Design and regioselective synthesis of a new generation of targeted therapeutics. Part 3: Folate conjugates of aminopterin hydrazide for the treatment of inflammation

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1202-1205

  Vlahov, Iontcho R ^a   You, Fei ^a   Santhapuram, Hari Krishna R ^a   Wang, Yu ^a   Vaughn, Jeremy F ^a   Hahn, Spencer J ^a   Kleindl, Paul J ^a   Fan, Mingjin ^a   Leamon, Christopher P ^a  

^a Endocyte Inc   (United States)

Author keywords

Disulfide linkers; Folate; Folate receptor targeting; Folate aminopterin hydrazide conjugate; Inflammation

Indexed keywords

2 [4 BENZOYLAMINO] 5 OXO 5 [N' [2 (PYRIDIN 2 YLDISULFANYL)ETHOXYCARBONYL]HYDRAZINO] PENTANOIC ACID; AMINOPTERIN; AMINOPTERIN DERIVATIVE; AMINOPTERIN HYDRAZIDE; ANTIINFLAMMATORY AGENT; CYSTEINE; FOLATE RECEPTOR; FOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONJUGATION; DRUG DESIGN; DRUG SYNTHESIS; INFLAMMATION;

AMINOPTERIN; ANTI-INFLAMMATORY AGENTS; DRUG DESIGN; FOLIC ACID; HUMANS; INFLAMMATION; STEREOISOMERISM;

EID: 79851511691     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.085     Document Type: Article

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