메뉴 건너뛰기




Volumn 62, Issue 1, 2013, Pages 31-43

Epithelial-mesenchymal transition in carcinomas of the female genital tract

Author keywords

Carcinoma; Cervix; EMT; Endometrium; Epithelial mesenchymal transition; Invasive front; MELF; Ovary

Indexed keywords

BETA CATENIN; CYCLIN D1; EPIDERMAL GROWTH FACTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FIBROBLAST GROWTH FACTOR; FIBRONECTIN; INTERSTITIAL COLLAGENASE; K RAS PROTEIN; MACROPHAGE ELASTASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NERVE CELL ADHESION MOLECULE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; VIMENTIN;

EID: 84871171526     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/his.12057     Document Type: Review
Times cited : (58)

References (83)
  • 1
    • 34250174504 scopus 로고    scopus 로고
    • The role of epithelial-mesenchymal transition in cancer pathology
    • Guarino M, Rubino B, Ballabio G. The role of epithelial-mesenchymal transition in cancer pathology. Pathology 2007; 39; 305-318.
    • (2007) Pathology , vol.39 , pp. 305-318
    • Guarino, M.1    Rubino, B.2    Ballabio, G.3
  • 2
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2002; 2; 442-454.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 3
    • 34848826864 scopus 로고    scopus 로고
    • Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression
    • Hugo H, Ackland ML, Blick T et al. Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J. Cell. Physiol. 2007; 213; 374-383.
    • (2007) J. Cell. Physiol. , vol.213 , pp. 374-383
    • Hugo, H.1    Ackland, M.L.2    Blick, T.3
  • 4
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 2005; 17; 548-558.
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 5
    • 75649151387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer development and its clinical significance
    • Iwatsuki M, Mimori K, Yokobori T et al. Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci. 2010; 101; 293-299.
    • (2010) Cancer Sci. , vol.101 , pp. 293-299
    • Iwatsuki, M.1    Mimori, K.2    Yokobori, T.3
  • 6
    • 84861802693 scopus 로고    scopus 로고
    • MicroRNAs: critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression
    • Bullock MD, Savan AE, Packham GK, Mirnezami AH. MicroRNAs: critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression. Biol. Cell 2012; 104; 3-12.
    • (2012) Biol. Cell , vol.104 , pp. 3-12
    • Bullock, M.D.1    Savan, A.E.2    Packham, G.K.3    Mirnezami, A.H.4
  • 7
    • 33645088428 scopus 로고    scopus 로고
    • Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment
    • Kopfstein L, Christofori G. Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment. Cell. Mol. Life Sci. 2006; 63; 449-468.
    • (2006) Cell. Mol. Life Sci. , vol.63 , pp. 449-468
    • Kopfstein, L.1    Christofori, G.2
  • 8
    • 0037899253 scopus 로고    scopus 로고
    • Role of tissue stroma in cancer cell invasion
    • De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J. Pathol. 2003; 200; 429-447.
    • (2003) J. Pathol. , vol.200 , pp. 429-447
    • De Wever, O.1    Mareel, M.2
  • 9
    • 84862495767 scopus 로고    scopus 로고
    • E. Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial cells. Int
    • Talbot LJ, Bhattacharya SD, Kuo PC. E. Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial cells. Int. J. Biochem. Mol. Biol. 2012; 3; 117-136.
    • (2012) J. Biochem. Mol. Biol. , vol.3 , pp. 117-136
    • Talbot, L.J.1    Bhattacharya, S.D.2    Kuo, P.C.3
  • 10
    • 22244473343 scopus 로고    scopus 로고
    • The fallacy of epithelial mesenchymal transition in neoplasia
    • Tarin D. The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res. 2005; 65; 5996-6000.
    • (2005) Cancer Res. , vol.65 , pp. 5996-6000
    • Tarin, D.1
  • 11
    • 39649102143 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition is important to metastasis, but questions remain
    • Garber K. Epithelial-to-mesenchymal transition is important to metastasis, but questions remain. J. Natl Cancer Inst. 2008; 100; 232-233.
    • (2008) J. Natl Cancer Inst. , vol.100 , pp. 232-233
    • Garber, K.1
  • 12
    • 33749024777 scopus 로고    scopus 로고
    • Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
    • Christiansen JJ, Rajasekaran AK. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res. 2006; 66; 8319-8326.
