NPY Intraperitoneal Injections Produce Antidepressant-Like Effects and Downregulate BDNF in the Rat Hypothalamus

CNS Neuroscience and Therapeutics

Volumn 18, Issue 6, 2012, Pages 487-492

  Gelfo, Francesca ^a   Tirassa, Paola ^b   De Bartolo, Paola ^a,c   Croce, Nicoletta ^a   Bernardini, Sergio ^d   Caltagirone, Carlo ^a   Petrosini, Laura ^a,c   Angelucci, Francesco ^a  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b CNR   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

BDNF; Forced swim test; Neurotrophins; NPY; Rat brain

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; NERVE GROWTH FACTOR RECEPTOR; NEUROPEPTIDE Y; NEUROTROPHIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FORCED SWIMMING TEST; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION; MALE; NONHUMAN; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIDEPRESSIVE AGENTS; BODY WEIGHT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; DEPRESSION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; EATING; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYPOTHALAMUS; MALE; NERVE GROWTH FACTOR; NEUROPEPTIDE Y; RATS; RATS, WISTAR; SWIMMING; TIME FACTORS;

EID: 84861911539     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/j.1755-5949.2012.00314.x     Document Type: Article

References (38)

1. Beck B. Neuropeptide Y in normal eating and in genetic and dietary-induced obesity. Philos Trans R Soc Lond B Biol Sci 2006;361:1159-1185.
2. Paschos KA, Veletza S, Chatzaki E. Neuropeptide and sigma receptors as novel therapeutic targets for the pharmacotherapy of depression. CNS Drugs 2009;23:755-772.
3. Redrobe JP, Dumont Y, Quirion R. Neuropeptide Y (NPY) and depression: From animal studies to the human condition. Life Sci 2002;71:2921-2937.
4. Heilig M. The NPY system in stress, anxiety and depression. Neuropeptides 2004;38:213-224.
5. Jiménez-Vasquez PA, Diaz-Cabiale Z, Caberlotto L, Bellido I, Overstreet D, Fuxe K, Mathé AA. Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPY Y(1) receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of depression. Eur Neuropsychopharmacol 2007;17:298-308.
6. Nikisch G, Mathé AA. CSF monoamine metabolites and neuropeptides in depressed patients before and after electroconvulsive therapy. Eur Psychiatry 2008;23:356-359.
7. Bjørnebekk A, Mathé AA, Brené S. The antidepressant effects of running and escitalopram are associated with levels of hippocampal NPY and Y1 receptor but not cell proliferation in a rat model of depression. Hippocampus 2010;20:820-828.
8. Redrobe JP, Dumont Y, Fournier A, Quirion R. The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology 2002;26:615-624.
9. Morales-Medina JC, Dumont Y, Quirion R. A possible role of neuropeptide Y in depression and stress. Brain Res 2010;1314:194-205.
10. Britton KT, Southerland S, Van Uden E, Kirby D, Rivier J, Koob G. Anxiolytic activity of NPY receptor agonists in the conflict test. Psychopharmacology (Berl) 1997;132:6-13.
11. Ehlers CL, Somes C, Seifritz E, Rivier JE. CRF/NPY interactions: A potential role in sleep dysregulation in depression and anxiety. Depress Anxiety 1997;6:1-9.
12. Kask A, Rägo L, Harro J. Alpha-helical CRF(9-41) prevents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226 in rats. Neuroreport 1997;8:3645-3647.
13. Thorsell A, Slawecki CJ, Ehlers CL. Effects of neuropeptide Y and corticotropin-releasing factor on ethanol intake in Wistar rats: Interaction with chronic ethanol exposure. Behav Brain Res 2005;161:133-140.
14. Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 2002;53:865-871.
15. Pardon MC. Role of neurotrophic factors in behavioral processes: Implications for the treatment of psychiatric and neurodegenerative disorders. Vitam Horm 2010;82:185-200.
16. Naert G, Ixart G, Maurice T, Tapia-Arancibia L, Givalois L. Brain-derived neurotrophic factor and hypothalamic-pituitary-adrenal axis adaptation processes in a depressive-like state induced by chronic restraint stress. Mol Cell Neurosci 2011;46:55-66.
17. Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat Neurosci 2007;10:1089-1093.
18. Marais L, van Rensburg SJ, van Zyl JM, Stein DJ, Daniels WM. Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus. Neurosci Res 2008;61:106-112.
19. Hansson AC, Rimondini R, Heilig M, Mathé AA, Sommer WH. Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats. J Psychopharmacol; in press. doi:
20. Hashimoto K. Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions. Psychiatry Clin Neurosci 2010;64:341-357.
21. Lang UE, Jockers-Scherübl MC, Hellweg R. State of the art of the neurotrophin hypothesis in psychiatric disorders: implications and limitations. J Neural Transm 2004;111:387-411.
22. Jockers-Scherübl MC, Zubraegel D, Baer T, Linden M, et al. Nerve growth factor serum concentrations rise after successful cognitive-behavioural therapy of generalized anxiety disorder. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:200-204.
23. Givalois L, Naert G, Rage F, Ixart G, Arancibia S, Tapia-Arancibia L. A single brain-derived neurotrophic factor injection modifies hypothalamo-pituitary-adrenocortical axis activity in adult male rats. Mol Cell Neurosci 2004;27:280-295.
24. Naert G, Ixart G, Tapia-Arancibia L, Givalois L. Continuous i.c.v. infusion of brain-derived neurotrophic factor modifies hypothalamic-pituitary-adrenal axis activity, locomotor activity and body temperature rhythms in adult male rats. Neuroscience 2006;139:779-789.
25. Scaccianoce S, Lombardo K, Nicolai R, Affricano D, Angelucci L. Studies on the involvement of histamine in the hypothalamic-pituitary-adrenal axis activation induced by nerve growth factor. Life Sci 2000;67:3143-3152.
26. Gelfo F, De Bartolo P, Tirassa P, Croce N, Caltagirone C, Petrosini L, Angelucci F. Intraperitoneal injection of neuropeptide Y (NPY) alters neurotrophin rat hypothalamic levels: Implications for NPY potential role in stress-related disorders. Peptides 2011;32:1320-1323.
27. Porsolt RD, Le Pichon M, Jalfre M. Depression: A new model sensitive to antidepressant treatments. Nature 1977;266:730-732.
28. Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioral despair in rats: A new model sensitive to antidepressant treatments. Eur J Pharmacol 1978;47:379-391.
29. Cryan JF, Valentino RJ, Lucki I. Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 2005;29:547-569.
30. Rotzinger S, Lovejoy DA, Tan LA. Behavioral effects of neuropeptides in rodent models of depression and anxiety. Peptides 2010;31:736-756.
31. Goyal SN, Kokare DM, Chopde CT, Subhedar NK. Alpha-melanocyte stimulating hormone antagonizes antidepressant-like effect of neuropeptide Y in Porsolt's test in rats. Pharmacol Biochem Behav 2006;85:369-377.
32. Nestler EJ, Hyman SE. Animal models of neuropsychiatric disorders. Nat Neurosci 2010;13:1161-1169.
33. Castagné V, Moser P, Roux S, Porsolt RD. Rodent models of depression: Forced swim and tail suspension behavioral despair tests in rats and mice. Curr Protoc Neurosci 2011;55:8.10A.1-8.10A.14.
34. Detke MJ, Johnson J, Lucki I. Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression. Exp Clin Psychopharmacol 1997;5:107-112.
35. Glowinski J, Iversen LL. Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Neurochem 1966;13:655-669.
36. Husum H, Mikkelsen JD, Hogg S, Mathé AA, Mørk A. Involvement of hippocampal neuropeptide Y in mediating the chronic actions of lithium, electroconvulsive stimulation and citalopram. Neuropharmacology 2000;39:1463-1473.
37. Stogner KA, Holmes PV. Neuropeptide-Y exerts antidepressant-like effects in the forced swim test in rats. Eur J Pharmacol 2000;387:R9-R10.
38. Aloe L, Bracci-Laudiero L, Alleva E, Lambiase A, Micera A, Tirassa P. Emotional stress induced by parachute jumping enhances blood nerve growth factor levels and the distribution of nerve growth factor receptors in lymphocytes. Proc Natl Acad Sci U S A 1994;91:10440-10444.