-
1
-
-
23144464363
-
Transcriptional regulation and transformation byMyc proteins
-
Adhikary S, Eilers M. 2005. Transcriptional regulation and transformation byMyc proteins. Nat Rev Mol Cell Biol 6: 635-645.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 635-645
-
-
Adhikary, S.1
Eilers, M.2
-
2
-
-
27844562649
-
Tuberous sclerosis complex: Linking growth and energy signaling pathways with human disease
-
Astrinidis A, Henske EP. 2005. Tuberous sclerosis complex: Linking growth and energy signaling pathways with human disease. Oncogene 24: 7475-7481.
-
(2005)
Oncogene
, vol.24
, pp. 7475-7481
-
-
Astrinidis, A.1
Henske, E.P.2
-
3
-
-
79952154009
-
Double- hit B-cell lymphomas
-
Aukema SM, Siebert R, Schuuring E, van Imhoff GW, Kluin-Nelemans HC, Boerma EJ, Kluin PM. 2011. Double- hit B-cell lymphomas. Blood 117: 2319-2331.
-
(2011)
Blood
, vol.117
, pp. 2319-2331
-
-
Aukema, S.M.1
Siebert, R.2
Schuuring, E.3
van Imhoff, G.W.4
Kluin-Nelemans, H.C.5
Boerma, E.J.6
Kluin, P.M.7
-
4
-
-
70449091786
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
-
Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, et al. 2009. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462: 108-112.
-
(2009)
Nature
, vol.462
, pp. 108-112
-
-
Barbie, D.A.1
Tamayo, P.2
Boehm, J.S.3
Kim, S.Y.4
Moody, S.E.5
Dunn, I.F.6
Schinzel, A.C.7
Sandy, P.8
Meylan, E.9
Scholl, C.10
-
5
-
-
62049084053
-
MYC-inducedmyeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family
-
Beverly LJ, Varmus HE. 2009. MYC-inducedmyeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family. Oncogene 28: 1274-1279.
-
(2009)
Oncogene
, vol.28
, pp. 1274-1279
-
-
Beverly, L.J.1
Varmus, H.E.2
-
6
-
-
0035881691
-
Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter
-
Bouchard C, Dittrich O, Kiermaier A, Dohmann K, Menkel A, Eilers M, Luscher B. 2001. Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Genes Dev 15: 2042-2047.
-
(2001)
Genes Dev
, vol.15
, pp. 2042-2047
-
-
Bouchard, C.1
Dittrich, O.2
Kiermaier, A.3
Dohmann, K.4
Menkel, A.5
Eilers, M.6
Luscher, B.7
-
7
-
-
78049371811
-
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
-
Campbell KJ, Bath ML, Turner ML, Vandenberg CJ, Bouillet P, Metcalf D, Scott CL, Cory S. 2010. Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance. Blood 116: 3197-3207.
-
(2010)
Blood
, vol.116
, pp. 3197-3207
-
-
Campbell, K.J.1
Bath, M.L.2
Turner, M.L.3
Vandenberg, C.J.4
Bouillet, P.5
Metcalf, D.6
Scott, C.L.7
Cory, S.8
-
8
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC. Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318-1321.
-
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
Frisch, S.7
Reed, J.C.8
-
9
-
-
79960055459
-
RAS interactionwith PI3K: More than just another effector pathway
-
Castellano E, Downward J. 2010. RAS interactionwith PI3K: More than just another effector pathway. Genes Cancer 2: 261-274.
-
(2010)
Genes Cancer
, vol.2
, pp. 261-274
-
-
Castellano, E.1
Downward, J.2
-
10
-
-
0033614962
-
Essential role for oncogenic Ras in tumour maintenance
-
Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, et al. 1999. Essential role for oncogenic Ras in tumour maintenance. Nature 400: 468-472.
-
(1999)
Nature
, vol.400
, pp. 468-472
-
-
Chin, L.1
Tam, A.2
Pomerantz, J.3
Wong, M.4
Holash, J.5
Bardeesy, N.6
Shen, Q.7
O'Hagan, R.8
Pantginis, J.9
Zhou, H.10
-
11
-
-
1642553461
-
The dark side of Ras: Regulation of apoptosis
-
Cox AD, Der CJ. 2003. The dark side of Ras: Regulation of apoptosis. Oncogene 22: 8999-9006.