    • (2006) Cancer Res. , vol.66 , pp. 8319-8326
    • Christiansen, J.J.1    Rajasekaran, A.K.2
  • 13
    • 84862333338 scopus 로고    scopus 로고
    • EMT in carcinoma progression and dissemination: facts, unanswered questions, and clinical considerations
    • Bastid J. EMT in carcinoma progression and dissemination: facts, unanswered questions, and clinical considerations. Cancer Metastasis Rev. 2012; 31; 277-283.
    • (2012) Cancer Metastasis Rev. , vol.31 , pp. 277-283
    • Bastid, J.1
  • 14
    • 84873094470 scopus 로고    scopus 로고
    • Insights into cancer metastasis from a clinicopathologic perspective: epithelial-mesenchymal transition is not a necessary step
    • Epub ahead of print] doi:10.1002/ijc.27745.
    • Chui MH. Insights into cancer metastasis from a clinicopathologic perspective: epithelial-mesenchymal transition is not a necessary step. Int. J. Cancer 2012; [Epub ahead of print] doi:10.1002/ijc.27745.
    • (2012) Int. J. Cancer
    • Chui, M.H.1
  • 15
    • 6944254408 scopus 로고    scopus 로고
    • A critical appraisal of the value of immunohistochemistry in diagnosis of uterine neoplasms
    • McCluggage WG. A critical appraisal of the value of immunohistochemistry in diagnosis of uterine neoplasms. Adv. Anat. Pathol. 2004; 11; 162-171.
    • (2004) Adv. Anat. Pathol. , vol.11 , pp. 162-171
    • McCluggage, W.G.1
  • 16
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J. Clin. Invest. 2009; 119; 1429-1437.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 17
    • 65649153358 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition. A cancer researcher's conceptual friend and foe
    • Klymkowsky MW, Savagner P. Epithelial-mesenchymal transition. A cancer researcher's conceptual friend and foe. Am. J. Pathol. 2009; 174; 1588-1593.
    • (2009) Am. J. Pathol. , vol.174 , pp. 1588-1593
    • Klymkowsky, M.W.1    Savagner, P.2
  • 18
    • 77952902430 scopus 로고    scopus 로고
    • Mechanisms of motility in metastasizing cells
    • Yilmaz M, Christofori G. Mechanisms of motility in metastasizing cells. Mol. Cancer Res. 2010; 8; 629-642.
    • (2010) Mol. Cancer Res. , vol.8 , pp. 629-642
    • Yilmaz, M.1    Christofori, G.2
  • 19
    • 33845599552 scopus 로고    scopus 로고
    • Tumour budding in colorectal carcinoma
    • 151-16
    • Prall P. Tumour budding in colorectal carcinoma. Histopathology 2007; 50(151-16); 2.
    • (2007) Histopathology , vol.50 , pp. 2
    • Prall, P.1
  • 20
    • 44949226873 scopus 로고    scopus 로고
    • Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness
    • Le NH, Franken P, Fodde R. Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness. Br. J. Cancer 2008; 98; 1886-1893.
    • (2008) Br. J. Cancer , vol.98 , pp. 1886-1893
    • Le, N.H.1    Franken, P.2    Fodde, R.3
  • 21
    • 84055212063 scopus 로고    scopus 로고
    • Overexpression of ZEB2 at the invasion front of colorectal cancer is an independent prognostic marker and regulates tumor invasion in vitro
    • Kahlert C, Lahes S, Radhakrishnan P et al. Overexpression of ZEB2 at the invasion front of colorectal cancer is an independent prognostic marker and regulates tumor invasion in vitro. Clin. Cancer Res. 2011; 17; 1-10.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 1-10
    • Kahlert, C.1    Lahes, S.2    Radhakrishnan, P.3
  • 23
    • 84862317685 scopus 로고    scopus 로고
    • Cancer stem cells and EMT in carcinoma
    • Epub ahead of print] doi:10.1007/s10555-012-9345-0.
    • Biddle A, Mackenzie IC. Cancer stem cells and EMT in carcinoma. Cancer Metastasis Rev. 2012; [Epub ahead of print] doi:10.1007/s10555-012-9345-0.
    • (2012) Cancer Metastasis Rev.
