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Volumn 7, Issue 12, 2012, Pages

Notch1 Is Not Required for Acinar-to-Ductal Metaplasia in a Model of Kras-Induced Pancreatic Ductal Adenocarcinoma

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; NOTCH1 RECEPTOR;

EID: 84871340599     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052133     Document Type: Article
Times cited : (22)

References (39)
  • 1
    • 0036883940 scopus 로고    scopus 로고
    • Pancreatic cancer biology and genetics
    • Bardeesy N, DePinho RA, (2002) Pancreatic cancer biology and genetics. Nat Rev Cancer 2: 897-909.
    • (2002) Nat Rev Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1    DePinho, R.A.2
  • 3
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, et al. (2003) Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4: 437-450.
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1    Petricoin, E.F.2    Maitra, A.3    Rajapakse, V.4    King, C.5
  • 4
    • 57749113202 scopus 로고    scopus 로고
    • Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
    • Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, et al. (2008) Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc Natl Acad Sci U S A 105: 18913-18918.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18913-18918
    • Habbe, N.1    Shi, G.2    Meguid, R.A.3    Fendrich, V.4    Esni, F.5
  • 5
    • 33847419143 scopus 로고    scopus 로고
    • Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
    • Guerra C, Schuhmacher AJ, Canamero M, Grippo PJ, Verdaguer L, et al. (2007) Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11: 291-302.
    • (2007) Cancer Cell , vol.11 , pp. 291-302
    • Guerra, C.1    Schuhmacher, A.J.2    Canamero, M.3    Grippo, P.J.4    Verdaguer, L.5
  • 7
    • 76649105065 scopus 로고    scopus 로고
    • Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    • Morris JPt, Cano DA, Sekine S, Wang SC, Hebrok M, (2010) Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest 120: 508-520.
    • (2010) J Clin Invest , vol.120 , pp. 508-520
    • Morris, J.P.1    Cano, D.A.2    Sekine, S.3    Wang, S.C.4    Hebrok, M.5
  • 8
    • 0033606972 scopus 로고    scopus 로고
    • Notch signalling controls pancreatic cell differentiation
    • Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, et al. (1999) Notch signalling controls pancreatic cell differentiation. Nature 400: 877-881.
    • (1999) Nature , vol.400 , pp. 877-881
    • Apelqvist, A.1    Li, H.2    Sommer, L.3    Beatus, P.4    Anderson, D.J.5
  • 10
    • 10744223624 scopus 로고    scopus 로고
    • Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
    • Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, et al. (2003) Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 3: 565-576.
    • (2003) Cancer Cell , vol.3 , pp. 565-576
    • Miyamoto, Y.1    Maitra, A.2    Ghosh, B.3    Zechner, U.4    Argani, P.5
  • 11
    • 37649023286 scopus 로고    scopus 로고
    • Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway
    • Sawey ET, Johnson JA, Crawford HC, (2007) Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway. Proc Natl Acad Sci U S A 104: 19327-19332.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19327-19332
    • Sawey, E.T.1    Johnson, J.A.2    Crawford, H.C.3
  • 12
    • 35349021929 scopus 로고    scopus 로고
    • Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas
    • Rooman I, De Medts N, Baeyens L, Lardon J, De Breuck S, et al. (2006) Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Am J Pathol 169: 1206-1214.
    • (2006) Am J Pathol , vol.169 , pp. 1206-1214
    • Rooman, I.1    De Medts, N.2    Baeyens, L.3    Lardon, J.4    De Breuck, S.5
  • 13
    • 77955827414 scopus 로고    scopus 로고
    • Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
    • Mazur PK, Einwachter H, Lee M, Sipos B, Nakhai H, et al. (2010) Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A 107: 13438-13443.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13438-13443
    • Mazur, P.K.1    Einwachter, H.2    Lee, M.3    Sipos, B.4    Nakhai, H.5
  • 14
    • 0037370310 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in mouse skin
    • Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, et al. (2003) Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33: 416-421.
