(2), 451-459 (2010).
32. Langermann S, Palaszynski S, Barnhart M et al. Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination. Science 276(5312), 607-611 (1997). (Pubitemid 27193687)
33. Bassinet L, Gueirard P, Maitre B, Housset B, Gounon P, Guiso N. Role of adhesins and toxins in invasion of human tracheal epithelial cells by Bordetella pertussis. Infect. Immun. 68(4), 1934-1941 (2000). (Pubitemid 30164820)
34. Greco D, Salmaso S, Mastrantonio P et al. A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group. N. Engl. J. Med. 334(6), 341-348 (1996). (Pubitemid 26053148)
35. Poolman JT, Hallander HO. Acellular pertussis vaccines and the role of pertactin and fimbriae. Expert Rev. Vaccines 6(1), 47-56 (2007). (Pubitemid 46232480)
36. Briles DE, Ades E, Paton JC et al. Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infect. Immun. 68(2), 796-800 (2000). (Pubitemid 30056538)
37. Ghosh S, Chakraborty K, Nagaraja T et al. An adhesion protein of Salmonella enterica serovar Typhi is required for pathogenesis and potential target for vaccine development. Proc. Natl Acad. Sci. USA 108(8), 3348-3353 (2011).
38. Arrecubieta C, Matsunaga I, Asai T, Naka Y, Deng MC, Lowy FD. Vaccination with clumping factor A and fibronectin binding protein A to prevent Staphylococcus aureus infection of an aortic patch in mice. J. Infect. Dis. 198(4), 571-575 (2008).
39. Whitney CG, Farley MM, Hadler J et al.; Active Bacterial Core Surveillance of the Emerging Infections Program Network. Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. N. Engl. J. Med. 348(18), 1737-1746 (2003). (Pubitemid 36514704)
40. Maiden MC, Stuart JM; UK Meningococcal Carraige Group. Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccination. Lancet 359(9320), 1829-1831 (2002).
41. Brandtzaeg P. Role of secretory antibodies in the defence against infections. Int. J. Med. Microbiol. 293(1), 3-15 (2003). (Pubitemid 36534594)
42. Evans CM, Pratt CB, Matheson M et al. Nasopharyngeal colonization by Neisseria lactamica and induction of protective immunity against Neisseria meningitidis. Clin. Infect. Dis. 52(1), 70-77 (2011).
43. Kenny B, DeVinney R, Stein M, Reinscheid DJ, Frey EA, Finlay BB. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91(4), 511-520 (1997). (Pubitemid 27508240)
44. Fan HY, Wang L, Luo J, Long BG. Protection against Escherichia coli O157:H7 challenge by immunization of mice with purified Tir proteins. Mol. Biol. Rep. 39(2), 989-997 (2012).
45. Kain R, Exner M, Brandes R et al. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat. Med. 14(10), 1088-1096 (2008).
46. Pinkner JS, Remaut H, Buelens F et al. Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proc. Natl Acad. Sci. USA 103(47), 17897-17902 (2006). (Pubitemid 44852257)
47. Cusumano CK, Pinkner JS, Han Z et al. Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Sci. Transl. Med. 3(109), 109ra115 (2011).
48. Cegelski L, Pinkner JS, Hammer ND et al. Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation. Nat. Chem. Biol. 5(12), 913-919 (2009).
49. Eidam O, Dworkowski FS, Glockshuber R, Grütter MG, Capitani G. Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD. FEBS Lett. 582(5), 651-655 (2008).
50. Björnham O, Axner O, Andersson M. Modeling of the elongation and retraction of Escherichia coli P pili under strain by Monte Carlo simulations. Eur. Biophys. J. 37(4), 381-391 (2008). (Pubitemid 351423114)
51. Klinth JE, Pinkner JS, Hultgren SJ, Almqvist F, Uhlin BE, Axner O. Impairment of the biomechanical compliance of P pili: A novel means of inhibiting uropathogenic bacterial infections? Eur. Biophys. J. 41(3), 285-295 (2012).
52. Ton-That H, Schneewind O. Anchor structure of staphylococcal surface proteins. IV. Inhibitors of the cell wall sorting reaction. J. Biol. Chem. 274(34), 24316-24320 (1999).
