-
1
-
-
33745867638
-
Poly(ADP-ribose): Novel functions for an old molecule
-
DOI 10.1038/nrm1963, PII NRM1963
-
Schreiber, V., Dantzer, F., Ame, J. C., and de Murcia, G. (2006) Poly(ADP-ribose): novel functions for an old molecule Nat. Rev. Mol. Cell Biol. 7, 517-528 (Pubitemid 44036457)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.7
, pp. 517-528
-
-
Schreiber, V.1
Dantzer, F.2
Ame, J.-C.3
De Murcia, G.4
-
2
-
-
0032842477
-
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
-
DOI 10.1038/12680
-
dAdda di Fagagna, F., Hande, M. P., Tong, W. M., Lansdorp, P. M., Wang, Z. Q., and Jackson, S. P. (1999) Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability Nat. Genet. 23, 76-80 (Pubitemid 29418792)
-
(1999)
Nature Genetics
, vol.23
, Issue.1
, pp. 76-80
-
-
Di Fagagna, F.D.1
Hande, M.P.2
Tong, W.-M.3
Lansdorp, P.M.4
Wang, Z.-Q.5
Jackson, S.P.6
-
3
-
-
34248363671
-
Modulation of transcription by PARP-1: Consequences in carcinogenesis and inflammation
-
DOI 10.2174/092986707780597998
-
Aguilar-Quesada, R., Munoz-Gamez, J. A., Martin-Oliva, D., Peralta-Leal, A., Quiles-Perez, R., Rodriguez-Vargas, J. M., Ruiz de Almodovar, M., Conde, C., Ruiz-Extremera, A., and Oliver, F. J. (2007) Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation Curr. Med. Chem. 14, 1179-1187 (Pubitemid 46739319)
-
(2007)
Current Medicinal Chemistry
, vol.14
, Issue.11
, pp. 1179-1187
-
-
Aguilar-Quesada, R.1
Munoz-Gamez, J.A.2
Martin-Oliva, D.3
Peralta-Leal, A.4
Quiles-Perez, R.5
Rodriguez-Vargas, J.M.6
Ruiz De Almodovar, M.7
Conde, C.8
Ruiz-Extremera, A.9
Oliver, F.J.10
-
4
-
-
0035425899
-
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism
-
DOI 10.1006/excr.2001.5263
-
Davidovic, L., Vodenicharov, M., Affar, E. B., and Poirier, G. G. (2001) Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism Exp. Cell Res. 268, 7-13 (Pubitemid 32678855)
-
(2001)
Experimental Cell Research
, vol.268
, Issue.1
, pp. 7-13
-
-
Davidovic, L.1
Vodenicharov, M.2
Affar, E.B.3
Poirier, G.G.4
-
5
-
-
0028246305
-
Poly(ADP-ribose) molecules formed during DNA repair in vivo
-
Malanga, M. and Althaus, F. R. (1994) Poly(ADP-ribose) molecules formed during DNA repair in vivo J. Biol. Chem. 269, 17691-17696 (Pubitemid 24218056)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.26
, pp. 17691-17696
-
-
Malanga, M.1
Althaus, F.R.2
-
6
-
-
19444362951
-
Clinical perspectives of PARP inhibitors
-
DOI 10.1016/j.phrs.2005.02.013, PII S1043661805000460
-
Graziani, G. and Szabo, C. (2005) Clinical perspectives of PARP inhibitors Pharmacol. Res. 52, 109-118 (Pubitemid 40725605)
-
(2005)
Pharmacological Research
, vol.52
, Issue.1 SPEC. ISS.
