A universal strategy for development of a method for absolute quantification of therapeutic monoclonal antibodies in biological matrices using differential dimethyl labeling coupled with ultra performance liquid chromatography-tandem mass spectrometry

Analytical Chemistry

Volumn 81, Issue 22, 2009, Pages 9321-9328

  Ji, Chengjie ^a   Sadagopan, Nalini ^a   Zhang, Yizhong ^a   Lepsy, Christopher ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE QUANTIFICATION; ACCURACY AND PRECISION; AMINO GROUP; ANALYTICAL APPROACH; BIOANALYTICAL; BIOLOGICAL MATRIXES; BIOPHARMACEUTICAL INDUSTRY; CLINICAL STUDY; COEFFICIENT OF VARIATION; CYNOMOLGUS MONKEYS; ENZYMATIC DIGESTIONS; INTERNAL STANDARDS; ISOTOPE DILUTION MASS SPECTROMETRY; MILD REACTION CONDITIONS; RATE-LIMITING STEPS; REACTION TIME; REDUCTIVE AMINATION; RUNTIMES; THERAPEUTIC MONOCLONAL ANTIBODIES; TRYPTIC PEPTIDES; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPLC-MS/MS;

AMINATION; AMINES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; FLUORINE CONTAINING POLYMERS; FORMALDEHYDE; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ISOTOPES; LABELING; MASS SPECTROMETERS; MASS SPECTROMETRY; MERGERS AND ACQUISITIONS; MONOCLONAL ANTIBODIES; PEPTIDES; STANDARDIZATION; STRATEGIC PLANNING; SURFACE PLASMON RESONANCE;

ALLERGIES;

FORMALDEHYDE; LYSINE; MONOCLONAL ANTIBODY;

ACCURACY; AMINATION; AMINO TERMINAL SEQUENCE; ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; FEMALE; ISOTOPE DILUTION ASSAY; LIQUID CHROMATOGRAPHY; MALE; MONKEY; NONHUMAN; QUANTITATIVE ANALYSIS; REACTION TIME; REDUCTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

ANIMALS; ANTIBODIES, MONOCLONAL; CHEMISTRY TECHNIQUES, ANALYTICAL; CHROMATOGRAPHY, LIQUID; FEMALE; ISOTOPE LABELING; MACACA FASCICULARIS; MALE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 70649105587     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac901800f     Document Type: Article

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