53. Oh KB, Oh MN, Kim JG, Shin DS, Shin J. Inhibition of sortase-mediated Staphylococcus aureus adhesion to fibronectin via fibronectin-binding protein by Sortase inhibitors. Appl. Microbiol. Biotechnol. 70(1), 102-106 (2006). (Pubitemid 43234535)
54. Maresso AW, Schneewind O. Sortase as a target of anti-infective therapy. Pharmacol. Rev. 60(1), 128-141 (2008). (Pubitemid 351439219)
55. Uddin R, Lodhi MU, Ul-Haq Z. Combined pharmacophore and 3D-QSAR study on a series of Staphylococcus aureus Sortase A inhibitors. Chem. Biol. Drug Des. 80(2), 300-314 (2012).
56. Cakan G, Turkoz M, Turan T, Ahmed K, Nagatake T. S-carboxymethylcysteine inhibits the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells. Microb. Pathog. 34(6), 261-265 (2003). (Pubitemid 36627551)
57. Sumitomo T, Nakata M, Yamaguchi M, Terao Y, Kawabata S. S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells. J. Med. Microbiol. 61(Pt 1), 101-108 (2012).
58. Green LR, Monk PN, Partridge LJ, Morris P, Gorringe AR, Read RC. Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells. Infect. Immun. 79(6), 2241-2249 (2011).
59. Mortensen NP, Fowlkes JD, Maggart M et al. Effects of sub-minimum inhibitory concentrations of ciprofloxacin on enteroaggregative Escherichia coli and the role of the surface protein dispersin. Int. J. Antimicrob. Agents 38(1), 27-34 (2011).
60. Wojnicz D, Jankowski S. Effects of subinhibitory concentrations of amikacin and ciprofloxacin on the hydrophobicity and adherence to epithelial cells of uropathogenic Escherichia coli strains. Int. J. Antimicrob. Agents 29(6), 700-704 (2007). (Pubitemid 46710359)
61. Fonseca AP, Sousa JC. Effect of antibioticinduced morphological changes on surface properties, motility and adhesion of nosocomial Pseudomonas aeruginosa strains under different physiological states. J. Appl. Microbiol. 103(5), 1828-1837 (2007). (Pubitemid 47620575)
62. Tsang KW, Rutman A, Kanthakumar K et al. Haemophilus influenzae infection of human respiratory mucosa in low concentrations of antibiotics. Am. Rev. Respir. Dis. 148(1), 201-207 (1993). (Pubitemid 23187242)
63. Balagué C, Fernández L, Pérez J, Grau R. Effect of ciprofloxacin on adhesive properties of non-P mannose-resistant uropathogenic Escherichia coli isolates. J. Antimicrob. Chemother. 51(2), 401-404 (2003). (Pubitemid 36231164)
64. Rasigade JP, Moulay A, Lhoste Y et al. Impact of sub-inhibitory antibiotics on fibronectin-mediated host cell adhesion and invasion by Staphylococcus aureus. BMC Microbiol. 11, 263 (2011).
65. Cars O. Pharmacokinetics of antibiotics in tissues and tissue fluids: A review. Scand. J. Infect. Dis. Suppl. 74, 23-33 (1990).
66. Signoretto C, Canepari P, Stauder M, Vezzulli L, Pruzzo C. Functional foods and strategies contrasting bacterial adhesion. Curr. Opin. Biotechnol. 23(2), 160-167 (2012).
67. Liu Y, Pinzón-Arango PA, Gallardo-Moreno AM, Camesano TA. Direct adhesion force measurements between E. coli and human uroepithelial cells in cranberry juice cocktail. Mol. Nutr. Food Res. 54(12), 1744-1752 (2010).
68. Toivanen M, Huttunen S, Lapinjoki S, Tikkanen-Kaukanen C. Inhibition of adhesion of Neisseria meningitidis to human epithelial cells by berry juice polyphenolic fractions. Phytother. Res. 25(6), 828-832 (2011).
