Hypoglycemia is associated with increased risk for brain injury and adverse neurodevelopmental outcome in neonates at risk for encephalopathy

Journal of Pediatrics

Volumn 161, Issue 1, 2012, Pages 88-93

  Tam, Emily W Y ^a   Haeusslein, Laurel A ^a   Bonifacio, Sonia L ^a   Glass, Hannah C ^a   Rogers, Elizabeth E ^a   Jeremy, Rita J ^b   Barkovich, A James ^a   Ferriero, Donna M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ARTICLE; BAYLEY SCALES OF INFANT DEVELOPMENT; BRAIN DISEASE; BRAIN INJURY; CLINICAL ASSESSMENT TOOL; COGNITION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; MAJOR CLINICAL STUDY; MALE; NERVOUS SYSTEM DEVELOPMENT; NEUROIMAGING; NEWBORN; NEWBORN DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PYRAMIDAL TRACT; RESUSCITATION;

BRAIN DISEASES; CHILD DEVELOPMENT; COHORT STUDIES; FEMALE; HUMANS; HYPOGLYCEMIA; INFANT, NEWBORN; MALE; NERVOUS SYSTEM; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84862763065     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2011.12.047     Document Type: Article

References (29)

1. J.J. Volpe Neurology of the Newborn 5th ed. 2008 Saunders Philadelphia, PA
2. S. Shankaran, A.R. Laptook, R.A. Ehrenkranz, J.E. Tyson, S.A. McDonald, and E.F. Donovan Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy N Engl J Med 353 2005 1574 1584
3. D. Azzopardi, P. Brocklehurst, D. Edwards, H. Halliday, M. Levene, and M. Thoresen The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial BMC Pediatr 8 2008 17
4. J.S. Wyatt, P.D. Gluckman, P.Y. Liu, D. Azzopardi, R. Ballard, and A.D. Edwards Determinants of outcomes after head cooling for neonatal encephalopathy Pediatrics 119 2007 912 921
5. S.E. Jacobs, C.J. Morley, T.E. Inder, M.J. Stewart, K.R. Smith, and P.J. McNamara Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial Arch Pediatr Adolesc Med 2011
6. H.C. Glass, and D.M. Ferriero Treatment of hypoxic-ischemic encephalopathy in newborns Curr Treat Options Neurol 9 2007 414 423
7. E.W.Y. Tam, E. Widjaja, S.I. Blaser, D.L. MacGregor, P. Satodia, and A.M. Moore Occipital lobe injury and cortical visual outcomes after neonatal hypoglycemia Pediatrics 122 2008 507 512
8. V. Udani, P. Munot, M. Ursekar, and S. Gupta Neonatal hypoglycemic brain injury: a common cause of infantile-onset remote symptomatic epilepsy Indian J Pediatr 46 2009 127 132
9. R.H. Caraballo, D. Sakr, M. Mozzi, A. Guerrero, J.N. Adi, and R.O. Cersosimo Symptomatic occipital lobe epilepsy following neonatal hypoglycemia Pediatr Neurol 31 2004 24 29
10. H. Montassir, Y. Maegaki, K. Ohno, and K. Ogura Long term prognosis of symptomatic occipital lobe epilepsy secondary to neonatal hypoglycemia Epilepsy Res 88 2010 93 99
11. A. Lucas, R. Morley, and T.J. Cole Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia BMJ 297 1988 1304 1308
12. C.B. Duvanel, C.L. Fawer, J. Cotting, P. Hohlfeld, and J.M. Matthieu Long-term effects of neonatal hypoglycemia on brain growth and psychomotor development in small-for-gestational-age preterm infants J Pediatr 134 1999 492 498
13. E. Stenninger, R. Flink, B. Eriksson, and C. Sahlen Long-term neurological dysfunction and neonatal hypoglycaemia after diabetic pregnancy Arch Dis Child Fetal Neonatal Ed 79 1998 F174 F179
14. R.C. Vannucci, and S.J. Vannucci Cerebral carbohydrate metabolism during hypoglycemia and anoxia in newborn rats Ann Neurol 4 1978 73 79
15. R.S. Young, B.E. Cowan, O.A. Petroff, E. Novotny, S.L. Dunham, and R.W. Briggs In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure Ann Neurol 22 1987 622 628
16. W.A. Salhab, M.H. Wyckoff, A.R. Laptook, and J.M. Perlman Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia Pediatrics 114 2004 361 366
17. P. Basu, S. Som, N. Choudhuri, and H. Das Contribution of the blood glucose level in perinatal asphyxia Eur J Pediatr 168 2009 833 838
18. M. Nadeem, D.M. Murray, G.B. Boylan, E.M. Dempsey, and C.A. Ryan Early blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy BMC Pediatr 11 2011 10
19. A.J. Barkovich, F.A. Ali, H.A. Rowley, and N. Bass Imaging patterns of neonatal hypoglycemia AJNR Am J Neuroradiol 19 1998 523 528
20. P.M. Filan, T.E. Inder, F.J. Cameron, M.J. Kean, and R.W. Hunt Neonatal hypoglycemia and occipital cerebral injury J Pediatr 148 2006 552 555
21. S.P. Miller, B. Latal, H. Clark, A. Barnwell, D.V. Glidden, and A.J. Barkovich Clinical signs predict 30-month neurodevelopmental outcome after neonatal encephalopathy Am J Obstet Gynecol 190 2004 93 99
22. S.P. Miller, V. Ramaswamy, D. Michelson, A.J. Barkovich, B. Holschouser, and N. Wycliffe Patterns of brain injury in term neonatal encephalopathy J Pediatr 146 2005 453 460
23. M.J. Harbert, E.W. Tam, H.C. Glass, S.L. Bonifacio, L.A. Haeusslein, and A.J. Barkovich Hypothermia is correlated with seizure absence in perinatal stroke J Child Neurol 26 9 2011 1126 1130
24. J.A. Spar, J.D. Lewine, and W.W. Orrison Jr. Neonatal hypoglycemia: CT and MR findings AJNR Am J Neuroradiol 15 1994 1477 1478
25. C.M. Burns, M.A. Rutherford, J.P. Boardman, and F.M. Cowan Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia Pediatrics 122 2008 65 74
26. P. Karimzadeh, S. Tabarestani, and M. Ghofrani Hypoglycemia-occipital syndrome: A specific neurologic syndrome following neonatal hypoglycemia? J Child Neurol 26 2011 152 159
27. A.J. Barkovich Pediatric Neuroimaging 4th ed. 2005 Lippincott Williams & Wilkins Philadelphia
28. E.H. Roland, K. Poskitt, E. Rodriguez, B.A. Lupton, and A. Hill Perinatal hypoxic-ischemic thalamic injury: clinical features and neuroimaging Ann Neurol 44 1998 161 166
29. H.B. Sarnat, and M.S. Sarnat Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study Arch Neurol 33 1976 696 705