IL-12 p40 Messenger RNA Expression in Target Organs during Acute Graft-Versus-Host Disease Possible Involvement of IFN-γ

Journal of Immunology

Volumn 157, Issue 7, 1996, Pages 2851-2856

  Kichian, Krikor ^a   Nestel, Frederick P ^a,b   Kim, Daniel ^a   Ponka, Premysl ^a   Lapp, Wayne S ^a  

^a MCGILL UNIVERSITY   (Canada)

^b SAGA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE SYNTHASE;

A J MOUSE; ACUTE DISEASE; ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CROSS BREEDING; ENZYME INDUCTION; GENETICS; GRAFT VERSUS HOST REACTION; LYMPHOID TISSUE; MACROPHAGE ACTIVATION; MALE; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PATHOLOGY; PERITONEUM MACROPHAGE; PHYSIOLOGY; TRANSPLANTATION;

ACUTE DISEASE; ANIMALS; BASE SEQUENCE; CROSSES, GENETIC; ENZYME INDUCTION; GRAFT VS HOST DISEASE; INTERFERON TYPE II; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; LYMPHOID TISSUE; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED A; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NITRIC OXIDE SYNTHASE; ORGAN SPECIFICITY; RNA, MESSENGER;

EID: 0030267472     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Gorer, P. A., and E. A. Boyse. 1959. Pathological changes in F1 hybrid mice following transplantation of spleen cells from donors of the parental strains. Immunology 2:182.
2. Blaese, R. M., C. Martinez, and R. A. Good. 1963. Immunologic incompetence of immunologically runted animals. J. Exp. Med. 119:211.
3. Lapp, W. S., T. Ghayur, M. Mendes, M. Seddik, and T. A. Seemayer. 1985. The functional and histological basis for graft-versus-host induced immunosuppression. Immunol. Rev. 88:107.
4. Xenocostas, A., W. S. Lapp, and D. G. Osmond,. 1987. Suppression of B lymphocyte genesis in the bone marrow by systemic graft-versus-host reactions. Transplantation 43:549.
5. + donor cells in graft-versus-host immune deficiency induced across a class I, class II, or whole H-2 difference. J. Immunol. 140:2600.
6. Korngold, R., and J. Sprent. 1990. T cell subsets in graft-vs-host disease. In Graft-vs-Host Disease: Immunology, Pathophysiology, and Treatment. S. J. Burakoff, H. J. Deeg, J. Ferrara, and K. Atkinson, eds. Marcel Dekker, New York, pp. 31-50.
7. Via, C. S. 1991. Kinetics of T cell activation in acute and chronic forms of murine graft-versus-host disease. J. Immunol. 146:2603.
8. Antin, J. H., and J. L. M. Ferrara. 1992. Cytokine dysregulation and acute graft-versus-host disease. Blood 80:2964.
9. Velardi, A., P. Varese, A. Terenzi, C. Dembech, N. Albi, C. E. Grossi, L. Moretta, M. F. Martelli, F. Grignani, and M. C. Mingari. 1989. Lymphokine production by T-cell clones after human bone marrow transplantation. Blood 74:1665.
10. Ghayur, T., T. A. Seemayer, P. A. L. Kongshavn, J. G. Gartner, and W. S. Lapp. 1987. Graft-versus-host reactions in the beige mouse: an investigation of the role of host and donor natural killer cells in the pathogenesis of graft-versus-host disease. Transplantation 44:261.
11. + cells of donor origin. Transplantation 45:586.
12. Mowat, A. Mcl., and M. V. Felstein. 1990. Intestinal graft-vs-host reaction. In Graft-vs-Host Disease: Immunology, Pathophysiology, and Treatment. S. J. Burakoff, H. J. Deeg, J. Ferrara, and K. Atkinson, eds. Marcel Dekker, New York, p. 205.
13. Via, C. S., S. O. Sharrow, and G. Shearer. 1987. Role of cytotoxic T lymphocytes in the prevention of lupus-like disease occurring in a murine model of graft-vs-host disease. J. Immunol. 139:1840.
14. Nestel, F. P., K. S. Price, T. A. Seemayer, and W. S. Lapp. 1992. Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor-alpha during graft-versus-host disease. J. Exp. Med. 175:405.
