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Volumn 7, Issue 11, 2012, Pages

Cerebrospinal Fluid IL-12p40, CXCL13 and IL-8 as a Combinatorial Biomarker of Active Intrathecal Inflammation

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CXCL13 CHEMOKINE; INTERLEUKIN 12P40; INTERLEUKIN 8;

EID: 84870722172     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048370     Document Type: Article
Times cited : (69)

References (62)
  • 2
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • Magliozzi R, Howell O, Vora A, Serafini B, Nicholas R, et al. (2007) Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 130: 1089-1104.
    • (2007) Brain , vol.130 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3    Serafini, B.4    Nicholas, R.5
  • 3
    • 78149481589 scopus 로고    scopus 로고
    • Meningeal T cells associate with diffuse axonal loss in multiple sclerosis spinal cords
    • Androdias G, Reynolds R, Chanal M, Ritleng C, Confavreux C, et al. (2010) Meningeal T cells associate with diffuse axonal loss in multiple sclerosis spinal cords. Ann Neurol 68: 465-476.
    • (2010) Ann Neurol , vol.68 , pp. 465-476
    • Androdias, G.1    Reynolds, R.2    Chanal, M.3    Ritleng, C.4    Confavreux, C.5
  • 4
    • 33751085414 scopus 로고    scopus 로고
    • Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
    • Cross AH, Stark JL, Lauber J, Ramsbottom MJ, Lyons JA, (2006) Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 180: 63-70.
    • (2006) J Neuroimmunol , vol.180 , pp. 63-70
    • Cross, A.H.1    Stark, J.L.2    Lauber, J.3    Ramsbottom, M.J.4    Lyons, J.A.5
  • 5
    • 0032943375 scopus 로고    scopus 로고
    • Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNbeta-1a) for relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group
    • Rudick RA, Cookfair DL, Simonian NA, Ransohoff RM, Richert JR, et al. (1999) Cerebrospinal fluid abnormalities in a phase III trial of Avonex (IFNbeta-1a) for relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group. J Neuroimmunol 93: 8-14.
    • (1999) J Neuroimmunol , vol.93 , pp. 8-14
    • Rudick, R.A.1    Cookfair, D.L.2    Simonian, N.A.3    Ransohoff, R.M.4    Richert, J.R.5
  • 6
    • 82955225356 scopus 로고    scopus 로고
    • Intrathecal effects of daclizumab treatment of multiple sclerosis
    • Bielekova B, Richert N, Herman ML, Ohayon J, Waldmann TA, et al. (2011) Intrathecal effects of daclizumab treatment of multiple sclerosis. Neurology 77: 1877-1886.
    • (2011) Neurology , vol.77 , pp. 1877-1886
    • Bielekova, B.1    Richert, N.2    Herman, M.L.3    Ohayon, J.4    Waldmann, T.A.5
  • 7
    • 0030047502 scopus 로고    scopus 로고
    • Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection
    • Kanangat S, Thomas J, Gangappa S, Babu JS, Rouse BT, (1996) Herpes simplex virus type 1-mediated up-regulation of IL-12 (p40) mRNA expression. Implications in immunopathogenesis and protection. J Immunol 156: 1110-1116.
    • (1996) J Immunol , vol.156 , pp. 1110-1116
    • Kanangat, S.1    Thomas, J.2    Gangappa, S.3    Babu, J.S.4    Rouse, B.T.5
  • 8
    • 0030267472 scopus 로고    scopus 로고
    • IL-12 p40 messenger RNA expression in target organs during acute graft-versus-host disease. Possible involvement of IFN-gamma
    • Kichian K, Nestel FP, Kim D, Ponka P, Lapp WS, (1996) IL-12 p40 messenger RNA expression in target organs during acute graft-versus-host disease. Possible involvement of IFN-gamma. J Immunol 157: 2851-2856.
    • (1996) J Immunol , vol.157 , pp. 2851-2856
    • Kichian, K.1    Nestel, F.P.2    Kim, D.3    Ponka, P.4    Lapp, W.S.5
  • 9
    • 33845606612 scopus 로고    scopus 로고
    • IL-12p40: an inherently agonistic cytokine
    • Cooper AM, Khader SA, (2007) IL-12p40: an inherently agonistic cytokine. Trends Immunol 28: 33-38.
