Synthesis and biological evaluation of a folate-targeted rhaponticin conjugate

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 1, 2013, Pages 178-185

  Liang, Xuhua ^a   Sun, Yang ^b   Zeng, Wenyuan ^c   Liu, Lusha ^a   Ma, Xuan ^a   Zhao, Yingyong ^a   Fan, Jun ^a  

^a NORTHWEST UNIVERSITY   (China)

^b XI'AN UNIVERSITY OF ARTS AND SCIENCE   (China)

^c ZHENGZHOU UNIVERSITY   (China)

Author keywords

Anticancer; Folate receptor; Rhaponticin (RHA); Targeted therapeutics; Toxicity

Indexed keywords

DISULFIDE; FOLATE RECEPTOR; FOLATE RECEPTOR TARGETED RHAPONTICIN CONJUGATE; FOLIC ACID; RHAPONTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISULFIDE BOND; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOSOME; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; MOUSE; NONHUMAN; PHARMACODYNAMICS; RECEPTOR AFFINITY; REDUCTION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; FOLATE RECEPTORS, GPI-ANCHORED; FOLIC ACID; HUMANS; MICE; MICE, INBRED BALB C; NEOPLASMS; STILBENES;

EID: 84870955595     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.10.044     Document Type: Article

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