Inhibition of the Jak-STAT pathway prevents CNTF-mediated survival of axotomized oxytocinergic magnocellular neurons in organotypic cultures of the rat supraoptic nucleus

Experimental Neurology

Volumn 240, Issue 1, 2013, Pages 75-87

  Askvig, Jason M ^a   Lo, David Y ^b   Sudbeck, Adam W ^a   Behm, Kathryn E ^a   Leiphon, Laura J ^a   Watt, John A ^a  

^a UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Axonal sprouting; CNTF; CNTFR ; Infundibular nerve crush; Jak STAT; Magnocellular neurosecretory system; PVN; STAT3

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CUCURBITACIN; JANUS KINASE; JANUS KINASE 2; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; OXYTOCIN RECEPTOR; STAT PROTEIN; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AXONAL INJURY; CELL CULTURE; CELL DIFFERENTIATION; CELL STRUCTURE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXPLANT; FEMALE; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MAGNOCELLULAR NUCLEUS; MALE; NERVE FIBER GROWTH; NERVE FIBER TRANSECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SUPRAOPTIC NUCLEUS; TREATMENT OUTCOME;

ANIMALS; ASTROCYTES; AXOTOMY; CELL SURVIVAL; CILIARY NEUROTROPHIC FACTOR; JANUS KINASES; MALE; MAP KINASE SIGNALING SYSTEM; NERVE CRUSH; ORGAN CULTURE TECHNIQUES; OXYTOCIN; PITUITARY GLAND, POSTERIOR; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; STAT3 TRANSCRIPTION FACTOR; SUPRAOPTIC NUCLEUS;

EID: 84870882204     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.10.023     Document Type: Article

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