CNTF receptor alpha is expressed by magnocellular neurons and expression is upregulated in the rat supraoptic nucleus during axonal sprouting

Experimental Neurology

Volumn 215, Issue 1, 2009, Pages 135-141

  Watt, John A ^a   Lo, David ^a   Cranston, Harwood J ^b   Paden, Charles M ^b  

^a UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b MONTANA STATE UNIVERSITY   (United States)

Author keywords

Axotomy; CNTFR ; Immunocytochemistry; In situ hybridization; Magnocellular neurosecretory system; Upregulation

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA; MESSENGER RNA; OXYTOCIN RECEPTOR; VASOPRESSIN RECEPTOR;

ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE LOCATION; GLIA CELL; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MAGNOCELLULAR NERVE CELL; MAGNOCELLULAR NEUROSECRETORY SYSTEM; MALE; NERVE CELL PLASTICITY; NERVE FIBER REGENERATION; NERVE FIBER TRANSECTION; NERVE SPROUTING; NEUROSECRETION; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SUPRAOPTIC NUCLEUS; UPREGULATION;

ANIMALS; AXONS; AXOTOMY; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; REGENERATION; RNA, MESSENGER; SUPRAOPTIC NUCLEUS; UP-REGULATION;

EID: 57449085318     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2008.09.021     Document Type: Article

References (52)