-
(2003)
Oncogene
, vol.22
, pp. 8999-9006
-
-
Cox, A.D.1
Der, C.J.2
-
12
-
-
1242317030
-
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
-
Dan HC, Sun M, Kaneko S, Feldman RI, Nicosia SV, Wang HG, Tsang BK, Cheng JQ. 2004. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 279: 5405-5412.
-
(2004)
J Biol Chem
, vol.279
, pp. 5405-5412
-
-
Dan, H.C.1
Sun, M.2
Kaneko, S.3
Feldman, R.I.4
Nicosia, S.V.5
Wang, H.G.6
Tsang, B.K.7
Cheng, J.Q.8
-
13
-
-
0033635235
-
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
-
Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME. 2000. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 6: 41-51.
-
(2000)
Mol Cell
, vol.6
, pp. 41-51
-
-
Datta, S.R.1
Katsov, A.2
Hu, L.3
Petros, A.4
Fesik, S.W.5
Yaffe, M.B.6
Greenberg, M.E.7
-
14
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, et al. 2002. Mutations of the BRAF gene in human cancer. Nature 417: 949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
-
15
-
-
58149398623
-
Translation of the Philadelphia chromosome into therapy for CML
-
Druker BJ. 2008. Translation of the Philadelphia chromosome into therapy for CML. Blood 112: 4808-4817.
-
(2008)
Blood
, vol.112
, pp. 4808-4817
-
-
Druker, B.J.1
-
17
-
-
0033569422
-
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis
-
Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL. 1999. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 13: 2658-2669.
-
(1999)
Genes Dev
, vol.13
, pp. 2658-2669
-
-
Eischen, C.M.1
Weber, J.D.2
Roussel, M.F.3
Sherr, C.J.4
Cleveland, J.L.5
-
18
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
-
Engelman JA. 2009. Targeting PI3K signalling in cancer: Opportunities, challenges and limitations. Nat Rev Cancer 9: 550-562.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
19
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC. 2006. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7: 606-619.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
20
-
-
0026642195
-
Induction of apoptosis in fibroblasts by c-myc protein
-
Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC. 1992. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69: 119-128.
-
(1992)
Cell
, vol.69
, pp. 119-128
-
-
Evan, G.I.1
Wyllie, A.H.2
Gilbert, C.S.3
Littlewood, T.D.4
Land, H.5
Brooks, M.6
Waters, C.M.7
Penn, L.Z.8
Hancock, D.C.9
-
21
-
-
73349129405
-
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
-
Faber AC, Li D, Song Y, Liang MC, Yeap BY, Bronson RT, Lifshits E, Chen Z, Maira SM, Garcia-Echeverria C, et al. 2009. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc Natl Acad Sci 106: 19503-19508.
-
(2009)
Proc Natl Acad Sci
, vol.106
, pp. 19503-19508
-
-
Faber, A.C.1
Li, D.2
Song, Y.3
Liang, M.C.4
Yeap, B.Y.5
Bronson, R.T.6
Lifshits, E.7
Chen, Z.8
Maira, S.M.9
Garcia-Echeverria, C.10
-
22
-
-
0033180211
-
Reversible tumorigenesis by MYC in hematopoietic lineages
-
Felsher DW, Bishop JM. 1999. Reversible tumorigenesis by MYC in hematopoietic lineages. Mol Cell 4 199-207.
-
(1999)
Mol Cell
, vol.4
, pp. 199-207
-
-
Felsher, D.W.1
Bishop, J.M.2
-
23
-
-
79960052850
-
Ras in cancer and developmental diseases
-
Fernandez-Medarde A, Santos E. 2011. Ras in cancer and developmental diseases. Genes Cancer 2: 344-358.
-
(2011)
Genes Cancer
, vol.2
, pp. 344-358
-
-
Fernandez-Medarde, A.1
Santos, E.2
-
24
-
-
33646843753
-
Activation by c-Myc of transcription by RNA polymerases I, II and III
-
Gomez-Roman N, Felton-Edkins ZA, Kenneth NS, Goodfellow SJ, Athineos D, Zhang J, Ramsbottom BA, Innes F, Kantidakis T, Kerr ER, et al. 2006. Activation by c-Myc of transcription by RNA polymerases I, II and III. Biochem Soc Symp 141-154.
-
(2006)
Biochem Soc Symp
, pp. 141-154
-
-
Gomez-Roman, N.1
Felton-Edkins, Z.A.2
Kenneth, N.S.3
Goodfellow, S.J.4
Athineos, D.5
Zhang, J.6
Ramsbottom, B.A.7
Innes, F.8
Kantidakis, T.9
Kerr, E.R.10
-
25
-
-
77749279644
-
Myc proteins as therapeutic targets
-
GustafsonWC,WeissWA
-
GustafsonWC,WeissWA. 2010.Myc proteins as therapeutic targets. Oncogene 29: 1249-1259.