, pp. 109-118
-
-
Graziani, G.1
Szabo, C.2
-
7
-
-
70249091814
-
PARP inhibitors blaze a trail in difficult-to-treat cancers
-
Kling, J. (2009) PARP inhibitors blaze a trail in difficult-to-treat cancers Nat. Biotechnol. 27, 784-786
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 784-786
-
-
Kling, J.1
-
8
-
-
25444498338
-
The road to survival goes through PARG
-
Koh, D. W., Dawson, V. L., and Dawson, T. M. (2005) The road to survival goes through PARG Cell Cycle 4, 397-399 (Pubitemid 41359723)
-
(2005)
Cell Cycle
, vol.4
, Issue.3
, pp. 397-399
-
-
Koh, D.W.1
Dawson, V.L.2
Dawson, T.M.3
-
9
-
-
79953717442
-
Activation of cell death mediated by apoptosis-inducing factor due to the absence of poly(ADP-ribose) glycohydrolase
-
Zhou, Y., Feng, X., and Koh, D. W. (2011) Activation of cell death mediated by apoptosis-inducing factor due to the absence of poly(ADP-ribose) glycohydrolase Biochemistry 50, 2850-2859
-
(2011)
Biochemistry
, vol.50
, pp. 2850-2859
-
-
Zhou, Y.1
Feng, X.2
Koh, D.W.3
-
10
-
-
0023020120
-
Purification and characterization of poly(ADP-ribose) glycohydrolase. Different modes of action on large and small poly(ADP-ribose)
-
Hatakeyama, K., Nemoto, Y., Ueda, K., and Hayaishi, O. (1986) Purification and characterization of poly(ADP-ribose) glycohydrolase. Different modes of action on large and small poly(ADP-ribose) J. Biol. Chem. 261, 14902-14911 (Pubitemid 17218047)
-
(1986)
Journal of Biological Chemistry
, vol.261
, Issue.32
, pp. 14902-14911
-
-
Hatakeyama, K.1
Nemoto, Y.2
Ueda, K.3
Hayaishi, O.4
-
11
-
-
2942707644
-
Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments
-
DOI 10.1016/j.yexcr.2004.03.050, PII S0014482704001843
-
Meyer-Ficca, M. L., Meyer, R. G., Coyle, D. L., Jacobson, E. L., and Jacobson, M. K. (2004) Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments Exp. Cell Res. 297, 521-532 (Pubitemid 38798412)
-
(2004)
Experimental Cell Research
, vol.297
, Issue.2
, pp. 521-532
-
-
Meyer-Ficca, M.L.1
Meyer, R.G.2
Coyle, D.L.3
Jacobson, E.L.4
Jacobson, M.K.5
-
12
-
-
33744986316
-
2-induced cell death
-
DOI 10.1042/BJ20051696
-
Blenn, C., Althaus, F. R., and Malanga, M. (2006) Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death Biochem. J. 396, 419-429 (Pubitemid 44228157)
-
(2006)
Biochemical Journal
, vol.396
, Issue.3
, pp. 419-429
-
-
Blenn, C.1
Althaus, F.R.2
Malanga, M.3
-
13
-
-
33847313804
-
Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression
-
DOI 10.1016/j.dnarep.2006.10.027, PII S1568786406003582
-
St-Laurent, J. F., Gagnon, S. N., Dequen, F., Hardy, I., and Desnoyers, S. (2007) Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression DNA Repair 6, 329-343 (Pubitemid 46329615)
-
(2007)
DNA Repair
, vol.6
, Issue.3
, pp. 329-343
-
-
St-Laurent, J.-F.1
Gagnon, S.N.2
Dequen, F.3
Hardy, I.4
Desnoyers, S.5
-
14
-
-
68949178566
-
Radiation-induced mitotic catastrophe in PARG-deficient cells
-
Ame, J. C., Fouquerel, E., Gauthier, L. R., Biard, D., Boussin, F. D., Dantzer, F., de Murcia, G., and Schreiber, V. (2009) Radiation-induced mitotic catastrophe in PARG-deficient cells J. Cell Sci. 122, 1990-2002
-
(2009)
J. Cell Sci.
, vol.122
, pp. 1990-2002
-
-
Ame, J.C.1
Fouquerel, E.2
Gauthier, L.R.3
Biard, D.4
Boussin, F.D.5
Dantzer, F.6
De Murcia, G.7
Schreiber, V.8
-
15
-
-
19944418213
-
Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality
-
DOI 10.1073/pnas.0406182101
-
Koh, D. W., Lawler, A. M., Poitras, M. F., Sasaki, M., Wattler, S., Nehls, M. C., Stoger, T., Poirier, G. G., Dawson, V. L., and Dawson, T. M. (2004) Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality Proc. Natl. Acad. Sci. U.S.A. 101, 17699-17704 (Pubitemid 40051949)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.51
, pp. 17699-17704
-
-
Koh, D.W.1
Lawler, A.M.2
Poitras, M.F.3
Sasaki, M.4
Wattler, S.5
Nehls, M.C.6
Stoger, T.7
Poirier, G.G.8
Dawson, V.L.9
Dawson, T.M.10
-
16
-
-
77956043225
-
Enhanced DNA accessibility and increased DNA damage induced by the absence of poly(ADP-ribose) hydrolysis
-
Zhou, Y., Feng, X., and Koh, D. W. (2010) Enhanced DNA accessibility and increased DNA damage induced by the absence of poly(ADP-ribose) hydrolysis Biochemistry 49, 7360-7366
-
(2010)
Biochemistry
, vol.49
, pp. 7360-7366
-
-
Zhou, Y.1
Feng, X.2
Koh, D.W.3
-
17
-
-
84889476358
-
The Promises and Pitfalls of Small-Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)
-
Wiley & Sons, Ltd. New York
-
Nottbohm, A. C. and Hergenrother, P. J. (2007) The Promises and Pitfalls of Small-Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG), in Drug Discovery Research: New Frontiers in the Post-Genomic Era, pp 163-185, Wiley & Sons, Ltd., New York.
