메뉴 건너뛰기




Volumn 18, Issue 6, 2012, Pages 665-673

Molecular-based and alternative therapies for pancreatic cancer: Looking "out of the box"

Author keywords

molecular based therapy; novel therapeutic options; Pancreatic ductal adenocarcinoma (PDA)

Indexed keywords

ANTINEOPLASTIC AGENT; AZD 8542; DIPHTHERIA VACCINE; FLUOROURACIL; FOLINIC ACID; GELATINASE A; GEMCITABINE; IRINOTECAN; K RAS PROTEIN; MARIMASTAT; MATRIX METALLOPROTEINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OXALIPLATIN; PACLITAXEL; SARIDEGIB; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

EID: 84871253900     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0b013e3182793ff6     Document Type: Review
Times cited : (7)

References (85)
  • 1
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (New York, NY). 2008;321:1801-1806.
    • (2008) Science (New York, NY). , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 2
    • 80054820265 scopus 로고    scopus 로고
    • An emerging entity: Pancreatic adenocarcinoma associated with a known BRCA mutation: Clinical descriptors, treatment implications, and future directions
    • Lowery MA, Kelsen DP, Stadler ZK, et al. An emerging entity: pancreatic adenocarcinoma associated with a known BRCA mutation: clinical descriptors, treatment implications, and future directions. Oncologist. 2011;16:1397-1402.
    • (2011) Oncologist. , vol.16 , pp. 1397-1402
    • Lowery, M.A.1    Kelsen, D.P.2    Stadler, Z.K.3
  • 3
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • Olive KP, Jacobetz MA, Davidson CJ, et al. Inhibition of hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (New York, NY). 2009;324:1457-1461.
    • (2009) Science (New York, NY). , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3
  • 4
    • 84864004791 scopus 로고    scopus 로고
    • Distinct genes related to drug response identified in ER positive and ER negative breast cancer cell lines
    • Shen K, Rice SD, Gingrich DA, et al. Distinct genes related to drug response identified in ER positive and ER negative breast cancer cell lines. PloS One. 2012;7:e40900.
    • (2012) PloS One. , vol.7
    • Shen, K.1    Rice, S.D.2    Gingrich, D.A.3
  • 6
    • 84865080615 scopus 로고    scopus 로고
    • The pancreas cancer microenvi-ronment
    • Feig C, Gopinathan A, Neesse A, et al. The pancreas cancer microenvi-ronment. Clin Cancer Res. 2012;18:4266-4276.
    • (2012) Clin Cancer Res. , vol.18 , pp. 4266-4276
    • Feig, C.1    Gopinathan, A.2    Neesse, A.3
  • 7
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • Coussens LM, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science (New York, NY). 2002;295:2387-2392.
    • (2002) Science (New York, NY). , vol.295 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 8
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
    • Bramhall SR, Rosemurgy A, Brown PD, et al. Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J Clin Oncol. 2001;19:3447-3455.
    • (2001) J Clin Oncol. , vol.19 , pp. 3447-3455
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3
  • 9
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J, et al. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer. 2002;87:161-167.
    • (2002) Br J Cancer. , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3
  • 10
    • 84855488454 scopus 로고    scopus 로고
    • Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer
    • Zhao M, Tominaga Y, Ohuchida K, et al. Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer. Cancer Sci. 2012;103:58-66.
    • (2012) Cancer Sci. , vol.103 , pp. 58-66
    • Zhao, M.1    Tominaga, Y.2    Ohuchida, K.3
  • 11
    • 60649108677 scopus 로고    scopus 로고
    • Selective inhibition of matrix metallo-proteinase-14 blocks tumor growth, invasion, and angiogenesis
    • Devy L, Huang L, Naa L, et al. Selective inhibition of matrix metallo-proteinase-14 blocks tumor growth, invasion, and angiogenesis. Cancer Res. 2009;69:1517-1526.
    • (2009) Cancer Res. , vol.69 , pp. 1517-1526
    • Devy, L.1    Huang, L.2    Naa, L.3
  • 13
    • 34248141223 scopus 로고    scopus 로고
    • Tumor-stroma interactions in pancreatic ductal adenocarcinoma
    • Mahadevan D, Von Hoff DD. Tumor-stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 2007;6:1186-1197.
