Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis

Journal of Infection

Volumn 62, Issue 4, 2011, Pages 292-300

  Wang, Xinjing ^a   Cao, Zhihong ^a   Jiang, Jing ^a   Li, Yanfeng ^a   Dong, Mei ^a   Ostrowski, Mario ^b   Cheng, Xiaoxing ^a  

^a 309TH HOSPITAL OF PLA   (China)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

CD8 T cells; Functional defects; Tim 3; Tuberculosis

Indexed keywords

GAMMA INTERFERON; PROTEIN TIM 3; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; BACTERIUM CULTURE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEGRANULATION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; LUNG TUBERCULOSIS; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM TUBERCULOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADULT; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; SEVERITY OF ILLNESS INDEX; TUBERCULOSIS, PULMONARY; UP-REGULATION; YOUNG ADULT;

EID: 79953050383     PISSN: 01634453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinf.2011.02.013     Document Type: Article

References (36)

1. Global tuberculosis control: epidemiology, strategy, financing 2009, WHO.
2. Kaufmann S.H., Parida S.K. Tuberculosis in Africa: learning from pathogenesis for biomarker identification. Cell Host Microbe 2008, 4(3):219-228.
3. Boom W.H., Canaday D.H., Fulton S.A., Gehring A.J., Rojas R.E., Torres M. Human immunity to M. tuberculosis: T cell subsets and antigen processing. Tuberculosis (Edinb) 2003, 83(1-3):98-106.
4. Salgame P. Host innate and Th1 responses and the bacterial factors that control Mycobacterium tuberculosis infection. Curr Opin Immunol 2005, 17(4):374-380.
5. + T cells and their role in immunity. Crit Rev Immunol 2006, 26(4):317-352.
6. Wang J., Santosuosso M., Ngai P., Zganiacz A., Xing Z. Activation of CD8 T cells by mycobacterial vaccination protects against pulmonary tuberculosis in the absence of CD4 T cells. J Immunol 2004, 173(7):4590-4597.
7. Chen Z.W. Immune regulation of gammadelta T cell responses in mycobacterial infections. Clin Immunol 2005, 116(3):202-207.
8. Sada-Ovalle I., Chiba A., Gonzales A., Brenner M.B., Behar S.M. Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria. PLoS Pathog 2008, 4(12):e1000239.
9. Cooper A.M., Dalton D.K., Stewart T.A., Griffin J.P., Russell D.G., Orme I.M. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 1993, 178(6):2243-2247.
10. Flynn J.L., Chan J., Triebold K.J., Dalton D.K., Stewart T.A., Bloom B.R. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 1993, 178(6):2249-2254.
11. Flynn J.L. Immunology of tuberculosis and implications in vaccine development. Tuberculosis (Edinb) 2004, 84(1-2):93-101.
12. Hougardy J.M., Place S., Hildebrand M., Drowart A., Debrie A.S., Locht C., et al. Regulatory T cells depress immune responses to protective antigens in active tuberculosis. Am J Respir Crit Care Med 2007, 176(4):409-416.
13. + regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis. Am J Respir Crit Care Med 2009, 179(11):1061-1070.
14. Guyot-Revol V., Innes J.A., Hackforth S., Hinks T., Lalvani A. Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis. Am J Respir Crit Care Med 2006, 173(7):803-810.
15. +) in patients with active tuberculosis. Clin Exp Immunol 2009, 156(3):463-470.
16. Jurado J.O., Alvarez I.B., Pasquinelli V., Martinez G.J., Quiroga M.F., Abbate E., et al. Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis. J Immunol 2008, 181(1):116-125.
17. Jones R.B., Ndhlovu L.C., Barbour J.D., Sheth P.M., Jha A.R., Long B.R., et al. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med 2008, 205(12):2763-2779.
18. + T cells. J Virol 2009, 83(18):9122-9130.
19. +) memory T cell subsets with outcome of pulmonary tuberculosis. J Infect 2010, 60(2):133-139.
20. + T cells correlates with persistent active tuberculosis. J Clin Immunol 2010, 30(4):566-573.
21. + T cells and regulates Th1 and Th17 cytokines. Eur J Immunol 2009, 39(9):2492-2501.
22. + T cells by a flow cytometric assay for degranulation. J Immunol Methods 2003, 281(1-2):65-78.
23. Aktas E., Kucuksezer U.C., Bilgic S., Erten G., Deniz G. Relationship between CD107a expression and cytotoxic activity. Cell Immunol 2009, 254(2):149-154.
24. + cells recognizing HER2/neu vaccine peptides. Breast Cancer Res Treat 2005, 92(1):85-93.
25. Gerdes J., Lemke H., Baisch H., Wacker H.H., Schwab U., Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984, 133(4):1710-1715.
26. + T cell exhaustion during chronic viral infection. Immunity 2007, 27(4):670-684.
27. + T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 2009, 10(1):29-37.
28. Dewan P.K., Grinsdale J., Kawamura L.M. Low sensitivity of a whole-blood interferon-gamma release assay for detection of active tuberculosis. Clin Infect Dis 2007, 44(1):69-73.
29. Okamoto M., Hasegawa Y., Hara T., Hashimoto N., Imaizumi K., Shimokata K., et al. T-helper type 1/T-helper type 2 balance in malignant pleural effusions compared to tuberculous pleural effusions. Chest 2005, 128(6):4030-4035.
30. Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 2002, 415(6871):536-541.
31. Sabatos C.A., Chakravarti S., Cha E., Schubart A., Sanchez-Fueyo A., Zheng X.X., et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol 2003, 4(11):1102-1110.
32. Zhu C., Anderson A.C., Schubart A., Xiong H., Imitola J., Khoury S.J., et al. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 2005, 6(12):1245-1252.
33. + T cells in murine acute graft-versus-host disease. J Immunol 2006, 177(7):4281-4287.
34. Mengshol J.A., Golden-Mason L., Arikawa T., Smith M., Niki T., McWilliams R., et al. A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS One 2010, 5(3):e9504.
35. Sehrawat S., Suryawanshi A., Hirashima M., Rouse B.T. Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators. J Immunol 2009, 182(5):3191-3201.
36. Jayaraman P., Sada-Ovalle I., Beladi S., Anderson A.C., Dardalhon V., Hotta C., et al. Tim3 binding to galectin-9 stimulates antimicrobial immunity. J Exp Med 2010, 207(11):2343-2354.