15. Hoffman, R. A., J. M. Langrehr, S. M. Wren, K. E. Dull, S. T. Ildstad, S. A. McCarthy, and R. L. Simmons. 1993. Characterization of the immunosuppressive effects of nitric oxide in graft-versus-host disease. J. Immunol. 151:1508.
16. Garside, P., A. K. Hutton, A. Severn, F. Y. Liew, and A. M. Mowat. 1992. Nitric oxide mediates intestinal pathology in graft-vs-host disease. Eur. J. Immunol. 22:2141.
17. Piguet, P.-F., G. E. Grau, B. Allet, and P. Vassalli. 1987. Tumour necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs-host disease. J. Exp. Med. 166:1280.
18. Chehimi, J., and G. Trinchieri. 1994. Interleukin 12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency. J. Clin. Immunol. 14:149.
19. Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor a are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
20. + T cell proliferation and cytotoxicity by natural killer cell stimulatory factor (interleukin-12). Jpn. J. Cancer Res. 85:853.
21. Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. F. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad Sci. USA 90:6115.
22. Seddik, M., T. A. Seemayer, and W. S. Lapp. 1984. The graft-versus-host reaction and immune function. I. T-helper cell immunodeficiency associated with graft-versus-host-induced thymic epithelial cell injury. Transplantation 37:281.
23. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
24. Allen, R. D., T. A. Staley, and C. L. Sidman. 1993. Differential cytokine expression in acute and chronic murine graft-versus-host-disease. Eur. J. Immunol. 23: 333.
25. Koprowski, H., Y. M. Zheng, E. Heber-Katz, N. Fraser, L. Rorke, Z. F. Fu, C. Hanlon, and B. Dietzschold. 1993. In vivo expression of inducible nitric oxide synthase in experimentally induced neurologic diseases. Proc. Natl. Acad. Sci. USA 90:3024.
26. 15N]nitrate in biological fluids. Anal. Biochem. 126:131.
27. Nestel, F. P., P. R. Casson, R. H. Wiltrout, and R. S. Kerbel. 1984. Alterations in sensitivity to nonspecific cell-mediated lysis associated with tumor progression: characterization of activated macrophage and natural killer cell resistant tumor variants. J. Natl. Cancer Inst. 73:483.
28. Kamijo, R., H. Harada, T. Matsuyama, M. Bosland, J. Gerecitano, D. Shapiro, J. Le, S. I. Koh, T. Kimura, S. J. Green, T. W. Mak, T. Taniguchi, and J. Vilcek. 1994. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science 263:1612.
29. Lorsbach, R. B., W. I. Murphy, C. J. Lowenstein, S. H. Snyder, and S. W. Russell. 1993. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. J. Biol. Chem. 268:1908.
30. Ding, A. H., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407.
31. Vodovotz, Y., N. S. Kwon, M. Pospischil, J. Manning, J. Paik, and C. Nathan. 1994. Inactivation of nitric oxide synthase after prolonged incubation of mouse macrophages with IFN-γ and bacterial lipopolysaccharide. J. Immunol. 152:4110.
32. Farrar, M. A., and R. D. Schreiber. 1993. The molecular cell biology of interferon-γ and its receptor. Annu. Rev. Immunol. 11:571.
33. Seemayer, T. A., W. S. Lapp, and R. P. Bolande. 1977. Thymic involution in murine graft-versus-host reaction. Am. J. Pathol. 88:119.
34. Sato, K., K. Miyakawa, M. Takeya, R. Hattori, Y. Yui, M. Sunamoto, Y. Ichimori, Y. Ushio, and K. Takahashi. 1995. Immunohistochemical expression of inducible nitric oxide synthase (iNOS) in reversible endotoxic shock studied by a novel monoclonal antibody against rat iNOS. J. Leukocyte Biol. 57:36.
35. d (endotoxin resistance) phenotype. J. Exp. Med. 164:1791.
