-
1
-
-
64249171029
-
Low density lipoprotein reduction and magnitude of cardiovascular risk reduction
-
Rahilly-Tierney, C. R., Lawler, E. V., Scranton, R. E., and Michael Gaziano, J. (2009) Low density lipoprotein reduction and magnitude of cardiovascular risk reduction. Prev. Cardiol. 12, 80-87
-
(2009)
Prev. Cardiol.
, vol.12
, pp. 80-87
-
-
Rahilly-Tierney, C.R.1
Lawler, E.V.2
Scranton, R.E.3
Michael Gaziano, J.4
-
2
-
-
11844264536
-
Prevalence of adequate control of increased serum low-density lipoprotein cholesterol in self-pay or Medicare patients versus Medicaid or private insurance patients followed in a University General Medicine Clinic
-
DOI 10.1016/j.amjcard.2004.08.095, PII S0002914904015383
-
Varma, R., Aronow, W. S., Gandelman, G., and Zammit, C. (2005) Prevalence of adequate control of increased serum low density lipoprotein cholesterol in self-pay or Medicare patients versus Medicaid or private insurance patients followed in a University General Medicine Clinic. Am. J. Cardiol. 95, 269-270 (Pubitemid 40092099)
-
(2005)
American Journal of Cardiology
, vol.95
, Issue.2
, pp. 269-270
-
-
Varma, R.1
Aronow, W.S.2
Gandelman, G.3
Zammit, C.4
-
3
-
-
33645103550
-
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
-
Cohen, J. C, Boerwinkle, E., Mosley, T. H., Jr., and Hobbs, H. H. (2006) Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354, 1264-1272
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1264-1272
-
-
Cohen, J.C.1
Boerwinkle, E.2
Mosley Jr., T.H.3
Hobbs, H.H.4
-
4
-
-
0024348038
-
Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors
-
Hobbs, H. H., Leitersdorf, E., Leffert, C. C., Cryer, D. R., Brown, M. S., and Goldstein, J. L. (1989) Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors. J. Clin. Invest. 84, 656-664 (Pubitemid 19197001)
-
(1989)
Journal of Clinical Investigation
, vol.84
, Issue.2
, pp. 656-664
-
-
Hobbs, H.H.1
Leitersdorf, E.2
Leffert, C.C.3
Cryer, D.R.4
Brown, M.S.5
Goldstein, J.L.6
-
5
-
-
0025597137
-
The LDL receptor locus in familial hypercholesterolemia: Mutational analysis of a membrane protein
-
Hobbs, H. H., Russell, D. W., Brown, M. S., and Goldstein, J. L. (1990) The LDL receptor locus in familial hypercholesterolemia. Mutational analysis of a membrane protein. Annu. Rev. Genet. 24, 133-170 (Pubitemid 120011544)
-
(1990)
Annual Review of Genetics
, vol.24
, Issue.1
, pp. 133-170
-
-
Hobbs, H.H.1
Russell, D.W.2
Brown, M.S.3
Goldstein, J.L.4
-
6
-
-
0027026881
-
Molecular genetics of the LDL receptor gene in familial hypercholesterolemia
-
Hobbs, H. H., Brown, M. S., and Goldstein, J. L. (1992) Molecular genetics of the LDL receptor gene in familial hypercholesterolemia. Hum. Mutat. 1, 445-466
-
(1992)
Hum. Mutat.
, vol.1
, pp. 445-466
-
-
Hobbs, H.H.1
Brown, M.S.2
Goldstein, J.L.3
-
7
-
-
0022965969
-
The LDL receptor in familial hypercholesterolemia: Use of human mutations to dissect a membrane protein
-
Russell, D. W., Lehrman, M. A., Südhof, T. C., Yamamoto, T., Davis, C. G., Hobbs, H. H., Brown, M. S., and Goldstein, J. L. (1986) The LDL receptor in familial hypercholesterolemia. Use of human mutations to dissect a membrane protein. Cold Spring Harbor Symp. Quant. Biol. 51, 811-819 (Pubitemid 17078596)
-
(1986)
Cold Spring Harbor Symposia on Quantitative Biology
, vol.51
, Issue.2
, pp. 811-819
-
-
Russel, D.W.1
Lehrman, M.A.2
Sudhof, T.C.3
-
8
-
-
58149343449
-
Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance
-
Liu, W., Mani, S., Davis, N. R., Sarrafzadegan, N., Kavathas, P. B., and Mani, A. (2008) Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance. Circ. Res. 103, 1280-1288
-
(2008)
Circ. Res.
