Effects of hypothermia on pharmacokinetics and pharmacodynamics: A systematic review of preclinical and clinical studies

Clinical Pharmacokinetics

Volumn 49, Issue 5, 2010, Pages 277-294

  Van Den Broek, Marcel P H ^a   Groenendaal, Floris ^b   Egberts, Antoine C G ^a,c   Rademaker, Carin M A ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG;

ANIMAL; BLOOD FLOW; CLINICAL TRIAL (TOPIC); DRUG EFFECT; DRUG SCREENING; HUMAN; HYPOTHERMIA; METABOLISM; METHODOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; CLINICAL TRIALS AS TOPIC; DRUG EVALUATION, PRECLINICAL; HUMANS; HYPOTHERMIA; PHARMACEUTICAL PREPARATIONS; REGIONAL BLOOD FLOW;

EID: 78649958503     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.2165/11319360-000000000-00000     Document Type: Review

References (95)

1. Varon J, Acosta P. Therapeutic hypothermia: past, present, and future. Chest 2008; 133 (5): 1267-74
2. Seder DB, Jarrah S. Therapeutic hypothermia for cardiac arrest: a practical approach. Curr Neurol Neurosci Rep 2008; 8 (6): 508-17
3. Ginsberg MD. Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology 2008; 55 (3): 363-89
4. Nathan HJ, Parlea L, Dupuis JY, et al. Safety of deliberate intraoperative and postoperative hypothermia for patients undergoing coronary artery surgery: a randomized trial. J Thorac Cardiovasc Surg 2004; 127 (5): 1270-5
5. Shiozaki T, Sugimoto H, Taneda M, et al. Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neuro-surg 1993; 79 (3): 363-8
6. van Bel F, Groenendaal F. Long-term pharmacologic neuroprotection after birth asphyxia: where do we stand? Neonatology 2008; 94 (3): 203-10
7. Edwards AD, Yue X, Squier MV, et al. Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. Biochem Biophys Res Commun 1995; 217 (3): 1193-9
8. Gonzalez FF, Ferriero DM. Therapeutics for neonatal brain injury. Pharmacol Ther 2008; 120 (1): 43-53
9. Groenendaal F, van Bel F. Neuroprotection after perinatal asphyxia: recent advances and future perspectives. In: Mishra OP, editor. Mechanisms of hypoxic brain injury in the newborn and potential strategies for neuroprotection. Trivandrum: Transworld Research Network, 2007: 77-97
10. Zhu C, Wang X, Xu F, et al. The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ 2005; 12 (2): 162-76
11. Azzopardi D, Brocklehurst P, Edwards D, et al. The TOBY study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial. BMC Pediatr 2008; 8: 17
12. Globus MY, Alonso O, Dietrich WD, et al. Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J Neurochem 1995; 65 (4): 1704-11
13. Roka A, Melinda KT, Vasarhelyi B, et al. Elevated morphine concentrations in neonates treated with morphine and prolonged hypothermia for hypoxic ischemic encephalopathy. Pediatrics 2008; 121 (4): e844-9
14. Subramanian S, Agarwal R, Deorari AK, et al. Acute renal failure in neonates. Indian J Pediatr 2008; 75 (4): 385-91
15. Tarcan A, Tiker F, Guvenir H, et al. Hepatic involvement in perinatal asphyxia. J Matern Fetal Neonatal Med 2007; 20 (5): 407-10
16. Bartelink IH, Rademaker CM, Schobben AF, et al. Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations. Clin Pharmacokinet 2006; 45 (11): 1077-97
17. Gupta BD, Sharma P, Bagla J, et al. Renal failure in asphyxiated neonates. Indian Pediatr 2005; 42 (9): 928-34
18. Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy: safety outcomes. Pediatr Neurol 2005; 32 (1): 18-24
19. Nouri S, Mahdhaoui N, Beizig S, et al. Acute renal failure in full term neonates with perinatal asphyxia: prospective study of 87 cases. Arch Pediatr 2008; 15 (3): 229-35
20. Karlsson M, Satas S, Stone J, et al. Liver enzymes cannot be used to predict liver damage after global hypoxia-ischemia in a neonatal pig model. Neonatology 2009; 96 (4): 211-8
21. Stavchansky S, Tung IL. Effect of hypothermia on the intestinal absorption of uracil and L-dopa in the rat. J Pharm Sci 1987; 76 (9): 688-91
22. Shepherd AMM, Emslie-Smith D, Stevenson IH. Antipyrine elimination in patients with hypothermia. Br J Clin Pharmacol 1976; 3 (5): 958-9P