-
(2010)
Oncogene
, vol.29
, pp. 1249-1259
-
-
-
26
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
27
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: The next generation. Cell 144: 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
28
-
-
3042601281
-
Suppression of tumorigenesis by the p53 target PUMA
-
Hemann MT, Zilfou JT, Zhao Z, Burgess DJ, Hannon GJ, Lowe SW. 2004. Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci 101: 9333-9338.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 9333-9338
-
-
Hemann, M.T.1
Zilfou, J.T.2
Zhao, Z.3
Burgess, D.J.4
Hannon, G.J.5
Lowe, S.W.6
-
29
-
-
12944281162
-
Identification of CDK4 as a target of c-MYC
-
Hermeking H, Rago C, Schuhmacher M, Li Q, Barrett JF, Obaya AJ, O'Connell BC, Mateyak MK, Tam W, Kohlhuber F, et al. 2000. Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci 97: 2229-2234.
-
(2000)
Proc Natl Acad Sci
, vol.97
, pp. 2229-2234
-
-
Hermeking, H.1
Rago, C.2
Schuhmacher, M.3
Li, Q.4
Barrett, J.F.5
Obaya, A.J.6
O'Connell, B.C.7
Mateyak, M.K.8
Tam, W.9
Kohlhuber, F.10
-
30
-
-
44949215822
-
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
-
Huang J, Dibble CC, Matsuzaki M, Manning BD. 2008. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 28: 4104-4115.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4104-4115
-
-
Huang, J.1
Dibble, C.C.2
Matsuzaki, M.3
Manning, B.D.4
-
31
-
-
0037025201
-
Sustained loss of a neoplastic phenotype by brief inactivation of MYC
-
Jain M, Arvanitis C, Chu K, Dewey W, Leonhardt E, Trinh M, Sundberg CD, Bishop JM, Felsher DW. 2002. Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science 297: 102-104.
-
(2002)
Science
, vol.297
, pp. 102-104
-
-
Jain, M.1
Arvanitis, C.2
Chu, K.3
Dewey, W.4
Leonhardt, E.5
Trinh, M.6
Sundberg, C.D.7
Bishop, J.M.8
Felsher, D.W.9
-
32
-
-
51349108718
-
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/ mTOR inhibitor prevents expansion of human BCRABL {thorn} leukemia cells
-
Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. 2008. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/ mTOR inhibitor prevents expansion of human BCRABL {thorn} leukemia cells. J Clin Invest 118: 3038-3050.
-
(2008)
J Clin Invest
, vol.118
, pp. 3038-3050
-
-
Kharas, M.G.1
Janes, M.R.2
Scarfone, V.M.3
Lilly, M.B.4
Knight, Z.A.5
Shokat, K.M.6
Fruman, D.A.7
-
33
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
Kinzler KW, Vogelstein B. 1996. Lessons from hereditary colorectal cancer. Cell 87: 159-170.
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
34
-
-
0032524104
-
Landscaping the cancer terrain
-
Kinzler KW, Vogelstein B. 1998. Landscaping the cancer terrain. Science 280: 1036-1037.
-
(1998)
Science
, vol.280
, pp. 1036-1037
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
35
-
-
54049088959
-
BCR/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress
-
Koptyra M, Cramer K, Slupianek A, Richardson C, Skorski T. 2008. BCR/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress. Leukemia 22: 1969-1972.
-
(2008)
Leukemia
, vol.22
, pp. 1969-1972
-
-
Koptyra, M.1
Cramer, K.2
Slupianek, A.3
Richardson, C.4
Skorski, T.5
-
36
-
-
0035839959
-
Mechanisms of chromosomal translocations in B cell lymphomas
-
Kuppers R, Dalla-Favera R. 2001. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 20: 5580-5594.
-
(2001)
Oncogene
, vol.20
, pp. 5580-5594
-
-
Kuppers, R.1
Dalla-Favera, R.2
-
37
-
-
36849078073
-
Cooperation of Haras and Bcl-2 during multistep skin carcinogenesis
-
Lee S, Chari NS, Kim HW, Wang X, Roop DR, Cho SH, DiGiovanni J, McDonnell TJ. 2007. Cooperation of Haras and Bcl-2 during multistep skin carcinogenesis. Mol Carcinog 46: 949-957.