-
(2007)
Drug Discovery Research: New Frontiers in the Post-Genomic Era
, pp. 163-185
-
-
Nottbohm, A.C.1
Hergenrother, P.J.2
-
18
-
-
79952148357
-
The ups and downs of tannins as inhibitors of poly(ADP-ribose) glycohydrolase
-
Blenn, C., Wyrsch, P., and Althaus, F. R. (2011) The ups and downs of tannins as inhibitors of poly(ADP-ribose)glycohydrolase Molecules 16, 1854-1877
-
(2011)
Molecules
, vol.16
, pp. 1854-1877
-
-
Blenn, C.1
Wyrsch, P.2
Althaus, F.R.3
-
19
-
-
4143154152
-
Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: Assessment of currently available pharmacological tools
-
DOI 10.1016/j.ejphar.2004.06.042, PII S001429990400665X
-
Falsig, J., Christiansen, S. H., Feuerhahn, S., Burkle, A., Oei, S. L., Keil, C., and Leist, M. (2004) Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools Eur. J. Pharmacol. 497, 7-16 (Pubitemid 39092421)
-
(2004)
European Journal of Pharmacology
, vol.497
, Issue.1
, pp. 7-16
-
-
Falsig, J.1
Christiansen, S.H.2
Feuerhahn, S.3
Burkle, A.4
Oei, S.L.5
Keil, C.6
Leist, M.7
-
20
-
-
0028823239
-
Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol
-
Slama, J. T., Aboul-Ela, N., and Jacobson, M. K. (1995) Mechanism of inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol J. Med. Chem. 38, 4332-4336
-
(1995)
J. Med. Chem.
, vol.38
, pp. 4332-4336
-
-
Slama, J.T.1
Aboul-Ela, N.2
Jacobson, M.K.3
-
21
-
-
0029020228
-
Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol
-
Slama, J. T., Aboul-Ela, N., Goli, D. M., Cheesman, B. V., Simmons, A. M., and Jacobson, M. K. (1995) Specific inhibition of poly(ADP-ribose) glycohydrolase by adenosine diphosphate (hydroxymethyl)pyrrolidinediol J. Med. Chem. 38, 389-393
-
(1995)
J. Med. Chem.
, vol.38
, pp. 389-393
-
-
Slama, J.T.1
Aboul-Ela, N.2
Goli, D.M.3
Cheesman, B.V.4
Simmons, A.M.5
Jacobson, M.K.6
-
22
-
-
0028452871
-
Synthesis of (2R,3R,4S)-2-hydroxymethylpyrrolidine-3,4-diol from (2S)-3,4-dehydroproline derivatives
-
Goli, D. M., Cheesman, B. V., Hassan, M. E., Lodaya, R., and Slama, J. T. (1994) Synthesis of (2R,3R,4S)-2-hydroxymethylpyrrolidine-3,4-diol from (2S)-3,4-dehydroproline derivatives Carbohydr. Res. 259, 219-241
-
(1994)
Carbohydr. Res.
, vol.259
, pp. 219-241
-
-
Goli, D.M.1
Cheesman, B.V.2
Hassan, M.E.3
Lodaya, R.4
Slama, J.T.5
-
23
-
-
19444366619
-
Role of poly(ADP-ribose) glycohydrolase (PARG) in shock, ischemia and reperfusion
-
DOI 10.1016/j.phrs.2005.02.009, PII S1043661805000411
-
Cuzzocrea, S. and Wang, Z. Q. (2005) Role of poly(ADP-ribose) glycohydrolase (PARG) in shock, ischemia and reperfusion Pharmacol. Res. 52, 100-108 (Pubitemid 40725604)
-
(2005)
Pharmacological Research
, vol.52
, Issue.1 SPEC. ISS.