1. Adams J.H., Daniel P.M., and Prichard M.M.l. Degeneration and regeneration of hypothalamic nerve fibers in the neurohypophysis after pituitary stalk section in the ferret. J. Comp. Neurol. 135 (1969) 121-144
2. Alonzi T., Middleton G., Wyatt S., Buchman V., Betz U.A.K., Muller W., Musiani P., Poli V., and Davies A.M. Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Mol. Cell. Neurosci. 18 (2001) 270-282
3. Antunes J.L., Louis K.M., Huang S., and Zimmerman E. Section of the pituitary stalk in the rhesus monkey: morphological and endocrine observations. Ann. Neurol. 8 (1980) 308-316
4. Armstrong W.E., Warach S., Hatton G.I., and McNeill T.H. Subnuclei in the hypothalamic paraventricular nucleus: a cytoarchitectural, horseradish peroxidase and immunocytochemical analysis. Neuroscience 5 (1980) 1931-1958
5. Beck E., Daniel P.M., and Prichard M.L. Regeneration of hypothalamic nerve fibers in the goat. Neuroendocrinology 5 (1969) 161-182
6. Billenstein D.C., and Leveque T.F. The reorganization of the neurohypophysial stalk following hypophysectomy in the rat. Endocrinology 56 (1955) 704-717
7. Breder C.D., Dinarello C.A., and Saper C.B. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 240 (1988) 321-323
8. Burnham P., Louis J.-C., Magal E., and Varon S. Effects of ciliary neurotrophic factor on the survival and response to nerve growth factor of cultured rat sympathetic neurons. Dev. Biol. 161 (1994) 96-106
9. Clatterbuck R.E., Price D.L., and Koliatos V.E. Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 2222-2226
10. Cooper D.N.V., and Barondes S.H. Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism. J. Cell Biol., 110 (1990) 681-691
11. Curtis R., Adryan K.M., Zhu Y., Harkness P.J., and Lindsay R.M. Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury. Nature 365 6443 (1993) 253-255
12. Giri J.G., Lomedico P.T., and Mizel S.B. Studies on the synthesis and secretion of interleukin 1. I. A 33,000 molecular weight precursor for interleukin 1. J. Immunol. 134 (1985) 343-349
13. Giulian D., Johnson B., Krebs J.F., George J.K., and Tapscott M. Microglial mitogens are produced in the developing and injured mammalian brain. J. Cell Biol. 112 (1991) 323-333
14. Gurney M.E., Yamamoto H., and Kwon Y. Induction of motor neuron sprouting by ciliary neurotrophic factor and basic fibroblast growth factor. J. Neurosci. 12 (1992) 3241-3247
15. Guthrie K.M., Woods A.G., Nguyen T., and Gall C.M. Astroglial ciliary neurotrophic factor mRNA expression is increased in fields of axonal sprouting in deafferented hippocampus. J. Comp. Neurol. 386 (1997) 137-148
16. Hudgins S.N., and Levison S.W. Ciliary neurotrophic factor stimulates astroglial hypertrophy in vivo and in vitro. Exp. Neurol. 150 (1998) 171-182
17. Huitinga I., van der Cammen M., Salm L., Erkut Z., Van Dam A.-M., Tilders F., and Swaab D. IL-1β immunoreactive neurons in the human hypothalamus: reduced numbers in multiple sclerosis. J. Neuroimmunol. 7 (2000) 8-20
18. Kahn M.A., Ellison J.A., Chang R.P., Speight G.J., and de Vellis J. CNTF induces GFAP in an S-100α brain cell population: the pattern of CNTF-αR suggests an indirect mode of action. Brain Res. Dev. Brain Res. 98 (1997) 221-233
19. Kamiguchi H., Yoshida K., Sagoh M., Sasaki H., Inaba M., Wakamoto H., Otani M., and Toya S. Release of ciliary neurotrophic factor from cultured astrocytes and its modulation by cytokines. Neurochem. Res. 20 (1995) 1187-1193
20. Kandel J., Bossy-Wetzel E., Radvanyi F., Klagsbrun M., Folkman J., and Hanahan D. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Cell 66 (1991) 1095-1104
21. Kirsch M., Terheggen U., and Hofmann H.-D. Ciliary neurotrophic factor is an early lesion-induced retrograde signal for axotomized facial motoneurons. Mol. Cell. Neurosci. 24 (2003) 130-138
22. Kwon Y.W., and Gurney M.E. Systemic injections of ciliary neurotrophic factor induce sprouting by adult motor neurons. NeuroReport 5 (1994) 789-792
23. Larkfors L., Lindsay R.M., and Alderson R.F. Ciliary neurotrophic factor enhances the survival of purkinje cells in vitro. Euro. J. Neurosci. 6 6 (1994) 1015-1025
24. Lee M.-Y., Deller T., Kirsch M., Frotscher M., and Hofmann H.-D. Differential regulation of ciliary neurotrophic factor (CNTF) and CNTF receptor alpha expression in astrocytes and neurons of the fascia dentata after entorhinal cortex lesion. J. Neurosci. 17 (1997) 1137-1146
25. MacLennan A.J., Vinson E.N., Marks L., McLaurin D.L., Pfeifer M., and Lee N. Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system. J. Neurosci. 16 (1996) 621-630
26. Magal E., Louis J.C., Oudega M., and Varon S. CNTF promotes the survival of neonatal rat corticospinal neurons in vitro. NeuroReport 4 6 (1993) 779-782
27. Miyata S., and Hatton G.I. Activity-related, dynamic neuron-glial interactions in the hypothalamo-neurohypophysial system. Micro. Res. Tech. 56 (2002) 143-157
