메뉴 건너뛰기




Volumn 39, Issue 8, 2012, Pages 709-714

Molecular regulaion of BACE1 and Its function at the early onset of Alzheimer's disease

Author keywords

A ; Alzheimer's disease; BACE1; Biomarkers

Indexed keywords


EID: 84870939173     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1206.2012.00217     Document Type: Review
Times cited : (6)

References (44)
  • 1
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encodingbrain amyloid of Alzheimer's disease
    • Goldgaber D, Lerman M I, McBride O W, et al. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science, 1987, 235(4791): 877-880 (Pubitemid 17019124)
    • (1987) Science , vol.235 , Issue.4791 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.W.3
  • 3
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • DOI 10.1038/325733a0
    • Kang J, Lemaire H G, Unterbeck A, et al. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature, 1987, 325(6106): 733-736 (Pubitemid 17054046)
    • (1987) Nature , vol.325 , Issue.6106 , pp. 733-736
    • Kang, J.1    Lemaire, H.-G.2    Unterbeck, A.3
  • 5
    • 0033518251 scopus 로고    scopus 로고
    • Purification and cloning of amyloid precursor protein beta-secretase from human brain
    • Sinha S, Anderson J P, Barbour R, et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature, 1999, 402( 6761): 537-540
    • (1999) Nature , vol.402 , Issue.6761 , pp. 537-540
    • Sinha, S.1    Anderson, J.P.2    Barbour, R.3
  • 6
    • 0033595706 scopus 로고    scopus 로고
    • Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
    • Vassar R, Bennett B D, Babu-Khan S, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science, 1999, 286( 5440): 735-741
    • (1999) Science , vol.286 , Issue.5440 , pp. 735-741
    • Vassar, R.1    Bennett, B.D.2    Babu-Khan, S.3
  • 7
    • 0035853821 scopus 로고    scopus 로고
    • A splice variant of betasecretase deficient in the amyloidogenic processing of the amyloid precursor protein
    • Bodendorf U, Fischer F, Bodian D, et al. A splice variant of betasecretase deficient in the amyloidogenic processing of the amyloid precursor protein. J Biol Chem, 2001, 276( 15): 12019-12023
    • (2001) J Biol Chem , vol.276 , Issue.15 , pp. 12019-12023
    • Bodendorf, U.1    Fischer, F.2    Bodian, D.3
  • 8
    • 0035971166 scopus 로고    scopus 로고
    • The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain
    • Shi X P, Chen E, Yin K C, et al. The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain. J Biol Chem, 2001, 276 ( 13): 10366-10373
    • (2001) J Biol Chem , vol.276 , Issue.13 , pp. 10366-10373
    • Shi, X.P.1    Chen, E.2    Yin, K.C.3
  • 9
    • 79959196089 scopus 로고    scopus 로고
    • Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
    • Hogl S, Kuhn P H, Colombo A, et al. Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase. PLoS One, 2011, 6( 6): e21337
    • (2011) PLoS One , vol.6 , Issue.6
    • Hogl, S.1    Kuhn, P.H.2    Colombo, A.3
  • 10
    • 7444250507 scopus 로고    scopus 로고
    • Degradation of BACE by the ubiquitin-proteasome pathway
    • Qing H, Zhou W, Christensen M A, el al. Degradation of BACE by the ubiquitin-proteasome pathway. Faseb J, 2004, 18( 13): 1571-1573
    • (2004) Faseb J , vol.18 , Issue.13 , pp. 1571-1573
    • Qing, H.1    Zhou, W.2    Christensen, M.A.3
  • 12
  • 13
    • 67649220624 scopus 로고    scopus 로고
    • Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons
    • Cho H J, Jin S M, Son S M, et al. Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons. Biochem Biophys Res Commun, 2009, 386( 1): 175-180
    • (2009) Biochem Biophys Res Commun , vol.386 , Issue.1 , pp. 175-180
    • Cho, H.J.1    Jin, S.M.2    Son, S.M.3
  • 14
    • 40549129366 scopus 로고    scopus 로고
    • Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling
    • DOI 10.1111/j.1474-9726.2007.00360.x
    • Cho H J, Jin S M, Youn H D, et al. Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling. Aging Cell, 2008, 7(2): 137-147 (Pubitemid 351359647)
