Nano-scale liquid chromatography/mass spectrometry and on-the-fly orthogonal array optimization for quantification of therapeutic monoclonal antibodies and the application in preclinical analysis

Journal of Chromatography A

Volumn 1251, Issue , 2012, Pages 63-73

  Duan, Xiaotao ^a   Dai, Lipeng ^a,b,c   Chen, Shang Chiung ^a   Balthasar, Joseph P ^a   Qu, Jun ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b TIANJIN UNIVERSITY   (China)

^c TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Anti CEA antibody; LC MS; Monoclonal antibody; Nano flow LC; Pharmacokinetics; Quantification

Indexed keywords

ACCURACY AND PRECISION; ACCURATE ANALYSIS; COMPREHENSIVE EVALUATION; DATA RELIABILITY; HIGH RESOLUTION; HIGH SPECIFICITY; HIGH-THROUGHPUT; LC/MS; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; LOW DETECTION LIMIT; LOW DOSE; MOUSE MODELS; NANO SCALE; NANO-FLOW LC; NANO-LC; NEGATIVE BIAS; ON-THE-FLY; ORTHOGONAL ARRAY; PRECLINICAL ANALYSIS; PROOF OF CONCEPT; QUANTIFICATION; QUANTITATIVE ACCURACY; QUANTITATIVE METHOD; SAMPLE CONSUMPTION; SELECTED REACTION MONITORING; SMALL-ANIMAL; TARGET PROTEINS; TECHNICAL ADVANCES; THERAPEUTIC MONOCLONAL ANTIBODIES; THERAPEUTIC PROTEIN; TIME COURSE;

BIOSYNTHESIS; CHROMATOGRAPHY; LIQUIDS; MAMMALS; MASS SPECTROMETRY; MATRIX ALGEBRA; MONOCLONAL ANTIBODIES; PEPTIDES; PHARMACOKINETICS; SURFACE PLASMON RESONANCE;

OPTIMIZATION;

CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL MODIFICATION; DEGRADATION KINETICS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSAGE FORM COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; EXPERIMENTAL MODEL; HIGH THROUGHPUT SCREENING; IMMUNOASSAY; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; ON-THE-FLY ORTHOGONAL ARRAY OPTIMIZATION; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN STABILITY; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; RELIABILITY; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; TIME TO MAXIMUM PLASMA CONCENTRATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, LIQUID; LINEAR MODELS; MALE; MASS SPECTROMETRY; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; NANOTECHNOLOGY; PEPTIDE FRAGMENTS; PROTEIN STABILITY; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; SENSITIVITY AND SPECIFICITY;

ANIMALIA; MUS;

EID: 84864068370     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.06.007     Document Type: Article

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