23. Stavchansky S, Tung IL. Effects of hypothermia on drug absorption. Pharm Res 1987; 4 (3): 248-50
24. Filippi L, la Marca G, Fiorini P, et al. Topiramate concentrations in neonates treated with prolonged whole body hypothermia for hypoxic ischemic encephalopathy. Epilepsia 2009; 50 (11): 2355-61
25. Koren G, Barker C, Bohn D, et al. Influence of hypothermia on the pharm-acokinetics of gentamicin and theophylline in piglets. Crit Care Med 1985; 13 (10): 844-7
26. Miller RD, Agoston S, van der Pol F, et al. Hypothermia and the pharmaco-kinetics and pharmacodynamics of pancuronium in the cat. J Pharmacol Exp Ther 1978; 207 (2): 532-8
27. Ham J, Miller RD, Benet LZ, et al. Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in the cat. Anesthesiology 1978; 49 (5): 324-9
28. Bansinath M, Turndorf H, Puig MM. Influence of hypo and hyperthermia on disposition of morphine. J Clin Pharmacol 1988; 28 (9): 860-4
29. Tortorici MA, Kochanek PM, Bies RR, et al. Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model. Crit Care Med 2006; 34 (3): 785-91
30. Schaible DH, Cupit GC, Swedlow DB, et al. High-dose pentobarbital pharmacokinetics in hypothermic brain-injured children. J Pediatr 1982; 100 (4): 655-60
31. Iida Y, Nishi S, Asada A. Effect of mild therapeutic hypothermia on phenytoin pharmacokinetics. Ther Drug Monit 2001; 23 (3): 192-7
32. Heier T, Clough D, Wright PM, et al. The influence ofmild hypothermia on the pharmacokinetics and time course of action of neostigmine in anesthetized volunteers. Anesthesiology 2002; 97 (1): 90-5
33. Fukuoka N, Aibiki M, Tsukamoto T, et al. Biphasic concentration change during continuous midazolam administration in brain-injured patients undergoing therapeutic moderate hypothermia. Resuscitation 2004; 60 (2): 225-30
34. Kadar D, Tang BK, Conn AW. The fate of phenobarbitone in children in hypothermia and at normal body temperature. Can Anaesth Soc J 1982; 29 (1): 16-23
35. Leslie K, Bjorksten AR, Ugoni A, et al. Mild core hypothermia and anesthetic requirement for loss of responsiveness during propofol anesthesia for craniotomy. Anesth Analg 2002; 94 (5): 1298-303
36. Delin NA, Kjartansson KB, Pollock L, et al. Redistribution of regional blood flow in hypothermia. J Thorac Cardiovasc Surg 1965; 49: 511-6
37. Lazenby WD, Ko W, Zelano JA, et al. Effects of temperature and flow rate on regional blood flow and metabolism during cardiopulmonary bypass. Ann Thorac Surg 1992; 53 (6): 957-64
38. Kondratiev TV, Myhre ES, Simonsen O, et al. Cardiovascular effects of epinephrine during rewarming from hypothermia in an intact animal model. J Appl Physiol 2006; 100 (2): 457-64
39. Chen RY, Chien S. Plasma volume, red cell volume, and thoracic duct lymph flow in hypothermia. Am J Physiol 1977; 233 (5): H605-12
40. Chen RY, Chien S. Hemodynamic functions and blood viscosity in surface hypothermia. Am J Physiol 1978; 235 (2): H136-43
41. D'Amato HE, Hegnauer AH. Blood volume in the hypothermic dog. Am J Physiol 1953; 173 (1): 100-2
42. Lofstrom B. Changes in blood volume in induced hypothermia. Acta Anaes-thesiol Scand 1957; 1 (1-2): 1-13
43. Wong KC. Physiology and pharmacology of hypothermia. West J Med 1983; 138 (2): 227-32
44. Groenendaal F, De Vooght KMK, van Bel F. Blood gas values during hypo-thermia in asphyxiated term neonates. Pediatrics 2009; 123: 170-2
45. Strichartz GR, Sanchez V, Arthur GR, et al. Fundamental properties of local anesthetics: II. Measured octanol: buffer partition coefficients and pKa values of clinically used drugs. Anesth Analg 1990; 71 (2): 158-70
46. Lönnqvist PA, Herngren L. Plasma protein binding of lidocaine during hypothermic conditions. Perfusion 1993; 8: 221-4
47. Kalser SC, Kelvington EJ, Randolph MM. Drug metabolism in hypothermia: uptake, metabolism and excretion of S35-sulfanilamide by the isolated, perfused rat liver. J Pharmacol Exp Ther 1968; 159 (2): 389-98
48. Perlovich GL, Volkova TV, Bauer-Brandl A. Thermodynamic study of sublimation, solubility, solvation, and distribution processes of atenolol and pindolol. Mol Pharm 2007; 4 (6): 929-35