, pp. 100-108
-
-
Cuzzocrea, S.1
Wang, Z.-Q.2
-
24
-
-
3543031621
-
Depletion of the 110-kilodalton isoform of poly(ABP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice
-
DOI 10.1128/MCB.24.16.7163-7178.2004
-
Cortes, U., Tong, W. M., Coyle, D. L., Meyer-Ficca, M. L., Meyer, R. G., Petrilli, V., Herceg, Z., Jacobson, E. L., Jacobson, M. K., and Wang, Z. Q. (2004) Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice Mol. Cell. Biol. 24, 7163-7178 (Pubitemid 39014442)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.16
, pp. 7163-7178
-
-
Cortes, U.1
Tong, W.-M.2
Coyle, D.L.3
Meyer-Ficca, M.L.4
Meyer, R.G.5
Petrilli, V.6
Herceg, Z.7
Jacobson, E.L.8
Jacobson, M.K.9
Wang, Z.-Q.10
-
25
-
-
20544475918
-
Identification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: Determining the PARG catalytic domain
-
DOI 10.1042/BJ20040942
-
Patel, C. N., Koh, D. W., Jacobson, M. K., and Oliveira, M. A. (2005) Identification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: determining the PARG catalytic domain Biochem. J. 388, 493-500 (Pubitemid 40839926)
-
(2005)
Biochemical Journal
, vol.388
, Issue.2
, pp. 493-500
-
-
Patel, C.N.1
Koh, D.W.2
Jacobson, M.K.3
Oliveira, M.A.4
-
26
-
-
85047693635
-
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function
-
Chang, P., Coughlin, M., and Mitchison, T. J. (2005) Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function Nat. Cell Biol. 7, 1133-1139
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 1133-1139
-
-
Chang, P.1
Coughlin, M.2
Mitchison, T.J.3
-
27
-
-
77954829745
-
Recognition of platinum-DNA damage by poly(ADP-ribose) polymerase-1
-
Zhu, G., Chang, P., and Lippard, S. J. (2010) Recognition of platinum-DNA damage by poly(ADP-ribose) polymerase-1 Biochemistry 49, 6177-6183
-
(2010)
Biochemistry
, vol.49
, pp. 6177-6183
-
-
Zhu, G.1
Chang, P.2
Lippard, S.J.3
-
28
-
-
77956627087
-
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
-
Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., and Schibler, U. (2010) Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding Cell 142, 943-953
-
(2010)
Cell
, vol.142
, pp. 943-953
-
-
Asher, G.1
Reinke, H.2
Altmeyer, M.3
Gutierrez-Arcelus, M.4
Hottiger, M.O.5
Schibler, U.6
-
29
-
-
34250198661
-
Haploinsufficiency of poly(ADP-ribose) polymerase-1-mediated poly(ADP-ribosyl)ation for centrosome duplication
-
DOI 10.1016/j.bbrc.2007.05.108, PII S0006291X07010728
-
Kanai, M., Tong, W. M., Wang, Z. Q., and Miwa, M. (2007) Haploinsufficiency of poly(ADP-ribose) polymerase-1-mediated poly(ADP-ribosyl)ation for centrosome duplication Biochem. Biophys. Res. Commun. 359, 426-430 (Pubitemid 46898968)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.359
, Issue.3
, pp. 426-430
-
-
Kanai, M.1
Tong, W.-M.2
Wang, Z.-Q.3
Miwa, M.4
-
30
-
-
79955957616
-
Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm
-
Leung, A. K., Vyas, S., Rood, J. E., Bhutkar, A., Sharp, P. A., and Chang, P. (2011) Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm Mol. Cell 42, 489-499
-
(2011)
Mol. Cell
, vol.42
, pp. 489-499
-
-
Leung, A.K.1
Vyas, S.2
Rood, J.E.3
Bhutkar, A.4
Sharp, P.A.5
Chang, P.6
-
31
-
-
10344234720
-
Poly(ADP-ribose) is required for spindle assembly and structure
-
DOI 10.1038/nature03061
-
Chang, P., Jacobson, M. K., and Mitchison, T. J. (2004) Poly(ADP-ribose) is required for spindle assembly and structure Nature 432, 645-649 (Pubitemid 39626273)
-
(2004)
Nature
, vol.432
, Issue.7017
, pp. 645-649
-
-
Chang, P.1
Jacobson, M.K.2
Mitchison, T.J.3
-
32
-
-
79953322962
-
Regulatory roles of tankyrase 1 at telomeres and in DNA repair: Suppression of T-SCE and stabilization of DNA-PKcs
-
Dregalla, R. C., Zhou, J., Idate, R. R., Battaglia, C. L., Liber, H. L., and Bailey, S. M. (2010) Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs Aging 2, 691-708
-
(2010)
Aging
, vol.2
, pp. 691-708
-
-
Dregalla, R.C.1
Zhou, J.2
Idate, R.R.3
Battaglia, C.L.4
Liber, H.L.5
Bailey, S.M.6
-
33
-
-
33846709501
-
Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes
-
DOI 10.1016/j.molcel.2006.12.022, PII S1097276507000068
-
Sanders, B. D., Zhao, K., Slama, J. T., and Marmorstein, R. (2007) Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes Mol. Cell 25, 463-472 (Pubitemid 46199287)
-
(2007)
Molecular Cell
, vol.25
, Issue.3
, pp. 463-472
-
-
Sanders, B.D.1
Zhao, K.2
Slama, J.T.3
Marmorstein, R.4
-
34
-
-
80053375417
-
The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
-
Slade, D., Dunstan, M. S., Barkauskaite, E., Weston, R., Lafite, P., Dixon, N., Ahel, M., Leys, D., and Ahel, I. (2011) The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase Nature 477, 616-620
-
(2011)
Nature
, vol.477
, pp. 616-620
-
-
Slade, D.1
Dunstan, M.S.2
Barkauskaite, E.3
Weston, R.4
Lafite, P.5
Dixon, N.6
Ahel, M.7
Leys, D.8
Ahel, I.9
-
35
-
-
84858645528
-
Replacing the Irreplaceable: Cyclic Compounds as Novel Phosphate Mimics
-
T. P. Begley, ed. John Wiley & Sons
-
Nottbohm, A. C. and Hergenrother, P. J. (2008) Replacing the Irreplaceable: Cyclic Compounds as Novel Phosphate Mimics, in Wiley Encyclopedia of Chemical Biology, T. P. Begley, ed., John Wiley & Sons.
