Hepatitis C virus NS4 protein impairs the Th1 polarization of immature dendritic cells

Journal of Viral Hepatitis

Volumn 17, Issue 8, 2010, Pages 555-562

  Takaki, A ^a   Tatsukawa, M ^a   Iwasaki, Y ^a   Koike, K ^a   Noguchi, Y ^a   Shiraha, H ^a   Sakaguchi, K ^a   Nakayama, E ^a   Yamamoto, K ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

dendritic cell; hepatitis C virus; T cell

Indexed keywords

CD86 ANTIGEN; CORE PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4; NONSTRUCTURAL PROTEIN 5; TUBERCULIN; CYTOKINE; NS4 PROTEIN, HEPATITIS C VIRUS; RECOMBINANT PROTEIN; VIRUS PROTEIN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FLOW CYTOMETRY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PLASMID; PRIORITY JOURNAL; TH1 CELL; CELL POLARITY; CYTOLOGY; HEPACIVIRUS; HEPATITIS C; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; NONPARAMETRIC TEST; VIROLOGY;

ADULT; CELL POLARITY; CYTOKINES; DENDRITIC CELLS; FLOW CYTOMETRY; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; LYMPHOCYTE ACTIVATION; MALE; PLASMIDS; RECOMBINANT PROTEINS; STATISTICS, NONPARAMETRIC; TH1 CELLS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 77954508223     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2009.01213.x     Document Type: Article

References (36)

1. Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001 345 (1 41 52.
2. Rehermann B. Chronic infections with hepatotropic viruses: mechanisms of impairment of cellular immune responses. Semin Liver Dis 2007 27 (2 152 160.
3. Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, Chisari FV. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 2001 194 (10 1395 1406.
4. Gerlach JT, Diepolder HM, Jung MC et al. Recurrence of hepatitis C virus after loss of virus-specific CD4(+) T-cell response in acute hepatitis C. Gastroenterology 1999 117 (4 933 941.
5. Wedemeyer H, He XS, Nascimbeni M et al. Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection. J Immunol 2002 169 (6 3447 3458.
6. Takaki A, Wiese M, Maertens G et al. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat Med 2000 6 (5 578 582.
7. Lauer GM, Barnes E, Lucas M et al. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology 2004 127 (3 924 936.
8. Rahman F, Heller T, Sobao Y et al. Effects of antiviral therapy on the cellular immune response in acute hepatitis C. Hepatology 2004 40 (1 87 97.
9. Liu YJ, Kanzler H, Soumelis V, Gilliet M. Dendritic cell lineage, plasticity and cross-regulation. Nat Immunol 2001 2 (7 585 589.
10. Itose I, Kanto T, Inoue M et al. Involvement of dendritic cell frequency and function in virological relapse in pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C patients. J Med Virol 2007 79 (5 511 521.
11. Kanto T, Hayashi N, Takehara T et al. Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol 1999 162 (9 5584 5591.
12. Kanto T, Inoue M, Miyazaki M et al. Impaired function of dendritic cells circulating in patients infected with hepatitis C virus who have persistently normal alanine aminotransferase levels. Intervirology 2006 2 : 58 63.
13. Dolganiuc A, Kodys K, Kopasz A et al. Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation. J Immunol 2003 170 (11 5615 5624.
14. Longman RS, Talal AH, Jacobson IM, Albert ML, Rice CM. Presence of functional dendritic cells in patients chronically infected with hepatitis C virus. Blood 2004 103 (3 1026 1029.
15. Longman RS, Talal AH, Jacobson IM, Rice CM, Albert ML. Normal functional capacity in circulating myeloid and plasmacytoid dendritic cells in patients with chronic hepatitis C. J Infect Dis 2005 192 (3 497 503.
16. Piccioli D, Tavarini S, Nuti S et al. Comparable functions of plasmacytoid and monocyte-derived dendritic cells in chronic hepatitis C patients and healthy donors. J Hepatol 2005 42 (1 61 67.
17. Larsson M, Babcock E, Grakoui A et al. Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus. J Virol 2004 78 (12 6151 6161.
18. Barnes E, Salio M, Cerundolo V et al. Monocyte derived dendritic cells retain their functional capacity in patients following infection with hepatitis C virus. J Viral Hepat 2008 15 (3 219 228.
19. Dolganiuc A, Chang S, Kodys K et al. Hepatitis C virus (HCV) core protein-induced, monocyte-mediated mechanisms of reduced IFN-alpha and plasmacytoid dendritic cell loss in chronic HCV infection. J Immunol 2006 177 (10 6758 6768.
20. Suzuki T, Ishii K, Aizaki H, Wakita T. Hepatitis C viral life cycle. Adv Drug Deliv Rev 2007 59 (12 1200 1212.
21. Foy E, Li K, Wang C et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003 300 (5622 1145 1148.
22. Konan KV, Giddings TH Jr., Ikeda M, Li K, Lemon SM, Kirkegaard K. Nonstructural protein precursor NS4A/B from hepatitis C virus alters function and ultrastructure of host secretory apparatus. J Virol 2003 77 (14 7843 7855.
23. Gale M Jr., Blakely CM, Kwieciszewski B et al. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol Cell Biol 1998 18 (9 5208 5218.
24. Kato N, Yoshida H, Ono-Nita SK et al. Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer. Hepatology 2000 32 (2 405 412.
25. Cassani F, Cataleta M, Valentini P et al. Serum autoantibodies in chronic hepatitis C: comparison with autoimmune hepatitis and impact on the disease profile. Hepatology 1997 26 (3 561 566.
26. Squadrito G, Previti M, Lenzi M et al. High prevalence of non-organ-specific autoantibodies in hepatitis C virus-infected cirrhotic patients from southern Italy. Dig Dis Sci 2003 48 (2 349 353.
27. Jeras M. The role of in vitro alloreactive T-cell functional tests in the selection of HLA matched and mismatched haematopoietic stem cell donors. Transpl Immunol 2002 10 (2-3 205 214.
28. Zavaglia C, Martinetti M, Silini E et al. Association between HLA class II alleles and protection from or susceptibility to chronic hepatitis C. J Hepatol 1998 28 (1 1 7.
29. Kuzushita N, Hayashi N, Moribe T et al. Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus. Hepatology 1998 27 (1 240 244.
30. Renou C, Halfon P, Pol S et al. Histological features and HLA class II alleles in hepatitis C virus chronically infected patients with persistently normal alanine aminotransferase levels. Gut 2002 51 (4 585 590.
31. Yamamoto S, Yamamoto T. Historical review of BCG vaccine in Japan. Jpn J Infect Dis 2007 60 (6 331 336.
32. Pope M, Betjes MG, Romani N et al. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell 1994 78 (3 389 398.
33. Chehimi J, Starr SE, Frank I et al. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J Exp Med 1994 179 (4 1361 1366.
34. Huang Y, Uchiyama Y, Fujimura T et al. A human hepatoma cell line expressing hepatitis c virus nonstructural proteins tightly regulated by tetracycline. Biochem Biophys Res Commun 2001 281 (3 732 740.
35. Hugle T, Fehrmann F, Bieck E et al. The hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein. Virol 2001 284 (1 70 81.
36. Kato J, Kato N, Yoshida H, Ono-Nita SK, Shiratori Y, Omata M. Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo. J Med Virol 2002 66 (2 187 199.