49. Kato Y, Hirate J, Sakaguchi K, et al. Enhancement of phenytoin binding to tissues in rats by heat treatment. J Pharm Pharmacol 1989; 41 (2): 125-6
50. McAllister Jr RG, Tan TG. Effect of hypothermia on drug metabolism: in vitro studies with propranolol and verapamil. Pharmacology 1980; 20 (2): 95-100
51. McAllister Jr RG, Tan TG, Todd EP. Effect of hypothermia onthe metabolism of propranolol, quinidine, and verapamil [abstract]. Clin Pharmacol Ther 1978; 23 (1): 121
52. Fritz HG, Holzmayr M, Walter B, et al. The effect of mild hypothermia on plasma fentanyl concentration and biotransformation injuvenile pigs. Anesth Analg 2005; 100 (4): 996-1002
53. Kalser SC, Kelvington EJ, Kunig R, et al. Drug metabolism in hypothermia: uptake, metabolism and excretion of C14-procaine by the isolated, perfused rat liver. J Pharmacol Exp Ther 1968; 164 (2): 396-404
54. Kalser SC, Kelvington EJ, Randolph MM, et al. Drug metabolism in hypothermia: I. Biliary excretion of C 14-atropine metabolites in the intact and nephrectomized rat. J Pharmacol Exp Ther 1965; 147: 252-9
55. Kalser SC, Kelvington EJ, Randolph MM, et al. Drug metabolism in hypothermia: II. C 14-atropine uptake, metabolism and excretion by the isolated, perfused rat liver. J Pharmacol Exp Ther 1965; 147: 260-9
56. Mortensen B, Dale O. Effects of hypothermia on the elimination of ethanol, diazepam and oxazepam in rat liver slice incubations. Acta Anaesthesiol Scand 1995; 39 (2): 199-204
57. Daemen MJ, Thijssen HH, Vervoort-Peters HT, et al. The effect of pento-barbitone anaesthesia and hypothermia on the hepatic clearance of indocyanine green and S(-)-acenocoumarol in the rat. J Pharm Pharmacol 1986; 38 (2): 122-5
58. Nishida K, Okazaki M, Sakamoto R, et al. Change in pharmacokinetics of model compounds with different elimination processes in rats during hypothermia. Biol Pharm Bull 2007; 30 (9): 1763-7
59. Beaufort TM, Proost JH, Maring J, et al. Effect of hypothermia on the hepatic uptake and biliary excretion of vecuronium in the isolated perfused rat liver. Anesthesiology 2001; 94 (2): 270-9
60. Lundgren-Eriksson L, Carlsson A, Eksborg S, et al. Pharmacokinetics of doxorubicin and epirubicin in mice during chlorpromazine-induced hypothermia. Cancer Chemother Pharmacol 1997; 40 (5): 419-24
61. Satas S, Hoem NO, Melby K, et al. Influence of mild hypothermia after hypoxia-ischemia on the pharmacokinetics of gentamicin in newborn pigs. Biol Neonate 2000; 77 (1): 50-7
62. Leslie K, Sessler DI, Bjorksten AR, et al. Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium. Anesth Analg 1995; 80 (5): 1007-14
63. Caldwell JE, Heier T, Wright PM, et al. Temperature-dependent pharmaco-kinetics and pharmacodynamics of vecuronium. Anesthesiology 2000; 92 (1): 84-93
64. Kalser SC, Kelly MP, Forbes EB, et al. Drug metabolism in hypothermia: uptake, metabolism and biliary excretion of pentobarbital-2-C14 by the isolated, perfused rat liver in hypothermia and euthermia. J Pharmacol Exp Ther 1969; 170 (1): 145-52
65. Greven J. The effect of hypothermia on the diuretic action of furosemide in anesthetized rats. Naunyn Schmiedebergs Arch Pharmacol 1973; 280 (1): 71-8
66. Tortorici MA, Kochanek PM, Poloyac SM. Effects of hypothermia on drug disposition, metabolism, and response: a focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system. Crit Care Med 2007; 35 (9): 2196-204
67. Taniguchi H, Pyerin W. Phospholipid bilayer membranes play decisive roles in the cytochrome P-450-dependent monooxygenase system. J Cancer Res Clin Oncol 1988; 114 (4): 335-40
68. Soons PA, De Boer A, Cohen AF, et al. Assessment of hepatic blood flow in healthy subjects by continuous infusion of indocyanine green. Br J Clin Pharmacol 1991; 32 (6): 697-704
69. Withey WR, Chapman BJ, Munday KA. Cause of the reduction in renal blood flow in the hypothermic (27 degrees C) dog. Resuscitation 1974; 3 (4): 265-71
70. Withey WR, Chapman BJ, Munday KA. Distribution of blood flow in the hypo-thermic (27 degrees C) dog kidney. Clin Sci Mol Med Suppl 1976; 51 (6): 583-8
