Carbohydrate-based synthetic approach to control toxicity profiles of folate-drug conjugates

Journal of Organic Chemistry

Volumn 75, Issue 11, 2010, Pages 3685-3691

  Vlahov, Iontcho R ^a   Santhapuram, Hari Krishna R ^a   You, Fei ^a   Wang, Yu ^a   Kleindl, Paul J ^a   Hahn, Spencer J ^a   Vaughn, Jeremy F ^a   Reno, Daniel S ^a   Leamon, Christopher P ^a  

^a Endocyte Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODISTRIBUTIONS; DEPROTECTION; DRUG-CONJUGATES; ENDOSOMES; GLUCITOL; GLUCONOLACTONE; GLUTAMIC ACID; ISOPROPYLIDENE; ROOM TEMPERATURE; SOLID PHASE PEPTIDE SYNTHESIS; SYNTHETIC APPROACH; THERAPEUTIC INDEX; VINBLASTINE;

CARBOHYDRATES; RESINS;

SYNTHESIS (CHEMICAL);

3,4;5,6 DI O ISOPROPYLIDENE 1 AMINO 1 DEOXY(9 FLUORENYLMETHYLOXYCARBONYLGUTAMYL HYDROXIDE) DEXTRO GLUCITOL; CARBOHYDRATE; CYSTEINE; DEACETYLVINBLASTINE 3 CARBOHYDRAZIDE; DITHIOTHREITOL; FOLIC ACID; GLUTAMIC ACID; GLYCOCONJUGATE; PTEROIC ACID GAMMA GLUTAMYL[GLUTAMYL(1 AMINO 1 DEOXY DEXTRO GLUCITOL)GLUTAMYL]2 GLUTAMYL(1 AMINO 1 DEOXY GLUCITOL)CYSTEINYL HYDROXIDE; PTEROIC ACID GAMMA GLUTAMYL[GLUTAMYL(1 AMINO 1 DEOXY DEXTRO GLUCITOL)GLUTAMYL]2 GLUTAMYL(1 AMINO 1 DEOXY GLUCITOL)CYSTEINYL[ETHYL 3 (4 DESCETYLVINBLASTINYL)HYDRAZINECARBOXYLATE]; RESIN; UNCLASSIFIED DRUG; VINBLASTINE;

ARTICLE; ENDOSOME; PEPTIDE SYNTHESIS; ROOM TEMPERATURE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBOHYDRATES; DRUG DESIGN; ENDOSOMES; FOLIC ACID; HUMANS; TISSUE DISTRIBUTION; VINBLASTINE; VINCA ALKALOIDS;

EID: 77952991467     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo100448q     Document Type: Article

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