Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast

Modern Pathology

Volumn 21, Issue 10, 2008, Pages 1192-1199

  Ellis, Patricia E ^a   Cano, Salvador Diaz ^b   Fear, Mark ^b   Kelsell, David P ^b   Ghali, Lucy ^b   Crow, Julie C ^a   Perrett, Christopher W ^a   MacLean, Allan B ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

E cadherin; Paget's disease; Vulva

Indexed keywords

BETA CATENIN; DIGOXIGENIN; MESSENGER RNA; PLAKOGLOBIN; UVOMORULIN;

ARTICLE; BREAST CARCINOMA; CARCINOMA IN SITU; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MOLECULAR PROBE; PAGET NIPPLE DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BETA CATENIN; BREAST NEOPLASMS; CADHERINS; CELL COUNT; DESMOPLAKINS; DISEASE PROGRESSION; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; PAGET'S DISEASE, EXTRAMAMMARY; PAGET'S DISEASE, MAMMARY; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL; VULVAR NEOPLASMS;

EID: 52549111325     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2008.50     Document Type: Article

References (34)

1. Dubreuilh W. Paget's disease of the vulva. Br J Dermatol 1901;13:407-413.
2. Chanda JJ. Extramammary Paget's disease: prognosis and relationship to internal malignancy. J. Am Acad Dermatol 1985;113:1009-10013.
3. Bohem F, Morris JMCL. Paget's disease and apocrine gland carcinoma. Obstet Gynaecol 1971;38:185-192.
4. Fox H, Wells M. Recent advances in the pathology of the vulva. Histopathology 2003;42:209-216.
5. Paget J. On the disease of the mammary areola preceding cancer of the mammary gland. St Bartholomew Hospital Reports 1874;10:87-89.
6. Fu W, Lobocki C, Silberberg B, et al. Molecular markers in Paget's disease of the breast. J Surg Oncol 2001;77:171-178.
7. Shiozaki H, Tahara H, Oka H, et al. Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol 1991;139:17-23.
8. Conman CR. Adhesiveness and stickiness: two independent properties of the cell surface. Cancer Res 1961;21:1436-1438.
9. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 1991;251:1451-1455.
10. Behrens J, Mareel MM, Van Roy FM, et al. Dissecting tumour cell invasion: epithelial cells acquire invasion properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 1989;108:2435-2447.
11. Vleminck K, Vakaet Jr L, Mareel M, et al. Genetic manipulation of E-cadherin expression by epithelial tumour cells reveals invasion suppressor role. Cell 1991;66:107-119.
12. Charpin C, Garcia S, Bonnier P, et al. Reduced E-cadherin immunohistochemical expression in node-negative breast carcinomas. Am J Clin Pathol 1997;109:431-438.
13. Fuller LC, Allen MH, Montesu M, et al. Expression of E-cadherin in human epidermal non-melanoma cutaneous tumours. Br J Dermatol 1996;134:28-32.
14. Bringuier PP, Umbas R, Schaafsma E. Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumours. Cancer Res 1993;52:5104-5109.
15. Ben Zee'ev A, Geiger B. Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signalling and cancer. Curr Opin Cell Biol 1998;10:629-639.
16. Barker N, Morin PJ, Clevers H. The Yin-Yang of TCF/beta-catenin signalling. Adv Cancer Res 2000;77:1-24.
17. Willert K, Nusse R. Beta-catenin: a key mediator of Wnt signalling. Curr Opin Genet Dev 1998;8:95-102.
18. Ellis PE, Wong Te Fong LF, Rolfe KJ, et al. The role of p53 and Ki67 in Paget's disease of the vulva and breast. Gynecol Oncol 2002;86:150-156.
19. Ellis PE, Wong Te Fong LF, Rolfe KJ, et al. The role of vascular endothelial growth factor-A (VEGF-A) and platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) in Paget's disease of the vulva and breast. Anticancer Res 2002;22:857-861.
20. Tada H, Hatoko M, Muramatsu T, et al. Expression of E-cadherin in skin carcinomas. J Dermatol 1996;23:104-110.
21. Shirahama S, Furukawa F, Wakita H, et al. E- and P-cadherin expression in tumour tissues and soluble E-cadherin levels in sera of patients with skin cancer. J Dermatol Sci 1996;13:30-36.
22. Oka H, Shiozaki H, Kobayashi K, et al. Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 1993;53:1696-1701.
23. Miyata M, Shiozaki H, Iihara K, et al. Relationship between E-cadherin expression and lymph node metastasis in human oesophageal cancer. Int J Oncol 1994;4:61-65.
24. Tada H, Hatoko M, Tanaka A, et al. Expression of desmoglein I and plakoglobin in skin carcinomas. qJ Cutan Pathol 2000;27:24-29.
25. Sparks PJ, Korinek V, Barker N, et al. Activation of β-catenin-Tcf signalling in colon cancer by mutations β-catenin or APC. Science 1994;275:1787-1790.
26. Morin P, Sparks A, Korinek V, et al. Activation of β-catenin-Tcf signalling in colon cancer by mutations in β-catenin or APC. Science 1997;275:1787-1790.
27. Oka H, Shiozaki H, Kobayashi K, et al. Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res 1993;53:1696-1701.
28. Lipponen P, Saarelainen E, Ji H, et al. Expression of E-cadherin (E-CD) as related to other prognostic factors and survival in breast cancer. J Pathol 1998;174:101-109.
29. Soler AP, Knudsen KA, Salazar H, et al. P-cadherin expression in breast carcinomas indicate poor survival. Cancer 1999;86:1263-1272.
30. Bukholm IK, Nesland JM, Karesen R, et al. E-cadherin and α-, β- and γ-catenin protein expression in relation to metastasis in human breast carcinoma. J Pathol 1995;185:262-266.
31. Zschiesche W, Schonborn I, Behrens J, et al. Expression of E-cadherin and catenins in invasive mammary carcinomas. Anticancer Res 1997;17:561-567.
32. Sommers CL, Gelmann EP, Kemler R, et al. Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells. Cancer Res 1994;54:3544-3552.
33. Aberle H, Bierkamp C, Torchard D, et al. The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Proc Natl Acad Sci USA 1995;92:6384-6388.
34. Muzio LO, Staibano S, Pannore G, et al. Beta and gamma catenin expression in oral squamous cell carcinoma. Anticancer Res 1999;19:3817-3826.