28. Moffet C.W., and Paden C.M. Microglia in the rat neurohypophysis increase expression of class I major histocompatibility antigens following central nervous system injury. J. Immunol. 50 (1994) 139-151
29. Moll J. Regeneration of the supraoptico-hypophysial and paraventriculo-hypophysial tracts in the hypophysectomized rat. Z. Zellforsch. 46 (1957) 686-709
30. Paden C.M., Zhou X., Watt J.A., Burton R., Pickett J., and Oblinger M.M. Coordinated upregulation of α1- and βII-tubulin mRNAs during collateral axonal sprouting of central peptidergic neurons. J. Neurosci. Res. 42 (1995) 402-412
31. Raisman G. Electron microscopic studies of the development of new neurohemal contacts in the median eminence of the rat after hypophysectomy. Brain Res. 55 (1973) 245-261
32. Rubartelli A., and Sitia R. Interleukin 1β and thioredoxin are secreted through a novel pathway of secretion. Biochem. Soc. Trans. 19 (1991) 255-259
33. Rubartelli A., Cozzolino F., Talio M., and Sitia R. A novel secretory pathway for interleukin 1β, a protein lacking a signal sequence. EMBO J. 9 (1990) 1503-1510
34. Rudge J.S., Li Y., Pasnikowski E.M., Mattsson K., Pan L., Yancopoulos G.D., Wiegand S.J., Lindsay R.M., and Ip N.Y. Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes. Eur. J. Neurosci. 6 (1994) 693-705
35. Rusnak M., House S.B., Arima H., and Gainer H. Ciliary neurotrophic factor increases the survival of magnocellular vasopressin and oxytocin neurons in rat supraoptic nucleus in organotypic cultures. Micro. Res. Tech. 56 (2002) 101-112
36. Rusnak M., House S.B., and Gainer H. Long term effects of ciliary neurotrophic factor on the survival of vasopressin magnocellular neurons in the rat supraoptic nucleus in vitro. J. Neuroendocrinol. 10 (2003) 933-939
37. Sendtner M., Kreutzberg G.W., and Thoenen H. Ciliary neurotrophic factor prevents the degeneration of motorneurons after axotomy. Nature 345 (1990) 440-441
38. Shahar T., House S.B., and Gainer H. Neural activity protects hypothalamic magnocellular neurons against axotomy-induced programmed cell death. J. Neurosci. 24 (2004) 6553-6562
39. Siders W.M., and Mizel S.B. Interleukin-1β secretion. A possible multistep process that is regulated in a cell type-specific manner. J. Biol. Chem. 270 (1995) 15264-16258
40. Siegel S.G., Patton B., and English A.W. Ciliary neurotrophic factor is required for motoneuron sprouting. Exp. Neurol. 166 (2000) 205-212
41. Silverman A.J., and Zimmerman E.A. Adrenalectomy increases sprouting in a peptidergic neurosecretory system. Neuroscience 7 (1982) 2705-2714
42. Steward O., Vinsant S.L., and Davis L. The process of reinnervation in the dentate gyrus of adult rats: An ultrastructural study of changes in presynaptic terminals as a result of sprouting. J. Comp. Neurol. 267 (1988) 203-210
43. Summy-Long J.Y., Hu A., Pruss X., Chen X., and Phillips T.M. Response of interleukin-1β in the magnocellular system to salt-loading. J. Neuroendocrinol. 18 (2006) 926-937
44. Tringali G., Mirtella A., Mancuso C., Guerriero G., Preziosi P., and Navarra P. The release of immunoreactive interleukin-1β from rat hypothalamic explants is modulated by neurotransmitters and corticotropin-releasing hormone. Pharm. Res. 36 (1997) 269-273
45. Vutskits L., Bartanusz V., Schultz M.F., and Kiss J.Z. Magnocellular vasopressinergic neurons in explant cultures are rescued from cell death by ciliary neurotrophic factor and leukemia inhibitory factor. Neuroscience 87 (1998) 571-582
46. Watt J.A., and Paden C.M. Compensatory sprouting of uninjured magnocellular neurosecretory axons in the rat neural lobe following unilateral hypothalamic lesion. Exp. Neurol. 111 (1991) 9-24
47. Watt J.A., and Hobbs N.K. Interleukin-1β immunoreactivity in identified neurons of the rat magnocellular neurosecretory system: evidence for activity-dependent release. J. Neurosci. Res. 60 (2000) 478-489
48. Watt J.A., and Paden C.M. Upregulation of the p75 low affinity neurotrophin receptor on active phagocytes during axonal degeneration in the rat neural lobe. Cell Tissue Res. 303 (2001) 81-91
49. Watt J.A., Moffet C.W., Zhou X., Short S., Herman J.P., and Paden C.M. Central peptidergic neurons are hyperactive during collateral sprouting and inhibition of activity suppresses sprouting. J. Neurosci. 19 (1999) 1586-1598
50. Watt J.A., Bone S., Pressler M., Cranston H.J., and Paden C.M. Ciliary neurotrophic factor is expressed in the magnocellular neurosecretory system of the rat in vivo: evidence for injury-and activity-induced upregulation. Exp. Neurol. 197 (2006) 206-214
51. Yasin S.A., Costa A., Forsling M.L., and Grossman A. Interleukin-1 beta and interleukin-6 stimulate neurohypophysial hormone release in vitro. J. Neuroendocrinol. 6 (1994) 179-184
52. Zhou X., Herman J.P., and Paden C.M. Evidence that IGF-1 acts as an autocrine/paracrine growth factor in the magnocellular neurosecretory system: neuronal synthesis and induction of axonal sprouting. Exp. Neurol. 159 (1999) 419-432