36. Niederwieser, D., M. Herold, W. Woloszczuk, W. Aulitzky, B. Meister, H. Tilg, G. Gastl, R. Bowden, and C. Huber. 1990. Endogenous IFN-gamma during human bone marrow transplantation: analysis of serum levels of interferon and interferon-dependent secondary messages. Transplantation 50:620.
37. Levy, R. B., M. Jones, and C. Cray. 1990. Isolated peripheral T cells from GVHR recipients exhibit defective IL-2R expression, IL-2 production, and proliferation in response to activation stimuli. J. Immunol. 145:3998.
38. Tsoi, M. S., T. Mori, S. Brikic, S. Dobbs, S. Gillis, E. Santos, E. D. Thomas, and R. Storb. 1984. Ineffective cellular interaction and interleukin 2 deficiency causing T cell defects in human allogeneic marrow recipients early after grafting and in those with chronic graft-versus-host disease. Transplant. Proc. 16:1470.
39. Klingemann, H. G., F. R. Kohn, and G. L. Phillips. 1991. Proliferation of peripheral lymphocytes to interleukin 2 and interleukin 4 after marrow transplantation. Eur. Cytokine Netw. 2:131.
40. fyn are reduced by a glucocorticoid-dependent mechanism in graft-versus-host reaction-induced T cell anergy. Cell. Immunol. 163:10.
41. Imammura, M., S. Hashino, H. Kobayashi, S. Kobayashi, S. Hirano, T. Minagawa, J. Tanaka, Y. Fujji, M. Kobayashi, M. Kasal, K. Sakurada, and T. Miyazaki. 1994. Serum cytokine levels in bone marrow transplantation: synergistic interaction of interleukin-6, interferon-γ, and tumor necrosis factor-α in graft-versus-host disease. Bone Marrow Transplant. 13:745.
42. Kennedy, M. K., D. S. Torrence, K. S. Picha, and K. M. Mohler. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:2496.
43. Raine, C. S. 1994. The Dale E. McFarlin memorial lecture: the immunology of multiple sclerosis. Ann. Neurol. 36(Suppl.):S61.
44. Fowler, D. H., K. Kurasawa, A. Husebekk, P. A. Cohen, and R. E. Gress. 1994. Cells of Th2 cytokines phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. J. Immunol. 152:1004.
45. Via, C. S., V. Rus, M. K. Gately, and F. D. Finkelman. 1994. IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease. J. Immunol. 153:4040.
46. D'Andrea, A., X. Ma, M. Aste-Amezaga, C. Paganin, and G. Trinchieri. 1995. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor a production. J. Exp. Med. 181:537.
47. van der Poun Kroan, T. C., L. C. Boeije, R. J. Smeenk, J. Wiojdenes, and L. A. Aorden. 1995. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:795.
48. Lapp, W. S., M. Mendes, H. Kirchner, and D. Gemsa. 1980. Prostaglandin synthesis by lymphoid tissue of mice experiencing a graft-versus-host reaction: relationship to immunosuppression. Cell. Immnunol. 50:271.
49. Baker, K. S., R. D. Allen, T. B. Roths, and C. L. Sidman. 1995. Kinetics and organ specific patterns of cytokine expression in acute graft-versus-host disease Bone Marrow Transplant. 15:595.
50. Matsudaira, T., H. Koda, S. Okamoto, K. Tani, A. Tojo, K. Osawa, K. Asano, and S. Asano. 1992. The allogeneic-specific immunosuppressive activity of estradiol-chlorambucil conjugate (KM2210) and its beneficial effect on allogeneic bone marrow transplantation in mice. Transplantation 54:676.
51. Heinzel, F., R. M. Rerko, P. Ling, J. Hakim, and D. S. Schoenhaut. 1994. Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect. Immun. 62:4244.
52. Ozmen, L., M. Pericin, J. Hakimi, R. A. Chizzonite, M. Wysocka, G. Trinchieri, M. Gately, and G. Garotta. 1994. Interleukin 12, interferon γ and tumor necrosis factor α are the key cytokines of the generalized Schwartzman reaction. J. Exp. Med. 180:907.