Differential roles of JNK, ERK1/2, and p38 mitogen-activated protein kinases on endothelial cell tissue repair functions in response to tumor necrosis factor-α

Journal of Vascular Research

Volumn 50, Issue 2, 2013, Pages 145-156

  Kanaji, Nobuhiro ^a   Nelson, Amy ^d   Wang, Xingqi ^d   Sato, Tadashi ^b   Nakanishi, Masanori ^c   Gunji, Yoko ^d   Basma, Hesham ^d   Michalski, Joel ^d   Farid, Maha ^d   Rennard, Stephen I ^d   Liu, Xiangde ^d  

^a KAGAWA UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Endothelial cells; Mitogen activated protein kinase; Wound repair

Indexed keywords

COLLAGEN GEL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME REPRESSION; GENE AMPLIFICATION; HUMAN PULMONARY ARTERY ENDOTHELIAL CELL; NONHUMAN; PRIORITY JOURNAL; TISSUE REPAIR; WOUND CLOSURE;

APOPTOSIS; CELLS, CULTURED; COLLAGEN; CULTURE MEDIA, SERUM-FREE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GELS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 14; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 8; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PULMONARY ARTERY; RECOMBINANT PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA; VASCULITIS; WOUND HEALING;

EID: 84871183351     PISSN: 10181172     EISSN: 14230135     Source Type: Journal    
DOI: 10.1159/000345525     Document Type: Article

References (35)