    • (2008) Aging Cell , vol.7 , Issue.2 , pp. 137-147
    • Cho, H.-J.1    Jin, S.M.2    Youn, H.D.3    Huh, K.4    Mook-Jung, I.5
  • 15
    • 84856428468 scopus 로고    scopus 로고
    • Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease
    • Chen C H, Zhou W, Liu S, et al. Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. Int J Neuropsychopharmacol, 2012, 15( 1): 77-90
    • (2012) Int J Neuropsychopharmacol , vol.15 , Issue.1 , pp. 77-90
    • Chen, C.H.1    Zhou, W.2    Liu, S.3
  • 16
    • 33644920657 scopus 로고    scopus 로고
    • Control of APP processing and Aβ generation level by BACE1 enzymatic activity and transcription
    • DOI 10.1096/fj.05-4986com
    • Li Y, Zhou W, Tong Y, et al. Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription. Faseb J, 2006, 20(2): 285-292 (Pubitemid 44933176)
    • (2006) FASEB Journal , vol.20 , Issue.2 , pp. 285-292
    • Li, Y.1    Zhou, W.2    Tong, Y.3    He, G.4    Song, W.5
  • 18
    • 33646244775 scopus 로고    scopus 로고
    • Leaky scanning and reinitiation regulate BACE1 gene expression
    • Zhou W, Song W. Leaky scanning and reinitiation regulate BACE1 gene expression. Mol Cell Biol, 2006, 26( 9): 3353-3364
    • (2006) Mol Cell Biol , vol.26 , Issue.9 , pp. 3353-3364
    • Zhou, W.1    Song, W.2
  • 20
    • 33746572249 scopus 로고    scopus 로고
    • Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in down syndrome
    • DOI 10.1096/fj.05-5628com
    • Sun X, Tong Y, Qing H, et al. Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome. Faseb J, 2006, 20(9):1361-1368 (Pubitemid 44943844)
    • (2006) FASEB Journal , vol.20 , Issue.9 , pp. 1361-1368
    • Sun, X.1    Tong, Y.2    Qing, H.3    Chen, C.-H.4    Song, W.5
  • 23
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-B transcription factor and HIV-1
    • Schreck R, Rieber P, Baeuerle P A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. Embo J, 1991, 10(8): 2247-2258 (Pubitemid 21905698)
    • (1991) EMBO Journal , vol.10 , Issue.8 , pp. 2247-2258
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 24
    • 0028982454 scopus 로고
    • Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease
    • Motter R, Vigo-Pelfrey C, Kholodenko D, et al. Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol, 1995, 38( 4): 643-648
    • (1995) Ann Neurol , vol.38 , Issue.4 , pp. 643-648
    • Motter, R.1    Vigo-Pelfrey, C.2    Kholodenko, D.3
  • 25
    • 0141738373 scopus 로고    scopus 로고
    • CSF markers for incipient Alzheimer's disease
    • DOI 10.1016/S1474-4422(03)00530-1
    • Blennow K, Hampel H. CSF markers for incipient Alzheimer's disease. Lancet Neurol, 2003, 2(10): 605-613 (Pubitemid 37162569)
    • (2003) Lancet Neurology , vol.2 , Issue.10 , pp. 605-613
    • Blennow, K.1    Hampel, H.2
  • 27
    • 49449108546 scopus 로고    scopus 로고
    • Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease
    • Zetterberg H, Andreasson U, Hansson O, et al. Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease. Arch Neurol, 2008, 65( 8): 1102-1107
    • (2008) Arch Neurol , vol.65 , Issue.8 , pp. 1102-1107
    • Zetterberg, H.1    Andreasson, U.2    Hansson, O.3
  • 29
    • 44949221768 scopus 로고    scopus 로고
    • Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease
    • Ewers M, Zhong Z, Burger K, et al. Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease. Brain, 2008, 131( Pt 5): 1252-1258
    • (2008) Brain , vol.131 , Issue.PART 5 , pp. 1252-1258
    • Ewers, M.1    Zhong, Z.2    Burger, K.3
  • 30
    • 80053484102 scopus 로고    scopus 로고
    • Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    • Jiang H, Hampel H, Prvulovic D, et al. Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Mol Neurodegener, 2011, 6( 1): 69
    • (2011) Mol Neurodegener , vol.6 , Issue.1 , pp. 69
    • Jiang, H.1    Hampel, H.2    Prvulovic, D.3
  • 31
    • 77951962298 scopus 로고    scopus 로고
