Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial

The Lancet Neurology

Volumn 9, Issue 1, 2010, Pages 39-45

  Rutherford, Mary ^a   Ramenghi, Luca A ^b   Edwards, A David ^c   Brocklehurst, Peter ^d   Halliday, Henry ^e   Levene, Malcolm ^f   Strohm, Brenda ^d   Thoresen, Marianne ^g   Whitelaw, Andrew ^h   Azzopardi, Denis ^c  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b IRCCS   (Italy)

^c MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^f UNIVERSITY OF LEEDS   (United Kingdom)

^g ST MICHAEL'S HOSPITAL   (United Kingdom)

^h UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BRAIN DAMAGE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; BRAIN REGION; CEREBRAL SINUS THROMBOSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; INDUCED HYPOTHERMIA; INFANT; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC EXAMINATION; NEUROMUSCULAR DISEASE; NEWBORN; NEWBORN INTENSIVE CARE; NEWBORN MORTALITY; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE;

AGE FACTORS; BRAIN; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; LOGISTIC MODELS; MAGNETIC RESONANCE IMAGING; MALE; NEUROMUSCULAR DISEASES; ODDS RATIO; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 72049097914     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(09)70295-9     Document Type: Article

References (29)

1. Nelson K.B. Neonatal encephalopathy: etiology and outcome. Dev Med Child Neurol 47 (2005) 292
2. Badawi N., Felix J.F., Kurinczuk J.J., et al. Cerebral palsy following term newborn encephalopathy: a population-based study. Dev Med Child Neurol 47 (2005) 293-298
3. Badawi N., Kurinczuk J.J., Keogh J.M., et al. Antepartum risk factors for newborn encephalopathy: the Western Australian case-control study. BMJ 317 (1998) 1549-1553
4. Cowan F., Rutherford M., Groenendaal F., et al. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet 361 (2003) 736-742
5. Toet M.C., Hellstrom-Westas L., Groenendaal F., Eken P., and de Vries L.S. Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 81 (1999) F19-F23
6. Al Naqueeb N., Edwards A.D., Cowan F., and Azzopardi D. Assessment of neonatal encepalopathy by amplitude integrated electroencephalography. Pediatrics 103 (1999) 1263-1271
7. Dixon G., Badawi N., Kurinczuk J.J., et al. Early developmental outcomes after newborn encephalopathy. Pediatrics 109 (2002) 26-33
8. Marlow N., Rose A.S., Rands C.E., and Draper E.S. Neuropsychological and educational problems at school age associated with neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed 90 (2005) F380-F387
9. Marlow N., and Budge H. Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy. Arch Dis Child Fetal Neonatal Ed 90 (2005) F193-F194
10. Gluckman P.D., Wyatt J.S., Azzopardi D., et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 365 (2005) 663-670
11. Shankaran S., Laptook A.R., Ehrenkranz R.A., et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 353 (2005) 1574-1584
12. Azzopardi D., Strohm B., Edwards A.D., et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 361 (2009) 1349-1358
13. Azzopardi D., Strohm B., Edwards A.D., et al. Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial. Arch Dis Child Fetal Neonatal Ed 94 (2009) F260-F264
14. Rutherford M.A., Pennock J.M., Counsell S.J., et al. Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy. Pediatrics 102 (1998) 323-328
15. Mercuri E., Ricci D., Cowan F.M., et al. Head growth in infants with hypoxic-ischemic encephalopathy: correlation with neonatal magnetic resonance imaging. Pediatrics 106 (2000) 235-243
16. Rutherford M., Ward P., Allsop J., Malamatentiou C., and Counsell S. Magnetic resonance imaging in neonatal encephalopathy. Early Hum Dev 81 (2005) 13-25
17. Okereafor A., Allsop J., Counsell S.J., et al. Patterns of brain injury in neonates exposed to perinatal sentinel events. Pediatrics 121 (2008) 906-914
18. Mercuri E., Haataja L., Guzzetta A., et al. Visual function in term infants with hypoxic-ischaemic insults: correlation with neurodevelopment at 2 years of age. Arch Dis Child Fetal Neonatal Ed 80 (1999) F99-F104
19. Kaufman S.A., Miller S.P., Ferriero D.M., Glidden D.H., Barkovich A.J., and Partridge J.C. Encephalopathy as a predictor of magnetic resonance imaging abnormalities in asphyxiated newborns. Pediatr Neurol 28 (2003) 342-346
20. Miller S.P., Ramaswamy V., Michelson D., et al. Patterns of brain injury in term neonatal encephalopathy. J Pediatr 146 (2005) 453-460
21. Barkovich A.J., Miller S.P., Bartha A., et al. MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. Am J Neuroradiol 27 (2006) 533-547
22. Bayley N. Bayley scales of infant development (1993), Harcourt, Brace & Co., San Antonio
23. Rosenbaum P.L., Palisano R.J., Bartlett D.J., Galuppi B.E., and Russell D.J. Development of the gross motor function classification system for cerebral palsy. Dev Med Child Neurol 50 (2008) 249-253
24. Palisano R.J., Hanna S.E., Rosenbaum P.L., et al. Validation of a model of gross motor function for children with cerebral palsy. Phys Ther 80 (2000) 974-985
25. Jacobs S., Hunt R., Tarnow-Mordi W., Inder T., and Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 4 (2007) CD003311.
26. Inder T.E., Hunt R.W., Morley C.J., et al. Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy. J Pediatr 145 (2004) 835-837
27. Rutherford M.A., Azzopardi D., Whitelaw A., et al. Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy. Pediatrics 116 (2005) 1001-1006
28. Gunn A.J., Wyatt J.S., Whitelaw A., et al. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J Pediatr 152 (2008) 55-58
29. Rutherford M., Counsell S., Allsop J., et al. Diffusion-weighted magnetic resonance imaging in term perinatal brain injury: a comparison with site of lesion and time from birth. Pediatrics 114 (2004) 1004-1014