    • (2007) Trends Immunol , vol.28 , pp. 33-38
    • Cooper, A.M.1    Khader, S.A.2
  • 10
    • 45449084797 scopus 로고    scopus 로고
    • Differences in the inducible gene expression and protein production of IL-12p40, IL-12p70 and IL-23: involvement of p38 and JNK kinase pathways
    • Dobreva ZG, Stanilova SA, Miteva LD, (2008) Differences in the inducible gene expression and protein production of IL-12p40, IL-12p70 and IL-23: involvement of p38 and JNK kinase pathways. Cytokine 43: 76-82.
    • (2008) Cytokine , vol.43 , pp. 76-82
    • Dobreva, Z.G.1    Stanilova, S.A.2    Miteva, L.D.3
  • 11
    • 0028819316 scopus 로고
    • Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity
    • Ling P, Gately MK, Gubler U, Stern AS, Lin P, et al. (1995) Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. J Immunol 154: 116-127.
    • (1995) J Immunol , vol.154 , pp. 116-127
    • Ling, P.1    Gately, M.K.2    Gubler, U.3    Stern, A.S.4    Lin, P.5
  • 12
    • 3142720381 scopus 로고    scopus 로고
    • The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases
    • Holscher C, (2004) The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases. Med Microbiol Immunol 193: 1-17.
    • (2004) Med Microbiol Immunol , vol.193 , pp. 1-17
    • Holscher, C.1
  • 13
    • 0029049359 scopus 로고
    • The IL-12 p40 homodimer as a specific antagonist of the IL-12 heterodimer
    • Germann T, Rude E, Mattner F, Gately MK, (1995) The IL-12 p40 homodimer as a specific antagonist of the IL-12 heterodimer. Immunol Today 16: 500-501.
    • (1995) Immunol Today , vol.16 , pp. 500-501
    • Germann, T.1    Rude, E.2    Mattner, F.3    Gately, M.K.4
  • 14
    • 0031964713 scopus 로고    scopus 로고
    • Reduced T helper 1 responses in IL-12 p40 transgenic mice
    • Yoshimoto T, Wang CR, Yoneto T, Waki S, Sunaga S, et al. (1998) Reduced T helper 1 responses in IL-12 p40 transgenic mice. J Immunol 160: 588-594.
    • (1998) J Immunol , vol.160 , pp. 588-594
    • Yoshimoto, T.1    Wang, C.R.2    Yoneto, T.3    Waki, S.4    Sunaga, S.5
  • 15
    • 33644830150 scopus 로고    scopus 로고
    • The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects
    • Shimozato O, Ugai S, Chiyo M, Takenobu H, Nagakawa H, et al. (2006) The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects. Immunology 117: 22-28.
    • (2006) Immunology , vol.117 , pp. 22-28
    • Shimozato, O.1    Ugai, S.2    Chiyo, M.3    Takenobu, H.4    Nagakawa, H.5
  • 16
    • 0036418867 scopus 로고    scopus 로고
    • IL-12: the role of p40 versus p75
    • Abdi K, (2002) IL-12: the role of p40 versus p75. Scand J Immunol 56: 1-11.
    • (2002) Scand J Immunol , vol.56 , pp. 1-11
    • Abdi, K.1
  • 17
    • 33646107620 scopus 로고    scopus 로고
    • The ratio of P40 monomer to dimer is an important determinant of IL-12 bioactivity
    • Klinke DJ 2nd, (2006) The ratio of P40 monomer to dimer is an important determinant of IL-12 bioactivity. J Theor Biol 240: 323-335.
    • (2006) J Theor Biol , vol.240 , pp. 323-335
    • Klinke 2nd, D.J.1
  • 18
    • 79960889728 scopus 로고    scopus 로고
    • Francisella tularensis LVS-induced Interleukin-12 p40 cytokine production mediates dendritic cell migration through IL-12 Receptor beta1
    • Slight SR, Lin Y, Messmer M, Khader SA, (2011) Francisella tularensis LVS-induced Interleukin-12 p40 cytokine production mediates dendritic cell migration through IL-12 Receptor beta1. Cytokine 55: 372-379.
