Micro- and nano-fabricated implantable drug-delivery systems

Therapeutic Delivery

Volumn 3, Issue 12, 2012, Pages 1457-1467

  Meng, Ellis ^a   Hoang, Tuan ^a  

^a University of Southern California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCETAXEL; EXENDIN 4; LEUPRORELIN; SUFENTANIL; VASOPRESSIN;

ACTIVE DRUG RESERVOIR; CHEMICAL MODIFICATION; CHRONIC PAIN; CLINICAL PRACTICE; CONTROLLED DRUG RELEASE; DIABETIC RETINOPATHY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG INFUSION; ELECTROCHEMICAL MICROPUMP; ELECTROSTATIC MICROPUMP; HUMAN; IMPLANTABLE DRUG DELIVERY SYSTEM; INFUSION MICROPUMP; INFUSION PUMP; MICROFLUIDICS; MICROTECHNOLOGY; NANOTECHNOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OSMOSIS; OSMOTIC MICROPUMP; PASSIVE DIFFUSION; PASSIVE DRUG RESERVOIR; PASSIVE MICROPUMP; PIZOELECTRIC MICROPUMP; PRIORITY JOURNAL; PROSTATE CANCER; RESERVOIR; RESERVOIR BASED DRUG DELIVERY SYSTEM; REVIEW; SPRING POWERED MICROPUMP; SURFACE MODIFICATION; THERMAL MICROPUMP;

EID: 84870719200     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.12.132     Document Type: Review

References (83)