-
(2007)
Mol Carcinog
, vol.46
, pp. 949-957
-
-
Lee, S.1
Chari, N.S.2
Kim, H.W.3
Wang, X.4
Roop, D.R.5
Cho, S.H.6
Digiovanni, J.7
McDonnell, T.J.8
-
38
-
-
70350241382
-
C-Myc and eIF4F constitute a feedforward loop that regulates cell growth: Implications for anticancer therapy
-
Lin CJ, Malina A, Pelletier J. 2009. c-Myc and eIF4F constitute a feedforward loop that regulates cell growth: Implications for anticancer therapy. Cancer Res 69: 7491-7494.
-
(2009)
Cancer Res
, vol.69
, pp. 7491-7494
-
-
Lin, C.J.1
Malina, A.2
Pelletier, J.3
-
40
-
-
9244224723
-
Intrinsic tumour suppression
-
Lowe SW, Cepero E, Evan G. 2004. Intrinsic tumour suppression. Nature 432: 307-315.
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
42
-
-
56649120608
-
In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
-
Mason KD, Vandenberg CJ, Scott CL, Wei AH, Cory S, Huang DC, Roberts AW. 2008. In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas. Proc Natl Acad Sci 105: 17961-17966.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 17961-17966
-
-
Mason, K.D.1
Vandenberg, C.J.2
Scott, C.L.3
Wei, A.H.4
Cory, S.5
Huang, D.C.6
Roberts, A.W.7
-
43
-
-
0030612937
-
Requirement of NF-kB activation to suppress p53-independent apoptosis induced byoncogenic Ras
-
Mayo MW, Wang CY, Cogswell PC, Rogers-Graham KS, Lowe SW, Der CJ, Baldwin AS Jr. 1997. Requirement of NF-kB activation to suppress p53-independent apoptosis induced byoncogenic Ras. Science 278: 1812-1815.
-
(1997)
Science
, vol.278
, pp. 1812-1815
-
-
Mayo, M.W.1
Wang, C.Y.2
Cogswell, P.C.3
Rogers-Graham, K.S.4
Lowe, S.W.5
Der, C.J.6
Baldwin Jr., A.S.7
-
44
-
-
56749184298
-
Reflecting on 25 years with MYC
-
Meyer N, Penn LZ. 2008. Reflecting on 25 years with MYC. Nat Rev Cancer 8: 976-990.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 976-990
-
-
Meyer, N.1
Penn, L.Z.2
-
45
-
-
70449109147
-
Requirement for NF-kB signalling in a mouse model of lung adenocarcinoma
-
Meylan E, Dooley AL, Feldser DM, Shen L, Turk E, Ouyang C, Jacks T. 2009. Requirement for NF-kB signalling in a mouse model of lung adenocarcinoma. Nature 462: 104-107.
-
(2009)
Nature
, vol.462
, pp. 104-107
-
-
Meylan, E.1
Dooley, A.L.2
Feldser, D.M.3
Shen, L.4
Turk, E.5
Ouyang, C.6
Jacks, T.7
-
46
-
-
67349129712
-
Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
-
Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK, Strasser A, Adams JM, Scott CL. 2009. Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death Differ 16: 684-696.
-
(2009)
Cell Death Differ
, vol.16
, pp. 684-696
-
-
Michalak, E.M.1
Jansen, E.S.2
Happo, L.3
Cragg, M.S.4
Tai, L.5
Smyth, G.K.6
Strasser, A.7
Adams, J.M.8
Scott, C.L.9
-
47
-
-
9444264703
-
BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks
-
Nowicki MO, Falinski R, Koptyra M, Slupianek A, Stoklosa T, Gloc E, Nieborowska-Skorska M, Blasiak J, Skorski T. 2004. BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks. Blood 104: 3746-3753.
-
(2004)
Blood
, vol.104
, pp. 3746-3753
-
-
Nowicki, M.O.1
Falinski, R.2
Koptyra, M.3
Slupianek, A.4
Stoklosa, T.5
Gloc, E.6
Nieborowska-Skorska, M.7
Blasiak, J.8
Skorski, T.9
-
48
-
-
0034584880
-
STI571: An inhibitor of the BCR-ABL tyrosine kinase for the treatment of chronic myelogenous leukaemia
-
O'Dwyer ME, Druker BJ. 2000. STI571: An inhibitor of the BCR-ABL tyrosine kinase for the treatment of chronic myelogenous leukaemia. Lancet Oncol 1: 207-211.