    • (2011) Cytokine , vol.55 , pp. 372-379
    • Slight, S.R.1    Lin, Y.2    Messmer, M.3    Khader, S.A.4
  • 19
    • 0345735824 scopus 로고    scopus 로고
    • IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1
    • Russell TD, Yan Q, Fan G, Khalifah AP, Bishop DK, et al. (2003) IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1. J Immunol 171: 6866-6874.
    • (2003) J Immunol , vol.171 , pp. 6866-6874
    • Russell, T.D.1    Yan, Q.2    Fan, G.3    Khalifah, A.P.4    Bishop, D.K.5
  • 20
    • 70450220226 scopus 로고    scopus 로고
    • IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1
    • Jana M, Dasgupta S, Pal U, Pahan K, (2009) IL-12 p40 homodimer, the so-called biologically inactive molecule, induces nitric oxide synthase in microglia via IL-12R beta 1. Glia 57: 1553-1565.
    • (2009) Glia , vol.57 , pp. 1553-1565
    • Jana, M.1    Dasgupta, S.2    Pal, U.3    Pahan, K.4
  • 21
    • 66549113544 scopus 로고    scopus 로고
    • Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70
    • Jana M, Pahan K, (2009) Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70. Immunology 127: 312-325.
    • (2009) Immunology , vol.127 , pp. 312-325
    • Jana, M.1    Pahan, K.2
  • 22
    • 0031567892 scopus 로고    scopus 로고
    • Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells
    • Piccotti JR, Chan SY, Li K, Eichwald EJ, Bishop DK, (1997) Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells. J Immunol 158: 643-648.
    • (1997) J Immunol , vol.158 , pp. 643-648
    • Piccotti, J.R.1    Chan, S.Y.2    Li, K.3    Eichwald, E.J.4    Bishop, D.K.5
  • 23
    • 0028809507 scopus 로고
    • Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions
    • Windhagen A, Newcombe J, Dangond F, Strand C, Woodroofe MN, et al. (1995) Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J Exp Med 182: 1985-1996.
    • (1995) J Exp Med , vol.182 , pp. 1985-1996
    • Windhagen, A.1    Newcombe, J.2    Dangond, F.3    Strand, C.4    Woodroofe, M.N.5
  • 24
    • 73349109797 scopus 로고    scopus 로고
    • Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS
    • Sellebjerg F, Bornsen L, Khademi M, Krakauer M, Olsson T, et al. (2009) Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS. Neurology 73: 2003-2010.
    • (2009) Neurology , vol.73 , pp. 2003-2010
    • Sellebjerg, F.1    Bornsen, L.2    Khademi, M.3    Krakauer, M.4    Olsson, T.5
  • 25
    • 84870657090 scopus 로고    scopus 로고
    • Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course
    • Khademi M, Kockum I, Andersson ML, Iacobaeus E, Brundin L, et al. (2010) Cerebrospinal fluid CXCL13 in multiple sclerosis: a suggestive prognostic marker for the disease course. Mult Scler.
    • (2010) Mult Scler
    • Khademi, M.1    Kockum, I.2    Andersson, M.L.3    Iacobaeus, E.4    Brundin, L.5
  • 26
    • 30344446249 scopus 로고    scopus 로고
    • Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment
    • Krumbholz M, Theil D, Cepok S, Hemmer B, Kivisakk P, et al. (2006) Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 129: 200-211.
    • (2006) Brain , vol.129 , pp. 200-211
    • Krumbholz, M.1    Theil, D.2    Cepok, S.3    Hemmer, B.4    Kivisakk, P.5
  • 27
    • 79959494654 scopus 로고    scopus 로고
    • Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid
    • Ragheb S, Li Y, Simon K, VanHaerents S, Galimberti D, et al. (2011) Multiple sclerosis: BAFF and CXCL13 in cerebrospinal fluid. Mult Scler 17: 819-829.
    • (2011) Mult Scler , vol.17 , pp. 819-829
    • Ragheb, S.1    Li, Y.2    Simon, K.3    VanHaerents, S.4    Galimberti, D.5
  • 28
    • 77957766615 scopus 로고    scopus 로고
    • The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS)
    • Brettschneider J, Czerwoniak A, Senel M, Fang L, Kassubek J, et al. (2010) The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS). PLoS One 5: e11986.