69. Yamanaka A, Kimizuka R, Kato T, Okuda K. Inhibitory effects of cranberry juice on attachment of oral streptococci and biofilm formation. Oral Microbiol. Immunol. 19(3), 150-154 (2004). (Pubitemid 38649607)
70. Avorn J, Monane M, Gurwitz JH, Glynn RJ, Choodnovskiy I, Lipsitz LA. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA 271(10), 751-754 (1994). (Pubitemid 24074521)
71. Kontiokari T, Sundqvist K, Nuutinen M, Pokka T, Koskela M, Uhari M. Randomised trial of cranberryYlingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women. BMJ 322(7302), 1571 (2001).
72. Barbosa-Cesnik C, Brown MB, Buxton M, Zhang L, DeBusscher J, Foxman B. Cranberry juice fails to prevent recurrent urinary tract infection: Results from a randomized placebo-controlled trial. Clin. Infect. Dis. 52(1), 23-30 (2011).
73. Foo LY, Lu Y, Howell AB, Vorsa N. A-type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli. J. Nat. Prod. 63(9), 1225-1228 (2000).
74. Tao Y, Pinzón-Arango PA, Howell AB, Camesano TA. Oral consumption of cranberry juice cocktail inhibits molecular-scale adhesion of clinical uropathogenic Escherichia coli. J. Med. Food 14(7-8), 739-745 (2011).
75. Morrow AL, Ruiz-Palacios GM, Jiang X, Newburg DS. Human-milk glycans that inhibit pathogen binding protect breast-feeding infants against infectious diarrhea. J. Nutr. 135(5), 1304-1307 (2005). (Pubitemid 40638353)
76. Gustafsson A, Hultberg A, Sjöström R et al. Carbohydrate-dependent inhibition of Helicobacter pylori colonization using porcine milk. Glycobiology 16(1), 1-10 (2006). (Pubitemid 43009802)
77. Coppa GV, Zampini L, Galeazzi T et al. Human milk oligosaccharides inhibit the adhesion to Caco-2 cells of diarrheal pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris. Pediatr. Res. 59(3), 377-382 (2006). (Pubitemid 43740074)
78. Candela M, Perna F, Carnevali P et al. Interaction of probiotic Lactobacillus and Bifidobacterium strains with human intestinal epithelial cells: Adhesion properties, competition against enteropathogens and modulation of IL-8 production. Int. J. Food Microbiol. 125(3), 286-292 (2008).
79. Mack DR, Michail S, Wei S, McDougall L, Hollingsworth MA. Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression. Am. J. Physiol. 276(4 Pt 1), G941-G950 (1999). (Pubitemid 29214108)
80. Sánchez B, Urdaci MC. Extracellular proteins from Lactobacillus plantarum BMCM12 prevent adhesion of enteropathogens to mucin. Curr. Microbiol. 64(6), 592-596 (2012).
81. Ya W, Reifer C, Miller LE. Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: A double-blind, randomized, placebo-controlled study. Am. J. Obstet. Gynecol. 203(2), 120.e1-120.e6 (2010).
82. Liévin V, Peiffer I, Hudault S et al. Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity. Gut 47(5), 646-652 (2000).
83. Zou J, Dong J, Yu X. Meta-analysis: Lactobacillus containing quadruple therapy versus standard triple first-line therapy for Helicobacter pylori eradication. Helicobacter 14(5), 97-107 (2009).
84. Kailasapathy K, Chin J. Survival and therapeutic potential of probiotic organisms with reference to Lactobacillus acidophilus and Bifidobacterium spp. Immunol. Cell Biol. 78(1), 80-88 (2000). (Pubitemid 30090993)
85. Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu Y, Weiser JN. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat. Med. 16(2), 228-231 (2010).
86. Lewis AL, Cumming ZL, Goreish HH, Kirkwood LC, Tolhurst LA, Stratford PW. Crosslinkable coatings from phosphorylcholine-based polymers. Biomaterials 22(2), 99-111 (2001).
87. Hirota K, Yumoto H, Miyamoto K et al. MPC-polymer reduces adherence and biofilm formation by oral bacteria. J. Dent. Res. 90(7), 900-905 (2011).
88. Prabu GR, Gnanamani A, Sadulla S. Guaijaverin Y a plant flavonoid as potential antiplaque agent against Streptococcus mutans. J. Appl. Microbiol. 101(2), 487-495 (2006). (Pubitemid 44060431)
89. Hu XL, Ho B, Lim CT, Hsu CS. Thermal treatments modulate bacterial adhesion to dental enamel. J. Dent. Res. 90(12), 1451-1456 (2011).
