Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Tucker, Julie A ^a   Bennett, Neil ^a   Brassington, Claire ^a   Durant, Stephen T ^a   Hassall, Giles ^a   Holdgate, Geoff ^a   McAlister, Mark ^a   Nissink, J Willem M ^a   Truman, Caroline ^a   Watson, Martin ^a,b  

^a ASTRAZENECA   (United Kingdom)

^b Conformetrix ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSIDASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLY(ADENOSINE DIPHOSPHATE RIBOSE) GLYCOHYDROLASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTALLIZATION; ENTROPY; ENZYME ANALYSIS; ENZYME STRUCTURE; HOMOLOGOUS RECOMBINATION; HUMAN; HYDROGEN BOND; HYDROLYSIS; ISOTHERMAL TITRATION CALORIMETRY; MUTAGENESIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE;

CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; GLYCOSIDE HYDROLASES; HUMANS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 84870910810     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050889     Document Type: Article

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