SAR analysis of adenosine diphosphate (hydroxymethyl)pyrrolidinediol inhibition of poly(ADP-ribose) glycohydrolase

Journal of Medicinal Chemistry

Volumn 46, Issue 20, 2003, Pages 4322-4332

  Koh, David W ^a   Coyle, Donna L ^b   Mehta, Nimish ^c   Ramsinghani, Sushma ^c   Kim, Hyuntae ^b   Slama, James T ^c   Jacobson, Myron K ^b  

^a University of Kentucky   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE (HYDROXYMETHYL)PYRROLIDINEDIOL; GLYCOSIDASE; GUANINE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLY(ADENOSINE DIPHOSPHATE RIBOSE) GLYCOHYDROLASE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; STRUCTURE ACTIVITY RELATION;

ADENOSINE DIPHOSPHATE; ANIMALS; BINDING SITES; CATTLE; ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; INHIBITORY CONCENTRATION 50; PEPTIDE FRAGMENTS; POLY ADENOSINE DIPHOSPHATE RIBOSE; PYRROLIDINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141792692     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020541u     Document Type: Article

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