Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway

Acta Pharmacologica Sinica

Volumn 33, Issue 12, 2012, Pages 1477-1487

  Zhai, Chang Lin ^a,b   Zhang, Mei Qi ^c   Zhang, Yun ^a   Xu, Hong Xia ^a   Wang, Jing Min ^b   An, Gui Peng ^a   Wang, Yuan Yuan ^a   Li, Li ^a  

^a SHANDONG UNIVERSITY   (China)

^b Tongxiang First People's Hospital   (China)

^c ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Apoptosis; Bax; Cytokine; Glycyrrhizin; Heart; High mobility group box 1 (HMGB1); Ischemia reperfusion injury; Phospho JNK; SP600125

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CYTOCHROME C; GLYCYRRHIZIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOLIC FRACTION; DRUG EFFECT; ENZYME ACTIVITY; HEART; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEMODYNAMIC PARAMETERS; HISTOPATHOLOGY; MALE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CYTOKINES; GLYCYRRHIZIC ACID; HMGB1 PROTEIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84870845880     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.112     Document Type: Article

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