Manganese ion enhances T1-weighted MRI during brain activation: An approach to direct imaging of brain function

Magnetic Resonance in Medicine

Volumn 38, Issue 3, 1997, Pages 378-388

  Lin, Yi Jen ^a   Koretsky, Alan P ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

Blood brain barrier; Functional MRI; Glutamate; Somatosensory stimulation

Indexed keywords

BLOOD; CALCIUM; CHEMICAL ACTIVATION; CHLORINE COMPOUNDS; HEMODYNAMICS; MAGNETIC RESONANCE IMAGING; MANGANESE; MANGANESE COMPOUNDS; NEURONS; RATS; SIGNAL DETECTION; SIGNAL SYSTEMS;

BLOOD-BRAIN BARRIER; DIVALENT MANGANESE IONS; EFFICIENT DETECTION; FUNCTIONAL MRI; GLUTAMATE; MRI CONTRAST AGENTS; NEURONAL ACTIVITIES; SOMATOSENSORY;

FUNCTIONAL NEUROIMAGING;

MANGANESE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN SCINTISCANNING; CALCIUM TRANSPORT; MALE; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SOMATOSENSORY STIMULATION;

EID: 0030963695     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910380305     Document Type: Article

References (52)

1. K. K. Kwong, J. W. Belliveau, D. A. Chesler, I. E. Goldberg, R. M. Weisskoff, B. P. Poncelet, D. N. Kennedy, Jr., B. E. Hoppel, M. S. Cohen, R. Turner, Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc. Natl Acad. Sci. USA 89, 5675-5679 (1992).
2. R. S. Menon, S. Ogawa, S.-G. Kim, J. M. Ellermann, H. Merkle, D. W. Tank, K. Ugurbil, Functional brain mapping using magnetic resonance imaging. Invest. Radial. 27(Suppl. 2), S47-S53 (1992).
3. S. Ogawa, D. W. Tank, R. S. Menon, J. M. Ellermann, S.-G. Kim, H. Merkle, K. Ugurbil, Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc. Natl. Acad. Sci. USA 89, 5951-5955 (1992).
4. S. Ogawa, R. S. Menon, D. W. Tank, S.-G. Kim, H. Merkle, J. M. Ellermann, K. Ugurhil, Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. Biophys. J. 64, 803-812 (1993).
5. A. C. e. Silva, W. Zhang, D. S. Williams, A. P. Koretsky, Multi-slice MRI of rat brain perfusion during amphetamine stimulation using arterial spin labeling. Magn. Reson. Med. 33, 209-214 (1995).
6. D. S. Williams, J. A. Detre, J. S. Leigh, Jr., A. P. Koretsky, Magnetic resonance imaging of perfusion using spin inversion of arterial water. Proc. Natl. Acad. Sci. USA 89, 212-216 (1992).
7. J. W. Belliveau, D. N. Kennedy, Jr., R. C. McKinstry, B. R. Buchbinder, R. M. Weisskoff, M. S. Cohen, J. M. Vevea, T. J. Brady, B. R. Rosen, Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254, 716-719 (1991).
8. J. L. Boxerman, P. A. Bandettini, K. K. Kwong, J. R. Baker, T. L. Davis, B. R. Rosen, R. M. Weisskoff, The intravascular contribution to fMRI signal change: Monte Carlo modeling and diffusion-weighted studies in vivo. Magn. Reson. Med. 34, 4-10 (1995).
9. A. W. Song, E. C. Wong, S. G. Tan, J. S. Hyde, Diffusion weighted fMRI at 1.5 T. Magn. Reson. Med. 35, 155-158 (1996).
10. J. G. Nichollis, A. R. Martin, B. G. Wallace, Principles of synaptic transmission, in "From Neuron to Brain," Chapt 7, pp. 214-219. 299-300, Sinauer Associates, Sunderland, MA, 1992.
11. 2+ fluxes in mitochondria of the perfused rat heart. Circ. Res. 47, 721 (1980).
12. P. Drapeau, D. A. Nachshen, Manganese fluxes and manganese-dependent neurotransmitter release in presynaptic nerve endings isolated from rat brain. J. Physiol. 348, 493-510 (1984).