    • (2007) Mol Cancer Ther. , vol.6 , pp. 1186-1197
    • Mahadevan, D.1    Von Hoff, D.D.2
  • 14
    • 79955068416 scopus 로고    scopus 로고
    • Analysis of the human pancreatic stellate cell secreted proteome
    • Wehr AY, Furth EE, Sangar V, et al. Analysis of the human pancreatic stellate cell secreted proteome. Pancreas. 40:557-566.
    • Pancreas. , vol.40 , pp. 557-566
    • Wehr, A.Y.1    Furth, E.E.2    Sangar, V.3
  • 15
    • 84855201311 scopus 로고    scopus 로고
    • StellaTUM: Current consensus and discussion on pancreatic stellate cell research
    • Erkan M, Adler G, Apte MV, et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 2012;61:172-178.
    • (2012) Gut. , vol.61 , pp. 172-178
    • Erkan, M.1    Adler, G.2    Apte, M.V.3
  • 16
    • 42049097658 scopus 로고    scopus 로고
    • Pancreatic stellate cells: Partners in crime with pancreatic cancer cells
    • Vonlaufen A, Joshi S, Qu C, et al. Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res. 2008;68:2085-2093.
    • (2008) Cancer Res. , vol.68 , pp. 2085-2093
    • Vonlaufen, A.1    Joshi, S.2    Qu, C.3
  • 17
    • 77957743993 scopus 로고    scopus 로고
    • Inhibition of pancreatic stellate cell activation by halofuginone prevents pancreatic xenograft tumor development
    • Spector I, Honig H, Kawada N, et al. Inhibition of pancreatic stellate cell activation by halofuginone prevents pancreatic xenograft tumor development. Pancreas. 2010;39:1008-1015.
    • (2010) Pancreas. , vol.39 , pp. 1008-1015
    • Spector, I.1    Honig, H.2    Kawada, N.3
  • 18
    • 84871251621 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer
    • Hwang RF, Moore TT, Mertens Hattersley M, et al. Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. Mol Cancer Res.
    • Mol Cancer Res
    • Hwang, R.F.1    Moore, T.T.2    Mertens Hattersley, M.3
  • 19
    • 83355169753 scopus 로고    scopus 로고
    • Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: A phase I/II trial
    • Von Hoff DD, Ramanathan RK, Borad MJ, et al. Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol. 2011;29:4548-4554.
    • (2011) J Clin Oncol. , vol.29 , pp. 4548-4554
    • Von Hoff, D.D.1    Ramanathan, R.K.2    Borad, M.J.3
  • 20
    • 34547770890 scopus 로고    scopus 로고
    • Human equilibrative nucleo-side transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer
    • Tsujie M, Nakamori S, Nakahira S, et al. Human equilibrative nucleo-side transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 2007;27:2241-2249.
    • (2007) Anticancer Res. , vol.27 , pp. 2241-2249
    • Tsujie, M.1    Nakamori, S.2    Nakahira, S.3
  • 21
    • 84865474189 scopus 로고    scopus 로고
    • Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma
    • Marechal R, Bachet JB, Mackey JR, et al. Levels of gemcitabine transport and metabolism proteins predict survival times of patients treated with gemcitabine for pancreatic adenocarcinoma. Gastroenterology. 2012;143:664-74 e6.
    • (2012) Gastroenterology. , vol.143
    • Marechal, R.1    Bachet, J.B.2    MacKey, J.R.3
  • 22
    • 33846916208 scopus 로고    scopus 로고
    • Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma
    • Infante JR, Matsubayashi H, Sato N, et al. Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol. 2007;25:319-325.
    • (2007) J Clin Oncol. , vol.25 , pp. 319-325
    • Infante, J.R.1    Matsubayashi, H.2    Sato, N.3
  • 23
    • 84865103094 scopus 로고    scopus 로고
    • Conceptual framework for cutting the pancreatic cancer fuel supply
    • Le A, Rajeshkumar NV, Maitra A, et al. Conceptual framework for cutting the pancreatic cancer fuel supply. Clin Cancer Res. 2012;18:4285-4290.
    • (2012) Clin Cancer Res. , vol.18 , pp. 4285-4290
    • Le Rajeshkumar, A.N.V.1    Maitra, A.2
  • 24
    • 1842430906 scopus 로고    scopus 로고
    • Shedding light on immunotherapy for cancer
    • Rosenberg SA. Shedding light on immunotherapy for cancer. N Engl J Med. 2004;350:1461-1463.
