The affect of chronic hepatitis C infection on dendritic cell function: A summary of the experimental evidence

Journal of Viral Hepatitis

Volumn 18, Issue 9, 2011, Pages 601-607

  Ryan, E J ^a   O'Farrelly, C ^a,b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

cellular immune response; cytokines; dendritic cell; hepatitis C Virus; immune evasion

Indexed keywords

RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR AGONIST; VIRUS PROTEIN;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; CELL CULTURE; CELL FUNCTION; DENDRITIC CELL; FLOW CYTOMETRY; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOMODULATION; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TREATMENT RESPONSE; VIRUS PARTICLE;

CELL LINE; CELL PROLIFERATION; CYTOKINES; DENDRITIC CELLS; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; IMMUNITY, CELLULAR; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS; VIRAL PROTEINS;

EID: 79960959972     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2011.01453.x     Document Type: Review

References (52)

1. Rehermann B,. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 2009; 119 (7): 1745-1754.
2. Steinman RM,. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9: 271-296.
3. Palucka K, Banchereau J, Mellman I,. Designing vaccines based on biology of human dendritic cell subsets. Immunity 2010; 33 (4): 464-478.
4. Hornung V, Schlender J, Guenthner-Biller M, et al. Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus. J Immunol 2004; 173 (10): 5935-5943. (Pubitemid 39487747)
5. Creagh EM, O'Neill LA,. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 2006; 27 (8): 352-357. (Pubitemid 44038661)
6. Liu B, Woltman AM, Janssen HL, Boonstra A,. Modulation of dendritic cell function by persistent viruses. J Leukoc Biol 2009; 85 (2): 205-214.
7. Ryan EJ, Stevenson NJ, Hegarty JE, O'Farrelly C,. Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-a and stimulate T-cell proliferation. J Viral Hepat 2011; doi:.
8. Auffermann-Gretzinger S, Keeffe EB, Levy S,. Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection. Blood 2001; 97 (10): 3171-3176.
9. Bain C, Fatmi A, Zoulim F, Zarski JP, Trepo C, Inchauspe G,. Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection. Gastroenterology 2001; 120 (2): 512-524. (Pubitemid 32147649)
10. Kanto T, Hayashi N, Takehara T, et al. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol 1999; 162 (9): 5584-5591. (Pubitemid 29307172)
11. Barnes E, Salio M, Cerundolo V, et al. Monocyte derived dendritic cells retain their functional capacity in patients following infection with hepatitis C virus. J Viral Hepat 2008; 15 (3): 219-228. (Pubitemid 351143744)
12. Pachiadakis I, Chokshi S, Cooksley H, et al. Early viraemia clearance during antiviral therapy of chronic hepatitis C improves dendritic cell functions. Clin Immunol 2009; 131 (3): 415-425.
13. Perrin-Cocon L, Agaugue S, Diaz O, et al. Th1 disabled function in response to TLR4 stimulation of monocyte-derived DC from patients chronically-infected by hepatitis C virus. PLoS ONE 2008; 3 (5): e2260.
14. Anthony DD, Yonkers NL, Post AB, et al. Selective impairments in dendritic cell-associated function distinguish hepatitis C virus and HIV infection. J Immunol 2004; 172 (8): 4907-4916. (Pubitemid 38456415)
15. Murakami H, Akbar SM, Matsui H, Horiike N, Onji M,. Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C. Clin Exp Immunol 2004; 137 (3): 559-565. (Pubitemid 39128083)