    • (2010) PLoS One , vol.5
    • Brettschneider, J.1    Czerwoniak, A.2    Senel, M.3    Fang, L.4    Kassubek, J.5
  • 29
    • 77951667048 scopus 로고    scopus 로고
    • CXCL13 as a cerebrospinal fluid marker for neurosyphilis in HIV-infected patients with syphilis
    • Marra CM, Tantalo LC, Sahi SK, Maxwell CL, Lukehart SA, (2010) CXCL13 as a cerebrospinal fluid marker for neurosyphilis in HIV-infected patients with syphilis. Sex Transm Dis 37: 283-287.
    • (2010) Sex Transm Dis , vol.37 , pp. 283-287
    • Marra, C.M.1    Tantalo, L.C.2    Sahi, S.K.3    Maxwell, C.L.4    Lukehart, S.A.5
  • 30
    • 79955540344 scopus 로고    scopus 로고
    • Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid
    • van Burgel ND, Bakels F, Kroes AC, van Dam AP, (2011) Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid. J Clin Microbiol 49: 2027-2030.
    • (2011) J Clin Microbiol , vol.49 , pp. 2027-2030
    • van Burgel, N.D.1    Bakels, F.2    Kroes, A.C.3    van Dam, A.P.4
  • 31
    • 83555176356 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of CXCL13 are elevated in neuromyelitis optica
    • Zhong X, Wang H, Dai Y, Wu A, Bao J, et al. (2011) Cerebrospinal fluid levels of CXCL13 are elevated in neuromyelitis optica. J Neuroimmunol 240-241: 104-108.
    • (2011) J Neuroimmunol , vol.240-241 , pp. 104-108
    • Zhong, X.1    Wang, H.2    Dai, Y.3    Wu, A.4    Bao, J.5
  • 33
    • 0035007877 scopus 로고    scopus 로고
    • BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo
    • Vissers JL, Hartgers FC, Lindhout E, Figdor CG, Adema GJ, (2001) BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo. Eur J Immunol 31: 1544-1549.
    • (2001) Eur J Immunol , vol.31 , pp. 1544-1549
    • Vissers, J.L.1    Hartgers, F.C.2    Lindhout, E.3    Figdor, C.G.4    Adema, G.J.5
  • 34
    • 8644249868 scopus 로고    scopus 로고
    • Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis
    • Carlsen HS, Baekkevold ES, Morton HC, Haraldsen G, Brandtzaeg P, (2004) Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis. Blood 104: 3021-3027.
    • (2004) Blood , vol.104 , pp. 3021-3027
    • Carlsen, H.S.1    Baekkevold, E.S.2    Morton, H.C.3    Haraldsen, G.4    Brandtzaeg, P.5
  • 35
    • 0037305275 scopus 로고    scopus 로고
    • Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma
    • Smith JR, Braziel RM, Paoletti S, Lipp M, Uguccioni M, et al. (2003) Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. Blood 101: 815-821.
    • (2003) Blood , vol.101 , pp. 815-821
    • Smith, J.R.1    Braziel, R.M.2    Paoletti, S.3    Lipp, M.4    Uguccioni, M.5
  • 36
    • 23744456876 scopus 로고    scopus 로고
    • B-Cells in ocular adnexal lymphoproliferative lesions express B-cell attracting chemokine 1 (CXCL13)
    • Falkenhagen KM, Braziel RM, Fraunfelder FW, Smith JR, (2005) B-Cells in ocular adnexal lymphoproliferative lesions express B-cell attracting chemokine 1 (CXCL13). Am J Ophthalmol 140: 335-337.
    • (2005) Am J Ophthalmol , vol.140 , pp. 335-337
    • Falkenhagen, K.M.1    Braziel, R.M.2    Fraunfelder, F.W.3    Smith, J.R.4
  • 37
    • 34347343930 scopus 로고    scopus 로고
    • Characterization of CXCL13+ neoplastic t cells in cutaneous lesions of angioimmunoblastic T-cell lymphoma (AITL)
    • Ortonne N, Dupuis J, Plonquet A, Martin N, Copie-Bergman C, et al. (2007) Characterization of CXCL13+ neoplastic t cells in cutaneous lesions of angioimmunoblastic T-cell lymphoma (AITL). Am J Surg Pathol 31: 1068-1076.