    • Biddle, A.1    Mackenzie, I.C.2
  • 24
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao M-J et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133; 704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.-J.3
  • 26
    • 79958779810 scopus 로고    scopus 로고
    • Strategies to target molecules that control the acquisition of a mesenchymal-like phenotype by carcinoma cells
    • Palena C, Fernando RI, Litzinger MT, Hamilton DH, Huang B, Schlom J. Strategies to target molecules that control the acquisition of a mesenchymal-like phenotype by carcinoma cells. Exp. Biol. Med. 2011; 236; 537-545.
    • (2011) Exp. Biol. Med. , vol.236 , pp. 537-545
    • Palena, C.1    Fernando, R.I.2    Litzinger, M.T.3    Hamilton, D.H.4    Huang, B.5    Schlom, J.6
  • 27
    • 79951592109 scopus 로고    scopus 로고
    • Changes in the expression of oestrogen receptors and E-cadherin as molecular markers of progression from normal epithelium to invasive cancer in elderly patients with vulvar squamous cell carcinoma
    • Zannoni GF, Prisco MG, Vellone VG, De Stefano I, Scambia G, Gallo D. Changes in the expression of oestrogen receptors and E-cadherin as molecular markers of progression from normal epithelium to invasive cancer in elderly patients with vulvar squamous cell carcinoma. Histopathology 2011; 58; 265-275.
    • (2011) Histopathology , vol.58 , pp. 265-275
    • Zannoni, G.F.1    Prisco, M.G.2    Vellone, V.G.3    De Stefano, I.4    Scambia, G.5    Gallo, D.6
  • 28
    • 80053344881 scopus 로고    scopus 로고
    • Expression profiling of vulvar carcinoma: clues for deranged extracellular matrix remodeling and effects on multiple signalling pathways combined with discrete patient subsets
    • Pappa KI, Jacob-Hirsch J, Vlachos GD et al. Expression profiling of vulvar carcinoma: clues for deranged extracellular matrix remodeling and effects on multiple signalling pathways combined with discrete patient subsets. Transl. Oncol. 2011; 4; 301-313.
    • (2011) Transl. Oncol. , vol.4 , pp. 301-313
    • Pappa, K.I.1    Jacob-Hirsch, J.2    Vlachos, G.D.3
  • 29
    • 47549089080 scopus 로고    scopus 로고
    • Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development
    • Orlichenko LS, Radisky DC. Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin. Exp. Metastasis 2008; 25; 593-600.
    • (2008) Clin. Exp. Metastasis , vol.25 , pp. 593-600
    • Orlichenko, L.S.1    Radisky, D.C.2
  • 30
    • 52549111325 scopus 로고    scopus 로고
    • Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast
    • Ellis PE, Cano SD, Fear M et al. Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast. Mod. Pathol. 2008; 21; 1192-1199.
    • (2008) Mod. Pathol. , vol.21 , pp. 1192-1199
    • Ellis, P.E.1    Cano, S.D.2    Fear, M.3
  • 31
    • 70849088390 scopus 로고    scopus 로고
    • Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study
    • Ellis PE, MacLean AB, Crow JC, Wong Te Fong LF, Rolfe KJ, Perrett CW. Expression of cyclin D1 and retinoblastoma protein in Paget's disease of the vulva and breast: an immunohistochemical study. Histopathology 2009; 55; 709-715.
    • (2009) Histopathology , vol.55 , pp. 709-715
    • Ellis, P.E.1    MacLean, A.B.2    Crow, J.C.3    Wong, T.F.L.4    Rolfe, K.J.5    Perrett, C.W.6
  • 36
    • 84863011646 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cervical carcinoma
    • Lee M-Y, Shen M-R. Epithelial-mesenchymal transition in cervical carcinoma. Am. J. Transl. Res. 2012; 4; 1-13.
    • (2012) Am. J. Transl. Res. , vol.4 , pp. 1-13
    • Lee, M.-Y.1    Shen, M.-R.2
  • 37
    • 67651039345 scopus 로고    scopus 로고
    • HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition
    • Hellner K, Mar J, Fang F, Quackenbush J, Munger K. HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition. Virology 2009; 391; 57-63.
    • (2009) Virology , vol.391 , pp. 57-63
    • Hellner, K.1    Mar, J.2    Fang, F.3    Quackenbush, J.4    Munger, K.5
  • 38
    • 84862933180 scopus 로고    scopus 로고
    • The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis
    • Cheng Y-M, Chou C-Y, Hsu Y-C, Chen M-J, Wing L-YC. The role of human papillomavirus type 16 E6/E7 oncoproteins in cervical epithelial-mesenchymal transition and carcinogenesis. Oncol. Lett. 2012; 3; 667-671.
