IL-7-producing stromal cells are critical for lymph node remodeling

Blood

Volumn 120, Issue 24, 2012, Pages 4675-4683

  Onder, Lucas ^a   Narang, Priyanka ^b   Scandella, Elke ^a   Chai, Qian ^a   Iolyeva, Maria ^c   Hoorweg, Kerim ^d   Halin, Cornelia ^c   Richie, Ellen ^e   Kaye, Paul ^b   Westermann, Jürgen ^f   Cupedo, Tom ^e   Coles, Mark ^b   Ludewig, Burkhard ^a  

^a CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^b UNIVERSITY OF YORK   (United Kingdom)

^c ETH ZURICH   (Switzerland)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF TEXAS   (United States)

^f UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; DIPHTHERIA TOXIN; INTERLEUKIN 7;

ANIMAL TISSUE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CELL STRUCTURE; CELL TRANSPLANTATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPH NODE; LYMPH VESSEL ENDOTHELIUM; MICROENVIRONMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RETICULUM CELL; STROMA CELL; TRANSGENIC MOUSE; UPREGULATION; VIRUS INFECTION;

EID: 84870733775     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-03-416859     Document Type: Article

References (47)

1. Kang J, Coles M. IL-7: the global builder of the innate lymphoid network and beyond, one niche at a time. Semin Immunol. 2012;24(3):190-197.
2. Kikuchi K, Lai AY, Hsu CL, Kondo M. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF. J Exp Med. 2005;201(8):1197-1203. (Pubitemid 40629064)
3. Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature. 1998;391(6670):904-907. (Pubitemid 28157669)
4. Bertolino E, Reddy K, Medina KL, et al. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nat Immunol. 2005; 6(8):836-843. (Pubitemid 43090470)
5. Kang J, Coles M, Raulet DH. Defective development of gamma/delta T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor gamma genes. J Exp Med. 1999;190(7):973-982. (Pubitemid 29480826)
6. Alves NL, Richard-Le GO, Huntington ND, et al. Characterization of the thymic IL-7 niche in vivo. Proc Natl Acad Sci U S A. 2009;106(5):1512-1517.
7. Surh CD, Sprent J. Homeostasis of naive and memory T cells. Immunity. 2008;29(6):848-862.
8. Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol. 2011;11(5):330-342.
9. Willems L, Li S, Rutgeerts O, et al. IL-7 is required for the development of the intrinsic function of marginal zone B cells and the marginal zone microenvironment. J Immunol. 2011;187(7): 3587-3594.
10. Vogt TK, Link A, Perrin J, Finke D, Luther SA. Novel function for interleukin-7 in dendritic cell development. Blood. 2009;113(17):3961-3968.
11. Boesteanu A, Silva AD, Nakajima H, et al. Distinct roles for signals relayed through the common cytokine receptor gamma chain and interleukin 7 receptor alpha chain in natural T cell development. J Exp Med. 1997;186(2):331-336. (Pubitemid 27328034)
12. Roozendaal R, Mebius RE. Stromal cell-immune cell interactions. Annu Rev Immunol. 2011;29:23-43.
13. Chappaz S, Finke D. The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes. J Immunol. 2010; 184(7):3562-3569.
14. Mebius RE. Organogenesis of lymphoid tissues. Nat Rev Immunol. 2003;3(4):292-303. (Pubitemid 37328682)
15. Luther SA, Ansel KM, Cyster JG. Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med. 2003;197(9):1191-1198. (Pubitemid 36570074)
16. Coles MC, Veiga-Fernandes H, Foster KE, et al. Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes. Proc Natl Acad Sci U S A. 2006;103(36):13457-13462. (Pubitemid 44380129)
17. Meier D, Bornmann C, Chappaz S, et al. Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue- inducer cells. Immunity. 2007; 26(5):643-654. (Pubitemid 46756355)
18. Mazzucchelli RI, Warming S, Lawrence SM, et al. Visualization and identification of IL-7 producing cells in reporter mice. PLoS One. 2009;4(11): e7637.
19. Mazzucchelli R, Durum SK. Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol. 2007;7(2):144-154. (Pubitemid 46178275)
20. Link A, Vogt TK, Favre S, et al. Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol. 2007;8(11):1255-1265. (Pubitemid 350011765)
