Chemiluminescence and LC-MS/MS analyses for the study of nitric oxide release and distribution following oral administration of nitroaspirin (NCX 4016) in healthy volunteers

Journal of Pharmaceutical and Biomedical Analysis

Volumn 35, Issue 2, 2004, Pages 277-287

  Carini, Marina ^a   Aldini, Giancarlo ^a   Orioli, Marica ^a   Piccoli, Angela ^a   Tocchetti, Paola ^b   Facino, Roberto Maffei ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b NicOx Research Institute Srl   (Italy)

Author keywords

Chemiluminescence; Human studies; Liquid chromatography tandem mass spectrometry; NCX 4016; Nitric oxide; Nitroaspirin; Plasma S nitrosothiols

Indexed keywords

ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; BIOLOGICAL MARKER; DRUG METABOLITE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; S NITROSOTHIOL;

ADULT; BLOOD LEVEL; CAUCASIAN; CHEMOLUMINESCENCE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG MONITORING; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SINGLE DRUG DOSE; URINE LEVEL; VOLUNTEER;

ADMINISTRATION, ORAL; ADULT; ASPIRIN; CHEMILUMINESCENT MEASUREMENTS; CHROMATOGRAPHY, LIQUID; HUMANS; MALE; MASS SPECTROMETRY; NITRIC OXIDE;

EID: 1942471789     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(03)00531-4     Document Type: Conference Paper

References (18)

1. Fiorucci S., Del Soldato P. Dig. Liver Dis. 35:2003;S9-S19.
2. Wallace J.L., McKnight W., Wilson T.L., Del Soldato P., Cirino G. Am. J. Physiol. 273:1997;G1246-G1251.
3. Fiorucci S., Cantucci L., Cirino G., Mencarelli A., Familiari L., Del Soldato P., Morelli A. J. Immunol. 165:2000;5245-5254.
4. al-Swayeh O.A., Clifford R.H., Del Soldato P., Moore P.K. Br. J. Pharmacol. 129:2000;343-350.
5. Wallace J.L., Muscara M.N., McKnight W., Dicay M., Del Soldato P., Cirino G. Thromb. Res. 93:1999;43-50.
6. Fiorucci S., Cantucci L., Gresele P., Maffei Facino R., Del Soldato P., Morelli A. Gastroenterology. 124:2003;600-607.
7. Cuzzolin L., Adami A., Degan M., Crivellente F., Bonapace S., Minuz P., Benoni G. Life Sci. 58:1996;PL207-210.
8. M. Carini, G. Aldini, M. Orioli, R. Maffei Facino, Presented at the Drug Analysis 2002 Symposium, P053, Bruges, 21-25 April 2002, p. 78.
9. Carini M., Aldini G., Stefani R., Orioli M., Maffei Facino R. J. Pharm. Biomed. Anal. 26:2001;509-518.
10. Braman R.S., Hendrix S.A. Anal. Chem. 61:1989;2715-2718.
11. Marley R., Feelisch M., Holt S., Moore K. Free Radic. Res. 32:2000;1-9.
12. Carini M., Aldini G., Orioli M., Maffei Facino R. J. Pharm. Biomed. Anal. 29:2002;1061-1071.
13. Marley R., Patel R.P., Orie N., Ceaser E., Darley-Usmar V., Moore K. Free Radic. Biol. Med. 31:2001;688-696.
14. Tsikas D., Sandmann J., Gutzki F.M., Stichtenoth D.O., Frolich J.C. J. Chromatogr. B. 726:1999;13-24.
15. Rassaf T., Bryan N.S., Kelm M., Feelisch M. Free Radic. Biol. Med. 33:2002;1590-1596.
16. Yang B.K., Vivas E.X., Reiter C.D., Gladwin M.T. Free Radic. Res. 37:2003;1-10.
17. Napoli C., Aldini G., Wallace J.L., De Nigris F., Maffei Facino R., Abete P., Bonaduce D., Condorelli G., Ignarro L.J. Proc. Natl. Acad. Sci. U.S.A. 99:2002;1689-1694.
18. Li H., Samouilov A., Liu X., Zweier J.L. Biochemistry. 42:2003;1150-1159.