    • (2012) Oncol. Lett. , vol.3 , pp. 667-671
    • Cheng, Y.-M.1    Chou, C.-Y.2    Hsu, Y.-C.3    Chen, M.-J.4    Wing, L.-Y.5
  • 39
    • 51049109014 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cervical cancer: correlation with tumor progression, epidermal growth factor receptor overexpression and Snail up-regulation
    • Lee M-Y, Chou C-Y, Tang M-J, Shen M-R. Epithelial-mesenchymal transition in cervical cancer: correlation with tumor progression, epidermal growth factor receptor overexpression and Snail up-regulation. Clin. Cancer Res. 2008; 14; 4743-4750.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 4743-4750
    • Lee, M.-Y.1    Chou, C.-Y.2    Tang, M.-J.3    Shen, M.-R.4
  • 40
    • 0036668842 scopus 로고    scopus 로고
    • TGFbeta1-mediated epithelial to mesenchymal transition is accompanied by invasion in the SiHa cell line
    • Yi JY, Hur KC, Lee E, Jin YJ, Arteaga CL, Son YS. TGFbeta1-mediated epithelial to mesenchymal transition is accompanied by invasion in the SiHa cell line. Eur. J. Cell Biol. 2002; 81; 457-468.
    • (2002) Eur. J. Cell Biol. , vol.81 , pp. 457-468
    • Yi, J.Y.1    Hur, K.C.2    Lee, E.3    Jin, Y.J.4    Arteaga, C.L.5    Son, Y.S.6
  • 41
    • 60749096511 scopus 로고    scopus 로고
    • SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway
    • Chung MT, Lai HC, Sytwu HK et al. SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol. Oncol. 2009; 112; 646-653.
    • (2009) Gynecol. Oncol. , vol.112 , pp. 646-653
    • Chung, M.T.1    Lai, H.C.2    Sytwu, H.K.3
  • 42
    • 58249107838 scopus 로고    scopus 로고
    • Promoter methylation of SFRPs gene family in cervical cancer
    • Chung MT, Sytwu HK, Yan MD et al. Promoter methylation of SFRPs gene family in cervical cancer. Gynecol. Oncol. 2009; 112; 301-306.
    • (2009) Gynecol. Oncol. , vol.112 , pp. 301-306
    • Chung, M.T.1    Sytwu, H.K.2    Yan, M.D.3
  • 43
    • 70349766097 scopus 로고    scopus 로고
    • Methylation analysis of SFRP genes family in cervical adenocarcinoma
    • Lin YW, Chung MT, Lai HC et al. Methylation analysis of SFRP genes family in cervical adenocarcinoma. J. Cancer Res. Clin. Oncol. 2009; 135; 1665-1674.
    • (2009) J. Cancer Res. Clin. Oncol. , vol.135 , pp. 1665-1674
    • Lin, Y.W.1    Chung, M.T.2    Lai, H.C.3
  • 44
    • 33846474766 scopus 로고    scopus 로고
    • Molecular profiling of cervical cancer progression
    • Hagemann T, Bozanovic T, Hooper S et al. Molecular profiling of cervical cancer progression. Br. J. Cancer 2007; 96; 321-328.
    • (2007) Br. J. Cancer , vol.96 , pp. 321-328
    • Hagemann, T.1    Bozanovic, T.2    Hooper, S.3
  • 45
    • 79954576306 scopus 로고    scopus 로고
    • Correlation between invasive pattern and immunophenotypic alterations in endocervical adenocarcinoma
    • Stewart CJR, Crook ML, Little L, Louwen K. Correlation between invasive pattern and immunophenotypic alterations in endocervical adenocarcinoma. Histopathology 2011; 58; 720-728.
    • (2011) Histopathology , vol.58 , pp. 720-728
    • Stewart, C.J.R.1    Crook, M.L.2    Little, L.3    Louwen, K.4
  • 46
    • 77950337412 scopus 로고    scopus 로고
    • Diagnostic value and implications of vimentin expression in normal, reactive and neoplastic endocervical epithelium
    • Stewart CJR, Little L. Diagnostic value and implications of vimentin expression in normal, reactive and neoplastic endocervical epithelium. Pathology 2010; 42; 217-223.
