Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: A novel DYRK1A inhibitor class

European Journal of Medicinal Chemistry

Volumn 49, Issue , 2012, Pages 379-396

  Neagoie, Cleopatra ^a,b   Vedrenne, Emeline ^a   Buron, Frédéric ^a   Mérour, Jean Yves ^a   Rosca, Sorin ^b   Bourg, Stéphane ^a   Lozach, Olivier ^c   Meijer, Laurent ^c   Baldeyrou, Brigitte ^d   Lansiaux, Amelie ^d   Routier, Sylvain ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b UNIVERSITY POLITEHNICA OF BUCHAREST   (Romania)

^c CNRS   (France)

^d UNIV LILLE   (France)

Author keywords

DYRK1A; Indoles; Kinase; Lamellarin; Topoisomerase inhibition

Indexed keywords

2 METHOXY 6 (METHOXYMETHOXY)PHENYLBORONIC ACID; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; ETHYL 3 (2 METHOYPHENYL) 1H INDOLE 2 CARBOXYLATE; ETHYL 3 (2,5 DIMETHOXYPHENYL) 1H INDOLE 2 CARBOXYLATE; ETHYL 3 ([2 METHOXY 6 (METHOXYMETHOXY)PHENYL] 1H INDOLE 2 CARBOXYLATE; ETHYL 5 (BENZYLOXY) 3 (2,4 DIMETHOXYPHENYL) 1H INDOLE 2 CARBOXYLATE; ETHYL 5 (BENZYLOXY) 3 (2,5 DIMETHOXYPHENYL) 1H INDOLE 2 CARBOXYLATE; ETHYL 7 IODO 5H [1,3]DIOXOLO[4,5 F]INDOLE 6 CARBOXYLATE; INDOLE DERIVATIVE; LAMELLARIN D DERIVATIVE; METHYL 3 (2 METHOXYPHENYL) 4 (4 METHOXYPHENYL) 1H INDOLE 2 CARBOXYLATE; METHYL 3 (2,5 DIMETHOXYPHENYL) 4 (4 METHOXYPHENYL) 1H INDOLE 2 CARBOXYLATE; METHYL 3 IODO 4 (4 METHOXYPHENYL) 1H INDOLE 2 CARBOXYLATE; METHYL 3 IODO 4 (TRIFLUOROMETHYL) 1H INDOLE 2 CARBOXYLATE; METHYL 3 IODO 4 BROMO 1H INDOLE 2 CARBOXYLATE; METHYL 3 IODO 4 METHYL 1H INDOLE 2 CARBOXYLATE; METHYL 3 IODO 4 PROPOXY 1H INDOLE 2 CARBOXYLATE; METHYL 3 IODO 5 (TRIFLUOROMETHYL) 1H INDOLE 2 CARBOXYLATE; METHYL 3 IODO 6 (4 METHOXYPHENYL) 1H INDOLE 2 CARBOXYLATE; METHYL 3 IODO 6 METHYL 1H INDOLE 2 CARBOXYLATE; METHYL 3 IODO 7 (TRIFLUOROMETHYL) 1H INDOLE 2 CARBOXYLATE; METHYL 3 IOXO 6 (BENZYLOXY) 1H INDOLE 2 CARBOXYLATE; METHYL 4 (4 METHOXYPHENYL) 1H INDOLE 2 CARBOXYLATE; METHYL 4 PROPOXY 1H INDOLE 2 CARBOXYLATE; METHYL 4 TRIFLUOROMETHYL 1H INDOLE 2 CARBOXYLATE; METHYL 5 TRIFLUOROMETHY 1H INDOLE 2 CARBOXYLATE; METHYL 6 (4 METHOXYPHENYL) 1H INDOLE 2 CARBOXYLATE; METHYL 7 TRIFLUOROMETHYL 1H INDOLE 2 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CYCLIZATION; DEPROTECTION REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

COUMARINS; DNA TOPOISOMERASES, TYPE I; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INDOLES; ISOQUINOLINES; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

EID: 84857236110     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.040     Document Type: Article

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