16. Goutagny N, Vieux C, Decullier E, et al. Quantification and functional analysis of plasmacytoid dendritic cells in patients with chronic hepatitis C virus infection. J Infect Dis 2004; 189 (9): 1646-1655. (Pubitemid 38648293)
17. Kanto T, Inoue M, Miyazaki M, et al. Impaired function of dendritic cells circulating in patients infected with hepatitis C virus who have persistently normal alanine aminotransferase levels. Intervirology 2006; 2: 58-63. (Pubitemid 41318177)
18. Kanto T, Inoue M, Miyatake H, et al. Reduced numbers and impaired ability of myeloid and plasmacytoid dendritic cells to polarize T helper cells in chronic hepatitis C virus infection. J Infect Dis 2004; 190 (11): 1919-1926. (Pubitemid 39564696)
19. Ulsenheimer A, Gerlach JT, Jung MC, et al. Plasmacytoid dendritic cells in acute and chronic hepatitis C virus infection. Hepatology 2005; 41 (3): 643-651. (Pubitemid 40292058)
20. Tsubouchi E, Akbar SM, Horiike N, Onji M,. Infection and dysfunction of circulating blood dendritic cells and their subsets in chronic hepatitis C virus infection. J Gastroenterol 2004; 39 (8): 754-762. (Pubitemid 39264144)
21. Dolganiuc A, Paek E, Kodys K, Thomas J, Szabo G,. Myeloid dendritic cells of patients with chronic HCV infection induce proliferation of regulatory T lymphocytes. Gastroenterology 2008; 135 (6): 2119-2127.
22. Della Bella S, Crosignani A, Riva A, et al. Decrease and dysfunction of dendritic cells correlate with impaired hepatitis C virus-specific CD4+ T-cell proliferation in patients with hepatitis C virus infection. Immunology 2007; 121 (2): 283-292. (Pubitemid 46663097)
23. Averill L, Lee WM, Karandikar NJ,. Differential dysfunction in dendritic cell subsets during chronic HCV infection. Clin Immunol 2007; 123 (1): 40-49. (Pubitemid 46401508)
24. Longman RS, Talal AH, Jacobson IM, Albert ML, Rice CM,. Presence of functional dendritic cells in patients chronically infected with hepatitis C virus. Blood 2004; 103 (3): 1026-1029. (Pubitemid 38129566)
25. Longman RS, Talal AH, Jacobson IM, Rice CM, Albert ML,. Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C. J Infect Dis 2005; 192 (3): 497-503. (Pubitemid 41023130)
26. Decalf J, Fernandes S, Longman R, et al. Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients. J Exp Med 2007; 204 (10): 2423-2437. (Pubitemid 47529327)
27. Piccioli D, Tavarini S, Nuti S, et al. Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors. J Hepatol 2005; 42 (1): 61-67. (Pubitemid 40038901)
28. Tsubouchi E, Akbar SM, Murakami H, Horiike N, Onji M,. Isolation and functional analysis of circulating dendritic cells from hepatitis C virus (HCV) RNA-positive and HCV RNA-negative patients with chronic hepatitis C: role of antiviral therapy. Clin Exp Immunol 2004; 137 (2): 417-423. (Pubitemid 39013090)
29. Barth H, Ulsenheimer A, Pape GR, et al. Uptake and presentation of hepatitis C virus-like particles by human dendritic cells. Blood 2005; 105 (9): 3605-3614. (Pubitemid 40628207)
30. Saito K, Ait-Goughoulte M, Truscott SM, et al. Hepatitis C virus inhibits cell surface expression of HLA-DR, prevents dendritic cell maturation, and induces interleukin-10 production. J Virol 2008; 82 (7): 3320-3328. (Pubitemid 351429910)
31. Liang H, Russell RS, Yonkers NL, et al. Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cells. J Virol 2009; 83 (11): 5693-5707.
32. Shiina M, Rehermann B,. Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function. Hepatology 2008; 47 (2): 385-395. (Pubitemid 351280706)
33. Zhang YL, Guo YJ, Bin L, Sun SH,. Hepatitis C virus single-stranded RNA induces innate immunity via Toll-like receptor 7. J Hepatol 2009; 51 (1): 29-38.