, vol.103
, pp. 1280-1288
-
-
Liu, W.1
Mani, S.2
Davis, N.R.3
Sarrafzadegan, N.4
Kavathas, P.B.5
Mani, A.6
-
9
-
-
33847656105
-
LRP6 mutation in a family with early coronary disease and metabolic risk factors
-
DOI 10.1126/science.1136370
-
Mani, A., Radhakrishnan, J., Wang, H., Mani, A., Mani, M. A., Nelson-Williams, C., Carew, K. S., Mane, S., Najmabadi, H., Wu, D., and Lifton, R. P. (2007) LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 315, 1278-1282 (Pubitemid 46364265)
-
(2007)
Science
, vol.315
, Issue.5816
, pp. 1278-1282
-
-
Mani, A.1
Radhakrishnan, J.2
Wang, H.3
Mani, A.4
Mani, M.-A.5
Nelson-Williams, C.6
Carew, K.S.7
Mane, S.8
Najmabadi, H.9
Wu, D.10
Lifton, R.P.11
-
10
-
-
69849086878
-
A common variant in low density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol
-
Tomaszewski, M., Charchar, F. J., Barnes, T., Gawron-Kiszka, M., Sedkowska, A., Podolecka, E., Kowalczyk, J., Rathbone, W., Kalarus, Z., Grzeszczak, W., Goodall, A. H., Samani, N. J., and Zukowska-Szczechowska, E. (2009) A common variant in low density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol. Arterioscler. Thromb. Vasc. Biol. 29, 1316-1321
-
(2009)
Arterioscler. Thromb. Vasc. Biol.
, vol.29
, pp. 1316-1321
-
-
Tomaszewski, M.1
Charchar, F.J.2
Barnes, T.3
Gawron-Kiszka, M.4
Sedkowska, A.5
Podolecka, E.6
Kowalczyk, J.7
Rathbone, W.8
Kalarus, Z.9
Grzeszczak, W.10
Goodall, A.H.11
Samani, N.J.12
Zukowska-Szczechowska, E.13
-
11
-
-
34250664283
-
Design and cloning of lentiviral vectors expressing small interfering RNAs
-
Tiscornia, G., Singer, O., and Verma, I. M. (2006) Design and cloning of lentiviral vectors expressing small interfering RNAs. Nat. Protoc. 1, 234-240
-
(2006)
Nat. Protoc.