13. U. Meiri, R. Rahamimoff, Neuromuscular transmission: inhibition by manganese ions. Science 176, 308-309 (1972).
14. T. J. Hallam, T. J. Rink, Agonists stimulate divalent cation channels in the plasma membrane of human platelets. FEBS Lett. 186, 175-179 (1985).
15. a; and that Cd preferentially blocks the latter. Cell Calcium 14, 33-44 (1993).
16. K. Narita, F. Kawasaki, H. Kita, Mn and Mg influxes through Ca channels of motor nerve terminals are prevented by verapamil in frogs. Brain Res. 510, 289-295 (1990).
17. 2+ -saline solutions. Brain Ras. 205, 111-121 (1981).
18. M. Aschner, J. L. Aschner, Manganese neurotoxicity: cellular effects and blood-brain barrier transport. Neurosci. Biobehev. Rav. 15, 333-340 (1991).
19. M. H. Dias, E. Gaggelli, P. C. Lauterbur, Paramagnetic contrast agents in nuclear magnetic resonance medical imaging. Semin. Nucl. Med. 13, 364-376 (1983).
20. 2: a potential alternative to iv injection for tissue contrast enhancement in magnetic resonance imaging. Magn. Reson. Imaging 2, 307-314 (1984).
21. D. A. Cory, D. J. Schwartzentruber, B. H. Mock, Ingested manganese chloride as a contrast agent in magnetic: resonance imaging. Magn. Reson. Imaging 5, 65-70 (1987).
22. D. Fornasiero, J. C. Bellen, R. J. Baker, B. E. Chatterton, Paramagnetic complexes of manganese (II), iron (III), and gadolinium (III) as contrast agents for magnetic resonance imaging. Invest. Radiol. 22, 322-327 (1987).
23. 3+ complexes of various polyaza macrocyclic ligand: implication for NMR Imaging. Magn. Reson. Med. 3, 242-250 (1986).
24. 15O in the monkey. Circ. Res. 37, 707-714 (1975).
25. 2 on cerebral blood volume, blood flow, and vascular mean transit time. Stroke 5, 630-639 (1974).
26. M. Ueki, G. Mies, K. A. Hossmann, Effect of alpha-chloralose, halothane, pentobarbital, and nitrous oxide anesthesia on metabolic coupling in somatosensory cortex of the rat. Acta Anaesthesiol. Scand. 36, 318-322 (1992).
27. F. Hyder, K. L. Behar, M. A. Martin, A. M. Blamire, R. G. Shulman, Dynamic magnetic resonance imaging of the rat brain during forepaw stimulation. J. Cereb. Blood Flow Metab. 14, 649-655 (1994).
28. M. L. Gyngell, C. Bock, B. Schmilz, M. Hoehn-Berlage, Variation of functional MRI signal in response to frequency of somatosensory stimulation in α-chloralose anesthetized rats. Magn. Reson. Med. 36, 13-15 (1996).
29. R. Dingledine, C. J. McBain, in "Basic Neurochemistry: Molecular, Cellular, and Medical Aspects," 5th ed., Raven Press, Ltd., New York, 1994.
30. A. B. Norman, K. J. Bertram, S. R. Thomas, R. G. Pratt, R. C. Samaratunga, P. R. Sanberg, Magnetic resonance imaging of rat brain following in vivo disruption of the cerebral vasculature. Magn. Reson. Med. 26, 593-597 (1991).
31. Y. Ashani, G. N. Catrava, W. A. Alter, An irreversible anticholinosterase probe for studying increased permeability of the rat blood-brain barrier. Biochem. Pharmacol. 30, 2585-2592 (1981).
32. T. Iroue, M. Fukui, S. Nishio, K. Kitamura, H. Nagara, Hyporosmotic blood-brain barrier disruption in brains of rats with an intracerebrally transplanted RG-C6 tumor. J. Neurosurg. 66, 256-263 (1987).
33. P. C. Warnker, R. G. Blasberg, D. R. Groothuis, The effect of hyperosmotic blood-brain barrier disruption on blood-to-tissue transport in ENU-induced gliomas. Ann. Neurol. 22, 300-305 (1987).
