Changes in the expression of oestrogen receptors and E-cadherin as molecular markers of progression from normal epithelium to invasive cancer in elderly patients with vulvar squamous cell carcinoma

Histopathology

Volumn 58, Issue 2, 2011, Pages 265-275

  Zannoni, Gian F ^a   Prisco, Maria G ^a   Vellone, Valerio G ^a   De Stefano, Ilaria ^a   Scambia, Giovanni ^a   Gallo, Daniela ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Cancer; E cadherin; Oestrogen; Premalignancy; Vulva

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; KI 67 ANTIGEN; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; PROTEIN P53; UVOMORULIN;

AGED; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VULVA CARCINOMA; VULVAR SQUAMOUS CELL CARCINOMA;

AGED; AGED, 80 AND OVER; CADHERINS; CARCINOMA, SQUAMOUS CELL; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; EPITHELIUM; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MIDDLE AGED; NEOPLASM STAGING; RECEPTORS, PROGESTERONE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; VULVAR NEOPLASMS;

HUMAN PAPILLOMAVIRUS;

EID: 79951592109     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.03744.x     Document Type: Article

References (28)

1. Sankaranarayanan R, Ferlay J. Worldwide burden of gynaecological cancer: the size of the problem. Best Pract. Res. Clin. Obstet. Gynaecol. 2006; 20; 207-225.
2. van de Nieuwenhof HP, van der Avoort IA, de Hullu JA. Review of squamous premalignant vulvar lesions. Crit. Rev. Oncol. Hematol. 2008; 68; 131-156. [Review].
3. Yang B, Hart WR. Vulvar intraepithelial neoplasia of the simplex (differentiated) type: a clinicopathologic study including analysis of HPV and p53 expression. Am. J. Surg. Pathol. 2000; 24; 429-441.
4. Fox H, Wells M. Recent advances in the pathology of the vulva. Histopathology 2003; 42; 209-216.
5. Mosny DS, Brito F, Bender HG. Immunohistochemical investigations of estrogen receptors in normal and neoplastic squamous epithelium of the vulva. Reprod. Med. 1990; 35; 1005-1007.
6. Heldring N, Pike A, Andersson S et al. Estrogen receptors: how do they signal and what are their targets. Physiol. Rev. 2007; 87; 905-931. [Review].
7. Schwartz PE. The oestrogen receptor (ER) in vulva, vagina and ovary. Eur. J. Cancer 2000; 36(Suppl. 4); S31-S32.
8. Taylor AH, Guzail M, Al-Azzawi F. Differential expression of oestrogen receptor isoforms and androgen receptor in the normal vulva and vagina compared with vulval lichen sclerosus and chronic vaginitis. Br. J. Dermatol. 2008; 158; 319-328.
9. Helguero LA, Lindberg K, Gardmo C, Schwend T, Gustafsson JA, Haldosén LA. Different roles of estrogen receptors alpha and beta in the regulation of E-cadherin protein levels in a mouse mammary epithelial cell line. Cancer Res. 2008; 68; 8695-8704.
10. Park SH, Cheung LW, Wong AS, Leung PC. Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha. Mol. Endocrinol. 2008; 22; 2085-2098.
11. Frankman O, Kabulski Z, Nilsson B, Silfverswärd C. Prognostic factors in invasive squamous cell carcinoma of the vulva. Int. J. Gynaecol. Obstet. 1991; 36; 219-228.
12. Vulva In Greene FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, Morrow M ed. American Joint Committee on Cancer: AJCC cancer staging manual, 6th edn. New York, NY: Springer, 2002; 243-249.
13. Hayat MA. Estrogens. In Microscopy, immunohistochemistry, and antigen retrieval methods for light and electron microscopy. New York, NY: Kluwer Academic/Plenum Publishers, 2002; 276-277.
14. Gallo D, Zannoni GF, Martinelli E et al. Estradiol and phytoestrogens differently influence the rodent postmenopausal mammary gland. Menopause 2006; 13; 72-79.
15. Hodgins MB, Spike RC, Mackie RM, MacLean AB. An immunohistochemical study of androgen, oestrogen and progesterone receptors in the vulva and vagina. Br. J. Obstet. Gynaecol. 1998; 105; 216-222.
16. Johannesson U, Sahlin L, Masironi B, Rylander E, Bohm-Starke N. Steroid receptor expression in the vulvar vestibular mucosa-effects of oral contraceptives and menstrual cycle. Contraception 2007; 76; 319-325.
17. Thornton MJ. The biological actions of estrogens on skin. Exp. Dermatol. 2002; 11; 487-502. [Review].
18. Shaaban AM, Green AR, Karthik S et al. Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients. Clin. Cancer Res. 2008; 14; 5228-5235.
19. Zhang G, Liu X, Farkas AM et al. Estrogen receptor beta functions through nongenomic mechanisms in lung cancer cells. Mol. Endocrinol. 2009; 23; 146-156.
20. Roger P, Sahla ME, Makela S, Gustafsson JA, Baldet P, Rochefort H. Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. Cancer Res. 2001; 61; 2537-2541.
21. Horvath LG, Henshall SM, Lee CS et al. Frequent loss of estrogen receptor-beta expression in prostate cancer. Cancer Res. 2001; 61; 5331-5335.
22. Lazennec G. Estrogen receptor beta, a possible tumor suppressor involved in ovarian carcinogenesis. Cancer Lett. 2006; 231; 151-157. [Review].
23. Foley EF, Jazaeri AA, Shupnik MA, Jazaeri O, Rice LW. Selective loss of estrogen receptor beta in malignant human colon. Cancer Res. 2000; 60; 245-248.
24. Mancuso M, Gallo D, Leonardi S et al. Modulation of basal and squamous cell carcinoma by endogenous estrogen in mouse models of skin cancer. Carcinogenesis 2009; 30; 340-347.
25. Jeanes A, Gottardi CJ, Yap AS. Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene 2008; 27; 6920-6929. [Review].
26. Cardamone MD, Bardella C, Gutierrez A et al. ERalpha as ligand-independent activator of CDH-1 regulates determination and maintenance of epithelial morphology in breast cancer cells. Proc. Natl Acad. Sci. USA 2009; 106; 7420-7425.
27. Chiesa-Vottero A, Dvoretsky PM, Hart WR. Histopathologic study of thin vulvar squamous cell carcinomas and associated cutaneous lesions: a correlative study of 48 tumors in 44 patients with analysis of adjacent vulvar intraepithelial neoplasia types and lichen sclerosus. Am. J. Surg. Pathol. 2006; 30; 310-318.
28. van der Avoort IA, van der Laak JA, Paffen A et al. MIB1 expression in basal cell layer: a diagnostic tool to identify premalignancies of the vulva. Mod. Pathol. 2007; 20; 770-778.