71. Munday KA, Noble AR. Renin secretion in the hypothermic dog. J Physiol 1970; 206 (2): 38-9P
72. Liu X, Borooah M, Stone S, et al. Serum gentamicin concentrations in encephalopathic infants are not affected by therapeutic hypothermia. Pediatrics 2009; 124 (1): 310-5
73. Meijer DK. Current concepts on hepatic transport of drugs. J Hepatol 1987; 4 (2): 259-68
74. Steen H, Merema M, Meijer DK. A multispecific uptake system for taurocholate, cardiac glycosides and cationic drugs in the liver. Biochem Pharmacol 1992; 44 (12): 2323-31
75. Tiribelli C, Lunazzi GC, Sottocasa GL. Biochemical and molecular aspects of the hepatic uptake of organic anions. Biochim Biophys Acta 1990; 1031 (3): 261-75
76. Rademaker CMA, de Vries LS. Pharmacology review: lidocaine for neonatal seizure management. Neoreviews 2008; 9: e585-9
77. Horrow JC, Bartkowski RR. Pancuronium, unlike other nondepolarizing relaxants, retains potency at hypothermia. Anesthesiology 1983; 58 (4): 357-61
78. Puig MM, Warner W, Tang CK, et al. Effects of temperature on the interaction of morphine with opioid receptors. Br J Anaesth 1987; 59: 1459-64
79. Riishede L, Nielsen-Kudsk F. Myocardial effects of adrenaline, isoprenaline and dobutamine at hypothermic conditions. Pharmacol Toxicol 1990; 66 (5): 354-60
80. Heier T, Caldwell JE, Sessler DI, et al. Mild intraoperative hypothermia in-creases duration of action and spontaneous recovery of vecuronium blockade during nitrous oxide-isoflurane anesthesia in humans. Anesthesiology 1991; 74 (5): 815-9
81. Swapna I, SathyaSaikumar KV, Murthy ChR, et al. Alterations in kinetic and thermotropic properties of cerebral membrane-bound acetylcholineesterase during thioacetamide-induced hepatic encephalopathy: correlation with membrane lipid changes. Brain Res 2007; 1153: 188-95
82. Broadley KJ, Duncan C. The contribution of metabolism to the hypothermia-induced supersensitivity of guinea-pig isolated atria; selective supersensitivity for beta-adrenoceptor agonists and their positive inotropic responses. Gen Pharmacol 1977; 8 (5-6): 305-10
83. Simantov R, Snowman AM, Snyder SH. Temperature and ionic influences on opiate receptor binding. Mol Pharmacol 1976; 12 (6): 977-86
84. Heier T, Caldwell JE, Sharma ML, et al. Mild intraoperative hypothermia does not change the pharmacodynamics (concentration-effect relationship) of vecuronium in humans. Anesth Analg 1994; 78 (5): 973-7
85. Tortorici MA, Mu Y, Kochanek PM, et al. Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats. Crit Care Med 2009; 37 (1): 263-9
86. Holley FO, Ponganis KV, Stanski DR. Effect of cardiopulmonary bypass on the pharmacokinetics of drugs. Clin Pharmacokinet 1982; 7 (3): 234-51
87. Mand'ak J, Zivny P, Lonsky V, et al. Changes in metabolism and blood flow in peripheral tissue (skeletal muscle) during cardiac surgery with cardiopulmonary bypass: the biochemical microdialysis study. Perfusion 2004; 19 (1): 53-63
88. Wissing H, Kuhn I, Rietbrock S, et al. Pharmacokinetics of inhaled anaes-thetics in a clinical setting: comparison of desflurane, isoflurane and sevoflurane. Br J Anaesth 2000; 84 (4): 443-9
89. Dale O, Brown Jr BR. Clinical pharmacokinetics of the inhalational anaes-thetics. Clin Pharmacokinet 1987; 12 (3): 145-67
90. Zhou JX, Liu J. The effect of temperature on solubility of volatile anesthetics in human tissues. Anesth Analg 2001; 93 (1): 234-8
91. Mager DE, Woo S, Jusko WJ. Scaling pharmacodynamics from in vitro and preclinical animal studies to humans. Drug Metab Pharmacokinet 2009; 24 (1): 16-24
92. Mahmood I. Interspecies scaling of renally secreted drugs. Life Sci 1998; 63 (26): 2365-71
93. Gomase VS, Tagore S. Species scaling and extrapolation. Curr Drug Metab 2008; 9 (3): 193-8
94. Goteti K, Brassil PJ, Good SS, et al. Estimation of human drug clearance using multiexponential techniques. J Clin Pharmacol 2008; 48 (10): 1226-36
95. Sui X, Sun J, Wu X, et al. Predicting the volume of distribution of drugs in humans. Curr Drug Metab 2008; 9 (6): 574-80