-
(2000)
Lancet Oncol
, vol.1
, pp. 207-211
-
-
O'Dwyer, M.E.1
Druker, B.J.2
-
49
-
-
0028356521
-
E2F-dependent regulation of human MYC: Trans-activation by cyclins D1 and A overrides tumour suppressor protein functions
-
Oswald F, Lovec H, Moroy T, Lipp M. 1994. E2F-dependent regulation of human MYC: Trans-activation by cyclins D1 and A overrides tumour suppressor protein functions. Oncogene 9: 2029-2036.
-
(1994)
Oncogene
, vol.9
, pp. 2029-2036
-
-
Oswald, F.1
Lovec, H.2
Moroy, T.3
Lipp, M.4
-
50
-
-
77954977940
-
Chronic myeloid leukemia: Mechanisms of blastic transformation
-
Perrotti D, Jamieson C, Goldman J, Skorski T. 2010. Chronic myeloid leukemia: Mechanisms of blastic transformation. J Clin Invest 120: 2254-2264.
-
(2010)
J Clin Invest
, vol.120
, pp. 2254-2264
-
-
Perrotti, D.1
Jamieson, C.2
Goldman, J.3
Skorski, T.4
-
51
-
-
37049024761
-
C-myc repression of TSC2 contributes to control of translation initiation and Myc-induced transformation
-
Ravitz MJ, Chen L, Lynch M, Schmidt EV. 2007. c-myc repression of TSC2 contributes to control of translation initiation and Myc-induced transformation. Cancer Res 67: 11209-11217.
-
(2007)
Cancer Res
, vol.67
, pp. 11209-11217
-
-
Ravitz, M.J.1
Chen, L.2
Lynch, M.3
Schmidt, E.V.4
-
52
-
-
35548956063
-
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo
-
Reimann M, Loddenkemper C, Rudolph C, Schildhauer I, Teichmann B, Stein H, Schlegelberger B, Dorken B, Schmitt CA. 2007. The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo. Blood 110: 2996-3004.
-
(2007)
Blood
, vol.110
, pp. 2996-3004
-
-
Reimann, M.1
Loddenkemper, C.2
Rudolph, C.3
Schildhauer, I.4
Teichmann, B.5
Stein, H.6
Schlegelberger, B.7
Dorken, B.8
Schmitt, C.A.9
-
53
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T, Hall MN. 2000. TOR, a central controller of cell growth. Cell 103: 253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
54
-
-
0033569423
-
INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
-
Schmitt CA, McCurrach ME, de Stanchina E, Wallace- Brodeur RR, Lowe SW. 1999. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes Dev 13: 2670-2677.
-
(1999)
Genes Dev
, vol.13
, pp. 2670-2677
-
-
Schmitt, C.A.1
McCurrach, M.E.2
de Stanchina, E.3
Wallace-Brodeur, R.R.4
Lowe, S.W.5
-
55
-
-
0036527761
-
Dissecting p53 tumor suppressor functions in vivo
-
Schmitt CA, Fridman JS, Yang M, Baranov E, Hoffman RM, Lowe SW. 2002. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 1: 289-298.
-
(2002)
Cancer Cell
, vol.1
, pp. 289-298
-
-
Schmitt, C.A.1
Fridman, J.S.2
Yang, M.3
Baranov, E.4
Hoffman, R.M.5
Lowe, S.W.6
-
56
-
-
13944252067
-
The life cycle of C-myc: From synthesis to degradation
-
Sears RC. 2004. The life cycle of C-myc: From synthesis to degradation. Cell Cycle 3: 1133-1137.
-
(2004)
Cell Cycle
, vol.3
, pp. 1133-1137
-
-
Sears, R.C.1
-
57
-
-
33745018419
-
Mutually exclusive NRASQ61R and BRAFV600E mutations at the single-cell level in the same human melanoma
-
Sensi M, Nicolini G, Petti C, Bersani I, Lozupone F, Molla A, Vegetti C, Nonaka D, Mortarini R, Parmiani G, et al. 2006. Mutually exclusive NRASQ61R and BRAFV600E mutations at the single-cell level in the same human melanoma. Oncogene 25: 3357-3364.
