Ligand-induced EGF receptor oligomerization is kinase-dependent and enhances internalization

Journal of Biological Chemistry

Volumn 285, Issue 50, 2010, Pages 39481-39489

  Hofman, Erik G ^a   Bader, Arjen N ^a   Voortman, Jarno ^a   Van Den Heuvel, Dave J ^a   Sigismund, Sara ^b   Verkleij, Arie J ^a   Gerritsen, Hans C ^a   Van Bergen en Henegouwen, Paul M P ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MODELS; ALLOSTERIC ACTIVATION; BEFORE AND AFTER; EGFR SIGNALING; FK506-BINDING PROTEINS; INTRACELLULAR DOMAIN; INTRACELLULAR STRUCTURES; LIGAND BINDING; PLASMA MEMBRANES; RECEPTOR ACTIVATION; REGULATORY MECHANISM; SIGNALING MOLECULES; TYROSINE KINASE;

AMINO ACIDS; CELL MEMBRANES; DIMERIZATION; DIMERS; LIGANDS; SIGNALING;

OLIGOMERIZATION;

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FK 506 BINDING PROTEIN; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL ORGANELLE; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; INTERNALIZATION; LIGAND BINDING; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANIMALS; ANISOTROPY; CELL LINE, TUMOR; EPIDERMAL GROWTH FACTOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; KINETICS; LIGANDS; MICE; NIH 3T3 CELLS; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SPECTROMETRY, FLUORESCENCE;

EID: 78649814933     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.164731     Document Type: Article

References (30)

1. Ullrich, A., Coussens, L., Hayflick, J. S., Dull, T. J., Gray, A., Tam, A. W., Lee, J., Yarden, Y., Libermann, T. A., and Schlessinger, J. (1984) Nature 309, 418-425
2. Garrett, T. P., McKern, N. M., Lou, M., Elleman, T. C., Adams, T. E., Lovrecz, G. O., Zhu, H. J., Walker, F., Frenkel, M. J., Hoyne, P. A., Jorissen, R. N., Nice, E. C., Burgess, A. W., and Ward, C. W. (2002) Cell 110, 763-773
3. Zhang, X., Gureasko, J., Shen, K., Cole, P. A., and Kuriyan, J. (2006) Cell 125, 1137-1149
4. Sigismund, S., Woelk, T., Puri, C., Maspero, E., Tacchetti, C., Transidico, P., Di Fiore, P. P., and Polo, S. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 2760-2765
5. van Belzen, N., Rijken, P. J., Hage, W. J., de Laat, S. W., Verkleij, A. J., and Boonstra, J. (1988) J. Cell. Physiol. 134, 413-420
6. Moriki, T., Maruyama, H., and Maruyama, I. N. (2001) J. Mol. Biol. 311, 1011-1026
7. Yu, X., Sharma, K. D., Takahashi, T., Iwamoto, R., and Mekada, E. (2002) Mol. Biol. Cell 13, 2547-2557
8. Zhu, H. J., Iaria, J., Orchard, S., Walker, F., and Burgess, A. W. (2003) Growth Factors 21, 15-30
9. Gadella, T. W., Jr., and Jovin, T. M. (1995) J. Cell Biol. 129, 1543-1558
10. Lidke, D. S., Nagy, P., Barisas, B. G., Heintzmann, R., Post, J. N., Lidke, K. A., Clayton, A. H., Arndt-Jovin, D. J., and Jovin, T. M. (2003) Biochem. Soc. Trans. 31, 1020-1027
11. Saffarian, S., Li, Y., Elson, E. L., and Pike, L. J. (2007) Biophys. J. 93, 1021-1031
12. Sako, Y., Minoghchi, S., and Yanagida, T. (2000) Nat. Cell Biol. 2, 168-172
13. Teramura, Y., Ichinose, J., Takagi, H., Nishida, K., Yanagida, T., and Sako, Y. (2006) EMBO J. 25, 4215-4222
14. Martin-Fernandez, M., Clarke, D. T., Tobin, M. J., Jones, S. V., and Jones, G. R. (2002) Biophys. J. 82, 2415-2427
15. Clayton, A. H., Walker, F., Orchard, S. G., Henderson, C., Fuchs, D., Rothacker, J., Nice, E. C., and Burgess, A. W. (2005) J. Biol. Chem. 280, 30392-30399
16. Jura, N., Endres, N. F., Engel, K., Deindl, S., Das, R., Lamers, M. H., Wemmer, D. E., Zhang, X., and Kuriyan, J. (2009) Cell 137, 1293-1307
17. Bader, A. N., Hofman, E. G., Voortman, J., en Henegouwen, P. M., and Gerritsen, H. C. (2009) Biophys. J. 97, 2613-2622
18. Zacharias, D. A., Violin, J. D., Newton, A. C., and Tsien, R. Y. (2002) Science 296, 913-916
19. Fallon, L., Bélanger, C. M., Corera, A. T., Kontogiannea, M., Regan-Klapisz, E., Moreau, F., Voortman, J., Haber, M., Rouleau, G., Thorarinsdottir, T., Brice, A., van Bergen En Henegouwen, P. M., and Fon, E. A. (2006) Nat. Cell Biol. 8, 834-842
20. Bader, A. N., Hofman, E. G., van Bergen en Henegouwen, P. M., and Gerritsen, H. C. (2007) Optics Express 15, 6934-6945
21. de Grauw, C. J., and Gerritsen, H. C. (2001) Appl. Spectrosc. 55, 670-678
22. Runnels, L. W., and Scarlata, S. F. (1995) Biophys. J. 69, 1569-1583
23. Stoorvogel, W., Kerstens, S., Fritzsche, I., den Hartigh, J. C., Oud, R., van der Heyden, M. A., Voortman, J., and van Bergen en Henegouwen, P. M. (2004) J. Biol. Chem. 279, 11562-11569
24. Hofman, E. G., Ruonala, M. O., Bader, A. N., van den Heuvel, D., Voortman, J., Roovers, R. C., Verkleij, A. J., Gerritsen, H. C., and van Bergen en Henegouwen, P. M. (2008) J. Cell Sci. 121, 2519-2528
25. Sigismund, S., Argenzio, E., Tosoni, D., Cavallaro, E., Polo, S., and Di Fiore, P. P. (2008) Dev. Cell 15, 209-219
26. Wang, Q., Zhu, F., and Wang, Z. (2007) Exp. Cell Res. 313, 3349-3363
27. Chung, I., Akita, R., Vandlen, R., Toomre, D., Schlessinger, J., and Mellman, I. (2010) Nature 464, 783-787
28. Goh, L. K., Huang, F., Kim, W., Gygi, S., and Sorkin, A. (2010) J. Cell Biol. 189, 871-883
29. Rappoport, J. Z., and Simon, S. M. (2009) J. Cell Sci. 122, 1301-1305
30. Yarden, Y., and Schlessinger, J. (1987) Biochemistry 26, 1434-1442