    • (2007) Am J Surg Pathol , vol.31 , pp. 1068-1076
    • Ortonne, N.1    Dupuis, J.2    Plonquet, A.3    Martin, N.4    Copie-Bergman, C.5
  • 38
    • 21044435315 scopus 로고    scopus 로고
    • Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis
    • Manzo A, Paoletti S, Carulli M, Blades MC, Barone F, et al. (2005) Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis. Eur J Immunol 35: 1347-1359.
    • (2005) Eur J Immunol , vol.35 , pp. 1347-1359
    • Manzo, A.1    Paoletti, S.2    Carulli, M.3    Blades, M.C.4    Barone, F.5
  • 39
    • 0036231050 scopus 로고    scopus 로고
    • Expression of the B cell-attracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sjogren's syndrome
    • Salomonsson S, Larsson P, Tengner P, Mellquist E, Hjelmstrom P, et al. (2002) Expression of the B cell-attracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sjogren's syndrome. Scand J Immunol 55: 336-342.
    • (2002) Scand J Immunol , vol.55 , pp. 336-342
    • Salomonsson, S.1    Larsson, P.2    Tengner, P.3    Mellquist, E.4    Hjelmstrom, P.5
  • 40
    • 0035152101 scopus 로고    scopus 로고
    • Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjogren's syndrome
    • Amft N, Curnow SJ, Scheel-Toellner D, Devadas A, Oates J, et al. (2001) Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjogren's syndrome. Arthritis Rheum 44: 2633-2641.
    • (2001) Arthritis Rheum , vol.44 , pp. 2633-2641
    • Amft, N.1    Curnow, S.J.2    Scheel-Toellner, D.3    Devadas, A.4    Oates, J.5
  • 41
    • 0035169196 scopus 로고    scopus 로고
    • Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients
    • Shi K, Hayashida K, Kaneko M, Hashimoto J, Tomita T, et al. (2001) Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients. J Immunol 166: 650-655.
    • (2001) J Immunol , vol.166 , pp. 650-655
    • Shi, K.1    Hayashida, K.2    Kaneko, M.3    Hashimoto, J.4    Tomita, T.5
  • 42
    • 33745939483 scopus 로고    scopus 로고
    • The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis
    • Meraouna A, Cizeron-Clairac G, Panse RL, Bismuth J, Truffault F, et al. (2006) The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis. Blood 108: 432-440.
    • (2006) Blood , vol.108 , pp. 432-440
    • Meraouna, A.1    Cizeron-Clairac, G.2    Panse, R.L.3    Bismuth, J.4    Truffault, F.5
  • 43
    • 34848853539 scopus 로고    scopus 로고
    • CXCL13 and CCL21 are expressed in ectopic lymphoid follicles in cutaneous lymphoproliferative disorders
    • Ohmatsu H, Sugaya M, Kadono T, Tamaki K, (2007) CXCL13 and CCL21 are expressed in ectopic lymphoid follicles in cutaneous lymphoproliferative disorders. J Invest Dermatol 127: 2466-2468.
    • (2007) J Invest Dermatol , vol.127 , pp. 2466-2468
    • Ohmatsu, H.1    Sugaya, M.2    Kadono, T.3    Tamaki, K.4
  • 44
    • 75649132169 scopus 로고    scopus 로고
    • The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis
    • Rupprecht TA, Plate A, Adam M, Wick M, Kastenbauer S, et al. (2009) The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis. J Neuroinflammation 6: 42.
    • (2009) J Neuroinflammation , vol.6 , pp. 42
    • Rupprecht, T.A.1    Plate, A.2    Adam, M.3    Wick, M.4    Kastenbauer, S.5
  • 45
    • 1242340285 scopus 로고    scopus 로고
    • Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis
    • Magliozzi R, Columba-Cabezas S, Serafini B, Aloisi F, (2004) Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol 148: 11-23.
    • (2004) J Neuroimmunol , vol.148 , pp. 11-23
    • Magliozzi, R.1    Columba-Cabezas, S.2    Serafini, B.3    Aloisi, F.4
  • 46
    • 70350447216 scopus 로고    scopus 로고
    • Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
    • van de Pavert SA, Olivier BJ, Goverse G, Vondenhoff MF, Greuter M, et al. (2009) Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. Nat Immunol 10: 1193-1199.