    • (2003) Nat Genet , vol.33 , pp. 416-421
    • Nicolas, M.1    Wolfer, A.2    Raj, K.3    Kummer, J.A.4    Mill, P.5
  • 15
    • 80055092549 scopus 로고    scopus 로고
    • Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
    • Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, et al. (2011) Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A 108: 17761-17766.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 17761-17766
    • Wang, N.J.1    Sanborn, Z.2    Arnett, K.L.3    Bayston, L.J.4    Liao, W.5
  • 16
    • 80555154065 scopus 로고    scopus 로고
    • Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway
    • Viatour P, Ehmer U, Saddic LA, Dorrell C, Andersen JB, et al. (2011) Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med 208: 1963-1976.
    • (2011) J Exp Med , vol.208 , pp. 1963-1976
    • Viatour, P.1    Ehmer, U.2    Saddic, L.A.3    Dorrell, C.4    Andersen, J.B.5
  • 17
    • 79955915582 scopus 로고    scopus 로고
    • A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
    • Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, et al. (2011) A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature 473: 230-233.
    • (2011) Nature , vol.473 , pp. 230-233
    • Klinakis, A.1    Lobry, C.2    Abdel-Wahab, O.3    Oh, P.4    Haeno, H.5
  • 18
    • 80052177544 scopus 로고    scopus 로고
    • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    • Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, et al. (2011) Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333: 1154-1157.
    • (2011) Science , vol.333 , pp. 1154-1157
    • Agrawal, N.1    Frederick, M.J.2    Pickering, C.R.3    Bettegowda, C.4    Chang, K.5
  • 19
    • 67649304460 scopus 로고    scopus 로고
    • Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment
    • Demehri S, Turkoz A, Kopan R, (2009) Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell 16: 55-66.
    • (2009) Cancer Cell , vol.16 , pp. 55-66
    • Demehri, S.1    Turkoz, A.2    Kopan, R.3
  • 20
    • 77953158971 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma
    • Hanlon L, Avila JL, Demarest RM, Troutman S, Allen M, et al. (2010) Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. Cancer Res 70: 4280-4286.
    • (2010) Cancer Res , vol.70 , pp. 4280-4286
    • Hanlon, L.1    Avila, J.L.2    Demarest, R.M.3    Troutman, S.4    Allen, M.5
  • 21
    • 24944441782 scopus 로고    scopus 로고
    • Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
    • Means AL, Meszoely IM, Suzuki K, Miyamoto Y, Rustgi AK, et al. (2005) Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development 132: 3767-3776.
    • (2005) Development , vol.132 , pp. 3767-3776
    • Means, A.L.1    Meszoely, I.M.2    Suzuki, K.3    Miyamoto, Y.4    Rustgi, A.K.5
  • 22
    • 0037213351 scopus 로고    scopus 로고
    • Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis
    • Gu G, Brown JR, Melton DA, (2003) Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev 120: 35-43.
    • (2003) Mech Dev , vol.120 , pp. 35-43
    • Gu, G.1    Brown, J.R.2    Melton, D.A.3
  • 24
    • 4444328365 scopus 로고    scopus 로고
    • Mastermind critically regulates Notch-mediated lymphoid cell fate decisions
    • Maillard I, Weng AP, Carpenter AC, Rodriguez CG, Sai H, et al. (2004) Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood 104: 1696-1702.
    • (2004) Blood , vol.104 , pp. 1696-1702
    • Maillard, I.1    Weng, A.P.2    Carpenter, A.C.3    Rodriguez, C.G.4    Sai, H.5
  • 25
    • 34147190365 scopus 로고    scopus 로고
    • Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration
    • Desai BM, Oliver-Krasinski J, De Leon DD, Farzad C, Hong N, et al. (2007) Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest 117: 971-977.
    • (2007) J Clin Invest , vol.117 , pp. 971-977
    • Desai, B.M.1    Oliver-Krasinski, J.2    De Leon, D.D.3    Farzad, C.4    Hong, N.5
  • 26
  • 27
    • 84858002179 scopus 로고    scopus 로고
    • Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues
    • Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, et al. (2012) Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues. J Pathol 226: 723-734.