    • (2004) N Engl J Med. , vol.350 , pp. 1461-1463
    • Rosenberg, S.A.1
  • 25
    • 77957981209 scopus 로고    scopus 로고
    • Adoptive cell therapy: Genetic modification to redirect effector cell specificity
    • Morgan RA, Dudley ME, Rosenberg SA. Adoptive cell therapy: genetic modification to redirect effector cell specificity. Cancer J (Sudbury, Mass). 2010;16:336-341.
    • (2010) Cancer J (Sudbury, Mass). , vol.16 , pp. 336-341
    • Morgan, R.A.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 26
    • 79151486551 scopus 로고    scopus 로고
    • A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, and immune activation
    • Lutz E, Yeo CJ, Lillemoe KD, et al. A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, and immune activation. Ann Surg. 2011;253:328-335.
    • (2011) Ann Surg. , vol.253 , pp. 328-335
    • Lutz, E.1    Yeo, C.J.2    Lillemoe, K.D.3
  • 27
    • 84871239383 scopus 로고    scopus 로고
    • Clinical implications and diagnostic usefulness of correlation between soluble major histocompatibility complex class i chain-related molecule a and protumorigenic cytokines in pancreatic ductal adenocarcinoma
    • Epub ahead of print
    • Chung HW, Jang S, Lim JB. Clinical implications and diagnostic usefulness of correlation between soluble major histocompatibility complex class I chain-related molecule a and protumorigenic cytokines in pancreatic ductal adenocarcinoma. Cancer. 2012; Epub ahead of print.
    • (2012) Cancer.
    • Chung, H.W.1    Jang, S.2    Lim, J.B.3
  • 28
    • 79953061206 scopus 로고    scopus 로고
    • MUC1 enhances invasive-ness of pancreatic cancer cells by inducing epithelial to mesenchymal transition
    • Roy LD, Sahraei M, Subramani DB, et al. MUC1 enhances invasive-ness of pancreatic cancer cells by inducing epithelial to mesenchymal transition. Oncogene. 2011;30:1449-1459.
    • (2011) Oncogene. , vol.30 , pp. 1449-1459
    • Roy, L.D.1    Sahraei, M.2    Subramani, D.B.3
  • 29
    • 80053119078 scopus 로고    scopus 로고
    • Human dendritic cells transfected with amplified MUC1 mRNA stimulate cytotoxic T lymphocyte responses against pancreatic cancer in vitro
    • Chen J, Li HY, Wang D, et al. Human dendritic cells transfected with amplified MUC1 mRNA stimulate cytotoxic T lymphocyte responses against pancreatic cancer in vitro. J Gastroenterol Hepatol. 26: 1509-1518.
    • J Gastroenterol Hepatol. , vol.26 , pp. 1509-1518
    • Chen, J.1    Li, H.Y.2    Wang, D.3
  • 30
    • 84871005809 scopus 로고    scopus 로고
    • Intratumoral delivery of CpG-conjugated anti-MUC1 antibody enhances NK cell anti-tumor activity
    • Epub ahead of print
    • Schettini J, Kidiyoor A, Besmer DM, et al. Intratumoral delivery of CpG-conjugated anti-MUC1 antibody enhances NK cell anti-tumor activity. Cancer Immunol Immunother. 2012; Epub ahead of print.
    • (2012) Cancer Immunol Immunother.
    • Schettini, J.1    Kidiyoor, A.2    Besmer, D.M.3
  • 31
    • 84863692393 scopus 로고    scopus 로고
    • A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as bio-markers
    • Winter JM, Tang LH, Klimstra DS, et al. A novel survival-based tissue microarray of pancreatic cancer validates MUC1 and mesothelin as bio-markers. PLoS One. 2012;7:e40157.
    • (2012) PLoS One. , vol.7
    • Winter, J.M.1    Tang, L.H.2    Klimstra, D.S.3
  • 32
    • 84863297929 scopus 로고    scopus 로고
    • Effects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin-27 mediated by retrovirus in human pancreatic carcinoma cells
    • Liu L, Meng J, Zhang C, et al. Effects on apoptosis and cell cycle arrest contribute to the antitumor responses of interleukin-27 mediated by retrovirus in human pancreatic carcinoma cells. Oncol Rep. 27:1497-1503.