    • (2009) Nat Immunol , vol.10 , pp. 1193-1199
    • van de Pavert, S.A.1    Olivier, B.J.2    Goverse, G.3    Vondenhoff, M.F.4    Greuter, M.5
  • 47
    • 0038558196 scopus 로고    scopus 로고
    • Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development
    • Luther SA, Ansel KM, Cyster JG, (2003) Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development. J Exp Med 197: 1191-1198.
    • (2003) J Exp Med , vol.197 , pp. 1191-1198
    • Luther, S.A.1    Ansel, K.M.2    Cyster, J.G.3
  • 48
    • 0026760984 scopus 로고
    • Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha
    • Aloisi F, Care A, Borsellino G, Gallo P, Rosa S, et al. (1992) Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha. J Immunol 149: 2358-2366.
    • (1992) J Immunol , vol.149 , pp. 2358-2366
    • Aloisi, F.1    Care, A.2    Borsellino, G.3    Gallo, P.4    Rosa, S.5
  • 49
    • 76449087805 scopus 로고    scopus 로고
    • Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid
    • Mellergard J, Edstrom M, Vrethem M, Ernerudh J, Dahle C, (2010) Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid. Mult Scler 16: 208-217.
    • (2010) Mult Scler , vol.16 , pp. 208-217
    • Mellergard, J.1    Edstrom, M.2    Vrethem, M.3    Ernerudh, J.4    Dahle, C.5
  • 50
    • 21044448355 scopus 로고    scopus 로고
    • Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis
    • Ishizu T, Osoegawa M, Mei FJ, Kikuchi H, Tanaka M, et al. (2005) Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis. Brain 128: 988-1002.
    • (2005) Brain , vol.128 , pp. 988-1002
    • Ishizu, T.1    Osoegawa, M.2    Mei, F.J.3    Kikuchi, H.4    Tanaka, M.5
  • 51
    • 79959593936 scopus 로고    scopus 로고
    • IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis
    • Pinto Junior VL, Rebelo MC, Gomes RN, Assis EF, Castro-Faria-Neto HC, et al. (2011) IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis. Braz J Infect Dis 15: 156-158.
    • (2011) Braz J Infect Dis , vol.15 , pp. 156-158
    • Pinto Jr., V.L.1    Rebelo, M.C.2    Gomes, R.N.3    Assis, E.F.4    Castro-Faria-Neto, H.C.5
  • 52
    • 0041589148 scopus 로고    scopus 로고
    • Approach to discriminate subgroups in multiple sclerosis with cerebrospinal fluid (CSF) basic inflammation indices and TNF-alpha, IL-1beta, IL-6, IL-8
    • Kleine TO, Zwerenz P, Graser C, Zofel P, (2003) Approach to discriminate subgroups in multiple sclerosis with cerebrospinal fluid (CSF) basic inflammation indices and TNF-alpha, IL-1beta, IL-6, IL-8. Brain Res Bull 61: 327-346.
    • (2003) Brain Res Bull , vol.61 , pp. 327-346
    • Kleine, T.O.1    Zwerenz, P.2    Graser, C.3    Zofel, P.4
  • 53
    • 70350721619 scopus 로고    scopus 로고
    • Detection of MCP-1 and IL-8 in the serum and cerebrospinal fluid of a child with Miller Fisher syndrome
    • Sato S, Suzuki K, Nagao R, Kashiwagi Y, Kawashima H, et al. (2009) Detection of MCP-1 and IL-8 in the serum and cerebrospinal fluid of a child with Miller Fisher syndrome. J Clin Neurosci 16: 1698-1699.
    • (2009) J Clin Neurosci , vol.16 , pp. 1698-1699
    • Sato, S.1    Suzuki, K.2    Nagao, R.3    Kashiwagi, Y.4    Kawashima, H.5
  • 54
    • 77952252552 scopus 로고    scopus 로고
    • IL-8 in cerebrospinal fluid from children with acute encephalopathy is higher than in that from children with febrile seizure
    • Asano T, Ichiki K, Koizumi S, Kaizu K, Hatori T, et al. (2010) IL-8 in cerebrospinal fluid from children with acute encephalopathy is higher than in that from children with febrile seizure. Scand J Immunol 71: 447-451.