-
(2008)
Wiley Encyclopedia of Chemical Biology
-
-
Nottbohm, A.C.1
Hergenrother, P.J.2
-
36
-
-
40749100178
-
Rhodanine derivatives as novel inhibitors of PDE4
-
DOI 10.1016/j.bmcl.2008.01.117, PII S0960894X0800142X
-
Irvine, M. W., Patrick, G. L., Kewney, J., Hastings, S. F., and MacKenzie, S. J. (2008) Rhodanine derivatives as novel inhibitors of PDE4 Bioorg. Med. Chem. Lett. 18, 2032-2037 (Pubitemid 351380882)
-
(2008)
Bioorganic and Medicinal Chemistry Letters
, vol.18
, Issue.6
, pp. 2032-2037
-
-
Irvine, M.W.1
Patrick, G.L.2
Kewney, J.3
Hastings, S.F.4
MacKenzie, S.J.5
-
37
-
-
35848944141
-
De novo discovery of serotonin N-acetyltransferase inhibitors
-
DOI 10.1021/jm0706463
-
Szewczuk, L. M., Saldanha, S. A., Ganguly, S., Bowers, E. M., Javoroncov, M., Karanam, B., Culhane, J. C., Holbert, M. A., Klein, D. C., Abagyan, R., and Cole, P. A. (2007) De novo discovery of serotonin N-acetyltransferase inhibitors J. Med. Chem. 50, 5330-5338 (Pubitemid 350057845)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.22
, pp. 5330-5338
-
-
Szewczuk, L.M.1
Saldanha, S.A.2
Ganguly, S.3
Bowers, E.M.4
Javoroncov, M.5
Karanam, B.6
Culhane, J.C.7
Holbert, M.A.8
Klein, D.C.9
Abagyan, R.10
Cole, P.A.11
-
38
-
-
44349186719
-
Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth
-
DOI 10.1021/ja8018687
-
Dykhuizen, E. C., May, J. F., Tongpenyai, A., and Kiessling, L. L. (2008) Inhibitors of UDP-galactopyranose mutase thwart mycobacterial growth J. Am. Chem. Soc. 130, 6706-6707 (Pubitemid 351748397)
-
(2008)
Journal of the American Chemical Society
, vol.130
, Issue.21
, pp. 6706-6707
-
-
Dykhuizen, E.C.1
May, J.F.2
Tongpenyai, A.3
Kiessling, L.L.4
-
39
-
-
2642555622
-
Identification of selective inhibitors for the glycosyltransferase murg via high-throughput screening
-
DOI 10.1016/j.chembiol.2004.02.024, PII S1074552104001103
-
Hu, Y., Helm, J. S., Chen, L., Ginsberg, C., Gross, B., Kraybill, B., Tiyanont, K., Fang, X., Wu, T., and Walker, S. (2004) Identification of selective inhibitors for the glycosyltransferase MurG via high-throughput screening Chem. Biol. 11, 703-711 (Pubitemid 38708839)
-
(2004)
Chemistry and Biology
, vol.11
, Issue.5
, pp. 703-711
-
-
Hu, Y.1
Helm, J.S.2
Chen, L.3
Ginsberg, C.4
Gross, B.5
Kraybill, B.6
Tiyanont, K.7
Fang, X.8
Wu, T.9
Walker, S.10
-
40
-
-
0034678644
-
4-Thiazolidinones: Novel inhibitors of the bacterial enzyme MurB
-
DOI 10.1016/S0960-894X(00)00073-1, PII S0960894X00000731
-
Andres, C. J., Bronson, J. J., DAndrea, S. V., Deshpande, M. S., Falk, P. J., Grant-Young, K. A., Harte, W. E., Ho, H.-T., Misco, P. F., Robertson, J. G., Stock, D., Sun, Y., and Walsh, A. W. (2000) 4-Thiazolidinones: novel inhibitors of the bacterial enzyme murB Bioorg. Med. Chem. Lett. 10, 715-717 (Pubitemid 30215869)
-
(2000)
Bioorganic and Medicinal Chemistry Letters
, vol.10
, Issue.8
, pp. 715-717
-
-
Andres, C.J.1
Bronson, J.J.2
D'Andrea, S.V.3
Deshpande, M.S.4
Falk, P.J.5
Grant-Young, K.A.6
Harte, W.E.7
Ho, H.-T.8
Misco, P.F.9
Robertson, J.G.10
Stock, D.11
Sun, Y.12
Walsh, A.W.13
-
41
-
-
77949484597
-
The bioisosteric similarity of the tetrazole and carboxylate anions: Clues from the topologies of the electrostatic potential and of the electron density
-
Matta, C. F., Arabi, A. A., and Weaver, D. F. (2010) The bioisosteric similarity of the tetrazole and carboxylate anions: clues from the topologies of the electrostatic potential and of the electron density Eur. J. Med. Chem. 45, 1868-1872
-
(2010)
Eur. J. Med. Chem.