    • Oncol Rep. , vol.27 , pp. 1497-1503
    • Liu, L.1    Meng, J.2    Zhang, C.3
  • 33
    • 51349141767 scopus 로고    scopus 로고
    • Inhibition of pancreatic carcinoma growth by adenovirus-mediated human interleukin-24 expression in animal model
    • Pan X, Sheng W, Zhu Q, et al. Inhibition of pancreatic carcinoma growth by adenovirus-mediated human interleukin-24 expression in animal model. Cancer Biother Radiopharm. 2008;23:425-434.
    • (2008) Cancer Biother Radiopharm. , vol.23 , pp. 425-434
    • Pan, X.1    Sheng, W.2    Zhu, Q.3
  • 34
    • 43049103779 scopus 로고    scopus 로고
    • Expression of indole-amine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection
    • discussion 54-56
    • Witkiewicz A, Williams TK, Cozzitorto J, et al. Expression of indole-amine 2,3-dioxygenase in metastatic pancreatic ductal adenocarcinoma recruits regulatory T cells to avoid immune detection. J Am Coll Surg. 2008;206:849-854; discussion 54-56.
    • (2008) J Am Coll Surg. , vol.206 , pp. 849-854
    • Witkiewicz, A.1    Williams, T.K.2    Cozzitorto, J.3
  • 35
    • 24944433410 scopus 로고    scopus 로고
    • Marrying immunotherapy with chemotherapy: Why say IDO?
    • Muller AJ, Prendergast GC. Marrying immunotherapy with chemotherapy: why say IDO? Cancer Res. 2005;65:8065-8068.
    • (2005) Cancer Res. , vol.65 , pp. 8065-8068
    • Muller, A.J.1    Prendergast, G.C.2
  • 36
    • 34249295962 scopus 로고    scopus 로고
    • Characterization of an indole-amine 2,3-dioxygenase-like protein found in humans and mice
    • Ball HJ, Sanchez-Perez A, Weiser S, et al. Characterization of an indole-amine 2,3-dioxygenase-like protein found in humans and mice. Gene. 2007;396:203-213.
    • (2007) Gene. , vol.396 , pp. 203-213
    • Ball, H.J.1    Sanchez-Perez, A.2    Weiser, S.3
  • 37
    • 41149132390 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape
    • Katz JB, Muller AJ, Prendergast GC. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol Rev. 2008;222: 206-221.
    • (2008) Immunol Rev. , vol.222 , pp. 206-221
    • Katz, J.B.1    Muller, A.J.2    Prendergast, G.C.3
  • 38
    • 67649216127 scopus 로고    scopus 로고
    • The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity
    • Scott GN, DuHadaway J, Pigott E, et al. The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity. J Immunol. 2009;182:7509-7517.
    • (2009) J Immunol. , vol.182 , pp. 7509-7517
    • Scott, G.N.1    Duhadaway, J.2    Pigott, E.3
  • 39
    • 0032555614 scopus 로고    scopus 로고
    • Prevention of allogeneic fetal rejection by tryptophan catabolism
    • Munn DH, Zhou M, Attwood JT, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science (New York, NY). 1998;281: 1191-1193.
    • (1998) Science (New York, NY). , vol.281 , pp. 1191-1193
    • Munn, D.H.1    Zhou, M.2    Attwood, J.T.3
  • 40
    • 34547643025 scopus 로고    scopus 로고
    • Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indole-amine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan
    • Metz R, Duhadaway JB, Kamasani U, et al. Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indole-amine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res. 2007;67:7082-7087.
    • (2007) Cancer Res. , vol.67 , pp. 7082-7087
    • Metz, R.1    Duhadaway, J.B.2    Kamasani, U.3
  • 41
    • 64949113986 scopus 로고    scopus 로고
    • Genotyping and expression analysis of IDO2 in human pancreatic cancer: A novel, active target
    • discussion 7-9
    • Witkiewicz AK, Costantino CL, Metz R, et al. Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. J Am Coll Surg. 2009;208:781-787; discussion 7-9.
    • (2009) J Am Coll Surg. , vol.208 , pp. 781-787
    • Witkiewicz, A.K.1    Costantino, C.L.2    Metz, R.3
  • 42
    • 25144445294 scopus 로고    scopus 로고
    • BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian
    • Friedenson B. BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian. MedGenMed. 2005;7:60.
