Ligand binding induces a conformational change in epidermal growth factor receptor dimers

Growth Factors

Volumn 30, Issue 6, 2012, Pages 394-409

  Walker, Francesca ^a,b,c   Rothacker, Julie ^a   Henderson, Christine ^a   Nice, Edouard C ^a   Catimel, Bruno ^a   Zhang, Hui Hua ^a,b   Scott, Andrew M ^d   Bailey, Michael F ^a   Orchard, Suzanne G ^a   Adams, Timothy E ^e   Liu, Zhanqi ^d   Garrett, Thomas P J ^b   Clayton, Andrew H A ^f   Burgess, Antony W ^a,b,c  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

^e CSIRO   (Australia)

^f SWINBURNE UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Aggregation; Asymmetric tetramer; Kinase activation; Structural models

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; HYBRID PROTEIN; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE;

ARTICLE; CELL SURFACE; DNA TRANSFECTION; ENZYME ACTIVATION; ENZYMIC BIOSENSOR; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOSENSING TECHNIQUES; CELL LINE; DIMERIZATION; EPITOPES; FLUORESCENT DYES; HEK293 CELLS; HUMANS; KINETICS; LIGANDS; MICE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84871074387     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.3109/08977194.2012.739619     Document Type: Article

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