    • (2010) Pathology , vol.42 , pp. 217-223
    • Stewart, C.J.R.1    Little, L.2
  • 47
    • 84857369464 scopus 로고    scopus 로고
    • Fascin expression in endocervical neoplasia: correlation with tumour morphology and growth pattern
    • Stewart CJR, Crook M, Loi S. Fascin expression in endocervical neoplasia: correlation with tumour morphology and growth pattern. J. Clin. Pathol. 2012; 65; 213-217.
    • (2012) J. Clin. Pathol. , vol.65 , pp. 213-217
    • Stewart, C.J.R.1    Crook, M.2    Loi, S.3
  • 48
    • 84870391257 scopus 로고    scopus 로고
    • Cyclin D1, E-cadherin and beta-catenin in FIGO stage IA cervical squamous carcinoma: diagnostic value and evidence for epithelial-mesenchymal transition
    • 2012; [Epub ahead of print] doi 10.1111/j.1365-2559.2012.04326.x.
    • Koay MHE, Crook M, Stewart CJR. Cyclin D1, E-cadherin and beta-catenin in FIGO stage IA cervical squamous carcinoma: diagnostic value and evidence for epithelial-mesenchymal transition. Histopathology 2012; [Epub ahead of print] doi 10.1111/j.1365-2559.2012.04326.x.
    • Histopathology
    • Koay, M.H.E.1    Crook, M.2    Stewart, C.J.R.3
  • 49
    • 70349140898 scopus 로고    scopus 로고
    • Molecular pathology of endometrial carcinoma; practical aspects from the diagnostic and therapeutical view points
    • Llobet D, Pallares J, Yeramian A et al. Molecular pathology of endometrial carcinoma; practical aspects from the diagnostic and therapeutical view points. J. Clin. Pathol. 2009; 62; 777-785.
    • (2009) J. Clin. Pathol. , vol.62 , pp. 777-785
    • Llobet, D.1    Pallares, J.2    Yeramian, A.3
  • 50
    • 84871151974 scopus 로고    scopus 로고
    • The EMT signalling pathways in endometrial carcinoma
    • Colas E, Pedrola N, Deva L et al. The EMT signalling pathways in endometrial carcinoma. Clin. Transl. Oncol. 2012; 14; 715-720.
    • (2012) Clin. Transl. Oncol. , vol.14 , pp. 715-720
    • Colas, E.1    Pedrola, N.2    Deva, L.3
  • 51
    • 84859893351 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in early stage endometrioid endometrial carcinoma
    • Montserrat N, Moros A, Llobet D et al. Epithelial to mesenchymal transition in early stage endometrioid endometrial carcinoma. Hum. Pathol. 2012; 43; 632-643.
    • (2012) Hum. Pathol. , vol.43 , pp. 632-643
    • Montserrat, N.1    Moros, A.2    Llobet, D.3
  • 52
    • 33645127568 scopus 로고    scopus 로고
    • High Twist expression is involved in infiltrative endometrial cancer and affects patient survival
    • Kyo S, Sakaguchi J, Ohno S et al. High Twist expression is involved in infiltrative endometrial cancer and affects patient survival. Hum. Pathol. 2006; 37; 431-438.
    • (2006) Hum. Pathol. , vol.37 , pp. 431-438
    • Kyo, S.1    Sakaguchi, J.2    Ohno, S.3
  • 53
    • 84858338803 scopus 로고    scopus 로고
    • Tumor budding and E-cadherin expression in endometrial carcinoma: are they prognostic factors in endometrial cancer?
    • Koyuncuoglu M, Okyay E, Saatli B, Olgan S, Akin M, Saygili U. Tumor budding and E-cadherin expression in endometrial carcinoma: are they prognostic factors in endometrial cancer? Gynecol. Oncol. 2012; 125; 208-213.
    • (2012) Gynecol. Oncol. , vol.125 , pp. 208-213
    • Koyuncuoglu, M.1    Okyay, E.2    Saatli, B.3    Olgan, S.4    Akin, M.5    Saygili, U.6
  • 54
    • 0141680994 scopus 로고    scopus 로고
    • Unusual epithelial and stromal changes in myoinvasive endometrioid adenocarcinomas: a study of their frequency, associated diagnostic problems, and prognostic significance
    • Murray SK, Young RH, Scully RE. Unusual epithelial and stromal changes in myoinvasive endometrioid adenocarcinomas: a study of their frequency, associated diagnostic problems, and prognostic significance. Int. J. Gynecol. Pathol. 2003; 22; 324-333.