    • (2005) MedGenMed , vol.7 , pp. 60
    • Friedenson, B.1
  • 43
    • 58549085226 scopus 로고    scopus 로고
    • BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma
    • Ferrone CR, Levine DA, Tang LH, et al. BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma. J Clin Oncol. 2009; 27:433-438.
    • (2009) J Clin Oncol. , vol.27 , pp. 433-438
    • Ferrone, C.R.1    Levine, D.A.2    Tang, L.H.3
  • 44
    • 0037420026 scopus 로고    scopus 로고
    • BRCA2 germline mutations in familial pancreatic carcinoma
    • Hahn SA, Greenhalf B, Ellis I, et al. BRCA2 germline mutations in familial pancreatic carcinoma. J Natl Cancer Inst. 2003;95:214-221.
    • (2003) J Natl Cancer Inst. , vol.95 , pp. 214-221
    • Hahn, S.A.1    Greenhalf, B.2    Ellis, I.3
  • 45
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 2005;434:913-917.
    • (2005) Nature. , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 46
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005;434: 917-921.
    • (2005) Nature. , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 47
    • 84861702357 scopus 로고    scopus 로고
    • Radiosensitization effect of poly(ADP-ribose) polymerase inhibition in cells exposed to low and high liner energy transfer radiation
    • Hirai T, Shirai H, Fujimori H, et al. Radiosensitization effect of poly(ADP-ribose) polymerase inhibition in cells exposed to low and high liner energy transfer radiation. Cancer Sci. 2012;103:1045-1050.
    • (2012) Cancer Sci. , vol.103 , pp. 1045-1050
    • Hirai, T.1    Shirai, H.2    Fujimori, H.3
  • 48
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) poly-merase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) poly-merase in tumors from BRCA mutation carriers. N Engl J Med. 2009; 361:123-134.
    • (2009) N Engl J Med. , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 49
    • 84860806404 scopus 로고    scopus 로고
    • Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1
    • Langelier MF, Planck JL, Roy S, et al. Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1. Science (New York, NY). 2012;336:728-732.
    • (2012) Science (New York, NY). , vol.336 , pp. 728-732
    • Langelier, M.F.1    Planck, J.L.2    Roy, S.3
  • 50
    • 77951985779 scopus 로고    scopus 로고
    • Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific pep-tidase 11 (USP11) as a regulator of DNA double-strand break repair
    • Wiltshire TD, Lovejoy CA, Wang T, et al. Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific pep-tidase 11 (USP11) as a regulator of DNA double-strand break repair. J Biol Chem. 2010;285:14565-14571.
    • (2010) J Biol Chem. , vol.285 , pp. 14565-14571
    • Wiltshire, T.D.1    Lovejoy, C.A.2    Wang, T.3
  • 51
    • 84871182759 scopus 로고    scopus 로고
    • FDA. Accessed on November 9, 2012
    • FDA. Mitoxantrone. Available at: http://www.accessdata.fda.gov/scripts/ cder/drugsatfda/index.cfm?fuseaction=Search.Overview&DrugName= MITOXANTRONE%20HYDROCHLORIDE. Accessed on November 9, 2012.
    • Mitoxantrone
  • 52
    • 84861694755 scopus 로고    scopus 로고
    • Emerging inorganic nanomaterials for pancreatic cancer diagnosis and treatment
    • Yang F, Jin C, Subedi S, et al. Emerging inorganic nanomaterials for pancreatic cancer diagnosis and treatment. Cancer Treat Rev. 2012; 38:566-579.
    • (2012) Cancer Treat Rev. , vol.38 , pp. 566-579
    • Yang, F.1    Jin, C.2    Subedi, S.3
  • 53
    • 54349091298 scopus 로고    scopus 로고
    • Nanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells
    • Showalter SL, Huang YH, Witkiewicz A, et al. Nanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells. Cancer Biol Ther. 2008;7:1584-1590.
    • (2008) Cancer Biol Ther. , vol.7 , pp. 1584-1590
    • Showalter, S.L.1    Huang, Y.H.2    Witkiewicz, A.3
  • 54
    • 40949151239 scopus 로고    scopus 로고
    • Targeted deliveryof gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent
    • Patra CR, Bhattacharya R, Wang E, et al. Targeted deliveryof gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent. Cancer Res. 2008;68:1970-1978.
