High-throughput method development for sensitive, accurate, and reproducible quantification of therapeutic monoclonal antibodies in tissues using orthogonal array optimization and nano liquid chromatography/selected reaction monitoring mass spectrometry

Analytical Chemistry

Volumn 84, Issue 10, 2012, Pages 4373-4382

  Duan, Xiaotao ^a   Abuqayyas, Lubna ^a   Dai, Lipeng ^a   Balthasar, Joseph P ^a   Qu, Jun ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALIBRATION CURVES; EFFICIENT STRATEGY; HEAVY CHAIN; HIGH RESOLUTION; HIGH SENSITIVITY; HIGH-THROUGHPUT; HIGH-THROUGHPUT METHOD; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; NANO LIQUID CHROMATOGRAPHY; NANO-LC; ON-THE-FLY; OPTIMIZED CONDITIONS; ORBITRAP; ORTHOGONAL ARRAY; PROOF OF CONCEPT; PROTEIN ANALYSIS; QUANTITATIVE METHOD; REACTION MONITORING; RELATIVE ERRORS; RELATIVE STANDARD DEVIATIONS; SELECTED REACTION MONITORING; THERAPEUTIC MONOCLONAL ANTIBODIES; TISSUE DISTRIBUTIONS; TISSUE LEVELS; TISSUE MATRIX; WIDE DYNAMIC RANGE; WILD TYPES;

BIOSYNTHESIS; CHROMATOGRAPHY; HISTOLOGY; LIQUIDS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; OPTIMIZATION; PEPTIDES;

TISSUE;

MONOCLONAL ANTIBODY; PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; MASS SPECTROMETRY; METABOLISM; MOUSE; NANOTECHNOLOGY; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; MASS SPECTROMETRY; MICE; NANOTECHNOLOGY; PEPTIDES; TISSUE DISTRIBUTION;

EID: 84861142055     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac2034166     Document Type: Article

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