    • Recent progress in neurodegenerative disorder research in China
    • Zhou J W. Recent progress in neurodegenerative disorder research in China. Sci China Life Sci, 2010, 53( 3): 348-355
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 348-355
    • Zhou, J.W.1
  • 32
    • 78449288804 scopus 로고    scopus 로고
    • Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease
    • Cong L, Jia J. Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease. Neurobiol Aging, 2011, 32( 1): 54-62
    • (2011) Neurobiol Aging , vol.32 , Issue.1 , pp. 54-62
    • Cong, L.1    Jia, J.2
  • 33
    • 84879265725 scopus 로고    scopus 로고
    • Accumulated hippocampal formaldehyde induces age-dependent memory decline
    • DOI: 10.1007/s11357-012-9388-8
    • Tong Z Q, Han C S, Luo W H, et al. Accumulated hippocampal formaldehyde induces age-dependent memory decline. AGE ( 2012) DOI: 10.1007/s11357-012-9388-8
    • (2012) AGE
    • Tong, Z.Q.1    Han, C.S.2    Luo, W.H.3
  • 35
    • 78449301205 scopus 로고    scopus 로고
    • Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia
    • Tong Z Q, Zhang J L, Luo W H, et al. Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia. Neurobiology of Aging, 2011, 32( 1): 31-41
    • (2011) Neurobiology of Aging , vol.32 , Issue.1 , pp. 31-41
    • Tong, Z.Q.1    Zhang, J.L.2    Luo, W.H.3
  • 36
    • 80051617317 scopus 로고    scopus 로고
    • A novel molecular mechanism for nitrated a-synuclein-induced cell death
    • Liu Y Y, Qiang M, Wei Y, et al. A novel molecular mechanism for nitrated a-synuclein-induced cell death. J Mol Cell Biol, 2011, 3( 4): 239-249
    • (2011) J Mol Cell Biol , vol.3 , Issue.4 , pp. 239-249
    • Liu, Y.Y.1    Qiang, M.2    Wei, Y.3
  • 38
    • 77951961804 scopus 로고    scopus 로고
    • Progress in neural plasticity
    • Zhang X H, Poo M M. Progress in neural plasticity. Sci China Life Sci, 2010, 53( 3): 322-329
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 322-329
    • Zhang, X.H.1    Poo, M.M.2
  • 39
    • 77951943759 scopus 로고    scopus 로고
    • Synapse formation and remodeling. Axon guidance and neuronal migration research in China
    • Luo Z G. Synapse formation and remodeling. Axon guidance and neuronal migration research in China. Sci China Life Sci, 2010, 53( 3): 315-321
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 315-321
    • Luo, Z.G.1
  • 40
    • 76649089967 scopus 로고    scopus 로고
    • A meta-analysis of oxidative stress markers in schizophrenia
    • Zhang M, Zhao Z M, He L, et al. A meta-analysis of oxidative stress markers in schizophrenia. Sci China Life Sci, 2010, 53( 1): 112-124
    • (2010) Sci China Life Sci , vol.53 , Issue.1 , pp. 112-124
    • Zhang, M.1    Zhao, Z.M.2    He, L.3
  • 41
    • 77949282876 scopus 로고    scopus 로고
    • TLR4 signaling induced TLR2 expression in the process of mimic cerebral ischemia/reperfusion in vitro
    • Sun P, Zhang Q, Han J Y, et al. TLR4 signaling induced TLR2 expression in the process of mimic cerebral ischemia/reperfusion in vitro. Sci China Life Sci, 2010, 53( 1): 112-124
    • (2010) Sci China Life Sci , vol.53 , Issue.1 , pp. 112-124
    • Sun, P.1    Zhang, Q.2    Han, J.Y.3
  • 42
    • 77951966903 scopus 로고    scopus 로고
    • Ion channels in neuronal survival
    • Wang Y Z, Xu T L. Ion channels in neuronal survival. Sci China Life Sci, 2010, 53 ( 3): 342-347
    • (2010) Sci China Life Sci , vol.53 , Issue.3 , pp. 342-347
    • Wang, Y.Z.1    Xu, T.L.2
  • 43
    • 79959613455 scopus 로고    scopus 로고
    • Copper ions influence the toxicity of β-amyloid (1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease
    • Luo Y F, Zhang J, Liu N Q, et al. Copper ions influence the toxicity of β-amyloid (1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease. Sci China Life Sci, 2011, 54( 6): 527-534
    • (2011) Sci China Life Sci , vol.54 , Issue.6 , pp. 527-534
    • Luo, Y.F.1    Zhang, J.2    Liu, N.Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.