1. Frost and Sullivan. Growth Opportunities in the Drug Discovery and Diagnostic Technologies Market (2006).
2. Kalorama Research. Drug Delivery Markets. (2009).
3. Lawson EF, Wallace MS. Advances in intrathecal drug delivery. Curr. Opin Anaesthesiol. 25(5), 572-576 (2012).
4. Pasquier E, Kavallaris M, Andre N. Metronomic chemotherapy: new rationale for new directions. Nat. Rev. Clin. Oncol. 7(8), 455-465 (2010).
5. Maas J, Kamm W, Hauck G. An integrated early formulation strategy-from hit evaluation to preclinical candidate profiling. Eur. J. Pharm. Biopharm. 66(1), 1-10 (2007).
6. Neervannan S. Preclinical formulations for discovery and toxicology: physicochemical challenges. Expert Opin. Drug Metab. Toxicol. 2(5), 715-731 (2006).
7. Turner PV, Brabb T, Pekow C, Vasbinder MA. Administration of substances to laboratory animals: routes of administration and factors to consider. J. Am. Assoc. Lab. Anim. Sci. 50(5), 600-613 (2011).
8. Turner PV, Pekow C, Vasbinder MA, Brabb T. Administration of substances to laboratory animals: equipment considerations, vehicle selection, and solute preparation. J. Am. Assoc. Lab. Anim. Sci. 50(5), 614-627 (2011).
9. Tan T, Watts SW, Davis RP. Drug delivery: enabling technology for drug discovery and development. iPRECIO® micro infusion pump: programmable, refillable and implantable. Front. Pharmacol. 2(44), (2011).
10. Paolino D, Sinha P, Fresta M, Ferrari M. Drug delivery systems. In: Encyclopedia of Medical Devices and Instrumentation (2nd Edition). Webster JG (Ed.). John Wiley & Sons, Inc., Hoboken, NJ, USA (2006).
11. Fisher DM, Kellet N, Lenhardt R. Pharmacokinetics of an implanted osmotic pump delivering sufentanil for the treatment of chronic pain. Anesthesiology 99(4), 929-937 (2003).
12. Desai TA, Hansford D, Ferrari M. Characterization of micromachined silicon membranes for immunoisolation and bioseparation applications. J. Memb. Sci. 159(1-2), 221-231 (1999).
13. Desai TA, Hansford DJ, Kulinsky L et al. Nanopore technology for biomedical applications. Biomed. Microdevices 2(1), 11-40 (1999).
14. Leoni L, Boiarski A, Desai TA. Characterization of nanoporous membranes for immunoisolation: diffusion properties and tissue effects. Biomed. Microdevices 4(2), 131-139 (2002).
15. Azam A, Laflin KE, Jamal M, Fernandes R, Gracias DH. Self-folding micropatterned polymeric containers. Biomed. Microdevices 13(1), 51-58 (2011).
16. Santini JT, Cima MJ, Langer R. A controlled-release microchip. Nature 397(6717), 335-338 (1999).
17. Santini JT Jr, Richards AC, Scheidt RA, Cima MJ, Langer RS. Microchip technology in drug delivery. Ann. Med. 32(6), 377-379 (2000).
18. Maloney JM, Uhland SA, Polito BF, Sheppard NF Jr, Pelta CM, Santini JT Jr. Electrothermally activated microchips for implantable drug delivery and biosensing. J. Control. Release 109(1-3), 244-255 (2005).
19. Prescott JH, Lipka S, Baldwin S et al. Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device. Nat. Biotechnol. 24(4), 437-438 (2006).
20. Farra R, Sheppard NF Jr, Mccabe L et al. First-in-human testing of a wirelessly controlled drug delivery microchip. Sci. Transl. Med. 4(122), 122ra121 (2012).
21. Rahimi S, Sarraf EH, Wong GK, Takahata K. Implantable drug delivery device using frequency-controlled wireless hydrogel microvalves. Biomed. Microdevices. 13(2), 267-277 (2011).
22. Ahmed A, Bonner C, Desai TA. Bioadhesive microdevices with multiple reservoirs: a new platform for oral drug delivery. J. Control. Release 81(3), 291-306 (2002).
23. Richards Grayson AC, Choi IS, Tyler BM et al. Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat. Mater. 2(11), 767-772 (2003).
24. Richards Grayson AC, Cima MJ, Langer R. Molecular release from a polymeric microreservoir device: influence of chemistry, polymer swelling, and loading on device performance. J. Biomed. Mater. Res. A 69(3), 502-512 (2004).
25. Chung AJ, Huh YS, Erickson D. A robust, electrochemically driven microwell drug delivery system for controlled vasopressin release. Biomed. Microdevices 11(4), 861-867 (2009).
26. Elman NM, Ho Duc HL, Cima MJ. An implantable MEMS drug delivery device for rapid delivery in ambulatory emergency care. Biomed. Microdevices 11(3), 625-631 (2009).
27. Li PY, Givrad TK, Holschneider DP, Maarek JM, Meng E. A Parylene MEMS electrothermal valve. J. Microelectromech. Syst. 18(6), 1184-1197 (2009).