90. Mulvey MA. Adhesion and entry of uropathogenic Escherichia coli. Cell. Microbiol. 4(5), 257-271 (2002). (Pubitemid 34567594)
91. Pieters RJ. Intervention with bacterial adhesion by multivalent carbohydrates. Med. Res. Rev. 27(6), 796-816 (2007). (Pubitemid 350035120)
92. Ruiz-Palacios GM, Cervantes LE, Ramos P, Chavez-Munguia B, Newburg DS. Campylobacter jejuni binds intestinal H(O) antigen (Fuc α 1, 2Gal β 1, 4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection. J. Biol. Chem. 278(16), 14112-14120 (2003). (Pubitemid 36799958)
93. Mysore JV, Wigginton T, Simon PM, Zopf D, Heman-Ackah LM, Dubois A. Treatment of Helicobacter pylori infection in rhesus monkeys using a novel antiadhesion compound. Gastroenterology 117(6), 1316-1325 (1999).
94. Ebersbach T, Andersen JB, Bergström A, Hutkins RW, Licht TR. Xylo-oligosaccharides inhibit pathogen adhesion to enterocytes in vitro. Res. Microbiol. 163(1), 22-27 (2012).
95. Idänpään-Heikkilä I, Simon PM, Zopf D et al. Oligosaccharides interfere with the establishment and progression of experimental pneumococcal pneumonia. J. Infect. Dis. 176(3), 704-712 (1997). (Pubitemid 27360537)
96. Thomas R, Brooks T. Attachment of Yersinia pestis to human respiratory cell lines is inhibited by certain oligosaccharides. J. Med. Microbiol. 55(Pt 3), 309-315 (2006).
97. Lee JH, Shim JS, Chung MS, Lim ST, Kim KH. In vitro anti-adhesive activity of green tea extract against pathogen adhesion. Phytother. Res. 23(4), 460-466 (2009).
98. Lee KH, Kim BS, Keum KS et al. Essential oil of Curcuma longa inhibits Streptococcus mutans biofilm formation. J. Food Sci. 76(9), H226-H230 (2011).
99. Xiao J, Zuo Y, Liu Y, Li J, Hao Y, Zhou X. Effects of Nidus Vespae extract and chemical fractions on glucosyltransferases, adherence and biofilm formation of Streptococcus mutans. Arch. Oral Biol. 52(9), 869-875 (2007). (Pubitemid 47125842)
100. Yamaguti-Sasaki E, Ito LA, Canteli VC et al. Antioxidant capacity and in vitro prevention of dental plaque formation by extracts and condensed tannins of Paullinia cupana. Molecules 12(8), 1950-1963 (2007).
101. Furiga A, Lonvaud-Funel A, Dorignac G, Badet C. In vitro anti-bacterial and anti-adherence effects of natural polyphenolic compounds on oral bacteria. J. Appl. Microbiol. 105(5), 1470-1476 (2008).
102. Newburg DS, Ruiz-Palacios GM, Altaye M et al. Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants. Glycobiology 14(3), 253-263 (2004). (Pubitemid 38324941)
103. Hakkarainen J, Toivanen M, Leinonen A et al. Human and bovine milk oligosaccharides inhibit Neisseria meningitidis pili attachment in vitro. J. Nutr. 135(10), 2445-2448 (2005). (Pubitemid 41429605)
104. Zinger-Yosovich KD, Iluz D, Sudakevitz D, Gilboa-Garber N. Blocking of Pseudomonas aeruginosa and Chromobacterium violaceum lectins by diverse mammalian milks. J. Dairy Sci. 93(2), 473-482 (2010).
105. Willer ED, Lima RD, Giugliano LG. In vitro adhesion and invasion inhibition of Shigella dysenteriae, Shigella flexneri and Shigella sonnei clinical strains by human milk proteins. BMC Microbiol. 4, 7 (2004).
106. Danielsson Niemi L, Hernell O, Johansson I. Human milk compounds inhibiting adhesion of mutans streptococci to host ligand-coated hydroxyapatite in vitro. Caries Res. 43(3), 171-178 (2009).