Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide

Chemical Research in Toxicology

Volumn 25, Issue 12, 2012, Pages 2725-2736

  Dunlap, Tareisha ^a   Piyankarage, Sujeewa C ^a   Wijewickrama, Gihani T ^a   Abdul Hay, Samer ^a   Vanni, Michael ^a   Litosh, Vladislav ^a   Luo, Jia ^a   Thatcher, Gregory R J ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,5 DIAMINOFLUORESCEIN DIACETATE; ACETYLSALICYLIC ACID DERIVATIVE; ELECTROPHILE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE P1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; NCX 4040; NITRIC OXIDE; QUINONE DERIVATIVE; QUINONE METHIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SALICYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL CULTURE; CELL PROTECTION; CELL STRAIN HEPG2; CHEMOPROPHYLAXIS; DNA DAMAGE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHILICITY; ENZYME ACTIVITY; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ASPIRIN; CELL LINE, TUMOR; DNA DAMAGE; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; INDOLEQUINONES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; NITRIC OXIDE; PRODRUGS;

EID: 84871252239     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx3003609     Document Type: Article

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