    • (2003) Int. J. Gynecol. Pathol. , vol.22 , pp. 324-333
    • Murray, S.K.1    Young, R.H.2    Scully, R.E.3
  • 55
    • 68049126022 scopus 로고    scopus 로고
    • MELF pattern invasion in endometrial carcinoma: association with low-grade, myoinvasive endometrioid tumours, focal mucinous differentiation and vascular invasion
    • Stewart CJR, Brennan BA, Leung YC, Little L. MELF pattern invasion in endometrial carcinoma: association with low-grade, myoinvasive endometrioid tumours, focal mucinous differentiation and vascular invasion. Pathology 2009; 41; 454-459.
    • (2009) Pathology , vol.41 , pp. 454-459
    • Stewart, C.J.R.1    Brennan, B.A.2    Leung, Y.C.3    Little, L.4
  • 56
    • 68049140928 scopus 로고    scopus 로고
    • Immunophenotypic features of MELF pattern invasion in endometrial adenocarcinoma: evidence for epithelial-mesenchymal transition
    • Stewart CJR, Little L. Immunophenotypic features of MELF pattern invasion in endometrial adenocarcinoma: evidence for epithelial-mesenchymal transition. Histopathology 2009; 55; 91-101.
    • (2009) Histopathology , vol.55 , pp. 91-101
    • Stewart, C.J.R.1    Little, L.2
  • 57
    • 67349268771 scopus 로고    scopus 로고
    • Expression of cell cycle regulatory proteins in endometrial adenocarcinoma: variations in conventional tumor areas and in microcystic, elongated and fragmented glands
    • Stewart CJR, Crook ML, Leung YC, Platten M. Expression of cell cycle regulatory proteins in endometrial adenocarcinoma: variations in conventional tumor areas and in microcystic, elongated and fragmented glands. Mod. Pathol. 2009; 22; 725-733.
    • (2009) Mod. Pathol. , vol.22 , pp. 725-733
    • Stewart, C.J.R.1    Crook, M.L.2    Leung, Y.C.3    Platten, M.4
  • 58
    • 80051795086 scopus 로고    scopus 로고
    • Cytokeratin 19 expression in normal endometrium and in low-grade endometrioid adenocarcinoma of the endometrium
    • Stewart CJ, Crook ML, Lacey J, Louwen K. Cytokeratin 19 expression in normal endometrium and in low-grade endometrioid adenocarcinoma of the endometrium. Int. J. Gynecol. Pathol. 2011; 30; 484-491.
    • (2011) Int. J. Gynecol. Pathol. , vol.30 , pp. 484-491
    • Stewart, C.J.1    Crook, M.L.2    Lacey, J.3    Louwen, K.4
  • 59
    • 79960467412 scopus 로고    scopus 로고
    • Fascin expression in low-grade uterine endometrioid adenocarcinoma; correlation with MELF type alteration at the deep invasive margin
    • Stewart CJR, Crook ML, Manso L. Fascin expression in low-grade uterine endometrioid adenocarcinoma; correlation with MELF type alteration at the deep invasive margin. Histopathology 2011; 59; 73-80.
    • (2011) Histopathology , vol.59 , pp. 73-80
    • Stewart, C.J.R.1    Crook, M.L.2    Manso, L.3
  • 60
    • 78149280141 scopus 로고    scopus 로고
    • Galectin-3 expression in uterine endometrioid adenocarcinoma: comparison of staining in conventional tumor glands and in areas of MELF pattern myometrial invasion
    • Stewart CJ, Crook ML. Galectin-3 expression in uterine endometrioid adenocarcinoma: comparison of staining in conventional tumor glands and in areas of MELF pattern myometrial invasion. Int. J. Gynecol. Pathol. 2010; 29; 555-561.
    • (2010) Int. J. Gynecol. Pathol. , vol.29 , pp. 555-561
    • Stewart, C.J.1    Crook, M.L.2
  • 61
    • 78650243835 scopus 로고    scopus 로고
    • CD147 (EMMPRIN) and matrix metalloproteinase-2 expression in uterine endometrioid adenocarcinoma
    • Stewart CJ, Crook ML. CD147 (EMMPRIN) and matrix metalloproteinase-2 expression in uterine endometrioid adenocarcinoma. Pathol. Res. Pract. 2011; 207; 30-36.
