Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons

Histochemistry and Cell Biology

Volumn 130, Issue 4, 2008, Pages 669-679

  Sango, Kazunori ^a   Yanagisawa, Hiroko ^a   Komuta, Yukari ^a   Si, Yang ^a   Kawano, Hitoshi ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

CNTF; gp130 mediated signaling pathways; Mature DRG neurons; Neurite outgrowth; Survival

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CARDIOTROPHIN 1; CILIARY NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 6; LEUKEMIA INHIBITORY FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; ONCOSTATIN M; PROTEIN INHIBITOR; PROTEIN KINASE B; STA 21; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; NERVE CELL; NERVE CELL CULTURE; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SPINAL GANGLION; WESTERN BLOTTING;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CHROMONES; CILIARY NEUROTROPHIC FACTOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLAVONOIDS; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; POLYCYCLIC COMPOUNDS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TYRPHOSTINS;

RATTUS;

EID: 51249093868     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-008-0484-x     Document Type: Article

References (50)

1. R Adler KB Landa M Manthorpe S Varon 1979 Cholinergic neuronotrophic factors: intraocular distribution of soluble trophic activity for ciliary neurons Science 204 1434 1436
2. T Alonzi G Middleton S Wyatt V Buchman UAK Betz W Müller P Musiani V Poli AM Davies 2001 Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons Mol Cell Neurosci 18 270 282
3. Apfel SC (1997) Clinical application of neurotrophic factor. Lippincott-Raven, Philadelphia
4. G Barbin M Manthorpe S Varon 1984 Purification of the chick eye ciliary neuronotrophic factor J Neurochem 43 1468 1478
5. JG Cheng PH Patterson 1997 LIF is an autocrine factor for sympathetic neurons Mol Cell Neurosci 9 372 380
6. S Davis TH Aldrich N Stahl L Pan T Taga T Kishimoto NY Ip GD Yancopoulos 1993 LIFRβ and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor Science 260 1805 1808
7. GM Dobrea JR Unnerstall MS Rao 1992 The expression of CNTF message and immunoreactivity in the central and peripheral nervous system of the rat Dev Brain Res 66 209 219
8. X Dolcet RM Soler TW Gould J Egea RW Oppenheim JX Comella 2001 Cytokines promote motoneuron survival through the Janus kinase-dependent activation of the phosphatidylinositol 3-kinase pathway Mol Cell Neurosci 18 619 631
9. B Friedman SS Scherer JS Rudge M Helgren D Morrisey J McClain D Wang SJ Wiegand ME Furth RM Lindsay NY Ip 1992 Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo Neuron 9 295 305
10. NJ Gardiner WB Cafferty SE Slack SW Thompson 2002 Expression of gp130 and leukaemia inhibitory factor receptor subunits in adult rat sensory neurones: regulation by nerve injury J Neurochem 83 100 109
11. I Gavazzi RD Kumar SB McMahon J Cohen 1999 Growth responses of different subpopulations of adult sensory neurons to neurotrophic factors in vitro Eur J NeuroSci 11 3405 3414
12. CG Grothe K Unsicker 1987 Neuron-enriched cultures of adult rat dorsal root ganglia: establishment, characterization, survival, and neuropeptide expression in response to trophic factors J Neurosci Res 18 539 550
13. Halvorsen SW, Kaur N (2006) CNTF and related neurokines. In: Lajtha A (ed) Handbook of neurochemistry and molecular neurobiology, 3rd edn. Lim R (vol ed) Neuroactive proteins and peptides, Springer Science+Business Media LLC, New York, pp 43-68
14. A Holst S Heller D Junghans M Geissen U Ernsberger H Rohrer 1997 Onset of CNTFRalpha expression and signal transduction during neurogenesis in chick sensory dorsal root ganglia Dev Biol 191 1 13
15. H Horie Y Bando H Chi T Takenaka 1991 NGF enhances neurite regeneration from nerve-transected terminals of young adult and aged mouse dorsal root ganglia in vitro Neurosci Lett 121 125 128
16. AR Horton PF Bartlett D Pennica AM Davies 1998 Cytokines promote the survival of mouse cranial sensory neurons at different developmental stages Eur J NeuroSci 10 673 679
17. AJ Hayter 1984 A proof of the conjecture that the Tukey-Kramer multiple comparisons procedure is conservative Ann Stat 12 61 75
18. Y Ito M Yamamoto M Li M Doyu F Tanaaka T Mutch T Mitsuma G Sobue 1998 Differential temporal expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFRα, LIFRβ, IL-6Rα and gp130) in injured peripheral nerves Brain Res 793 321 327
19. N Kaur RK Monroe SM Ward SW Halvorson 2005 Inducers of oxidative stress block ciliary neurotrophic factor activation of Jak/STAT signaling in neurons J Neurochem 92 1521 1530
20. P Leclere P Ekström A Edström J Priestley S Averill DA Tonge 1998 Effects of glial cell line-derived neurotrophic factor on axonal growth and apoptosis in adult mammalian sensory neurons in vitro Neuroscience 82 545 558