, vol.1
, pp. 234-240
-
-
Tiscornia, G.1
Singer, O.2
Verma, I.M.3
-
12
-
-
0019427474
-
Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts
-
Basu, S. K., Goldstein, J. L., Anderson, R. G., and Brown, M. S. (1981) Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts. Cell 24, 493-502
-
(1981)
Cell
, vol.24
, pp. 493-502
-
-
Basu, S.K.1
Goldstein, J.L.2
Anderson, R.G.3
Brown, M.S.4
-
13
-
-
33846862687
-
Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor
-
DOI 10.1194/jlr.M600292-JLR200
-
Loeffler, B., Heeren, J., Blaeser, M., Radner, H., Kayser, D., Aydin, B., and Merkel, M. (2007) Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor. J. Lipid Res. 48, 288-298 (Pubitemid 46220595)
-
(2007)
Journal of Lipid Research
, vol.48
, Issue.2
, pp. 288-298
-
-
Loeffler, B.1
Heeren, J.2
Blaeser, M.3
Radner, H.4
Kayser, D.5
Aydin, B.6
Merkel, M.7
-
14
-
-
33746482870
-
Caveolin Is Necessary for Wnt-3a-Dependent Internalization of LRP6 and Accumulation of beta-Catenin
-
DOI 10.1016/j.devcel.2006.07.003, PII S1534580706003042
-
Yamamoto, H., Komekado, H., and Kikuchi, A. (2006) Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of β-catenin. Dev. Cell 11, 213-223 (Pubitemid 44138502)
-
(2006)
Developmental Cell
, vol.11
, Issue.2
, pp. 213-223
-
-
Yamamoto, H.1
Komekado, H.2
Kikuchi, A.3
-
15
-
-
77956547695
-
Roles of AP-2 in clathrin-mediated endocytosis
-
Boucrot, E., Saffarian, S., Zhang, R., and Kirchhausen, T. (2010) Roles of AP-2 in clathrin-mediated endocytosis. PLoS One 5, e10597
-
(2010)
PLoS One
, vol.5
-
-
Boucrot, E.1
Saffarian, S.2
Zhang, R.3
Kirchhausen, T.4
-
16
-
-
58149510578
-
Caveolin-1 and Rac regulate endothelial capillary-like tubular formation and fenestral contraction in sinusoidal endothelial cells
-
Yokomori, H., Oda, M., Yoshimura, K., Nagai, T., Fujimaki, K., Watanabe, S., and Hibi, T. (2009) Caveolin-1 and Rac regulate endothelial capillary-like tubular formation and fenestral contraction in sinusoidal endothelial cells. Liver Int. 29, 266-276
-
(2009)
Liver Int.
, vol.29
, pp. 266-276
-
-
Yokomori, H.1
Oda, M.2
Yoshimura, K.3
Nagai, T.4
Fujimaki, K.5
Watanabe, S.6
Hibi, T.7
-
17
-
-
0034172858
-
Role of cholesterol in developing T-tubules. Analogous mechanisms for T-tubule and caveolae biogenesis
-
Carozzi, A. J., Ikonen, E., Lindsay, M. R., and Parton, R. G. (2000) Role of cholesterol in developing T-tubules. Analogous mechanisms for T-tubule and caveolae biogenesis. Traffic 1, 326-341
-
(2000)
Traffic
, vol.1
, pp. 326-341
-
-
Carozzi, A.J.1
Ikonen, E.2
Lindsay, M.R.3
Parton, R.G.4
-
18
-
-
67649452503
-
Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis
-
Fernández-Hernando, C., Yu, J., Suárez, Y., Rahner, C., Dávalos, A., Lasunción, M. A., and Sessa, W. C. (2009) Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metab. 10, 48-54
-
(2009)
Cell Metab.
, vol.10
, pp. 48-54
-
-
Fernández-Hernando, C.1
Yu, J.2
Suárez, Y.3
Rahner, C.4
Dávalos, A.5
Lasunción, M.A.6
Sessa, W.C.7
-
19
-
-
77957279577
-
Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice
-
Fernández-Hernando, C., Yu, J., Dávalos, A., Prendergast, J., and Sessa, W. C. (2010) Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. Am. J. Pathol. 177, 998-1003
-
(2010)
Am. J. Pathol.
, vol.177
, pp. 998-1003
-
-
Fernández-Hernando, C.1
Yu, J.2
Dávalos, A.3
Prendergast, J.4
Sessa, W.C.5
-
20
-
-
28844497903
-
The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits
-
DOI 10.1074/jbc.M509394200
-
Garuti, R., Jones, C., Li, W. P., Michaely, P., Herz, J., Gerard, R. D., Cohen, J. C., and Hobbs, H. H. (2005) The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits. J. Biol. Chem. 280, 40996-41004 (Pubitemid 41780595)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.49
, pp. 40996-41004
-
-
Garuti, R.1
Jones, C.2
Li, W.-P.3
Michaely, P.4
Herz, J.5
Gerard, R.D.6
Cohen, J.C.7
Hobbs, H.H.8
-
21
-
-
0015890890
-
Familial hypercholesterolemia. Identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol
-
Goldstein, J. L., and Brown, M. S. (1973) Familial hypercholesterolemia. Identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol. Proc. Natl. Acad. Sci. U.S.A. 70, 2804-2808
-
(1973)
Proc. Natl. Acad. Sci. U.S.A.
