Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d] pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases

European Journal of Medicinal Chemistry

Volumn 59, Issue , 2013, Pages 283-295

  Loidreau, Yvonnick ^a   Marchand, Pascal ^b   Dubouilh Benard, Carole ^a   Nourrisson, Marie Renée ^b   Duflos, Muriel ^b   Loaëc, Nadège ^c,d   Meijer, Laurent ^d   Besson, Thierry ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c Protein Phosphorylation and Human Disease Group   (France)

^d Centre de Perharidy   (France)

Author keywords

Alzheimer's disease; Benzo b furo 3,2 d pyrimidin 4 amines; Benzo b thieno 3,2 d pyrimidin 4 amines; CLK; DYRK; Kinase inhibitors; Microwave assisted chemistry

Indexed keywords

7 METHOXY N (3,4 DIMETHOXYPHENYL)BENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; 7 METHOXY N (3,4,5 TRIMETHOXYPHENYL)BENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; 7 METHOXY N (4 METHOXYPHENYL)BENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; 7 METHOXY N (4 TOLYL)BENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; 7 METHOXY N (M TOLYL)BENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; 7 METHOXY N PHENYLBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; AMIDE; CASEIN KINASE I; CDC2 LIKE KINASE 1 INHIBITOR; CYCLIN DEPENDENT KINASE 5; DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 1A INHIBITOR; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; N (2 CHLOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (2,4 DICHLOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (2,4 DIFLUOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (3 CHLORO 4 FLUOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (3 CHLOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (3,4 DICHLOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (3,5 DICHLOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (4 BROMO 2 FLUOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (4 BROMOPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (4 CHLORO 2 FLUOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (4 CHLOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (4 FLUOROPHENYL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; N (BENZO[D][1,3]DIOXOL 5 YL) 7 METHOXYBENZOFURO[3,2 D]PYRIMIDIN 4 AMINE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; MICROWAVE IRRADIATION;

AMINES; ENZYME ACTIVATION; ENZYME INHIBITORS; FURANS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; THIOPHENES;

EID: 84870724248     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.11.030     Document Type: Article

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