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Volumn 31, Issue 1-2, 2012, Pages 277-283

EMT in carcinoma progression and dissemination: Facts, unanswered questions, and clinical considerations

Author keywords

Epithelial to mesenchymal transition; Metastasis; Tumor progression

Indexed keywords

CALVASCULIN; K RAS PROTEIN; UVOMORULIN; VIMENTIN;

EID: 84862333338     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/s10555-011-9344-6     Document Type: Review
Times cited : (80)

References (53)
  • 2
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J. P., Acloque, H., Huang, R. Y., & Nieto, M. A. (2009). Epithelial-mesenchymal transitions in development and disease. Cell, 139(5), 871-890.
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 3
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak, K., & Weinberg, R. A. (2009). Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nature Reviews. Cancer, 9(4), 265-273.
    • (2009) Nature Reviews. Cancer , vol.9 , Issue.4 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 4
    • 0038745381 scopus 로고    scopus 로고
    • The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis
    • Xue, C., Plieth, D., Venkov, C., Xu, C., & Neilson, E. G. (2003). The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Research, 63(12), 3386-3394. (Pubitemid 36735899)
    • (2003) Cancer Research , vol.63 , Issue.12 , pp. 3386-3394
    • Xue, C.1    Plieth, D.2    Venkov, C.3    Xu, C.4    Neilson, E.G.5
  • 6
    • 33748116186 scopus 로고    scopus 로고
    • A Transient, EMT-Linked Loss of Basement Membranes Indicates Metastasis and Poor Survival in Colorectal Cancer
    • DOI 10.1053/j.gastro.2006.06.016, PII S0016508506012868
    • Spaderna, S., Schmalhofer, O., Hlubek, F., Berx, G., Eger, A., Merkel, S., et al. (2006). A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology, 131(3), 830-840. (Pubitemid 44307069)
    • (2006) Gastroenterology , vol.131 , Issue.3 , pp. 830-840
    • Spaderna, S.1    Schmalhofer, O.2    Hlubek, F.3    Berx, G.4    Eger, A.5    Merkel, S.6    Jung, A.7    Kirchner, T.8    Brabletz, T.9
  • 7
    • 33845599552 scopus 로고    scopus 로고
    • Tumour budding in colorectal carcinoma
    • Prall, F. (2007). Tumour budding in colorectal carcinoma. Histopathology, 50(1), 151-162.
    • (2007) Histopathology , vol.50 , Issue.1 , pp. 151-162
    • Prall, F.1
  • 9
    • 79958003343 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget
    • Zlobec, I., & Lugli, A. (2010). Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget. Oncotarget, 1(7), 651-661.
    • (2010) Oncotarget , vol.1 , Issue.7 , pp. 651-661
    • Zlobec, I.1    Lugli, A.2
  • 11
    • 35348914681 scopus 로고    scopus 로고
    • High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations
    • DOI 10.1016/j.humpath.2007.04.002, PII S0046817707001906
    • Prall, F., & Ostwald, C. (2007). High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations. Human Pathology, 38(11), 1696-1702. (Pubitemid 47589093)
    • (2007) Human Pathology , vol.38 , Issue.11 , pp. 1696-1702
    • Prall, F.1    Ostwald, C.2
  • 13
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • Aktas, B., Tewes, M., Fehm, T., Hauch, S., Kimmig, R., & Kasimir-Bauer, S. (2009). Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Research, 11(4).
    • (2009) Breast Cancer Research , vol.11 , Issue.4
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 14
    • 82955187028 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients
    • doi:10.1007/s10549-011-1373-x
    • Raimondi, C., Gradilone, A., Naso, G., Vincenzi, B., Petracca, A., Nicolazzo, C., et al. (2011). Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients. Breast Cancer Research and Treatment. doi:10.1007/s10549-011-1373-x.
    • (2011) Breast Cancer Research and Treatment
    • Raimondi, C.1    Gradilone, A.2    Naso, G.3    Vincenzi, B.4    Petracca, A.5    Nicolazzo, C.6
  • 15
    • 33750311251 scopus 로고    scopus 로고
    • In vivo and in vitro evidence for transforming growth factor-beta1- mediated epithelial to mesenchymal transition in esophageal adenocarcinoma
    • DOI 10.1158/0008-5472.CAN-06-1842