    • (2012) J Pathol , vol.226 , pp. 723-734
    • Aichler, M.1    Seiler, C.2    Tost, M.3    Siveke, J.4    Mazur, P.K.5
  • 28
    • 84860374357 scopus 로고    scopus 로고
    • Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma
    • Cook N, Frese KK, Bapiro TE, Jacobetz MA, Gopinathan A, et al. (2012) Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. J Exp Med 209: 437-444.
    • (2012) J Exp Med , vol.209 , pp. 437-444
    • Cook, N.1    Frese, K.K.2    Bapiro, T.E.3    Jacobetz, M.A.4    Gopinathan, A.5
  • 29
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, et al. (2005) Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7: 469-483.
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3    Combs, C.4    Deramaudt, T.B.5
  • 30
    • 34547667454 scopus 로고    scopus 로고
    • Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia
    • Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF, (2007) Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Am J Pathol 171: 263-273.
    • (2007) Am J Pathol , vol.171 , pp. 263-273
    • Zhu, L.1    Shi, G.2    Schmidt, C.M.3    Hruban, R.H.4    Konieczny, S.F.5
  • 31
    • 65249125270 scopus 로고    scopus 로고
    • Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma
    • Plentz R, Park JS, Rhim AD, Abravanel D, Hezel AF, et al. (2009) Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology 136: 1741-1749 e1746.
    • (2009) Gastroenterology , vol.136
    • Plentz, R.1    Park, J.S.2    Rhim, A.D.3    Abravanel, D.4    Hezel, A.F.5
  • 32
    • 34249740225 scopus 로고    scopus 로고
    • The notch regulator MAML1 interacts with p53 and functions as a coactivator
    • Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, et al. (2007) The notch regulator MAML1 interacts with p53 and functions as a coactivator. J Biol Chem 282: 11969-11981.
    • (2007) J Biol Chem , vol.282 , pp. 11969-11981
    • Zhao, Y.1    Katzman, R.B.2    Delmolino, L.M.3    Bhat, I.4    Zhang, Y.5
  • 33
    • 77950441537 scopus 로고    scopus 로고
    • Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells
    • Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, et al. (2010) Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A 107: 5012-5017.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 5012-5017
    • Mazzone, M.1    Selfors, L.M.2    Albeck, J.3    Overholtzer, M.4    Sale, S.5
  • 34
  • 35
    • 24944572259 scopus 로고    scopus 로고
    • Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
    • Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, et al. (2005) Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 8: 185-195.
    • (2005) Cancer Cell , vol.8 , pp. 185-195
    • Stanger, B.Z.1    Stiles, B.2    Lauwers, G.Y.3    Bardeesy, N.4    Mendoza, M.5
  • 36
    • 78751515624 scopus 로고    scopus 로고
    • Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas
    • Kopinke D, Brailsford M, Shea JE, Leavitt R, Scaife CL, et al. (2011) Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development 138: 431-441.
    • (2011) Development , vol.138 , pp. 431-441
    • Kopinke, D.1    Brailsford, M.2    Shea, J.E.3    Leavitt, R.4    Scaife, C.L.5
  • 37
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    • Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, et al. (2001) Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 15: 3243-3248.
    • (2001) Genes Dev , vol.15 , pp. 3243-3248
    • Jackson, E.L.1    Willis, N.2    Mercer, K.3    Bronson, R.T.4    Crowley, D.5
  • 38
    • 0033136717 scopus 로고    scopus 로고
    • Deficient T cell fate specification in mice with an induced inactivation of Notch1
    • Radtke F, Wilson A, Stark G, Bauer M, van Meerwijk J, et al. (1999) Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10: 547-558.
    • (1999) Immunity , vol.10 , pp. 547-558
    • Radtke, F.1    Wilson, A.2    Stark, G.3    Bauer, M.4    van Meerwijk, J.5
  • 39
    • 0036070308 scopus 로고    scopus 로고
    • Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes
    • Wolfer A, Wilson A, Nemir M, MacDonald HR, Radtke F, (2002) Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. Immunity 16: 869-879.
    • (2002) Immunity , vol.16 , pp. 869-879
    • Wolfer, A.1    Wilson, A.2    Nemir, M.3    MacDonald, H.R.4    Radtke, F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.