Serum gentamicin concentrations in encephalopathic infants are not affected by therapeutic hypothermia

Pediatrics

Volumn 124, Issue 1, 2009, Pages 310-315

  Liu, Xun ^a   Borooah, Manobi ^b   Stone, Janet ^c   Chakkarapani, Ela ^a   Thoresen, Marianne ^a,d  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b SOUTHMEAD HOSPITAL   (United Kingdom)

^c BRISTOL ROYAL INFIRMARY   (United Kingdom)

^d ST MICHAEL'S HOSPITAL   (United Kingdom)

Author keywords

Encephalopathy; Gentamicin; Hypothermia; Newborn

Indexed keywords

CREATININE; GENTAMICIN;

ARTICLE; BODY TEMPERATURE; BRAIN DISEASE; CONTINUOUS INFUSION; COOLING; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG MONITORING; HUMAN; INDUCED HYPOTHERMIA; INFANT; KIDNEY DYSFUNCTION; MAJOR CLINICAL STUDY; MAXIMUM PLASMA CONCENTRATION; NEPHROTOXICITY; NEWBORN; NEWBORN INTENSIVE CARE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SINGLE DRUG DOSE; TREATMENT DURATION;

BODY TEMPERATURE; CREATININE; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FEMALE; GENTAMICINS; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; KIDNEY FUNCTION TESTS; MALE; OTOACOUSTIC EMISSIONS, SPONTANEOUS; RETROSPECTIVE STUDIES;

EID: 67649593001     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2008-2942     Document Type: Article

References (33)