    • Rees, J. R., Onwuegbusi, B. A., Save, V. E., Alderson, D., &Fitzgerald, R. C. (2006). In vivo and in vitro evidence for transforming growth factor-beta1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma. Cancer Research, 66 (19), 9583-9590. (Pubitemid 44623657)
    • (2006) Cancer Research , vol.66 , Issue.19 , pp. 9583-9590
    • Rees, J.R.E.1    Onwuegbusi, B.A.2    Save, V.E.3    Alderson, D.4    Fitzgerald, R.C.5
  • 16
    • 84859893351 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in early stage endometrioid endometrial carcinoma
    • doi:10.1016/j.humpath.2011.06.021
    • Montserrat, N., Mozos, A., Llobet, D., Dolcet, X., Pons, C., de Herreros, A. G., et al. (2011). Epithelial to mesenchymal transition in early stage endometrioid endometrial carcinoma. Human Pathology. doi:10.1016/j.humpath.2011. 06.021.
    • (2011) Human Pathology
    • Montserrat, N.1    Mozos, A.2    Llobet, D.3    Dolcet, X.4    Pons, C.5    De Herreros, A.G.6
  • 19
    • 0030978732 scopus 로고    scopus 로고
    • Identical clonality of both components of mammary carcinosarcoma with differential loss of heterozygosity
    • Zhuang, Z., Lininger, R. A., Man, Y. G., Albuquerque, A., Merino, M. J., & Tavassoli, F. A. (1997). Identical clonality of both components of mammary carcinosarcoma with differential loss of heterozygosity. Modern Pathology, 10(4), 354-362. (Pubitemid 27228884)
    • (1997) Modern Pathology , vol.10 , Issue.4 , pp. 354-362
    • Zhuang, Z.1    Lininger, R.A.2    Man, Y.-G.3    Albuquerque, A.4    Merino, M.J.5    Tavassoli, F.A.6
  • 20
    • 0031979316 scopus 로고    scopus 로고
    • Cytogenetic analysis shows that carcinosarcomas of the breast are of monoclonal origin
    • DOI 10.1002/(SICI)1098-2264(199806)22:2<145::AID-GCC9>3.0.CO;2-X
    • Teixeira, M. R., Qvist, H., Bohler, P. J., Pandis, N., & Heim, S. (1998). Cytogenetic analysis shows that carcinosarcomas of the breast are of monoclonal origin. Genes, Chromosomes & Cancer, 22(2), 145-151. (Pubitemid 28208807)
    • (1998) Genes Chromosomes and Cancer , vol.22 , Issue.2 , pp. 145-151
    • Teixeira, M.R.1    Qvist, H.2    Bohler, P.J.3    Pandis, N.4    Heim, S.5
  • 21
    • 0033958685 scopus 로고    scopus 로고
    • Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity
    • Fujii, H., Yoshida, M., Gong, Z. X., Matsumoto, T., Hamano, Y., Fukunaga, M., et al. (2000). Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity. Cancer Research, 60(1), 114-120. (Pubitemid 30058740)
    • (2000) Cancer Research , vol.60 , Issue.1 , pp. 114-120
    • Fujii, H.1    Yoshida, M.2    Gong, Z.X.3    Matsumoto, T.4    Hamano, Y.5    Fukunaga, M.6    Hruban, R.H.7    Gabrielson, E.8    Shirai, T.9
  • 22
    • 22244473343 scopus 로고    scopus 로고
    • The fallacy of epithelial mesenchymal transition in neoplasia
    • discussion 6000-5991
    • Tarin, D., Thompson, E. W., & Newgreen, D. F. (2005). The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Research, 65(14), 5996-6000. discussion 6000-5991.
    • (2005) Cancer Research , vol.65 , Issue.14 , pp. 5996-6000
    • Tarin, D.1    Thompson, E.W.2    Newgreen, D.F.3
  • 23
    • 33750987299 scopus 로고    scopus 로고
    • Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression
    • DOI 10.1016/j.lungcan.2006.08.010, PII S0169500206004351
    • Sivertsen, S., Hadar, R., Elloul, S., Vintman, L., Bedrossian, C., Reich, R., et al. (2006). Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression. Lung Cancer, 54 (3), 309-317. (Pubitemid 44740263)
    • (2006) Lung Cancer , vol.54 , Issue.3 , pp. 309-317
    • Sivertsen, S.1    Hadar, R.2    Elloul, S.3    Vintman, L.4    Bedrossian, C.5    Reich, R.6    Davidson, B.7
  • 24
    • 38549154187 scopus 로고    scopus 로고
    • The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients
    • DOI 10.1038/sj.bjc.6604115, PII 6604115
    • Blechschmidt, K., Sassen, S., Schmalfeldt, B., Schuster, T., Hofler, H., & Becker, K. F. (2008). The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients. British Journal of Cancer, 98(2), 489-495. (Pubitemid 351161237)
    • (2008) British Journal of Cancer , vol.98 , Issue.2 , pp. 489-495
    • Blechschmidt, K.1    Sassen, S.2    Schmalfeldt, B.3    Schuster, T.4    Hofler, H.5    Becker, K.-F.6
