Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3419-3423

  Testard, Alexandra ^a   Logé, Cédric ^b   Léger, Benoît ^b   Robert, Jean Michel ^b   Lozach, Olivier ^c   Blairvacq, Mélina ^c   Meijer, Laurent ^c   Thiéry, Valérie ^a   Besson, Thierry ^a  

^a FRE CNRS 2766   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c STATION BIOLOGIQUE DE ROSCOFF   (France)

Author keywords

Glycogen synthase kinase 3 inhibitors; Microwave assisted chemistry; Molecular modeling; Quinazolines

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMIDINE; CYCLIN B; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; IMIDAZOLINE DERIVATIVE; PROTEIN P25; THIAZOLO[5,4 F]QUINAZOLIN 9 ONE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; HYDROGEN BOND; HYDROPHOBICITY; MICROWAVE RADIATION; MOLECULAR MODEL;

ADENOSINE TRIPHOSPHATE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HYDROGEN BONDING; MICROWAVES; MODELS, MOLECULAR; QUINAZOLINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 33744927132     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.04.006     Document Type: Article

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