The synthesis of pteroyl-lys conjugates and its application as Technetium-99m labeled radiotracer for folate receptor-positive tumor targeting

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 7, 2011, Pages 2025-2029

  Guo, Hongjuan ^a   Xie, Fang ^a   Zhu, Meilin ^a   Li, Yan ^a,b   Yang, Zhi ^b   Wang, Xuebin ^a   Lu, Jie ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

99mTc; Folate receptor; Folate drug conjugates; Pteroyl lys HYNIC; Tumor imaging

Indexed keywords

CHEMICAL COMPOUND; FOLATE RECEPTOR; FOLIC ACID; FOLIC ACID DERIVATIVE; RADIOPHARMACEUTICAL AGENT; SUCCINIMIDYL 6 [2 (4 DIMETHYLAMINO)BENZALDEHYDEHYDRAZONO]NICOTINATE; TECHNETIUM 99M; TRACER; TRISODIUM TRIPHENYLPHOSPHINE 3,3',3'' TRISULFONATE; UNCLASSIFIED DRUG;

ARTICLE; CANCER SCREENING; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG LABELING; DRUG PURIFICATION; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RADIOCHEMISTRY; TUMOR CELL;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FOLIC ACID TRANSPORTERS; LYSINE; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; RADIOPHARMACEUTICALS;

EID: 79952487149     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.014     Document Type: Article

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