21. AC Lo L Li RW Oppenheim D Prevette LJ Houenou 1995 Ciliary neurotrophic factor promotes the survival of spinal sensory neurons following axotomy but not during the period of programmed cell death Exp Neurol 134 49 55
22. L Madhavan V Ourednik J Ourednik 2008 Neural stem/progenitor cells initiate the formation of cellular networks that provide neuroprotection by growth factor-modulated antioxidant expression Stem Cells 26 254 265
23. P März U Otten S Rose-John 1999 Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors Eur J NeuroSci 11 2995 3004
24. McMahon SB, Bennett DLH (2000) Glial cell line-derived neurotrophic factor and nociceptive neurons. In: Wood JN (ed) Molecular basis of pain modulation. Wiley-Liss, New York, pp 65-86
25. T Miao D Wu Y Zhang X Bo MC Subang P Wang PM Richardson 2006 Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons J Neurosci 26 9512 9519
26. V Mittoux S Ouary C Monville F Lisovoski T Poyot F Conde C Escartin R Robichon E Brouillet M Peschanski P Hantraye 2002 Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degeneration J Neurosci 22 4478 4486
27. AP Mizisin Y Vu M Shuff NA Calcutt 2004 Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats Diabetes 53 1807 1812
28. H Nishimune S Vasseur S Wiese MC Birling B Holtmann M Sendtner JL Iovanna CE Henderson 2000 Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway Nat Cell Biol 2 906 914
29. K Park J-M Luo S Hisheh AR Harvey Q Cui 2004 Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells J Neurosci 24 10806 10815
30. SW Perry JP Norman A Litzburg HA Gelbard 2004 Antioxidants are required during the early critical period, but not later, for neuronal survival J Neurosci Res 78 485 492
31. J Qiu WB Cafferty SB McMahon SW Thompson 2005 Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation J Neurosci 25 1645 1653
32. M Rende D Muir E Ruoslahti T Hagg S Varon M Manthorpe 1992 Immunolocalization of ciliary neurotrophic factor in adult rat sciatic nerve Glia 5 25 32
33. KD Rhee O Goureau S Chen XJ Yang 2004 Cytokine-induced activation of signal transducer and activator of transcription in photoreceptor precursors regulates rod differentiation in the developing mouse retina J Neurosci 24 9779 9788
34. Z Sahenk J Seharaseyon JR Mendell 1994 CNTF potentiates peripheral nerve regeneration Brain Res 655 246 250
35. H Saito K Sango H Horie K Takeshita H Ikeda Y Ishigatsubo Y Ishikawa 2002 Trachea enhances neurite regeneration from adult rat nodose ganglia in vitro Life Sci 70 1935 1946
36. K Sango A Oohira K Ajiki A Tokashiki M Horie H Kawano 2003 Phosphacan and neurocan are repulsive substrata for adhesion and neurite extension of adult rat dorsal root ganglion neurons in vitro Exp Neurol 182 1 11
37. K Sango H Yanagisawa S Takaku 2007 Expression and histochemical localization of ciliary neurotrophic factor in cultured adult rat dorsal root ganglion neurons Histochem Cell Biol 128 35 43
38. G Segond von Banchet M Kiehl H-G Schaible 2005 Acute and long-term effects of IL-6 on cultured dorsal root ganglion neurons from adult rat J Neurochem 94 238 248
39. M Sendtner KA Stockli H Thoenen 1992 Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration J Cell Biol 118 139 148
40. M Sendtner P Carroll B Holtmann RA Hughes H Thoenen 1994 Ciliary neurotrophic factor J Neurobiol 25 1436 1453
41. M Sendtner R Gotz B Holtmann H Thoenen 1997 Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice J Neurosci 17 6999 7006
42. T Shuto H Horie N Hikawa K Sango A Tokashiki H Murata I Yamamoto Y Ishikawa 2001 IL-6 up-regulates CNTF mRNA expression and enhances neurite regeneration NeuroReport 12 1081 1085
43. SG Siegel B Patton AW English 2000 Ciliary neurotrophic factor is required for motoneuron sprouting Exp Neurol 166 205 212
44. R Simon M Thier A Kruttgen S Rose-John O Weiergraber PC Heinrich JM Schder J Weis 1995 Human CNTF and related cytokines: effects on DRG neurone survival NeuroReport 7 153 157
45. GM Smith ED Rabinovsky JL McManaman HD Shine 1993 Temporal and spatial expression of ciliary neurotrophic factor after peripheral nerve injury Exp Neurol 121 239 247
46. H Song R Wang S Wang J Lin 2005 A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells Proc Natl Acad Sci USA 102 4700 4705
47. T Taga T Kishimoto 1997 GP130 and the interleukin-6 family of cytokines Annu Rev Immunol 15 797 819
48. M Thier P März U Otten J Weis S Rose-John 1999 Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons J Neurosci Res 55 411 422
49. C Vergara B Ramirez 2004 CNTF, a pleiotrophic cytokine: emphasis on its myotrophic role Brain Res Rev 47 161 173
50. J Zhang WC Lineaweaver T Oswald Z Chen Z Chen F Zhang 2004 Ciliary neurotrophic factor for acceleration of peripheral nerve regeneration: an experimental study J Reconstr Microsurg 20 323 327