34. Dolganiuc A, Chang S, Kodys K, et al. Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection. J Immunol 2006; 177 (10): 6758-6768. (Pubitemid 44715040)
35. Dolganiuc A, Kodys K, Kopasz A, et al. Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J Immunol 2003; 170 (11): 5615-5624. (Pubitemid 36617852)
36. Zimmermann M, Flechsig C, La Monica N, Tripodi M, Adler G, Dikopoulos N,. Hepatitis C virus core protein impairs in vitro priming of specific T cell responses by dendritic cells and hepatocytes. J Hepatol 2008; 48 (1): 51-60. (Pubitemid 350191988)
37. Brady MT, MacDonald AJ, Rowan AG, Mills KH,. Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. Eur J Immunol 2003; 33 (12): 3448-3457. (Pubitemid 37541123)
38. Amjad M, Abdel-Haq N, Faisal M, Kamal M, Moudgal V,. Decreased interferon-alpha production and impaired regulatory function of plasmacytoid dendritic cells induced by the hepatitis C virus NS 5 protein. Microbiol Immunol 2008; 52 (10): 499-507.
39. Siavoshian S, Abraham JD, Thumann C, Kieny MP, Schuster C,. Hepatitis C virus core, NS3, NS5A, NS5B proteins induce apoptosis in mature dendritic cells. J Med Virol 2005; 75 (3): 402-411. (Pubitemid 40175905)
40. Pohlmann S, Zhang J, Baribaud F, et al. Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR. J Virol 2003; 77 (7): 4070-4080. (Pubitemid 36350947)
41. Nattermann J, Zimmermann H, Iwan A, et al. Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C. Hepatology 2006; 44 (4): 945-954. (Pubitemid 46489559)
42. Zhou Y, Lukes Y, Anderson J, Fileta B, Reinhardt B, Sjogren M,. Hepatitis C virus E2 envelope protein induces dendritic cell maturation. J Viral Hepat 2007; 14 (12): 849-858. (Pubitemid 350211407)
43. Ryan EJ, Dring M, Ryan CM, et al. Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection. Hum Immunol 2010; 71 (8): 829-832.
44. Li K, Foy E, Ferreon JC, et al. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A 2005; 102 (8): 2992-2997. (Pubitemid 40299904)
45. Foy E, Li K, Sumpter R Jr, et al. Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci U S A 2005; 102 (8): 2986-2991. (Pubitemid 40299903)
46. Miyazaki M, Kanto T, Inoue M, et al. Impaired cytokine response in myeloid dendritic cells in chronic hepatitis C virus infection regardless of enhanced expression of Toll-like receptors and retinoic acid inducible gene-I. J Med Virol 2008; 80 (6): 980-988. (Pubitemid 351657008)
47. Dolganiuc A, Garcia C, Kodys K, Szabo G,. Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection. World J Gastroenterol 2006; 12 (8): 1198-1204.
48. Yonkers NL, Rodriguez B, Milkovich KA, et al. TLR ligand-dependent activation of naive CD4 T cells by plasmacytoid dendritic cells is impaired in hepatitis C virus infection. J Immunol 2007; 178 (7): 4436-4444. (Pubitemid 46492395)
49. Yakushijin T, Kanto T, Inoue M, et al. Reduced expression and functional impairment of Toll-like receptor 2 on dendritic cells in chronic hepatitis C virus infection. Hepatol Res 2006; 34 (3): 156-162.
50. Tajuddin T, Ryan EJ, Norris S, Hegarty JE, O'Farrelly C,. Interferon-alpha suppressed granulocyte colony stimulating factor production is reversed by CL097, a TLR7/8 agonist. J Gastroenterol Hepatol 2010; 25 (12): 1883-1890.
51. Libri NA, Barker SJ, Rosenberg WM, Semper AE,. A class C CpG toll-like receptor 9 agonist successfully induces robust interferon-alpha production by plasmacytoid dendritic cells from patients chronically infected with hepatitis C. J Viral Hepat 2009; 16 (5): 315-324.
52. Thomson AW, Knolle PA,. Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol 2010; 10 (11): 753-766.