34. M. C. Newland, C. Cox, R. Hamada, G. Oberdoerster, R. Weiss, The clearance of manganese chloride in the primate. Fundam. Appl. Toxicol. 9, 314-328 (1987).
35. M. C. Newland, T. L. Checkler, J. Kordower, B. Weiss, Visualizing manganese in the primate basal ganglia with magnetic resonance imaging. Exp. Neurol. 106, 251-258 (1889).
36. G. C. Cotzias, M. S. Horiuchi, S. Fuenzalida, I. Mena, Clearance of tissue manganese concentrations with persistence of the neurological picture. Neurology 18, 376-382 (1968).
37. R. E. London, G. Toney, S. A. Gabel, A. Funk, Magnetic resonance imaging studies of the brains of anesthetized rats treated with manganese chloride. Brain Res. Bull. 23, 229-235 (1989).
38. B. Gerdin, E. Mccann, C. Lundberg, K.-E. Arfors, Selective tissue accumulation of manganese and its effect on regional blood flow and haemodynamics after intravenous infusion of its chloride salt in the rat. Int. J. Tissue React. 7, 373-380 (1985).
39. M. Aschner, M. Gannon, Manganese (Mn) transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanisms. Brain Res. Bull. 33 345-349 (1994).
40. H. Kabata, A. Matsuda, K. Yokoi, M. Kimura, Y. Itokawa, Effect of the dosage and route of manganese administration on manganese concentration in rat brain. Jpn. J. Hyg. 44, 667-672 (1989).
41. V. A. Murphy, K. C. Wadhwani, Q. R. Smith, S. I. Rapoport, Saturable transport of manganese (II) across the rat blood-brain barrier. J. Neurochem. 57, 948-954 (1991).
42. O. Rabin, L. Hegedus, J.-M. Bourre, Q. R. Smith, Rapid brain uptake of manganese (II) across the blood-brain barrier. J. Neurochem. 61, 509-517 (1993).
43. M. Aschner, J. L. Aschner, Manganese transport across the blood-brain barrier: relationship to iron homeostasis. Brain Res. Bull. 24, 857-860 (1990).
44. G. Kaur, S. K. Hasan, R. C. Srivastava, The distribution of manganose-54 in fetal, young, and adult rats. Toxicol. Lett. 5, 423-426 (1980).
45. C. E. Gavin, K. K. Gunter, T. E. Gunter, Manganese and calcium efflux kinetics in brain mitochondria. Biochem. J. 266, 329-334 (1990).
46. N. R. Saunders, K. Mallgard, Development of the blood brain harrier. J. Dev. Physiol. 6, 45-57 (1984).
47. P. A. Stewart, E. M. Hayakawa, Inter endothelial junctional changes underlie the developmental tightening of the blood-brain barrier. Dev. Brain Res. 32, 271-281 (1987).
48. A. H. Schinkel, J. J. M. Smit, O. v. Tellingen, J. H. Beijnen, E. Wagenaar, L. v. Deetmor, M. A. v. d. Valk, B. C. Robanus-Maandag, H. P. J. t. Tiele, A. J. M. Berns, P. Borst, Disruption of the mouse mdr1a P-Glycoprotein gene leads to a deficiency in the blood brain barrier and to increased sensitivity to drugs. Cell 77, 491-502 (1994).
49. N. H. Neff, R. E. Barrett, E. Costa, Selective depletion of caudate nucleus dopamine and serotonin during chronic manganese dioxide administration to squirrel monkeys. Experientia 25, 1140-1141 (1969).
50. A. Barbeau, Manganese and extrapyramidal disorders. Neurotoxicology 5, 13-36 (1984).
51. W. H. Horner, P. Kligfield, Antidysrhythmic and dose-related hemodynamic effects of manganese in perfused isolated rabbit hearts. J. Cardiovasc. Pharmacol. 4, 149 (1982).
52. 2+ pump in rat brain synaptic plasma membrane vesicles. Biochem. Pharmacol. 42, 1537-1543 (1991).