    • (2011) Pathol. Res. Pract. , vol.207 , pp. 30-36
    • Stewart, C.J.1    Crook, M.L.2
  • 62
    • 77954545658 scopus 로고    scopus 로고
    • Micro-anatomical variation in cellular proliferation in endometrial adenocarcinoma, and inverse correlation between Ki67 and cytokeratin 7 expression
    • Stewart CJR, Crook ML, Doherty DA. Micro-anatomical variation in cellular proliferation in endometrial adenocarcinoma, and inverse correlation between Ki67 and cytokeratin 7 expression. Histopathology 2010; 57; 46-54.
    • (2010) Histopathology , vol.57 , pp. 46-54
    • Stewart, C.J.R.1    Crook, M.L.2    Doherty, D.A.3
  • 63
    • 0035148988 scopus 로고    scopus 로고
    • The pathology of intermediate trophoblastic tumors and tumor-like lesions
    • Shih I-M, Kurman RJ. The pathology of intermediate trophoblastic tumors and tumor-like lesions. Int. J. Gynecol. Pathol. 2001; 20; 31-47.
    • (2001) Int. J. Gynecol. Pathol. , vol.20 , pp. 31-47
    • Shih, I.-M.1    Kurman, R.J.2
  • 64
    • 77956342316 scopus 로고    scopus 로고
    • Cadherins in the human placenta - epithelial-mesenchymal transition (EMT) and placental development
    • Kokkinos MI, Murthi O, Wafai R, Thompson EW, Newgreen DF. Cadherins in the human placenta - epithelial-mesenchymal transition (EMT) and placental development. Placenta 2010; 31; 747-755.
    • (2010) Placenta , vol.31 , pp. 747-755
    • Kokkinos, M.I.1    Murthi, O.2    Wafai, R.3    Thompson, E.W.4    Newgreen, D.F.5
  • 65
    • 0037447351 scopus 로고    scopus 로고
    • INK4A and an intact Rb pathway illustrated by a model system of basal cell carcinoma
    • INK4A and an intact Rb pathway illustrated by a model system of basal cell carcinoma. Cancer Res. 2003; 63; 1737-1742.
    • (2003) Cancer Res. , vol.63 , pp. 1737-1742
    • Svensson, S.1    Nilsson, K.2    Ringberg, A.3    Landberg, G.4
  • 67
    • 0032904651 scopus 로고    scopus 로고
    • Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers
    • Palmqvist R, Sellberg P, Oberg A et al. Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers. Br. J. Cancer 1999; 79; 577-581.
    • (1999) Br. J. Cancer , vol.79 , pp. 577-581
    • Palmqvist, R.1    Sellberg, P.2    Oberg, A.3
  • 68
    • 84870233792 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in ovarian carcinoma
    • Davidson B, Trope CG, Reich R. Epithelial-mesenchymal transition in ovarian carcinoma. Front. Oncol. 2012; 2; 33.
    • (2012) Front. Oncol. , vol.2 , pp. 33
    • Davidson, B.1    Trope, C.G.2    Reich, R.3
  • 69
    • 77949876005 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in ovarian cancer
    • Vergara D, Merlot B, Lucot J-P et al. Epithelial-mesenchymal transition in ovarian cancer. Cancer Lett. 2010; 291; 59-66.
    • (2010) Cancer Lett. , vol.291 , pp. 59-66
    • Vergara, D.1    Merlot, B.2    Lucot, J.-P.3
  • 70
    • 79955758096 scopus 로고    scopus 로고
    • Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer
    • Tseng CH, Muaary KD, Jou MF, Hsu SM, Cheng HJ, Huang PH. Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer. PLoS ONE 2011; 6; 319-396.
    • (2011) PLoS ONE , vol.6 , pp. 319-396
    • Tseng, C.H.1    Muaary, K.D.2    Jou, M.F.3    Hsu, S.M.4    Cheng, H.J.5    Huang, P.H.6
  • 71
    • 84859138356 scopus 로고    scopus 로고
    • EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells?
    • Cheng J-C, Auersperg N, Leung PCK. EGF-induced EMT and invasiveness in serous borderline ovarian tumor cells: a possible step in the transition to low-grade serous carcinoma cells? PLoS ONE 2012; 7; e34071.
    • (2012) PLoS ONE , vol.7
    • Cheng, J.-C.1    Auersperg, N.2    Leung, P.C.K.3
  • 72
    • 29144495415 scopus 로고    scopus 로고
    • Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells
    • Rosano L, Spinella F, Di Castro V et al. Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. Cancer Res. 2005; 65; 11649-11657.
