Francisella tularensis LVS-induced Interleukin-12 p40 cytokine production mediates dendritic cell migration through IL-12 Receptor β1

Cytokine

Volumn 55, Issue 3, 2011, Pages 372-379

  Slight, Samantha R ^a   Lin, Yinyao ^a   Messmer, Michelle ^a   Khader, Shabaana A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Dendritic cells; IL 12p40; Intracellular pathogens; Tularemia

Indexed keywords

INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 12P40; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; TOLL LIKE RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; CELL ACTIVATION; CELL MIGRATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FRANCISELLA TULARENSIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TULAREMIA;

ANIMALS; CELL MOVEMENT; CHEMOKINE CCL19; DENDRITIC CELLS; FRANCISELLA TULARENSIS; INTERLEUKIN-12 RECEPTOR BETA 1 SUBUNIT; INTERLEUKIN-12 SUBUNIT P40; LUNG; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; RECEPTORS, CCR7; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2;

FRANCISELLA TULARENSIS;

EID: 79960889728     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.05.017     Document Type: Article

References (31)

1. Dennis D.T., Inglesby T.V., Henderson D.A., Bartlett J.G., Ascher M.S., Eitzen E., et al. Tularemia as a biological weapon: medical and public health management. Jama 2001, 285:2763-2773.
2. Khader S.A., Partida-Sanchez S., Bell G., Jelley-Gibbs D.M., Swain S., Pearl J.E., et al. Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. J Exp Med 2006, 203:1805-1815.
3. Robinson R.T., Khader S.A., Locksley R.M., Lien E., Smiley S.T., Cooper A.M. Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration. J Immunol 2008, 181:5560-5567.
4. Luther S.A., Tang H.L., Hyman P.L., Farr A.G., Cyster J.G. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc Natl Acad Sci USA 2000, 97:12694-12699.
5. MartIn-Fontecha A., Sebastiani S., Hopken U.E., Uguccioni M., Lipp M., Lanzavecchia A., et al. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J Exp Med 2003, 198:615-621.
6. Wolf A.J., Linas B., Trevejo-Nunez G.J., Kincaid E., Tamura T., Takatsu K., et al. Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo. J Immunol 2007, 179:2509-2519.
7. Wolf A.J., Desvignes L., Linas B., Banaiee N., Tamura T., Takatsu K., et al. Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. J Exp Med 2008, 205:105-115.
8. McCormick S., Santosuosso M., Small C.L., Shaler C.R., Zhang X., Jeyanathan M., et al. Mucosally delivered dendritic cells activate T cells independently of IL-12 and endogenous APCs. J Immunol 2008, 181:2356-2367.
9. Robinson R.T., Khader S.A., Martino C.A., Fountain J.J., Teixeira-Coelho M., Pearl J.E., et al. Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration. J Exp Med 2010, 207:591-605.
10. Trinchieri G. Interleukin 12: a cytokine at the interface of inflammation and immunity. Adv Immunol 1998, 70:83-243.
11. Oppmann B., Lesley R., Blom B., Timans J., Xu Y., Hunte B., et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000, 13:715-725.
12. Duckett N.S., Olmos S., Durrant D.M., Metzger D.W. Intranasal interleukin-12 treatment for protection against respiratory infection with the Francisella tularensis live vaccine strain. Infect Immun 2005, 73:2306-2311.
13. Elkins K.L., Cooper A., Colombini S.M., Cowley S.C., Kieffer T.L. In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70. Infect Immun 2002, 70:1936-1948.
14. Lin Y., Ritchea S., Logar A., Slight S., Messmer M., Rangel-Moreno J., et al. Interleukin-17 Is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity 2009, 31:799-810.
15. Hong K.J., Wickstrum J.R., Yeh H.W., Parmely M.J. Toll-like receptor 2 controls the gamma interferon response to Francisella tularensis by mouse liver lymphocytes. Infect Immun 2007, 75:5338-5345.
16. Cole L.E., Santiago A., Barry E., Kang T.J., Shirey K.A., Roberts Z.J., et al. Macrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathways. J Immunol 2008, 180:6885-6891.
17. Loegering D.J., Drake J.R., Banas J.A., McNealy T.L., Mc Arthur D.G., Webster L.M., et al. Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitro. Microb Pathog 2006, 41:218-225.
18. Butchar J.P., Rajaram M.V., Ganesan L.P., Parsa K.V., Clay C.D., Schlesinger L.S., et al. Francisella tularensis induces IL-23 production in human monocytes. J Immunol 2007, 178:4445-4454.
19. Piccotti J., Li K., Chan S., Eichwald E., Bishop D. Interleukin-12 (IL-12)-driven alloimmune responses in vitro and in vivo:requirement for beta1 subunit of the IL-12 receptor. Transplantation 1999, 67:1453-1460.
20. Khader S.A., Pearl J.E., Sakamoto K., Gilmartin L., Bell G.K., Jelley-Gibbs D.M., et al. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J Immunol 2005, 175:788-795.
21. Reinhardt R., Hong S., Kang S., Wang Z., Locksley R. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol 2006, 177:1618-1627.
22. Hall J.D., Woolard M.D., Gunn B.M., Craven R.R., Taft-Benz S., Frelinger J.A., et al. Infected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112. Infect Immun 2008, 76:5843-5852.
23. Katz J., Zhang P., Martin M., Vogel S.N., Michalek S.M. Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS. Infect Immun 2006, 74:2809-2816.
24. Cole L.E., Shirey K.A., Barry E., Santiago A., Rallabhandi P., Elkins K.L., et al. Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages. Infect Immun 2007, 75:4127-4137.
25. Pompei L., Jang S., Zamlynny B., Ravikumar S., McBride A., Hickman S.P., et al. Disparity in IL-12 release in dendritic cells and macrophages in response to Mycobacterium tuberculosis is due to use of distinct TLRs. J Immunol 2007, 178:5192-5199.
26. Presky D., Minetti L., Gillessen S., Wilkinson V., Wu C., Gubler U., et al. Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex. J Immunol 1998, 160:2174-2179.
27. Ha S., Lee C.H., Lee S.B., Kim C.M., Jang K.L., Shin H.S., et al. A novel function of IL-12p40 as a chemotactic molecule for macropahges. J Immunol 1999, 163:2902-2908.
28. Russell T.D., Yan Q., Fan G., Khalifah A.P., Bishop D.K., Brody S.L., et al. IL-12p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor b1. J Immunol 2003, 171:6866-6874.
29. Pahan K., Sheikh F.G., Liu X., Hilger S., McKinney M., Petro T.M. Induction of nitric-oxide synthase and activation of NF-kB by interleukin-12 p40 in microglial cells. J Biol Chem 2001, 276:7899-7905.
30. Heinzel F.P., Rerko R.M., Ling P., Hakimi J., Schoenhaut D.S. Interleukin-12 is produced in vivo during endotoxemia and stimulates synthesis of g interferon. Infect Immun 1994, 62:4244.
31. D'Andrea A., Rengaraju M., Valiante N.M., Chehimi J., Kubin M., Aste M., et al. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 1992, 176:1387-1398.