    • (2008) Cancer Res. , vol.68 , pp. 1970-1978
    • Patra, C.R.1    Bhattacharya, R.2    Wang, E.3
  • 55
    • 37549037486 scopus 로고    scopus 로고
    • PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma
    • Gold DV, Karanjawala Z, Modrak DE, et al. PAM4-reactive MUC1 is a biomarker for early pancreatic adenocarcinoma. Clin Cancer Res. 2007; 13:7380-7387.
    • (2007) Clin Cancer Res. , vol.13 , pp. 7380-7387
    • Gold, D.V.1    Karanjawala, Z.2    Modrak, D.E.3
  • 56
    • 78650322382 scopus 로고    scopus 로고
    • Noninvasive radiofrequency field destruction of pancreatic adenocarcinoma xenografts treated with targeted gold nanoparticles
    • Glazer ES, Zhu C, Massey KL, et al. Noninvasive radiofrequency field destruction of pancreatic adenocarcinoma xenografts treated with targeted gold nanoparticles. Clin Cancer Res. 2010;16:5712-5721.
    • (2010) Clin Cancer Res. , vol.16 , pp. 5712-5721
    • Glazer, E.S.1    Zhu, C.2    Massey, K.L.3
  • 57
    • 62549142754 scopus 로고    scopus 로고
    • Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis
    • Huang YH, Bao Y, Peng W, et al. Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis. Proc Natl Acad Sci USA. 2009;106:3426-3430.
    • (2009) Proc Natl Acad Sci USA. , vol.106 , pp. 3426-3430
    • Huang, Y.H.1    Bao, Y.2    Peng, W.3
  • 58
    • 66349114705 scopus 로고    scopus 로고
    • The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine ki-nase
    • Costantino CL, Witkiewicz AK, Kuwano Y, et al. The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine ki-nase. Cancer Res. 2009;69:4567-4572.
    • (2009) Cancer Res. , vol.69 , pp. 4567-4572
    • Costantino, C.L.1    Witkiewicz, A.K.2    Kuwano, Y.3
  • 59
    • 77956222392 scopus 로고    scopus 로고
    • HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients
    • discussion 6
    • Richards NG, Rittenhouse DW, Freydin B, et al. HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients. Ann Surg. 2010;252:499-505; discussion 6.
    • (2010) Ann Surg. , vol.252 , pp. 499-505
    • Richards, N.G.1    Rittenhouse, D.W.2    Freydin, B.3
  • 62
    • 84864539012 scopus 로고    scopus 로고
    • HuR's post-transcriptional regulation of death receptor 5 in pancreatic cancer cells
    • Pineda DM, Rittenhouse DW, Valley CC, et al. HuR's post-transcriptional regulation of death receptor 5 in pancreatic cancer cells. Cancer Biol Ther. 2012;13:946-955.
    • (2012) Cancer Biol Ther. , vol.13 , pp. 946-955
    • Pineda, D.M.1    Rittenhouse, D.W.2    Valley, C.C.3
  • 63
    • 34247862190 scopus 로고    scopus 로고
    • MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
    • Bloomston M, Frankel WL, Petrocca F, et al. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA. 2007;297:1901-1908.
    • (2007) JAMA , vol.297 , pp. 1901-1908
    • Bloomston, M.1    Frankel, W.L.2    Petrocca, F.3
  • 64
    • 68949213672 scopus 로고    scopus 로고
    • Let-7 MicroRNA transfer in pancreatic canceryderived cells inhibits in vitro cell proliferation but fails to alter tumor progression
    • Torrisani J, Bournet B, du Rieu MC, et al. let-7 MicroRNA transfer in pancreatic cancerYderived cells inhibits in vitro cell proliferation but fails to alter tumor progression. Human Gene Ther. 2009;20:831-844.
    • (2009) Human Gene Ther. , vol.20 , pp. 831-844
    • Torrisani, J.1    Bournet, B.2    Du Rieu, M.C.3
  • 65
    • 69249096109 scopus 로고    scopus 로고
    • Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
    • Li Y, VandenBoom TG 2nd, Kong D, et al. Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res. 2009;69:6704-6712.