21. Young AJ, Marston WL, Dudler L. Subset-specific regulation of the lymphatic exit of recirculating lymphocytes in vivo. J Immunol. 2000;165(6): 3168-3174.
22. Chennupati V, Worbs T, Liu X, et al. Intra- and intercompartmental movement of gammadelta T cells: intestinal intraepithelial and peripheral gammadelta T cells represent exclusive nonoverlapping populations with distinct migration characteristics. J Immunol. 2010;185(9):5160-5168.
23. Kim MY, Rossi S, Withers D, et al. Heterogeneity of lymphoid tissue inducer cell populations present in embryonic and adult mouse lymphoid tissues. Immunology. 2008;124(2):166-174. (Pubitemid 351692897)
24. Repass JF, Laurent MN, Carter C, et al. IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Genesis. 2009;47(4):281-287.
25. Srinivas S, Watanabe T, Lin CS, et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol. 2001;1:4.
26. Buch T, Heppner FL, Tertilt C, et al.ACre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods. 2005; 2(6):419-426. (Pubitemid 40916560)
27. Ludewig B, Ehl S, Karrer U, et al. Dendritic cells efficiently induce protective antiviral immunity. J Virol. 1998;72(5):3812-3818. (Pubitemid 28188680)
28. Pabst R, Rothkotter HJ. Regeneration of autotransplanted lymph node fragments. Cell Tissue Res. 1988;251(3):597-601. (Pubitemid 18060090)
29. Vignali DA. Multiplexed particle-based flow cytometric assays. J Immunol Methods. 2000;243(1): 243-255.
30. Scandella E, Bolinger B, Lattmann E, et al. Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone. Nat Immunol. 2008; 9(6):667-675. (Pubitemid 351712637)
31. Kumar V, Scandella E, Danuser R, et al. Global lymphoid tissue remodeling during a viral infection is orchestrated by a B cell-lymphotox-independent pathway. Blood. 2010;115(23):4725-4733.
32. Odermatt B, Eppler M, Leist TP, Hengartner H, Zinkernagel RM. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc Natl Acad Sci U S A. 1991; 88(18):8252-8256. (Pubitemid 21915335)
33. Junt T, Scandella E, Ludewig B. Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence. Nat Rev Immunol. 2008;8(10):764-775.
34. Buettner M, Bode U. Lymph node transplantation and its immunological significance in animal models. Clin Dev Immunol. 2011;2011:353510.
35. Blum KS, Pabst R. Keystones in lymph node development. J Anat. 2006;209(5):585-595. (Pubitemid 44614689)
36. Hara T, Shitara S, Imai K, et al. Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. J Immunol. 2012;189(4):1577-1584.
37. Alitalo K. The lymphatic vasculature in disease. Nat Med. 2011;17(11):1371-1380.
38. Pflicke H, Sixt M. Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels. J Exp Med. 2009;206(13):2925-2935.
39. Tal O, Lim HY, Gurevich I, et al. DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling. J Exp Med. 2011;208(10):2141-2153.
40. Grigorova IL, Panteleev M, Cyster JG. Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure. Proc Natl Acad Sci U S A. 2010;107(47): 20447-20452.
41. Braun A, Worbs T, Moschovakis GL, et al. Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nat Immunol. 2011;12(9):879-887.
42. Junt T, Moseman EA, Iannacone M, et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007;450(7166):110-114. (Pubitemid 350070574)
43. Iannacone M, Moseman EA, Tonti E, et al. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature. 2010;465(7301):1079-1083.
44. Mueller SN, Hosiawa-Meagher KA, Konieczny BT, et al. Regulation of homeostatic chemokine expression and cell trafficking during immune responses. Science. 2007;317(5838):670-674. (Pubitemid 47229967)
45. Mueller SN, Matloubian M, Clemens DM, et al. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A. 2007;104(39):15430-15435. (Pubitemid 47502934)
46. Zeng M, Smith AJ, Wietgrefe SW, et al. Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. J Clin Invest. 2011;121(3):998-1008.
47. Levy Y, Lacabaratz C, Weiss L, et al. Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest. 2009;119(4):997-1007.