-
(2006)
Oncogene
, vol.25
, pp. 3357-3364
-
-
Sensi, M.1
Nicolini, G.2
Petti, C.3
Bersani, I.4
Lozupone, F.5
Molla, A.6
Vegetti, C.7
Nonaka, D.8
Mortarini, R.9
Parmiani, G.10
-
58
-
-
0037126303
-
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
-
Seoane J, Le HV, Massague J. 2002. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419: 729-734.
-
(2002)
Nature
, vol.419
, pp. 729-734
-
-
Seoane, J.1
Le, H.V.2
Massague, J.3
-
59
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. 1997. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88: 593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
60
-
-
0017647580
-
Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma
-
Staal SP, Hartley JW, Rowe WP. 1977. Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma. Proc Natl Acad Sci 74: 3065-3067.
-
(1977)
Proc Natl Acad Sci
, vol.74
, pp. 3065-3067
-
-
Staal, S.P.1
Hartley, J.W.2
Rowe, W.P.3
-
61
-
-
0025251664
-
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
-
Strasser A, Harris AW, Bath ML, Cory S. 1990. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 348: 331-333.
-
(1990)
Nature
, vol.348
, pp. 331-333
-
-
Strasser, A.1
Harris, A.W.2
Bath, M.L.3
Cory, S.4
-
62
-
-
74549193993
-
EGF receptor in relation to tumor development:Molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors
-
Takeuchi K, Ito F. 2010. EGF receptor in relation to tumor development:Molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors. FEBS J 277: 316-326.
-
(2010)
FEBS J
, vol.277
, pp. 316-326
-
-
Takeuchi, K.1
Ito, F.2
-
63
-
-
0036285034
-
C-Myc can include DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
-
Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM. 2002. c-Myc can include DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability. Mol Cell 9: 1031-1044.
-
(2002)
Mol Cell
, vol.9
, pp. 1031-1044
-
-
Vafa, O.1
Wade, M.2
Kern, S.3
Beeche, M.4
Pandita, T.K.5
Hampton, G.M.6
Wahl, G.M.7
-
64
-
-
33748192942
-
The Myc oncoprotein as a therapeutic target for human cancer
-
Vita M, Henriksson M. 2006. The Myc oncoprotein as a therapeutic target for human cancer. Semin Cancer Biol 16: 318-330.
-
(2006)
Semin Cancer Biol
, vol.16
, pp. 318-330
-
-
Vita, M.1
Henriksson, M.2
-
65
-
-
0036632368
-
The phosphatidylinositol 3- kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. 2002. The phosphatidylinositol 3- kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
66
-
-
0037025173
-
Cancer. Addiction to oncogenes-The Achilles heal of cancer
-
Weinstein IB. 2002. Cancer. Addiction to oncogenes-The Achilles heal of cancer. Science 297: 63-64.
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
67
-
-
1642586272
-
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
-
Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J, Lowe SW. 2004. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428: 332-337.
-
(2004)
Nature
, vol.428
, pp. 332-337
-
-
Wendel, H.G.1
de Stanchina, E.2
Fridman, J.S.3
Malina, A.4
Ray, S.5
Kogan, S.6
Cordon-Cardo, C.7
Pelletier, J.8
Lowe, S.W.9
-
68
-
-
77956268839
-
Understanding resistance to EGFR inhibitors-impact on future treatment strategies
-
Wheeler DL, Dunn EF, Harari PM. 2010. Understanding resistance to EGFR inhibitors-impact on future treatment strategies. Nat Rev Clin Oncol 7: 493-507.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 493-507
-
-
Wheeler, D.L.1
Dunn, E.F.2
Harari, P.M.3
-
69
-
-
61949111202
-
Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors
-
Whitecross KF, Alsop AE, Cluse LA, Wiegmans A, Banks KM, Coomans C, Peart MJ, Newbold A, Lindemann RK, Johnstone RW. 2009. Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors. Blood 113: 1982-1991.
-
(2009)
Blood
, vol.113
, pp. 1982-1991
-
-
Whitecross, K.F.1
Alsop, A.E.2
Cluse, L.A.3
Wiegmans, A.4
Banks, K.M.5
Coomans, C.6
Peart, M.J.7
Newbold, A.8
Lindemann, R.K.9
Johnstone, R.W.10
-
70
-
-
51849111556
-
PI3K pathway alterations in cancer: Variations on a theme
-
Yuan TL, Cantley LC. 2008. PI3K pathway alterations in cancer: Variations on a theme. Oncogene 27: 5497-5510.
-
(2008)
Oncogene
, vol.27
, pp. 5497-5510
-
-
Yuan, T.L.1
Cantley, L.C.2
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