  • 25
    • 84868972987 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition markers in pancreatic ductal adenocarcinoma
    • doi:10.1097/MPA.0b013e3181878b7f
    • Cates, J. M., Byrd, R. H., Fohn, L. E., Tatsas, A. D., Washington, M. K., & Black, C. C. (2009). Epithelial-mesenchymal transition markers in pancreatic ductal adenocarcinoma. Pancreas, 38(1), e1-6. doi:10.1097/MPA. 0b013e3181878b7f.
    • (2009) Pancreas , vol.38 , Issue.1
    • Cates, J.M.1    Byrd, R.H.2    Fohn, L.E.3    Tatsas, A.D.4    Washington, M.K.5    Black, C.C.6
  • 26
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce andmaintain mesenchymal and stem cell states in the breast
    • Scheel, C., Eaton, E. N., Li, S. H., Chaffer, C. L., Reinhardt, F., Kah, K. J., et al. (2011). Paracrine and autocrine signals induce andmaintain mesenchymal and stem cell states in the breast. Cell, 145 (6), 926-940.
    • (2011) Cell , vol.145 , Issue.6 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3    Chaffer, C.L.4    Reinhardt, F.5    Kah, K.J.6
  • 27
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • DOI 10.1038/nrm1835, PII NRM1835
    • Thiery, J. P., & Sleeman, J. P. (2006). Complex networks orchestrate epithelial-mesenchymal transitions. Nature Reviews Molecular Cell Biology, 7(2), 131-142. (Pubitemid 43278296)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.2 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 28
    • 33947528384 scopus 로고    scopus 로고
    • Snail silencing effectively suppresses tumour growth and invasiveness
    • DOI 10.1038/sj.onc.1209997, PII 1209997
    • Olmeda, D., Jorda, M., Peinado, H., Fabra, A., & Cano, A. (2007). Snail silencing effectively suppresses tumour growth and invasiveness. [Research Support, Non-U.S. Gov't]. Oncogene, 26(13), 1862-1874. (Pubitemid 46474642)
    • (2007) Oncogene , vol.26 , Issue.13 , pp. 1862-1874
    • Olmeda, D.1    Jorda, M.2    Peinado, H.3    Fabra, A.4    Cano, A.5
  • 29
    • 33845809125 scopus 로고    scopus 로고
    • Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2
    • DOI 10.1158/0008-5472.CAN-06-2044
    • Chaffer, C. L., Brennan, J. P., Slavin, J. L., Blick, T., Thompson, E. W., & Williams, E. D. (2006). Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2. Cancer Research, 66(23), 11271-11278. (Pubitemid 46009956)
    • (2006) Cancer Research , vol.66 , Issue.23 , pp. 11271-11278
    • Chaffer, C.L.1    Brennan, J.P.2    Slavin, J.L.3    Blick, T.4    Thompson, E.W.5    Williams, E.D.6
  • 30
    • 84865217666 scopus 로고    scopus 로고
    • A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer
    • doi:10.1038/onc.2011.540
    • Bonnomet, A., Syne, L., Brysse, A., Feyereisen, E., Thompson, E. W., Noel, A., et al. (2011). A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer. Oncogene. doi:10.1038/onc.2011.540.
    • (2011) Oncogene
    • Bonnomet, A.1    Syne, L.2    Brysse, A.3    Feyereisen, E.4    Thompson, E.W.5    Noel, A.6
  • 34
    • 40249113328 scopus 로고    scopus 로고
    • Direct regulation of TWIST by HIF-1alpha promotes metastasis
    • Research Support, Non-U.S. Gov't doi:10.1038/ncb1691
    • Yang, M. H., Wu, M. Z., Chiou, S. H., Chen, P. M., Chang, S. Y., Liu, C. J., et al. (2008). Direct regulation of TWIST by HIF-1alpha promotes metastasis. [Research Support, Non-U.S. Gov't]. Nature Cell Biology, 10(3), 295-305. doi:10.1038/ncb1691.
    • (2008) Nature Cell Biology , vol.10 , Issue.3 , pp. 295-305
    • Yang, M.H.1    Wu, M.Z.2    Chiou, S.H.3    Chen, P.M.4    Chang, S.Y.5    Liu, C.J.6
  • 38
    • 0020358296 scopus 로고
    • Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells
    • DOI 10.1083/jcb.95.1.333
    • Greenburg, G., & Hay, E. D. (1982). Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. The Journal of Cell Biology, 95(1), 333-339. (Pubitemid 13197104)
    • (1982) Journal of Cell Biology , vol.95 , Issue.1 , pp. 333-339
    • Greenburg, G.1    Hay, E.D.2
  • 39
    • 0022269174 scopus 로고
    • An epithelial scatter factor released by embryo fibroblasts
    • Stoker, M., & Perryman, M. (1985). An epithelial scatter factor released by embryo fibroblasts. Journal ofCell Science, 77, 209-223.
    • (1985) Journal OfCell Science , vol.77 , pp. 209-223