    • (2005) Cancer Res. , vol.65 , pp. 11649-11657
    • Rosano, L.1    Spinella, F.2    Di Castro, V.3
  • 73
    • 70349254048 scopus 로고    scopus 로고
    • Expression profiles of genes involved in poor prognosis of epithelial ovarian carcinoma. A review
    • Yoshida S, Furukawa N, Haruta S et al. Expression profiles of genes involved in poor prognosis of epithelial ovarian carcinoma. A review. Int. J. Gynecol. Cancer 2009; 19; 992-997.
    • (2009) Int. J. Gynecol. Cancer , vol.19 , pp. 992-997
    • Yoshida, S.1    Furukawa, N.2    Haruta, S.3
  • 74
    • 80053211466 scopus 로고    scopus 로고
    • Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile
    • Latifi A, Abubaker K, Castrechini N et al. Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile. J. Cell. Biochem. 2011; 112; 2850-2864.
    • (2011) J. Cell. Biochem. , vol.112 , pp. 2850-2864
    • Latifi, A.1    Abubaker, K.2    Castrechini, N.3
  • 76
    • 84863632636 scopus 로고    scopus 로고
    • The stromal origin of some epithelial ovarian neoplasms. 'Fere ex nihilo'
    • Silva EG. The stromal origin of some epithelial ovarian neoplasms. 'Fere ex nihilo'. Int. J. Gynecol. Cancer 2012; 22; 906-907.
    • (2012) Int. J. Gynecol. Cancer , vol.22 , pp. 906-907
    • Silva, E.G.1
  • 77
    • 78650215830 scopus 로고    scopus 로고
    • Pathologic and molecular features of uterine carcinosarcomas
    • Lopez-Garcia MA, Palacios J. Pathologic and molecular features of uterine carcinosarcomas. Semin. Diagn. Pathol. 2010; 27; 274-286.
    • (2010) Semin. Diagn. Pathol. , vol.27 , pp. 274-286
    • Lopez-Garcia, M.A.1    Palacios, J.2
  • 78
    • 0036261049 scopus 로고    scopus 로고
    • Malignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas?
    • McCluggage WG. Malignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas? J. Clin. Pathol. 2002; 55; 321-325.
    • (2002) J. Clin. Pathol. , vol.55 , pp. 321-325
    • McCluggage, W.G.1
  • 79
    • 0036854296 scopus 로고    scopus 로고
    • Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas
    • McCluggage WG. Uterine carcinosarcomas (malignant mixed Mullerian tumors) are metaplastic carcinomas. Int. J. Gynecol. Cancer 2002; 12; 687-690.
    • (2002) Int. J. Gynecol. Cancer , vol.12 , pp. 687-690
    • McCluggage, W.G.1
  • 80
    • 84855511967 scopus 로고    scopus 로고
    • Expression profiles of carcinosarcoma of the uterine corpus - are these similar to carcinoma or sarcoma?
    • Chiyoda T, Tsuda H, Tanaka H et al. Expression profiles of carcinosarcoma of the uterine corpus - are these similar to carcinoma or sarcoma? Genes Chromosom. Cancer 2012; 51; 229-239.
    • (2012) Genes Chromosom. Cancer , vol.51 , pp. 229-239
    • Chiyoda, T.1    Tsuda, H.2    Tanaka, H.3
  • 81
    • 78649993667 scopus 로고    scopus 로고
    • Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma
    • Castilla MA, Moreno-Bueno G, Romero-Perez L et al. Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma. J. Pathol. 2011; 223; 72-80.
    • (2011) J. Pathol. , vol.223 , pp. 72-80
    • Castilla, M.A.1    Moreno-Bueno, G.2    Romero-Perez, L.3
  • 82
    • 67049164999 scopus 로고    scopus 로고
    • Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug
    • Saegusa M, Hashimura M, Kuwata T, Okayasu I. Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug. Am. J. Pathol. 2009; 174; 2107-2115.
    • (2009) Am. J. Pathol. , vol.174 , pp. 2107-2115
    • Saegusa, M.1    Hashimura, M.2    Kuwata, T.3    Okayasu, I.4
  • 83
    • 84861527239 scopus 로고    scopus 로고
    • To differentiate or not - routes towards metastasis
    • Brabletz T. To differentiate or not - routes towards metastasis. Nat. Rev. Cancer 2012; 12; 425-436.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 425-436
    • Brabletz, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.