    • (2009) Cancer Res. , vol.69 , pp. 6704-6712
    • Li, Y.1    Van Den Boom II, T.G.2    Kong, D.3
  • 66
    • 70349904531 scopus 로고    scopus 로고
    • Antisense inhibition of microRNA-21 or-221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma
    • Park JK, Lee EJ, Esau C, et al. Antisense inhibition of microRNA-21 or-221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma. Pancreas. 2009;38:e190-9.
    • (2009) Pancreas. , vol.38
    • Park, J.K.1    Lee, E.J.2    Esau, C.3
  • 67
    • 84855417964 scopus 로고    scopus 로고
    • Rapid generation of microRNA sponges for microRNA inhibition
    • Kluiver J, Gibcus JH, Hettinga C, et al. Rapid generation of microRNA sponges for microRNA inhibition. PloS One. 2012;7:e29275.
    • (2012) PloS One. , vol.7
    • Kluiver, J.1    Gibcus, J.H.2    Hettinga, C.3
  • 68
    • 69949087531 scopus 로고    scopus 로고
    • MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    • Ji Q, Hao X, Zhang M, et al. MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PloS One. 2009;4:e6816.
    • (2009) PloS One. , vol.4
    • Ji, Q.1    Hao, X.2    Zhang, M.3
  • 69
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann PC, Huber SL, Herrler T, et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell. 2007;1:313-323.
    • (2007) Cell Stem Cell. , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3
  • 70
    • 80555145216 scopus 로고    scopus 로고
    • Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: Molecular mechanisms
    • Singh BN, Fu J, Srivastava RK, et al. Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PloS One. 2011;6:e27306.
    • (2011) PloS One. , vol.6
    • Singh, B.N.1    Fu, J.2    Srivastava, R.K.3
  • 71
    • 35148900228 scopus 로고    scopus 로고
    • The fuzzy math of solid tumor stem cells: A perspective
    • Kern SE, Shibata D. The fuzzy math of solid tumor stem cells: a perspective. Cancer Res. 2007;67:8985-8988.
    • (2007) Cancer Res. , vol.67 , pp. 8985-8988
    • Kern, S.E.1    Shibata, D.2
  • 72
    • 84865087341 scopus 로고    scopus 로고
    • Heterogeneity and targeting of pancreatic cancer stem cells
    • Penchev VR, Rasheed ZA, Maitra A, et al. Heterogeneity and targeting of pancreatic cancer stem cells. Clin Cancer Res. 2012;18:4277-4284.
    • (2012) Clin Cancer Res. , vol.18 , pp. 4277-4284
    • Penchev, V.R.1    Rasheed, Z.A.2    Maitra, A.3
  • 73
    • 84871233784 scopus 로고    scopus 로고
    • New cancer research angle from a surprising source
    • New Cancer Research Angle from a Surprising Source. Jefferson Surgical Solutions; 2009;4.
    • (2009) Jefferson Surgical Solutions , vol.4
  • 74
    • 2342593369 scopus 로고    scopus 로고
    • Disruption of cancer cell replication by alternating electric fields
    • Kirson ED, Gurvich Z, Schneiderman R, et al. Disruption of cancer cell replication by alternating electric fields. Cancer Res. 2004;64: 3288-3295.
    • (2004) Cancer Res. , vol.64 , pp. 3288-3295
    • Kirson, E.D.1    Gurvich, Z.2    Schneiderman, R.3
  • 75
    • 84865528882 scopus 로고    scopus 로고
    • NovoTTF-100Aversus physician's choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality
    • Stupp R, Wong ET, Kanner AA, et al. NovoTTF-100Aversus physician's choice chemotherapy in recurrent glioblastoma: a randomised phase III trial of a novel treatment modality. Eur J Cancer. 2012;48:2192-2202.
    • (2012) Eur J Cancer. , vol.48 , pp. 2192-2202
    • Stupp, R.1    Wong, E.T.2    Kanner, A.A.3
  • 76
    • 84871197716 scopus 로고    scopus 로고
    • HIFU for palliative treatment of pancreatic cancer
    • Khokhlova TD, Hwang JH. HIFU for palliative treatment of pancreatic cancer. J Gastrointest Oncol. 2011;2:175-184.
    • (2011) J Gastrointest Oncol. , vol.2 , pp. 175-184
    • Khokhlova, T.D.1    Hwang, J.H.2
  • 77
    • 77949422386 scopus 로고    scopus 로고
    • Concurrent gemcitabine and high-intensity focused ultrasound therapy in patients with locally advanced pancreatic cancer
    • Zhao H, Yang G, Wang D, et al. Concurrent gemcitabine and high-intensity focused ultrasound therapy in patients with locally advanced pancreatic cancer. Anticancer Drugs. 2010;21:447-452.