    • (2010) Scand J Immunol , vol.71 , pp. 447-451
    • Asano, T.1    Ichiki, K.2    Koizumi, S.3    Kaizu, K.4    Hatori, T.5
  • 55
    • 35148815034 scopus 로고    scopus 로고
    • Diagnostic reliability of cerebral spinal fluid tests for acute confusional state (delirium) in patients with systemic lupus erythematosus: interleukin 6 (IL-6), IL-8, interferon-alpha, IgG index, and Q-albumin
    • Katsumata Y, Harigai M, Kawaguchi Y, Fukasawa C, Soejima M, et al. (2007) Diagnostic reliability of cerebral spinal fluid tests for acute confusional state (delirium) in patients with systemic lupus erythematosus: interleukin 6 (IL-6), IL-8, interferon-alpha, IgG index, and Q-albumin. J Rheumatol 34: 2010-2017.
    • (2007) J Rheumatol , vol.34 , pp. 2010-2017
    • Katsumata, Y.1    Harigai, M.2    Kawaguchi, Y.3    Fukasawa, C.4    Soejima, M.5
  • 56
    • 1442303813 scopus 로고    scopus 로고
    • IL-8 is a key mediator of neuroinflammation in severe traumatic brain injuries
    • Kushi H, Saito T, Makino K, Hayashi N, (2003) IL-8 is a key mediator of neuroinflammation in severe traumatic brain injuries. Acta Neurochir Suppl 86: 347-350.
    • (2003) Acta Neurochir Suppl , vol.86 , pp. 347-350
    • Kushi, H.1    Saito, T.2    Makino, K.3    Hayashi, N.4
  • 57
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis
    • McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, et al. (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 50: 121-127.
    • (2001) Ann Neurol , vol.50 , pp. 121-127
    • McDonald, W.I.1    Compston, A.2    Edan, G.3    Goodkin, D.4    Hartung, H.P.5
  • 58
    • 78751630983 scopus 로고    scopus 로고
    • Diagnostic accuracy and receiver-operating characteristics curve analysis in surgical research and decision making
    • Soreide K, Korner H, Soreide JA, (2011) Diagnostic accuracy and receiver-operating characteristics curve analysis in surgical research and decision making. Ann Surg 253: 27-34.
    • (2011) Ann Surg , vol.253 , pp. 27-34
    • Soreide, K.1    Korner, H.2    Soreide, J.A.3
  • 59
    • 77958550314 scopus 로고    scopus 로고
    • Analysis of biomarker data: logs, odds ratios, and receiver operating characteristic curves
    • Grund B, Sabin C, (2010) Analysis of biomarker data: logs, odds ratios, and receiver operating characteristic curves. Curr Opin HIV AIDS 5: 473-479.
    • (2010) Curr Opin HIV AIDS , vol.5 , pp. 473-479
    • Grund, B.1    Sabin, C.2
  • 60
    • 0027457620 scopus 로고
    • Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine
    • Zweig MH, Campbell G, (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39: 561-577.
    • (1993) Clin Chem , vol.39 , pp. 561-577
    • Zweig, M.H.1    Campbell, G.2
  • 61
    • 48849087125 scopus 로고    scopus 로고
    • Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study
    • Segal BM, Constantinescu CS, Raychaudhuri A, Kim L, Fidelus-Gort R, et al. (2008) Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study. Lancet Neurol 7: 796-804.
    • (2008) Lancet Neurol , vol.7 , pp. 796-804
    • Segal, B.M.1    Constantinescu, C.S.2    Raychaudhuri, A.3    Kim, L.4    Fidelus-Gort, R.5
  • 62
    • 84864558396 scopus 로고    scopus 로고
    • Inhibition of LTi Cell Development by CD25 Blockade Is Associated with Decreased Intrathecal Inflammation in Multiple Sclerosis
    • Perry JS, Han S, Xu Q, Herman ML, Kennedy LB, et al. (2012) Inhibition of LTi Cell Development by CD25 Blockade Is Associated with Decreased Intrathecal Inflammation in Multiple Sclerosis. Sci Transl Med 4: 145ra106.
    • (2012) Sci Transl Med , vol.4
    • Perry, J.S.1    Han, S.2    Xu, Q.3    Herman, M.L.4    Kennedy, L.B.5


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