Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability

Free Radical Biology and Medicine

Volumn 37, Issue 11, 2004, Pages 1834-1844

  Won, Je Seong ^a,b   Im, Yeong Bin ^a   Singh, Avtar K ^b,c   Singh, Inderjit ^a,d  

^a Department of Pediatrics ^*  (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c RALPH H JOHNSON VA MEDICAL CENTER   (United States)

^d Med Univ S Carolina 135 C   (United States)

Author keywords

ATF 2; cAMP; Forskolin; Free radicals; Glial cells; iNOS; Macrophages; p38 MAPK; Proteasome

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLIC AMP; FORSKOLIN; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; ARTICLE; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME STABILITY; GENE CONTROL; GENE EXPRESSION; GLIA CELL; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; TRANSCRIPTION INITIATION; UBIQUITINATION;

ACTIVATING TRANSCRIPTION FACTOR 2; ANIMALS; CELL LINE, TUMOR; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FORSKOLIN; GENE EXPRESSION; LEUPEPTINS; LIPOPOLYSACCHARIDES; MACROPHAGES; NEUROGLIA; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RNA, MESSENGER; TRANSCRIPTION FACTORS; UBIQUITIN;

EID: 7444243223     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.08.017     Document Type: Article

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