Il-6 and Il-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: Their potential role as a marker for differential diagnosis

Brazilian Journal of Infectious Diseases

Volumn 15, Issue 2, 2011, Pages 156-158

  Pinto Junior, Vitor Laerte Laerte ^a   Rebelo, Maria Cristina ^b   Gomes, Rachel Novaes ^c   de Assis, Edson Fernandes ^c   Castro Faria Neto, Hugo C ^c   Bóia, Marcio Neves ^c  

^a UNIVERSIDADE CATÓLICA DE BRASÍLIA   (Brazil)

^b Meningitis Reference Laboratory   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Aseptic meningitis; Bacteria; CSF; IL 6; IL 8; Infammation meningitis

Indexed keywords

GLUCOSE; INTERLEUKIN 6; INTERLEUKIN 8; PROTEIN;

ADOLESCENT; ADULT; AREA UNDER THE CURVE; ARTICLE; ASEPTIC MENINGITIS; BACTERIAL MENINGITIS; CASE CONTROL STUDY; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID CYTOLOGY; CHILD; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIFFERENTIAL DIAGNOSIS; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; PROTEIN CEREBROSPINAL FLUID LEVEL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY;

EID: 79959593936     PISSN: 14138670     EISSN: 16784391     Source Type: Journal    
DOI: 10.1590/S1413-86702011000200011     Document Type: Article

References (10)

1. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 6 ed. Philadelphia: Saunders Elsevier; 2007.
2. Nagafuchi M, Nagafuchi Y, Sato R et al. Adult meningism and viral meningitis, 1997-2004: clinical data and cerebrospinal fuid cytokines. Intern Med 2006; 45(21):1209-12.
3. Lopez-Cortes LF, Cruz-Ruiz M, Gomez-Mateos J et al. Interleukin 6 in cerebrospinal fuid of patients with meningitis is not a useful diagnostic marker in the differential diagnosis of meningitis. Ann Clin Biochem 1997; 34 (Pt 2):165-9.
4. Lopez-Cortes LF, Cruz-Ruiz M, Gomez-Mateos J, Viciana-Fernandez P, Martinez-Marcos FJ, Pachon J. Interleukin-8 in cerebrospinal fuid from patients with meningitis of different etiologies: its possible role as neutrophil chemotactic factor. J Infect Dis 1995;172(2):581-4.
5. Seki T, Joh K, Ohishi T. Augmented production of interleukin-8 in cerebrospinal fuid in bacterial meningitis. Immunology 1993; 80(2):333-5.
6. Nigrovic LE, Kuppermann N, Macias CG et al. Clinical prediction rule for identifying children with cerebrospinal fuid pleocytosis at very low risk of bacterial meningitis. Jama 2007; 297(1):52-60.
7. Ostergaard C, Benfeld TL, Sellebjerg F, Kronborg G, Lohse N, Lundgren JD. Interleukin-8 in cerebrospinal fuid from patients with septic and aseptic meningitis. Eur J Clin Microbiol Infect Dis 1996; 15(2):166-9.
8. Spanos A, Harrell FE, Jr., Durack DT. Differential diagnosis of acute meningitis. An analysis of the predictive value of initial observations. Jama 1989; 262(19):2700-7.
9. Chavanet P, Bonnotte B, Guiguet M et al. High concentrations of intrathecal interleukin-6 in human bacterial and nonbacterial meningitis. J Infect Dis 1992; 166(2):428-31.
10. Mukai AO, Krebs VL, Bertoli CJ, Okay TS. TNF-alpha and IL-6 in the diagnosis of bacterial and aseptic meningitis in children. Pediatr Neurol 2006; 34(1):25-9.