1. Agarwal G, Rastogi A, Pyati S, Wilks A, Pildes RS. Comparison of once-daily versus twice-daily gentamicin dosing regimens in infants ≥2500 g. J Perinatol. 2002;22(4):268-274 (Pubitemid 34619097)
2. Martínez-Salgado C, Lopez-Hernandez FJ, Lopez-Novoa JM. Glomerular nephrotoxicity of aminoglycosides. Toxicol Appl Pharmacol. 2007;223(1):86-98 (Pubitemid 47211265)
3. Rybak LP, Ramkumar V. Ototoxicity. Kidney Int. 2007;72(8):931-935
4. Nagai J, Takano M. Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity. Drug Metab Pharmacokinet. 2004;19(3):159-170
5. Yow MD. An overview of pediatric experience with amikacin. Am J Med. 1977;62(6):954-958 (Pubitemid 8131979)
6. Schentag JJ, Jusko WJ, Plaut ME, Cumbo TJ, Vance JW, Abrutyn E. Tissue persistence of gentamicin in man. JAMA. 1977;238(4):327-329 (Pubitemid 8156720)
7. Rodriguez-Barbero A, Lopez-Novoa JM, Arevalo M. Involvement of platelet-activating factor in gentamicin nephrotoxicity in rats. Exp Nephrol. 1997;5 (1):47-54 (Pubitemid 27105123)
8. Tran Ba Huy P, Meulemans A, Wassef M, Manuel C, Sterkers O, Amiel C. Gentamicin persistence in rat endolymph and perilymph after a two-day constant infusion. Antimicrob Agents Chemother. 1983;23(2):344-346 (Pubitemid 13137554)
9. Brion LP, Fleischman AR, Schwartz GJ. Gentamicin interval in newborn infants as determined by renal function and postconceptional age. Pediatr Nephrol. 1991;5(6):675-679
10. Thureen PJ, Reiter PD, Gresores A, Stolpman NM, Kawato K, Hall DM. Once-versus twice-daily gentamicin dosing in neonates ≥34 weeks' gestation: cost-effectiveness analyses. Pediatrics. 1999;103(3):594-598 (Pubitemid 29274506)
11. Royal College of Paediatrics and Child Health, the Neonatal and Paediatric Pharmacists Group, the British Medical Association and the Royal Pharmaceutical Society of Great Britain. BNF for Children. London, United Kingdom: BMJ Publishing Group Ltd; 2006
12. Pickering LK, ed. Red Book: Report of the Committee on Infectious Diseases. 25th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2000:241-242
13. Smith CR, Lipsky JJ, Laskin OL, et al. Double-blind comparison of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin. N Engl J Med. 1980;302(20):1106-1109 (Pubitemid 10107526)
14. Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol. 2005;32(1):11-17 (Pubitemid 40018099)
15. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005;365(9460):663-670 (Pubitemid 40260887)
16. Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353(15):1574-1584 (Pubitemid 41434636)
17. Hoehn T, Hansmann G, Bührer C, et al. Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units. Resuscitation. 2008;78(1):7-12 (Pubitemid 351787826)
18. Tortorici MA, Kochanek PM, Poloyac SM. Effects of hypothermia on drug disposition, metabolism, and response: a focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system. Crit Care Med. 2007;35(9):2196-2204 (Pubitemid 47326460)
19. Guignard JP, Gillieron P. Effect of modest hypothermia on the immature kidney. Acta Paediatr. 1997;86(10):1040-1041
20. Thoresen M, Whitelaw A. Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy. Pediatrics. 2000;106(1 pt 1):92-99 (Pubitemid 30436878)
21. Róka A, Melinda KT, Vasarhelyi B, Machay T, Azzopardi D, Szabo M. Elevated morphine concentrations in neonates treated with morphine and prolonged hypothermia for hypoxic ischemic encephalopathy. Pediatrics. 2008;121(4). Available at: www.pediatrics.org/cgi/content/full/121/4/e844
22. Thoresen MHN, Brun C. Hypothermia after perinatal asphyxia more than doubles the plasma half-life of phenobarbitone [abstract]. Pediatr Res. 2003;53(5):873
23. Withington D, Menard G, Harris J, Kulkarni P, Donati F, Varin F. Vecuronium pharmacokinetics and pharmacodynamics during hypothermic cardiopulmonary bypass in infants and children. Can J Anaesth. 2000;47(12):1188-1195 (Pubitemid 32098994)
24. DiCenzo R, Forrest A, Slish JC, Cole C, Guillet R. A gentamicin pharmacokinetic population model and once-daily dosing algorithm for neonates. Pharmacotherapy. 2003;23(5):585-591 (Pubitemid 36539039)
25. Kirkpatrick CM, Duffull SB, Begg EJ, Frampton C. The use of a change in gentamicin clearance as an early predictor of gentamicin-induced nephrotoxicity. Ther Drug Monit. 2003;25(5):623-630 (Pubitemid 37238897)
26. Lorian V, ed. Antibiotics in Laboratory Medicine: Making a Difference. Philadelphia, PA: Lippincott Williams & Wilkins; 2005
27. Auron A, Mhanna MJ. Serum creatinine in very low birth weight infants during their first days of life. J Perinatol. 2006;26(12):755-760 (Pubitemid 44811510)
28. Bertotti A, De Marchi S, Brovedani P, Gaeta G, Peratoner L, Mangiarotti MA. Neonatal hypoxic-ischemic nephropathy and urinary diagnostic indices: the utility of measuring tubular enzymes (NAG and AAP). Pediatr Med Chir. 1990;12(4):347-349
29. Richardson GP, Russell IJ. Cochlear cultures as a model system for studying aminoglycoside induced ototoxicity. Hear Res. 1991;53(2):293-311
30. Tablan OC, Reyes MP, Rintelmann WF, Lerner AM. Renal and auditory toxicity of high-dose, prolonged therapy with gentamicin and tobramycin in pseudomonas endocarditis. J Infect Dis. 1984;149(2):257-263 (Pubitemid 14198929)
31. Bitner-Glindzicz M, Rahman S. Ototoxicity caused by aminoglycosides. BMJ. 2007;335(7624):784-785 (Pubitemid 350057252)
32. Forge A, Schacht J. Aminoglycoside antibiotics. Audiol Neurootol. 2000;5(1):3-22 (Pubitemid 30093591)
33. Satas S, Hoem NO, Melby K, et al. Influence of mild hypothermia after hypoxia-ischemia on the pharmacokinetics of gentamicin in newborn pigs. Biol Neonate. 2000;77(1):50-57