28. Li PY, Givrad TK, Sheybani R, Holschneider DP, Maarek JMI, Meng E. A low power, on demand electrothermal valve for wireless drug delivery applications. Lab Chip 10(1), 101-110 (2010).
29. Pirmoradi FN, Jackson JK, Burt HM, Chiao M. On-demand controlled release of docetaxel from a battery-less MEMS drug delivery device. Lab Chip 11(16), 2744-2752 (2011).
30. Su YC, Lin LW. A water-powered micro drug delivery system. J. Microelectromech. Syst. 13(1), 75-82 (2004).
31. Su YC, Lin LW, Pisano AP. A water-powered osmotic microactuator. J. Microelectromech. Syst. 11(6), 736-742 (2002).
32. Li YH, Su YC. Miniature osmotic actuators for controlled maxillofacial distraction osteogenesis. J. Micromech. Microeng. 20(6), (2010).
33. Ryu WH, Huang ZN, Prinz FB, Goodman SB, Fasching R. Biodegradable micro-osmotic pump for long-term and controlled release of basic fibroblast growth factor. J. Control. Release 124(1-2), 98-105 (2007).
34. Evans AT, Chiravuri S, Gianchandani YB. Transdermal power transfer for recharging implanted drug delivery devices via the refill port. Biomed. Microdevices 12(2), 179-185 (2010).
35. Evans AT, Chiravuri S, Gianchandani YB. A multidrug delivery system using a piezoelectrically actuated silicon valve manifold with embedded sensors. J. Microelectromech. Syst. 20(1), 231-238 (2011).
36. Evans AT, Park JM, Chiravuri S, Gianchandani YB. A low power, microvalve regulated architecture for drug delivery systems. Biomed. Microdevices 12(1), 159-168 (2010).
37. Ackerman LL, Follett KA, Rosenquist RW. Long-term outcomes during treatment of chronic pain with intrathecal clonidine or clonidine/opioid combinations. J. Pain Symptom Manage. 26(1), 668-677 (2003).
38. Rainov NG, Heidecke V, Burkert W. Long-term intrathecal infusion of drug combinations for chronic back and leg pain. J. Pain Symptom Manage. 22(4), 862-871 (2001).
39. Yun KS, Cho IJ, Bu JU, Kim CJ, Yoon E. A surface-tension driven micropump for low-voltage and low-power operations. J. Microelectromech. Syst. 11(5), 454-461 (2002).
40. Bourouina T, Bosseboeuf A, Grandchamp JP. Design and simulation of an electrostatic micropump for drug-delivery applications. J. Micromech. Microeng. 7(3), 186-188 (1997).
41. Yih TC, Wei C, Hammad B. Modeling and characterization of a nanoliter drug-delivery MEMS micropump with circular bossed membrane. Nanomedicine 1(2), 164-175 (2005).
42. Teymoori MM, Abbaspour-Sani E. Design and simulation of a novel electrostatic peristaltic micromachined pump for drug delivery applications. Sens. Actuators. A Phys. 117(2), 222-229 (2005).
43. Lin Q, Yang BZ, Xie J, Tai YC. Dynamic simulation of a peristaltic micropump considering coupled fluid flow and structural motion. J. Micromech. Microeng. 17(2), 220-228 (2007).
44. Xie J, Shih J, Lin QA, Yang BZ, Tai YC. Surface micromachined electrostatically actuated micro peristaltic pump. Lab Chip 4(5), 495-501 (2004).
45. Schneeberger N, Allendes R, Bianchi F et al. Drug delivery micropump with built-in monitoring. Procedia Chemistry 1(1), 1339-1342 (2009).
46. Esashi M, Shoji S, Nakano A. Normally closed microvalve and micropump fabricated on a silicon wafer. Sens. Actuators. 20(1-2), 163-169 (1989).
47. Maillefer D, Van Lintel H, Rey-Mermet G, Hirschi R. A high-performance silicon micropump for an implantable drug delivery system. Presented at: Micro Electro Mechanical Systems 1999. Orlando, FL, USA, 17-21 January 1999.
48. Mescher M, Abe T, Brunett B, Metla H, Schlesinger TE, Reed M. Piezoelectric lead-zirconate-titanate actuator films for microelectromechanical system applications. Presented at: Micro Electro Mechanical Systems 1995. Amsterdam, The Netherlands, 29 January - 2 February 1995.
49. Cao L, Mantell S, Polla D. Design and simulation of an implantable medical drug delivery system using microelectromechanical systems technology. Sens. Actuators. A Phys. 94(1-2), 117-125 (2001).
50. Su GG, Pidaparti RM. Drug Particle delivery investigation through a valveless micropump. J. Microelectromech. Syst. 19(6), 1390-1399 (2010).
51. Su GG, Pidaparti RM. Transport of drug particles in micropumps through novel actuation. Microsyst. Technol. 16(4), 595-606 (2010).
52. Kan JW, Yang ZG, Peng TJ, Cheng GM, Wu B. Design and test of a high-performance piezoelectric micropump for drug delivery. Sens. Actuators. A Phys.121(1), 156-161 (2005).
53. Cui QF, Liu CL, Zha XF. Study on a piezoelectric micropump for the controlled drug delivery system. Microfluid. Nanofluidics 3(4), 377-390 (2007).