, vol.45
, pp. 1868-1872
-
-
Matta, C.F.1
Arabi, A.A.2
Weaver, D.F.3
-
42
-
-
38349008365
-
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
-
Dupre, A., Boyer-Chatenet, L., Sattler, R. M., Modi, A. P., Lee, J. H., Nicolette, M. L., Kopelovich, L., Jasin, M., Baer, R., Paull, T. T., and Gautier, J. (2008) A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex Nat. Chem. Biol. 4, 119-125
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 119-125
-
-
Dupre, A.1
Boyer-Chatenet, L.2
Sattler, R.M.3
Modi, A.P.4
Lee, J.H.5
Nicolette, M.L.6
Kopelovich, L.7
Jasin, M.8
Baer, R.9
Paull, T.T.10
Gautier, J.11
-
43
-
-
79954576671
-
Small molecule inhibitors of human DNA polymerase lambda
-
Strittmatter, T., Bareth, B., Immel, T. A., Huhn, T., Mayer, T. U., and Marx, A. (2011) Small molecule inhibitors of human DNA polymerase lambda ACS Chem. Biol. 6, 314-319
-
(2011)
ACS Chem. Biol.
, vol.6
, pp. 314-319
-
-
Strittmatter, T.1
Bareth, B.2
Immel, T.A.3
Huhn, T.4
Mayer, T.U.5
Marx, A.6
-
44
-
-
72249122328
-
Design, synthesis, and structure-activity relationship of a novel series of 2-aryl 5-(4-oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 entry inhibitors
-
Katritzky, A. R., Tala, S. R., Lu, H., Vakulenko, A. V., Chen, Q. Y., Sivapackiam, J., Pandya, K., Jiang, S., and Debnath, A. K. (2009) Design, synthesis, and structure-activity relationship of a novel series of 2-aryl 5-(4-oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 entry inhibitors J. Med. Chem. 52, 7631-7639
-
(2009)
J. Med. Chem.
, vol.52
, pp. 7631-7639
-
-
Katritzky, A.R.1
Tala, S.R.2
Lu, H.3
Vakulenko, A.V.4
Chen, Q.Y.5
Sivapackiam, J.6
Pandya, K.7
Jiang, S.8
Debnath, A.K.9
-
45
-
-
0035150803
-
L
-
DOI 10.1038/35055085
-
Degterev, A., Lugovskoy, A., Cardone, M., Mulley, B., Wagner, G., Mitchison, T., and Yuan, J. (2001) Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL Nat. Cell Biol. 3, 173-182 (Pubitemid 32118371)
-
(2001)
Nature Cell Biology
, vol.3
, Issue.2
, pp. 173-182
-
-
Degterev, A.1
Lugovskoy, A.2
Cardone, M.3
Mulley, B.4
Wagner, G.5
Mitchison, T.6
Yuan, J.7
-
46
-
-
79955046668
-
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway
-
Gonsalves, F. C., Klein, K., Carson, B. B., Katz, S., Ekas, L. A., Evans, S., Nagourney, R., Cardozo, T., Brown, A. M. C., and DasGupta, R. (2011) An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway, Proc. Natl. Acad. Sci. U.S.A.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
-
-
Gonsalves, F.C.1
Klein, K.2
Carson, B.B.3
Katz, S.4
Ekas, L.A.5
Evans, S.6
Nagourney, R.7
Cardozo, T.8
Brown, A.M.C.9
Dasgupta, R.10
-
47
-
-
22144478634
-
Efficient synthetic inhibitors of anthrax lethal factor
-
DOI 10.1073/pnas.0502733102
-
Forino, M., Johnson, S., Wong, T. Y., Rozanov, D. V., Savinov, A. Y., Li, W., Fattorusso, R., Becattini, B., Orry, A. J., Jung, D., Abagyan, R. A., Smith, J. W., Alibek, K., Liddington, R. C., Strongin, A. Y., and Pellecchia, M. (2005) Efficient synthetic inhibitors of anthrax lethal factor Proc. Natl. Acad. Sci. U.S.A. 102, 9499-9504 (Pubitemid 40981710)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.27
, pp. 9499-9504
-
-
Forino, M.1
Johnson, S.2
Wong, T.Y.3
Rozanov, D.V.4
Savinov, A.Y.5
Li, W.6
Fattorusso, R.7
Becattini, B.8
Orry, A.J.9
Jung, D.10
Abagyan, R.A.11
Smith, J.W.12
Alibek, K.13
Liddington, R.C.14
Strongin, A.Y.15
Pellecchia, M.16
-
48
-
-
79953768776
-
Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2, 4-dione derivatives for the treatment of inflammatory diseases
-
Ma, L., Xie, C., Ma, Y., Liu, J., Xiang, M., Ye, X., Zheng, H., Chen, Z., Xu, Q., Chen, T., Chen, J., Yang, J., Qiu, N., Wang, G., Liang, X., Peng, A., Yang, S., Wei, Y., and Chen, L. (2011) Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases J. Med. Chem. 54, 2060-2068
-
(2011)