    • (2010) Anticancer Drugs. , vol.21 , pp. 447-452
    • Zhao, H.1    Yang, G.2    Wang, D.3
  • 78
    • 77956792595 scopus 로고    scopus 로고
    • High-intensity focused ultrasound ablation: Effective and safe therapy for solid tumors in difficult locations
    • Orsi F, Zhang L, Arnone P, et al. High-intensity focused ultrasound ablation: effective and safe therapy for solid tumors in difficult locations. AJR. 2010;195:W245-252.
    • (2010) AJR , vol.195
    • Orsi, F.1    Zhang, L.2    Arnone, P.3
  • 79
    • 84870323491 scopus 로고    scopus 로고
    • Genetically defined subsets of human pancreatic cancer demonstrate unique in vitro chemosensitivity
    • Epub ahead of print
    • Cui Y, Brosnan JA, Blackford AL, et al. Genetically defined subsets of human pancreatic cancer demonstrate unique in vitro chemosensitivity. Clin Cancer Res. 2012; Epub ahead of print.
    • (2012) Clin Cancer Res.
    • Cui, Y.1    Brosnan, J.A.2    Blackford, A.L.3
  • 80
    • 84865062750 scopus 로고    scopus 로고
    • Translational therapeutic opportunities in ductal adenocarcinoma of the pancreas
    • Hidalgo M, Von Hoff DD. Translational therapeutic opportunities in ductal adenocarcinoma of the pancreas. Clin Cancer Res. 2012;18: 4249-4256.
    • (2012) Clin Cancer Res. , vol.18 , pp. 4249-4256
    • Hidalgo, M.1    Von Hoff, D.D.2
  • 81
    • 74949110667 scopus 로고    scopus 로고
    • The 'RNA-binding ome': Future implications for chemotherapeutic efficacy
    • Brody JR, Witkiewicz AK, Yeo CJ, et al. The 'RNA-binding ome': future implications for chemotherapeutic efficacy. Future oncology (London, England). 2009;5:1317-1319.
    • (2009) Future Oncology (London, England). , vol.5 , pp. 1317-1319
    • Brody, J.R.1    Witkiewicz, A.K.2    Yeo, C.J.3
  • 82
    • 84857720786 scopus 로고    scopus 로고
    • HuR's role in gemcitabine efficacy: An exception or opportunity?
    • Brody JR, Gonye GE. HuR's role in gemcitabine efficacy: an exception or opportunity? WIREs RNA. 2011;2:435-444.
    • (2011) WIREs RNA. , vol.2 , pp. 435-444
    • Brody, J.R.1    Gonye, G.E.2
  • 83
    • 84865076498 scopus 로고    scopus 로고
    • Genetic basis of pancreas cancer development and progression: Insights from whole-exome and whole-genome sequencing
    • Iacobuzio-Donahue CA, Velculescu VE, Wolfgang CL, et al. Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing. Clin Cancer Res. 2012; 18:4257-4265.
    • (2012) Clin Cancer Res. , vol.18 , pp. 4257-4265
    • Iacobuzio-Donahue, C.A.1    Velculescu, V.E.2    Wolfgang, C.L.3
  • 84
    • 33751093171 scopus 로고    scopus 로고
    • A proposed clinical test for monitoring fluoropyrimidine therapy: Detection and stability of thymi-dylate synthase ternary complexes
    • Brody JR, Gallmeier E, Yoshimura K, et al. A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymi-dylate synthase ternary complexes. Cancer Biol Ther. 2006;5:923-927.
    • (2006) Cancer Biol Ther. , vol.5 , pp. 923-927
    • Brody, J.R.1    Gallmeier, E.2    Yoshimura, K.3
  • 85
    • 84868617118 scopus 로고    scopus 로고
    • A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluor-opyrimidines dosing
    • Patel K, Yerram SR, Azad NA, et al. A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluor-opyrimidines dosing. Oncotarget. 2012;3:678-685.
    • (2012) Oncotarget. , vol.3 , pp. 678-685
    • Patel, K.1    Yerram, S.R.2    Azad, N.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.