54. Geipel A, Goldschmidtboeing F, Jantscheff P, Esser N, Massing U, Woias P. Design of an implantable active microport system for patient specific drug release. Biomed. Microdevices 10(4), 469-478 (2008).
55. Geipel A, Goldschmidtoing F, Doll A et al. An implantable active microport based on a self-priming high-performance two-stage micropump. Sens. Actuators. A. Phys. 145, 414-422 (2008).
56. Li PY, Sheybani R, Gutierrez C, Kuo JTW, Meng E. A parylene bellows electrochemical actuator. J. Microelectromech. Syst. 19, 215-228 (2010).
57. Li PY, Shih J, Lo R et al. An electrochemical intraocular drug delivery device. Sensors and Actuators A Phys. 143(1), 41-48 (2008).
58. Saati S, Lo R, Li PY, Meng E, Varma R, Humayun MS. Mini drug pump for ophthalmic use. Trans. Am. Ophthalmol. Soc. 107, 60-71 (2009).
59. Saati S, Lo R, Li PY, Meng E, Varma R, Humayun MS. Mini drug pump for ophthalmic use. Curr. Eye Res. 35(3), 192-201 (2010).
60. Gensler H, Sheybani R, Li PY, Lo Mann R, Meng E. An implantable MEMS micropump system for drug delivery in small animals. Biomed. Microdevices 14(3), 483-496 (2012).
61. Gensler H, Sheybani R, Li Py et al. Implantable mems drug delivery devices for cancer radiation reduction. Presented at: MEMS 2010. Hong Kong, China, 24-28 January 2010.
62. Sheybani R, Gensler H, Meng E. Rapid and repeatable bolus drug delivery enabled by high efficiency electrochemical bellows actuators. Presented at: Transducers 2011. Beijing, China, 5-9 June 2011.
63. Sheybani R, Meng E. High efficiency wireless electrochemical actuators: design, fabrication and characterization by electrochemical impedance spectroscopy. Presented at: Micro Electro Mechanical Systems 2011. Cancun, Mexico, 23-27 January 2011.
64. Sheybani R, Meng E. High Efficiency MEMS Electrochemical actuators and electrochemical impedance spectroscopy characterization. J. Microelectromech. Syst., 21(5), 1197-1208 (2012).
65. Jeong OC, Tang SS. Fabrication of a thermopneumatic microactuator with a corrugated p + silicon diaphragm. Sens. Actuators. 80(1), 62-67 (2000).
66. Ha S-M, Cho W, Ahn Y. Disposable thermo-pneumatic micropump for bio lab-on-a-chip application. Microelectron. Eng. 86(4-6), 1337-1339 (2009).
67. Mousoulis C, Ochoa M, Papageorgiou D, Ziaie B. A skin-contact-actuated micropump for transdermal drug delivery. Biomed. Eng. 58(5), 1492-1498 (2011).
68. Cooney CG, Towe BC. A thermopneumatic dispensing micropump. Sens. Actuators. A Phys. 116(3), 519-524 (2004).
69. Spieth S, Schumacher A, Holtzman T et al. An intra-cerebral drug delivery system for freely moving animals. Biomed. Microdevices 14(5), 799-809(2012).
70. Benard WL, Kahn H, Heuer AH, Huff MA. Thin-film shape-memory alloy actuated micropumps. J. Microelectromech. Syst. 7(2), 245-251 (1998).
71. Reynaerts D, Peirs J, Vanbrussel H. An implantable drug-delivery system based on shape memory alloy micro-actuation. Sens. Actuators. A Phys. 61(1-3), 455-462 (1997).
72. Woias P. Micropumps - past, progress and future prospects. Sens. Actuators. B Chem. 105(1), 28-38 (2005).
73. Tsai NC, Sue CY. Review of MEMS-based drug delivery and dosing systems. Sens. Actuators. A Phys. 134(2), 555-564 (2007).
74. Amirouche F, Zhou Y, Johnson T. Current micropump technologies and their biomedical applications. Microsyst. Technol. 15(5), 647-666 (2009).
75. Laser DJ, Santiago JG. A review of micropumps. J. Micromech. Microeng. 14(6), R35-R64 (2004).
76. Madou MJ. Fundamentals of microfabrication and nanotechnology. In: Solid-State Physics, Fluidics, and Analytical Techniques in Micro-and Nanotechnology (3rd edition). CRC Press, Boca Raton, FL, USA (2011).
77. Ameri H, Chader GJ, Kim JG, Sadda SR, Rao NA, Humayun MS. The effects of intravitreous bevacizumab on retinal neovascular membrane and normal capillaries in rabbits. Invest. Ophthalmol. Vis. Sci. 48(12), 5708-5715 (2007).
78. Saati S, Agrawal RN, Louie S, Chader GJ, Humayun MS. Effect of multiple injections of small divided doses vs single injection of intravitreal bevacizumab on retinal neovascular model in rabbits. Graefes. Arch. Clin. Exp. Ophthalmol. 248(4), 457-466 (2009).
79. Samel B, Griss P, Stemme G. A thermally responsive PDMS composite and its microfluidic applications. J. Microelectromech. Syst. 16(1), 50-57 (2007).
80. Alzet® Osmotic pumps. www.alzet.com
81. Intarcia therapeutic, Inc. www.intarcia.com
82. Spring: simple and clever diabetes solutions. www.springnow.com/insulin- pumps.html
83. Debiotech, Switzerland. www.debiotech.com