, vol.70
, pp. 2804-2808
-
-
Goldstein, J.L.1
Brown, M.S.2
-
22
-
-
9444235153
-
Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis
-
DOI 10.1242/dev.01405
-
Kokubu, C., Heinzmann, U., Kokubu, T., Sakai, N., Kubota, T., Kawai, M., Wahl, M. B., Galceran, J., Grosschedl, R., Ozono, K., and Imai, K. (2004) Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis. Development 131, 5469-5480 (Pubitemid 39562189)
-
(2004)
Development
, vol.131
, Issue.21
, pp. 5469-5480
-
-
Kokubu, C.1
Heinzmann, U.2
Kokubu, T.3
Sakai, N.4
Kubota, T.5
Kawai, M.6
Wahl, M.B.7
Galceran, J.8
Grosschedl, R.9
Ozono, K.10
Imai, K.11
-
23
-
-
67149111600
-
The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development
-
Lindvall, C., Zylstra, C. R., Evans, N., West, R. A., Dykema, K., Furge, K. A., and Williams, B. O. (2009) The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development. PLoS One 4, e5813
-
(2009)
PLoS One
, vol.4
-
-
Lindvall, C.1
Zylstra, C.R.2
Evans, N.3
West, R.A.4
Dykema, K.5
Furge, K.A.6
Williams, B.O.7
-
24
-
-
0028969610
-
Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism
-
Nesterov, A., Kurten, R. C., and Gill, G. N. (1995) Association of epidermal growth factor receptors with coated pit adaptins via a tyrosine phosphorylation-regulated mechanism. J. Biol. Chem. 270, 6320-6327
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 6320-6327
-
-
Nesterov, A.1
Kurten, R.C.2
Gill, G.N.3
-
25
-
-
0029889579
-
Epidermal growth factor receptor interaction with clathrin adaptors is mediated by the Tyr-974-containing internalization motif
-
Sorkin, A., Mazzotti, M., Sorkina, T., Scotto, L., and Beguinot, L. (1996) Epidermal growth factor receptor interaction with clathrin adaptors is mediated by the Tyr-974-containing internalization motif. J. Biol. Chem. 271, 13377-13384
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 13377-13384
-
-
Sorkin, A.1
Mazzotti, M.2
Sorkina, T.3
Scotto, L.4
Beguinot, L.5
-
26
-
-
0030718549
-
Partitioning of proteins into plasma membrane microdomains. Clustering of mutant influenza virus hemagglutinins into coated pits depends on the strength of the internalization signal
-
Fire, E., Brown, C. M., Roth, M. G., Henis, Y. I., and Petersen, N. O. (1997) Partitioning of proteins into plasma membrane microdomains. Clustering of mutant influenza virus hemagglutinins into coated pits depends on the strength of the internalization signal. J. Biol. Chem. 272, 29538-29545
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 29538-29545
-
-
Fire, E.1
Brown, C.M.2
Roth, M.G.3
Henis, Y.I.4
Petersen, N.O.5
-
27
-
-
0030989801
-
Identification of cytoplasmic motifs required for short prolactin receptor internalization
-
DOI 10.1074/jbc.272.11.7062
-
Vincent, V., Goffin, V., Rozakis-Adcock, M., Mornon, J. P., and Kelly, P. A. (1997) Identification of cytoplasmic motifs required for short prolactin receptor internalization. J. Biol. Chem. 272, 7062-7068 (Pubitemid 27166409)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.11
, pp. 7062-7068
-
-
Vincent, V.1
Goffin, V.2
Rozakis-Adcock, M.3
Mornon, J.-P.4
Kelly, P.A.5
-
28
-
-
0030611358
-
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
-
Zhang, Y., and Allison, J. P. (1997) Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. Proc. Natl. Acad. Sci. U.S.A. 94, 9273-9278
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 9273-9278
-
-
Zhang, Y.1
Allison, J.P.2
|