1. Peinado VI, Pizarro S, Barbera JA: Pulmonary vascular involvement in COPD. Chest 2008; 134: 808-814.
2. Bradley JR: TNF-mediated inflammatory disease. J Pathol 2008; 214: 149-160.
3. Chaudhuri V, Zhou L, Karasek M: Inflammatory cytokines induce the transformation of human dermal microvascular endothelial cells into myofibroblasts: a potential role in skin fibrogenesis. J Cutan Pathol 2007; 34: 146-153.
4. Kanaji N, Sato T, Nelson A, Wang X, Li Y, Kim M, Nakanishi M, Basma H, Michalski J, Farid M, Chandler M, Pease W, Patil A, Rennard SI, Liu X: Inflammatory cytokines regulate endothelial cell survival and tissue repair functions via NF-kappaB signaling. J Inflamm Res 2011; 4: 127-138.
5. Sprague AH, Khalil RA: Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol 2009; 78: 539-552.
6. Madge LA, Pober JS: A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J Biol Chem 2000; 275: 15458-15465.
7. Raman M, Chen W, Cobb MH: Differential regulation and properties of MAPKs. Oncogene 2007; 26: 3100-3112.
8. Saklatvala J, Rawlinson L, Waller RJ, Sarsfield S, Lee JC, Morton LF, Barnes MJ, Farndale RW: Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue. J Biol Chem 1996; 271: 6586-6589.
9. Rossa C, Ehmann K, Liu M, Patil C, Kirkwood KL: MKK3/6-p38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells. J Interferon Cytokine Res 2006; 26: 719-729.
10. Yoshida K, Kuwano K, Hagimoto N, Watanabe K, Matsuba T, Fujita M, Inoshima I, Hara N: MAP kinase activation and apoptosis in lung tissues from patients with idiopathic pulmonary fibrosis. J Pathol 2002; 198: 388-396.
11. Chopra P, Kanoje V, Semwal A, Ray A: Therapeutic potential of inhaled p38 mitogen-activated protein kinase inhibitors for inflammatory pulmonary diseases. Expert Opin Investig Drugs 2008; 17: 1411-1425.
12. Renda T, Baraldo S, Pelaia G, Bazzan E, Turato G, Papi A, Maestrelli P, Maselli R, Vatrella A, Fabbri LM, Zuin R, Marsico SA, Saetta M: Increased activation of p38 MAPK in COPD. Eur Respir J 2008; 31: 62-69.
13. Schett G, Zwerina J, Firestein G: The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis. Ann Rheum Dis 2008; 67: 909-916.
14. Medhora M, Dhanasekaran A, Pratt PF Jr, Cook CR, Dunn LK, Gruenloh SK, Jacobs ER: Role of JNK in network formation of human lung microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol 2008; 294:L676-L685.
15. Grossini E, Molinari C, Caimmi PP, Uberti F, Vacca G: Levosimendan induces no production through p38 MAPK, ERK and Akt in porcine coronary endothelial cells: role for mitochondrial K(ATP) channel. Br J Pharmacol 2009; 156: 250-261.
16. Sumioka T, Ikeda K, Okada Y, Yamanaka O, Kitano A, Saika S: Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium. Mol Vis 2008; 14: 2272-2281.
17. Kanaji N, Nelson A, Allen-Gipson DS, Sato T, Nakanishi M, Wang X, Li Y, Basma H, Michalski J, Farid M, Rennard SI, Liu X: The p38 mitogen-activated protein kinases modulate endothelial cell survival and tissue repair. Inflamm Res 2011; 61: 233-244.
18. Grethe S, Ares MP, Andersson T, Porn-Ares MI: p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L). Exp Cell Res 2004; 298: 632-642.
19. Gorina R, Font-Nieves M, Marquez-Kisinousky L, Santalucia T, Planas AM: Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFkappaB signaling, MAPK, and Jak1/Stat1 pathways. Glia 2011; 59: 242-255.
20. Bladh LG, Johansson-Haque K, Rafter I, Nilsson S, Okret S: Inhibition of extracellular signal-regulated kinase (ERK) signaling participates in repression of nuclear factor (NF)-kappaB activity by glucocorticoids. Biochim Biophys Acta 2009; 1793: 439-446.
21. Ji G, Liu D, Liu J, Gao H, Yuan X, Shen G: P38 mitogen-activated protein kinase up-regulates NF-kappaB transcriptional activation through RelA phosphorylation during stretch-induced myogenesis. Biochem Biophys Res Commun 2010; 391: 547-551.
22. Ben-Othman R, Dellagi K, Guizani-Tabbane L: Leishmania major parasites induced macrophage tolerance: implication of MAPK and NF-kappaB pathways. Mol Immunol 2009; 46: 3438-3444.
23. Jung YS, Jeong EM, Park EK, Kim YM, Sohn S, Lee SH, Baik EJ, Moon CH: Cadmium induces apoptotic cell death through p38 MAPK in brain microvessel endothelial cells. Eur J Pharmacol 2008; 578: 11-18.
24. Moriue T, Igarashi J, Yoneda K, Nakai K, Kosaka H, Kubota Y: Sphingosine 1-phosphate attenuates H 2 O 2-induced apoptosis in endothelial cells. Biochem Biophys Res Commun 2008; 368: 852-857.
25. Silva G, Cunha A, Gregoire IP, Seldon MP, Soares MP: The antiapoptotic effect of heme oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform. J Immunol 2006; 177: 1894-1903.
26. Porras A, Zuluaga S, Black E, Valladares A, Alvarez AM, Ambrosino C, Benito M, Nebreda AR: p38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli. Mol Biol Cell 2004; 15: 922-933.
27. Grethe S, Coltella N, Di Renzo MF, Porn-Ares MI: P38 MAPK downregulates phosphorylation of bad in doxorubicin-induced endothelial apoptosis. Biochem Biophys Res Commun 2006; 347: 781-790.
28. Guo YL, Kang B, Han J, Williamson JR: p38beta MAP kinase protects rat mesangial cells from TNF-alpha-induced apoptosis. J Cell Biochem 2001; 82: 556-565.
29. Takayama Y, Takezawa T: Lactoferrin promotes collagen gel contractile activity of fibroblasts mediated by lipoprotein receptors. Biochem Cell Biol 2006; 84: 268-274.
30. Liu Y, Ko JA, Yanai R, Kimura K, Chikama T, Sagara T, Nishida T: Induction by latanoprost of collagen gel contraction mediated by human tenon fibroblasts: role of intracellular signaling molecules. Invest Ophthalmol Vis Sci 2008; 49: 1429-1436.
31. Meyer-Ter-Vehn T, Gebhardt S, Sebald W, Buttmann M, Grehn F, Schlunck G, Knaus P: p38 inhibitors prevent TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci 2006; 47: 1500-1509.
32. David L, Mallet C, Vailhe B, Lamouille S, Feige JJ, Bailly S: Activin receptor-like kinase 1 inhibits human microvascular endothelial cell migration: potential roles for JNK and ERK. J Cell Physiol 2007; 213: 484-489.
33. Shin EY, Kim SY, Kim EG: C-jun N-terminal kinase is involved in motility of endothelial cell. Exp Mol Med 2001; 33: 276-283.
34. Hoefen RJ, Berk BC: The role of MAP kinases in endothelial activation. Vascul Pharmacol 2002; 38: 271-273.
35. Voelkel NF, Cool CD: Pulmonary vascular involvement in chronic obstructive pulmonary disease. Eur Respir J Suppl 2003; 46: 28s-32s.