Lovastatin protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt and ERK1/2

Journal of Cellular Biochemistry

Volumn 103, Issue 1, 2008, Pages 256-269

  Xu, Ruixia ^a   Chen, Jinghai ^a   Cong, Xiangfeng ^a   Hu, Shengshou ^a   Chen, Xi ^a  

^a FUWAI HOSPITAL   (China)

Author keywords

Apoptosis; Lovastatin; Mesenchymal stem cells; Signaling pathway; Survival

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CYTOCHROME C; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOSOL; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEART INFARCTION; HYPOXIA; MESENCHYMAL STEM CELL TRANSPLANTATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CASPASE 3; CELL HYPOXIA; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; CYTOCHROMES C; CYTOPROTECTION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LOVASTATIN; MAP KINASE SIGNALING SYSTEM; MESENCHYMAL STEM CELLS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 38149111737     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21402     Document Type: Article

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