    • Stoker, M.1    Perryman, M.2
  • 40
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker, M., Gherardi, E., Perryman, M., & Gray, J. (1987). Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature, 327(6119), 239-242. (Pubitemid 17071053)
    • (1987) Nature , vol.326 , Issue.6119 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 42
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano, A., Perez-Moreno, M. A., Rodrigo, I., Locascio, A., Blanco, M. J., del Barrio, M. G., et al. (2000). The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biology, 2(2), 76-83.
    • (2000) Nature Cell Biology , vol.2 , Issue.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3    Locascio, A.4    Blanco, M.J.5    Del Barrio, M.G.6
  • 43
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • Batlle, E., Sancho, E., Franci, C., Dominguez, D., Monfar, M., Baulida, J., et al. (2000). The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nature Cell Biology, 2(2), 84-89.
    • (2000) Nature Cell Biology , vol.2 , Issue.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3    Dominguez, D.4    Monfar, M.5    Baulida, J.6
  • 44
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery, J. P. (2002). Epithelial-mesenchymal transitions in tumour progression. Nature Reviews. Cancer, 2(6), 442-454.
    • (2002) Nature Reviews. Cancer , vol.2 , Issue.6 , pp. 442-454
    • Thiery, J.P.1
  • 46
    • 4344662447 scopus 로고    scopus 로고
    • Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress
    • DOI 10.1128/MCB.24.17.7559-7566.2004
    • Kajita, M., McClinic, K. N., & Wade, P. A. (2004). Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Molecular and Cellular Biology, 24 (17), 7559-7566. (Pubitemid 39121483)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.17 , pp. 7559-7566
    • Kajita, M.1    McClinic, K.N.2    Wade, P.A.3
  • 47
    • 27744547091 scopus 로고    scopus 로고
    • Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
    • DOI 10.1016/j.cell.2005.09.029, PII S0092867405010317
    • Wu, W. S., Heinrichs, S., Xu, D., Garrison, S. P., Zambetti, G. P., Adams, J. M., et al. (2005). Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell, 123 (4), 641-653. (Pubitemid 41613746)
    • (2005) Cell , vol.123 , Issue.4 , pp. 641-653
    • Wu, W.-S.1    Heinrichs, S.2    Xu, D.3    Garrison, S.P.4    Zambetti, G.P.5    Adams, J.M.6    Look, A.T.7
  • 48
  • 49
    • 34249289041 scopus 로고    scopus 로고
    • Snail, ZEB and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • DOI 10.1038/nrc2131, PII NRC2131
    • Peinado, H., Olmeda, D., & Cano, A. (2007). Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype? Nature Reviews. Cancer, 7(6), 415-428. (Pubitemid 46809165)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.6 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 51
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • doi:10.1371/journal.pone.0002888
    • Morel, A. P., Lievre, M., Thomas, C., Hinkal, G., Ansieau, S., &Puisieux, A. (2008). Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One, 3(8), e2888. doi:10.1371/journal. pone.0002888.
    • (2008) PLoS One , vol.3 , Issue.8
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 52
    • 79952283482 scopus 로고    scopus 로고
    • P53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs
    • Chang, C. J., Chao, C. H., Xia, W., Yang, J. Y., Xiong, Y., Li, C. W., et al. (2011). p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nature Cell Biology, 13(3), 317-323.
    • (2011) Nature Cell Biology , vol.13 , Issue.3 , pp. 317-323
    • Chang, C.J.1    Chao, C.H.2    Xia, W.3    Yang, J.Y.4    Xiong, Y.5    Li, C.W.6
  • 53
    • 66149131111 scopus 로고    scopus 로고
    • Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
    • Santisteban, M., Reiman, J. M., Asiedu, M. K., Behrens, M. D., Nassar, A., Kalli, K. R., et al. (2009). Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Research, 69(7), 2887-2895.
    • (2009) Cancer Research , vol.69 , Issue.7 , pp. 2887-2895
    • Santisteban, M.1    Reiman, J.M.2    Asiedu, M.K.3    Behrens, M.D.4    Nassar, A.5    Kalli, K.R.6


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