J. Med. Chem.
, vol.54
, pp. 2060-2068
-
-
Ma, L.1
Xie, C.2
Ma, Y.3
Liu, J.4
Xiang, M.5
Ye, X.6
Zheng, H.7
Chen, Z.8
Xu, Q.9
Chen, T.10
Chen, J.11
Yang, J.12
Qiu, N.13
Wang, G.14
Liang, X.15
Peng, A.16
Yang, S.17
Wei, Y.18
Chen, L.19
-
49
-
-
42949097094
-
Epalrestat: An aldose reductase inhibitor for the treatment of diabetic neuropathy
-
DOI 10.1592/phco.28.5.646
-
Ramirez, M. A. and Borja, N. L. (2008) Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy Pharmacotherapy 28, 646-655 (Pubitemid 351620031)
-
(2008)
Pharmacotherapy
, vol.28
, Issue.5 PART 1
, pp. 646-655
-
-
Ramirez, M.A.1
Borja, N.L.2
-
50
-
-
33746456027
-
Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: The 3-year, multicenter, comparative aldose reductase inhibitor-diabetes complications trial
-
DOI 10.2337/dc05-2370
-
Hotta, N., Akanuma, Y., Kawamori, R., Matsuoka, K., Oka, Y., Shichiri, M., Toyota, T., Nakashima, M., Yoshimura, I., Sakamoto, N., and Shigeta, Y. (2006) Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial Diabetes Care 29, 1538-1544 (Pubitemid 44127578)
-
(2006)
Diabetes Care
, vol.29
, Issue.7
, pp. 1538-1544
-
-
Hotta, N.1
Akanuma, Y.2
Kawamori, R.3
Matsuoka, K.4
Oka, Y.5
Shichiri, M.6
Toyota, T.7
Nakashima, M.8
Yoshimura, I.9
Sakamoto, N.10
Shigeta, Y.11
-
51
-
-
0030152978
-
Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: Multicenter study
-
Hotta, N., Sakamoto, N., Shigeta, Y., Kikkawa, R., and Goto, Y. (2006) Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: Multicenter study J. Diabetes Complicat. 10, 168-172
-
(2006)
J. Diabetes Complicat.
, vol.10
, pp. 168-172
-
-
Hotta, N.1
Sakamoto, N.2
Shigeta, Y.3
Kikkawa, R.4
Goto, Y.5
-
52
-
-
77950571108
-
New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays
-
Baell, J. B. and Holloway, G. A. (2010) New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays J. Med. Chem. 53, 2719-2740
-
(2010)
J. Med. Chem.
, vol.53
, pp. 2719-2740
-
-
Baell, J.B.1
Holloway, G.A.2
-
53
-
-
33751321865
-
A detergent-based assay for the detection of promiscuous inhibitors
-
Feng, B. Y. and Shoichet, B. K. (2006) A detergent-based assay for the detection of promiscuous inhibitors Nat. Protoc. 1, 550-553
-
(2006)
Nat. Protoc.
, vol.1
, pp. 550-553
-
-
Feng, B.Y.1
Shoichet, B.K.2
-
54
-
-
33845491449
-
Interpreting steep dose-response curves in early inhibitor discovery
-
DOI 10.1021/jm061103g
-
Shoichet, B. K. (2006) Interpreting steep dose-response curves in early inhibitor discovery J. Med. Chem. 49, 7274-7277 (Pubitemid 44913388)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.25
, pp. 7274-7277
-
-
Shoichet, B.K.1
-
55
-
-
33745188660
-
Screening in a spirit haunted world
-
Shoichet, B. K. (2006) Screening in a spirit haunted world Drug Discovery Today 11, 607-615
-
(2006)
Drug Discovery Today
, vol.11
, pp. 607-615
-
-
Shoichet, B.K.1
-
56
-
-
74849118854
-
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease
-
Jadhav, A., Ferreira, R. S., Klumpp, C., Mott, B. T., Austin, C. P., Inglese, J., Thomas, C. J., Maloney, D. J., Shoichet, B. K., and Simeonov, A. (2010) Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease J. Med. Chem. 53, 37-51
-
(2010)
J. Med. Chem.
, vol.53
, pp. 37-51
-
-
Jadhav, A.1
Ferreira, R.S.2
Klumpp, C.3
Mott, B.T.4
Austin, C.P.5
Inglese, J.6
Thomas, C.J.7
Maloney, D.J.8
Shoichet, B.K.9
Simeonov, A.10
-
57
-
-
33847094111
-
Stability and equilibria of promiscuous aggregates in high protein milieus
-
DOI 10.1039/b616314a
-
Coan, K. E. and Shoichet, B. K. (2007) Stability and equilibria of promiscuous aggregates in high protein milieus Mol. Biosyst. 3, 208-213 (Pubitemid 46293327)
-
(2007)
Molecular BioSystems
, vol.3
, Issue.3
, pp. 208-213
-
-
Coan, K.E.D.1
Shoichet, B.K.2
-
58
-
-
0141923641
-
Identification and prediction of promiscuous aggregating inhibitors among known drugs
-
DOI 10.1021/jm030191r
-
Seidler, J., McGovern, S. L., Doman, T. N., and Shoichet, B. K. (2003) Identification and prediction of promiscuous aggregating inhibitors among known drugs J. Med. Chem. 46, 4477-4486 (Pubitemid 37238749)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.21
, pp. 4477-4486
-
-
Seidler, J.1
McGovern, S.L.2
Doman, T.N.3
Shoichet, B.K.4
-
59
-
-
33644849513
-
Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase
-
Oka, S., Kato, J., and Moss, J. (2006) Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase J. Biol. Chem. 281, 705-713
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 705-713
-
-
Oka, S.1
Kato, J.2
Moss, J.3
-
60
-
-
33750940806
-
The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases
-
DOI 10.1073/pnas.0607911103
-
Ono, T., Kasamatsu, A., Oka, S., and Moss, J. (2006) The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases Proc. Natl. Acad. Sci. U.S.A. 103, 16687-16691 (Pubitemid 44737314)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.45
, pp. 16687-16691
-
-
Ono, T.1
Kasamatsu, A.2
Oka, S.3
Moss, J.4
-
61
-
-
37849013404
-
Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix
-
Niere, M., Kernstock, S., Koch-Nolte, F., and Ziegler, M. (2007) Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix Mol. Cell. Biol. 28, 814-824
-
(2007)
Mol. Cell. Biol.
, vol.28
, pp. 814-824
-
-
Niere, M.1
Kernstock, S.2
Koch-Nolte, F.3
Ziegler, M.4
-
62
-
-
33750065699
-
The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation
-
DOI 10.1073/pnas.0606762103
-
Mueller-Dieckmann, C., Kernstock, S., Lisurek, M., von Kries, J. P., Haag, F., Weiss, M. S., and Koch-Nolte, F. (2006) The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation Proc. Natl. Acad. Sci. U.S.A. 103, 15026-15031 (Pubitemid 44583158)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.41
, pp. 15026-15031
-
-
Mueller-Dieckmann, C.1
Kernstock, S.2
Lisurek, M.3
Von Kries, J.P.4
Haag, F.5
Weiss, M.S.6
Koch-Nolte, F.7
-
63
-
-
0035289536
-
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke
-
Abdelkarim, G. E., Gertz, K., Harms, C., Katchanov, J., Dirnagl, U., Szabo, C., and Endres, M. (2001) Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke Int. J. Mol. Med. 7, 255-260
-
(2001)
Int. J. Mol. Med.
, vol.7
, pp. 255-260
-
-
Abdelkarim, G.E.1
Gertz, K.2
Harms, C.3
Katchanov, J.4
Dirnagl, U.5
Szabo, C.6
Endres, M.7
-
64
-
-
79961233161
-
Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG)
-
Steffen, J. D., Coyle, D. L., Damodaran, K., Beroza, P., and Jacobson, M. K. (2011) Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG) J. Med. Chem. 54, 5403-5413
-
(2011)
J. Med. Chem.
, vol.54
, pp. 5403-5413
-
-
Steffen, J.D.1
Coyle, D.L.2
Damodaran, K.3
Beroza, P.4
Jacobson, M.K.5
-
65
-
-
33747335931
-
Chemical Probes of UDP-Galactopyranose Mutase
-
DOI 10.1016/j.chembiol.2006.06.007, PII S1074552106002171
-
Carlson, E. E., May, J. F., and Kiessling, L. L. (2006) Chemical probes of UDP-galactopyranose mutase Chem. Biol. 13, 825-837 (Pubitemid 44247773)
-
(2006)
Chemistry and Biology
, vol.13
, Issue.8
, pp. 825-837
-
-
Carlson, E.E.1
May, J.F.2
Kiessling, L.L.3
-
66
-
-
0023375254
-
Rapid assay of poly(ADP-ribose) glycohydrolase
-
Menard, L. and Poirier, G. G. (1987) Rapid assay of poly(ADP-ribose) glycohydrolase Biochem. Cell Biol. 65, 668-673
-
(1987)
Biochem. Cell Biol.
, vol.65
, pp. 668-673
-
-
Menard, L.1
Poirier, G.G.2
|